@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5A1_HUMAN: (2016-01-13 )
MSITKAWNSSSVTMFILLGFTDHPELQALLFVTFLGIYLTTLAWNLALIFLIRGDTHLHTPMYFFLSNLSFIDICYSSAVAPNMLTDFFWEQKTISFVGCAAQFFFFVGMGLSECLLLTAMAYDRYAAISSPLLYPTIMTQGLCTRMVVGAYVGGFLSSLIQASSIFRLHFCGPNIINHFFCDLPPVLALSCSDTFLSQVVNFLVVVTVGGTSFLQLLISYGYIVSAVLKIPSAEGRWKACNTCASHLMVVTLLFGTALFVYLRPSSSYLLGRDKVVSVFYSLVIPMLNPLIYSLRNKEIKDALWKVLERKKVFS
Atome Classification :
(20 SA)
--------.........10........20--.--.......30....-----.---...40........50---........60........70......----..80.-.......----.-90........100.......110.......120.......130......---.140.......150.......160.......170.......180.......190-------.-------....--..200.......210.......220.......230.------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------..----...240.......250.......260.......------------270----------.---.---...-------....280.......290.......300......-------------------.310...--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------M
S
I
T
KAWNSS
S
V
T
M
F
I
L
LGFT--D--
H
P
E
L
Q
A
L
L
F
V
T
F
L
-----
G
---
I
Y
L
T
T
L
A
W
N
L
A
L
I
F
L
---
I
RGDTHLH
T
P
M
Y
F
F
L
SNL
S
F
I
D
I
C
YS----SAV-
A
-
P
N
M
L
T
D
F
----
F
-WEQ
K
T
I
S
F
V
G
C
A
A
Q
F
F
F
F
V
G
M
G
L
S
E
C
L
L
L
T
A
M
A
Y
D
R
Y
AAISSPL
L
Y
P
T
I
---
M
T
Q
G
L
C
T
R
M
V
V
G
A
Y
V
G
G
F
L
S
S
L
I
Q
AS
S
I
F
R
L
HFC
G
P
N
I
I
N
H
F
F
CDLP
P
V
L
A
LSC-------
S
-------
D
T
F
L
--
S
Q
V
V
N
F
L
V
V
V
T
VG
G
T
S
F
L
Q
L
L
I
S
Y
G
Y
I
V
S
A
V
L
KIPS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------EG----R
W
K
A
C
N
T
C
A
S
H
L
M
V
V
T
L
L
F
G
T
A
L
F
V
Y
LRPSSSY------------L------------L---G---
R
D
K
-------
V
V
S
V
F
Y
S
L
V
I
P
M
L
N
P
L
I
Y
S
LRN
K
E
I
K
D
A
L
W
K
V
L
-------------------
E
R
K
KVFS--------------
49
HHSearch
89.83
18%
-141
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------
P
L
V
V
V
L
S
-----
T
---
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
---
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
----
A
V
V
-
M
-
P
M
N
I
L
Y
L
----
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
N
H
--------
R
R
E
D
K
C
E
T
D
F
Y
D
-------------------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
----
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
------------
N
CC----------
N
---
E
---
H
L
H
-------
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
-------------------
H
I
-------------------
65
Fugue
88.73
15%
-124
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
--
Y
LA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
-----
L
---
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
---
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
-
T
T
T
L
Y
T
S
----
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-----------------
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
------------
F
------------
T
---
H
---
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------------------
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A
48
HHSearch
87.86
18%
-139
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------------------------
V
V
G
M
G
I
V
M
S
-----
L
---
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
---
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
----
L
A
V
-
V
-
P
F
G
A
A
H
I
----
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
----
H
Q
E
A
I
N
C
Y
A
E
----
E
T
C
-------
C
-------
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF-
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
----
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
NL----------
I
------------
R
---
K
---
E
V
Y
-------
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
-------------------
C
L
-------------------
52
HHSearch
87.49
17%
-146
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-470]
--------------------------------------
S
S
V
Y
I
T
V
E
L
-----
A
---
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
---
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
----
V
L
A
-
I
-
P
F
A
I
T
I
S
----
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
---
V
A
C
-------
L
-------
F
E
D
V
VP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
----
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
DCSH--------
A
------------
P
---
L
---
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-------------------
R
S
H
V
L
R
Q
--------------
53
HHSearch
86.78
16%
-134
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-333]
------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
-----
I
---
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
---
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
----
L
V
N
G
F
-
P
L
M
T
I
S
C
----
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
----
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
-------------------
D
S
T
--
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
----
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
LEW---------
V
------------
T
---
P
---
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
-------------------
P
W
V
L
T
C
C
--------------
46
HHSearch
84.94
16%
-141
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
---------------------------------------
V
F
I
V
L
V
A
G
-----
S
---
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
---
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
----
V
F
S
-
M
-
N
L
Y
T
L
Y
T
----
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
--
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
F
-----------------------
S
--
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
----
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
PC----------
I
------------
P
---
N
---
T
V
W
-------
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
-------------------
M
--------------------
57
HHSearch
80.07
16%
-140
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-325]
---------------------------------------
V
L
W
A
A
A
Y
T
-----
V
---
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
---
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
----
A
F
N
-
T
-
V
V
N
F
T
Y
A
----
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-----
E
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
N
-----------------
K
I
Y
--
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
----
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
------------
D
------------
L
YLK
K
FI
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
-------------------
R
C
C
P
F
I
S
--------------
66
Fugue
78.32
15%
-114
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
YL
A
--
E
P
W
Q
F
S
M
L
A
A
Y
M
F
-----
L
---
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
---
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
-
T
T
T
L
Y
T
S
----
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
------------------
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
ESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
------------
F
------------
T
---
H
---
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A-------------
54
HHSearch
77.64
18%
-133
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
------------------------------------
N
S
I
K
L
T
S
V
V
F
I
-----
L
---
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
---
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
----
V
A
Y
-
T
-
A
N
L
L
L
S
G
----
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
-------
I
S
A
L
S
S
C
S
T
V
L
P
L
-------------------------
Y
H
K
H
Y
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
----
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
------------
V
KTC
D
--------
I
---
L
---
F
R
A
-------
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
-------------------
G
R
P
L
-----------------
55
HHSearch
77.54
17%
-143
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------
Y
A
L
S
Y
C
-----
A
---
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
---
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
----
T
L
V
-
M
-
P
W
V
V
Y
L
E
----
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
-------
T
G
D
P
T
V
C
S
I
S
N
------------------------
P
--
D
--
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
----
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
TCH---------
V
------------
S
---
P
---
E
L
Y
-------
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
-------------------
S
C
-------------------
56
HHSearch
73.77
14%
-123
- C3 -
1U19
14
OPSD_BOVIN
A:
[40-327]
--------------------------------------
F
S
M
L
A
A
Y
M
F
-----
L
---
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
---
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
-
T
T
T
L
Y
T
S
----
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
----
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
-----------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
GSD---------
F
------------
G
---
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------------------
C
C
G
K
N
P
L
--------------
58
HHSearch
73.52
16%
-127
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
-------------------------------------
N
K
Y
V
V
I
I
A
Y
A
-----
L
---
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
---
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
----
L
T
--
L
-
P
I
W
A
A
S
K
------
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
----
Y
H
P
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
------------------
T
A
K
W
--
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
----
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
------------
T
QVIQE
S
C
E
R
R
N
N
I
---
G
---
R
A
L
-------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
-------------------
A
M
H
G
-----------------
47
HHSearch
71.77
16%
-126
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-497]
------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
-----
I
---
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
---
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-----
I
T
-
L
-
P
F
W
A
V
D
A
----
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
-----
S
E
A
D
D
R
Y
I
C
D
R
F
Y
P
N
D
--------------------
L
W
--
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
----
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
------------
V
---
H
---
K
W
I
-------
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
-------------------
T
S
G
R
P
L
E
--------------
6
PsiBlast_PDB
56.91
23%
-159
- C3 -
4MQT
2
ACM2_HUMAN
A:
[36-170]
---------------------------------------
K
T
F
E
V
V
F
I
V
L
V
A
G
S
---
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
---
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
-----
V
F
-
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
-
W
P
---
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
F
S
N
A
A
V
T
F
-------
G
-------
T
A
I
A
--
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
----
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
------------
Y
------------
I
---
N
---
S
T
I
-------
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
C
---------------------------------------------------
5
PsiBlast_PDB
55.40
23%
-156
- C3 -
4MQS
1
?
A:
[36-170]
---------------------------------------
K
T
F
E
V
V
F
I
V
L
V
A
G
S
---
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
---
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
-----
V
F
-
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
-
W
P
---
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
F
S
N
A
A
V
T
F
-------
G
-------
T
A
I
A
--
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
P
P
P
S
R
E
K
K
V
T
R
T
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
----
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
I
P
N
T
V
W
T
I
G
Y
------------
W
------------
L
---
C
---
Y
I
N
-------
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------------------
8
PsiBlast_PDB
54.03
23%
-153
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[35-153]
----------------------------------------------------------
L
V
T
I
I
G
N
I
L
V
M
V
S
---
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
-----
V
F
-
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
-
W
P
---
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
F
S
N
A
A
V
T
F
-------
G
-------
T
A
I
A
--
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
E
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
----
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
------------
I
------------
G
---
R
---
N
T
N
-------
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
-------------------
D
S
L
D
A
V
R
--------------
9
PsiBlast_PDB
49.20
23%
-117
- C3 -
2Z73
3
OPSD_TODPA
A:
[57-157]
---------------------------------------------------------------------
Y
L
---
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
----
L
V
N
-
G
F
P
L
M
T
I
S
C
----
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
N
-------
I
-------
L
C
M
F
--
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
E
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
------------
A
------------
V
---
V
---
A
L
L
-------
A
Q
F
G
P
L
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
-------------------
V
S
H
P
K
F
R
--------------
10
PsiBlast_PDB
49.12
23%
-115
- C3 -
3AYM
3
OPSD_TODPA
A:
[57-157]
---------------------------------------------------------------------
Y
L
---
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
----
L
V
N
-
G
F
P
L
M
T
I
S
C
----
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
N
-------
I
-------
L
C
M
F
--
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
E
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
------------
A
------------
V
---
V
---
A
L
L
-------
A
Q
F
G
P
L
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
-------------------
V
S
H
P
K
F
R
--------------
12
PsiBlast_PDB
49.06
23%
-115
- C3 -
2ZIY
1
OPSD_TODPA
A:
[56-156]
---------------------------------------------------------------------
Y
L
---
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
----
L
V
N
-
G
F
P
L
M
T
I
S
C
----
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
T
T
R
S
N
-------
I
-------
L
C
M
F
--
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
----
E
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
------------
A
------------
V
---
V
---
A
L
L
-------
A
Q
F
G
P
L
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
-------------------
V
S
H
P
K
F
R
--------------
4
PsiBlast_PDB
49.06
27%
-142
- C3 -
4WZ9
1
?
A:
[640-758]
---------------------------------------
A
L
R
F
M
T
Y
L
-----
R
NER
E
Y
A
P
W
T
A
A
N
V
A
L
T
Y
F
N
N
R
L
R
G
T
A
E
Y
H
N
---
F
L
I
F
V
D
A
L
I
E
D
I
Y
S
LLTI
D
A
V
-
S
-
P
D
D
T
L
L
H
----
K
-
Y
L
V
Q
T
I
S
T
W
A
C
S
--------
M
G
Y
T
D
C
L
M
K
T
A
A
L
L
K
A
E
A
S
G
T
G
P
A
V
H
P
D
I
---
A
S
V
T
Y
C
Y
G
M
R
S
A
L
E
S
E
F
Q
Y
L
Y
R
K
M
M
N
S
K
N
L
A
E
R
T
M
L
I
D
S
L
G
C
S
N
N
K
E
F
L
K
A
F
L
T
-------
T
-------
A
L
G
S
--
I
N
Y
R
A
D
E
R
R
R
V
V
Q
A
I
Y
S
G
G
R
T
G
V
D
A
L
I
E
F
L
M
D
P
A
L
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
----
V
S
T
L
S
T
S
T
L
N
S
A
L
S
A
I
A
S
R
T
N
N
V
E
E
M
N
K
L
N
A
L
I
------------
T
------------
A
---
L
---
G
S
R
-------
V
N
S
Q
T
A
A
N
L
R
T
T
A
Q
A
N
L
D
W
V
N
G
F
E
G
L
M
L
S
N
F
L
A
-------------------
E
A
-------------------