@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5DE_HUMAN: (2016-01-13 )
MMMVLRNLSMEPTFALLGFTDYPKLQIPLFLVFLLMYVITVVGNLGMIIIIKINPKFHTPMYFFLSHLSFVDFCYSSIVTPKLLENLVMADKSIFYFSCMMQYFLSCTAVVTESFLLAVMAYDRFVAICNPLLYTVAMSQRLCALLVAGSYLWGMFGPLVLLCYALRLNFSGPNVINHFFCEYTALISVSGSDILIPHLLLFSFATFNEMCTLLIILTSYVFIFVTVLKIRSVSGRHKAFSTWASHLTSITIFHGTILFLYCVPNSKNSRQTVKVASVFYTVVNPMLNPLIYSLRNKDVKDAFWKLIHTQVPFH
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........---10.....-...20........30...--.-....40........50........60........70......----..-80.......-.90......-..100....-----...110.......120.......--130.....---..140.......150.--...---...160-------.........170.......180---.......190..-.--....200-------........210...-------....220.......230------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------......240.......250-----.......260.....------------.---.------------270..-----------....--.280.......290.......300......--------------------.310..----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
M
M
V
LRNLS---MEP
T
F
A
L
-LGFTDYPKL
Q
I
P
L
F
L
V
F
L
--
L
-
M
Y
V
I
T
V
VGNL
G
M
I
I
I
I
K
INPKFH
T
P
M
Y
F
F
L
S
H
L
S
F
V
D
F
C
Y
S
S----IV-
T
P
K
L
L
E
N
L
V
-
M
ADK
S
I
F
Y
F
-
S
C
M
M
Q
Y
F
L
S
-----
C
T
A
V
V
T
E
S
F
L
L
A
V
M
A
Y
D
R
F
V
A
I
C
--
N
P
L
L
Y
T
V
A
---
M
S
Q
R
L
C
A
L
L
V
A
G
S
Y
L
W
--
G
M
F
---
G
P
L
V
---------
L
L
C
Y
A
L
RLNFSG
P
N
V
I
N
H
F
F
C
E
---
Y
T
A
L
I
S
VSGS
D
I
-
L
--
I
P
H
L
L
L
--------
F
S
F
A
T
F
N
E
M
C
T
L
L
I
-------
I
L
T
S
Y
V
F
I
F
V
T
V
L
K
I
RS------------------------------------------------------------------------------------------------------------------------------------------------------------------V-------------------------------------------------------------------------------------------------------------------------------------------------------------------SG
R
H
K
A
F
S
T
W
A
S
HL
T
S
I
T
I
-----FH
G
T
I
L
F
L
Y
C
VPNSK------------N---S------------
R
Q
T
V
K
-----------
V
A
S
V
--
F
Y
T
V
V
N
P
M
L
N
P
L
I
Y
S
L
RNK
D
V
K
D
A
F
W
K
L
I
H--------------------TQVPFH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
89.38
19%
-145
* C5 *
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
--
T
-
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
----
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
-
L
C
L
F
W
L
S
M
D
-----
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
--
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
--
S
F
L
---
W
V
I
P
---------
I
L
G
-
W
N
H
--------
R
R
E
D
K
C
E
---
T
D
F
Y
D
------------
V
T
W
F
K
--------
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
-------
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
-----
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
------------
K
NC-
C
------------
N
E
H
L
H
-----------
M
F
T
I
--
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
--------------------
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
86.96
19%
-143
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
--
L
-
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
----
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
-
W
C
E
F
W
T
S
I
D
-----
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
--
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
--
S
G
L
---
T
S
F
L
---------
P
I
Q
M
H
W
Y
-
R
A
---
T
H
Q
E
A
I
N
C
Y
---
A
E
E
----
T
C
C
D
F
-
F
--
T
N
Q
A
Y
A
--------
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
-------
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
-----
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
------------
D
NL-
I
------------
R
K
E
V
Y
-----------
I
L
L
N
--
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
--------------------
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
83.92
18%
-141
- C5 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
A
A
A
Y
T
--
V
-
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
----
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
-
Y
C
K
F
H
N
F
F
P
-----
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
--
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
--
A
L
L
---
L
A
F
P
---------
Q
G
Y
Y
S
-
T
----
T
E
T
M
P
S
R
V
V
C
M
---
I
E
W
P
E
H
P
---
N
K
-
I
--
Y
E
K
V
Y
H
--------
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
-------
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
-----
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
------------
P
---
D
LYLKKF------
I
Q
Q
V
Y
-----------
L
A
I
M
--
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
--------------------
C
C
P
F
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
81.64
14%
-143
- C5 -
2Z73
5
OPSD_TODPA
A:
[32-333]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
--
I
-
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
----
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
-
A
C
K
V
Y
G
F
I
G
-----
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
--
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
--
S
V
L
---
W
A
I
G
---------
P
I
F
G
W
G
A
----
Y
T
L
E
G
V
L
C
N
C
S
---
F
D
Y
I
S
R
-----
D
-
S
--
T
T
R
S
N
I
--------
L
C
M
F
I
L
G
F
F
G
P
I
L
I
-------
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
-----
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
------------
P
LEW
V
------------
T
P
Y
A
A
-----------
Q
L
P
V
--
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
--------------------
W
V
L
T
C
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
81.24
15%
-154
- C5 -
3EML
13
ENLYS_BPT4
A:
[21-469]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
--
A
-
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
----
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
-
G
C
L
F
I
A
C
F
V
-----
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
--
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
--
S
F
A
---
I
G
L
T
---------
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
---
E
G
Q
V
---
A
C
L
F
E
-
D
VV
P
M
N
Y
M
V
--------
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-------
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
-----
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
PDCS--------
H
---
A
------------
P
L
W
L
M
-----------
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--------------------
S
H
V
L
R
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
81.17
18%
-148
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
--
A
-
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
----
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
-
C
C
D
V
F
V
T
L
D
-----
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
--
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
--
A
F
A
---
V
S
C
P
---------
L
L
F
G
F
N
T
-------
T
G
D
P
T
V
C
S
---
I
S
N
--------------
P
D
F
-
V
--------
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
-------
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
-----
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
------------
Q
TCH
V
------------
S
P
E
L
Y
-----------
S
A
T
T
--
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
--------------------
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
80.23
17%
-146
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
--
S
-
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
----
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
-
V
C
D
L
W
L
A
L
D
-----
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
--
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
--
S
F
I
---
L
W
A
P
---------
A
I
L
F
W
Q
F
I
V
--
G
V
R
T
V
E
D
G
E
C
Y
---
I
Q
F
F
S
------------
N
A
A
V
T
--------
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
-------
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
-----
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
------------
A
PC-
I
------------
P
N
T
V
W
-----------
T
I
G
Y
--
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
78.90
18%
-143
- C5 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
I
K
L
T
S
V
V
F
I
--
L
-
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
----
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
-
Q
W
F
L
R
E
G
S
M
-----
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
--
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
--
S
L
I
---
L
G
G
L
---------
P
I
M
G
W
N
C
-------
I
S
A
L
S
S
C
S
---
T
V
L
P
L
-----------
Y
H
K
H
Y
I
--------
L
-
F
C
T
T
V
F
T
L
L
L
L
S
-------
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
-----
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
------------
K
---
V
KTC
D
--------
I
L
F
R
A
-----------
E
Y
F
L
--
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
--------------------
R
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
78.73
15%
-130
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
GVV
R
S
P
F
E
A
P
-
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
--
L
-
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
----
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
-
G
C
N
L
E
G
F
F
A
-----
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
--
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
--
A
L
A
---
C
A
A
P
---------
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
----
S
C
G
I
DY
Y
T
-----
P
H
E
E
T
-
N
--
N
E
S
F
V
I
--------
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
-------
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
------------
G
---
S
------------
D
F
G
P
I
-----------
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
--------------------
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
78.61
16%
-138
- C5 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-497]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
--
I
-
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-----
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
-
L
C
K
A
V
H
V
I
Y
-----
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
--
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
--
A
L
L
---
L
T
I
P
---------
D
F
I
F
A
N
V
-----
S
E
A
D
D
R
Y
I
C
D
---
R
F
Y
P
N
D
-------
L
--
W
V
V
V
F
Q
--------
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
-------
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
-----
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
---
T
------------
V
H
K
W
I
-----------
S
I
T
E
--
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
--------------------
S
G
R
P
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
70.67
15%
-133
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
---
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
--
L
-
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
----
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
-
G
C
N
L
E
G
F
F
A
-----
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
--
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
--
A
L
A
---
C
A
A
P
---------
P
L
V
G
W
S
R
Y
I
P
E
G
M
----
Q
C
S
C
G
I
DY
Y
T
-----
P
H
E
E
T
-
N
--
N
E
S
F
V
I
--------
Y
M
F
V
V
H
F
-
I
I
P
L
I
V
-------
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
------------
V
---
A
------------
F
Y
I
F
T
H
QGSDFGPIFM
T
I
P
A
--
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
TET
S
Q
V
A
P
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
70.48
15%
-129
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
--
L
-
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
----
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
-
L
C
K
V
V
S
L
L
K
-----
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
--
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
--
S
M
N
---
L
S
L
P
---------
F
F
L
F
R
Q
A
--
Y
--
H
P
N
N
S
S
P
V
C
Y
---
E
V
L
G
N
D
----
T
A
-
K
--
W
R
M
V
L
R
--------
I
L
P
H
T
F
G
F
I
V
P
L
F
V
-------
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
-----
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
------------
R
---
T
QVIQE
S
C
E
R
R
N
N
I
G
R
A
L
-----------
D
A
T
E
--
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
--------------------
M
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
68.84
13%
-144
- C5 -
1U19
14
OPSD_BOVIN
A:
[40-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
M
L
A
A
Y
M
F
--
L
-
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
----
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
-
G
C
N
L
E
G
F
F
A
-----
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
--
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
--
A
L
A
---
C
A
A
P
---------
P
L
V
G
W
S
R
--
Y
--
I
P
E
G
M
Q
C
S
C
G
---
I
D
Y
Y
T
P
H
---
E
E
-
T
--
N
N
E
S
F
V
--------
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
-------
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
-----
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS---------
D
---
F
------------
G
P
I
F
M
-----------
T
I
P
A
--
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
--------------------
C
G
K
N
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
62.74
12%
-152
* C4 *
1UAL
1
TRMD_HAEIN
A:
[19-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
W
I
G
V
I
S
---
L
F
P
E
M
F
K
-
A
I
T
E
F
G
------------------
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
----
K
H
K
T
V
D
D
R
P
Y
G
G
GPGM
L
M
-
M
V
Q
P
L
R
D
A
I
-
H
T
A
K
A
A
A
G
E
-
G
A
K
V
I
Y
L
S
P
-----
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
---
I
Q
T
E
I
D
E
E
W
S
I
G
D
Y
V
L
TG
G
E
L
---
P
A
M
T
---------
L
I
D
A
V
A
R
F
I
---
P
G
V
L
S
F
----------------
A
D
G
-
L
--
L
D
C
P
H
Y
--------
T
R
P
E
V
L
E
G
L
T
V
P
P
V
-------
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
-----
W
L
R
R
-------------------------------------------------------------------
P
E
L
L
E
G
L
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
H
---------------------
N
S
L
E
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.54
24%
-173
- C5 -
4IAQ
1
5HT1B_HUMAN (first)
A:
[20-142]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
L
V
M
L
L
A
--
L
-
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
----
L
V
-
M
P
I
S
T
M
Y
T
V
-
T
G
R
W
T
L
G
Q
V
-
V
C
--
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
---
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
--
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
--
S
I
S
---
I
S
L
P
---------
P
F
F
W
R
Q
A
S
E
C
V
V
N
T
D
H
I
L
Y
T
V
Y
---
S
T
V
G
A
F
Y
F
P
T
L
L
-
L
--
I
A
L
Y
G
R
--------
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
-------
N
W
E
T
L
N
D
N
L
K
V
I
N
A
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
D
-----
S
P
E
M
K
D
F
R
H
G
F
D
I
L
V
------------
G
---
Q
------------
I
D
D
A
L
-----------
K
L
A
N
--
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
L
M
A
A
--------------------
R
E
R
K
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.19
24%
-177
- C5 -
4IAR
1
C562_ECOLX
A:
[20-142]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
L
V
M
L
L
A
--
L
-
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
----
L
V
-
M
P
I
S
T
M
Y
T
V
-
T
G
R
W
T
L
G
Q
V
-
V
C
--
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
---
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
--
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
--
S
I
S
---
I
S
L
P
---------
P
F
F
W
R
Q
A
S
E
C
V
V
N
T
D
H
I
L
Y
T
V
Y
---
S
T
V
G
A
F
Y
F
P
T
L
L
-
L
--
I
A
L
Y
G
R
--------
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
-------
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
-----
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
------------
M
---
K
------------
D
F
R
H
G
-----------
F
D
I
L
--
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
--------------------
N
A
Y
I
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
56.73
20%
-71
- C2 -
4C2M
-
RPA2_YEAST
B:
[8-1203]
PGQ
A
R
T
A
D
FR
T
L
E
R
E
S
R
F
I
N
PPKDKSAF
P
L
L
Q
E
A
V
Q
P
H
I
G
S
F
N
A
L
T
EGPDGG
L
L
N
L
G
V
K
D
I
G
E
K
V
I
F
DGKPLNSNSGYL
G
N
K
L
S
V
S
V
E
Q
V
S
I
A
K
PMSNDGVSSA
V
E
R
K
V
Y
P
S
E
S
R
Q
R
LTSY
R
G
K
L
L
L
K
L
K
W
S
V
NNGE
E
N
L
F
E
V
R
DCGG
L
P
V
M
L
QSNRCHLNKMS
P
Y
E
L
V
Q
H
KEESDEIGG
Y
F
I
V
NG
I
E
K
L
I
R
M
L
I
V
Q
RRN
H
P
M
A
I
I
R
P
S
F
A
N
RGASYSH
Y
G
I
Q
I
R
S
V
R
PDQ
T
S
Q
T
N
V
L
H
Y
L
NDG
Q
V
T
F
R
F
S
W
RK
N
E
Y
L
V
P
V
V
M
I
L
K
A
L
CHTS
D
R
E
I
F
D
G
I
IGNDVKD
S
F
L
T
D
R
L
E
L
L
L
R
G
F
K
K
R
Y
PHLQN
R
T
Q
V
L
Q
Y
L
G
D
K
F
R
VVFQASPDQS
D
L
E
V
G
Q
E
V
L
D
R
IVLVHLGKDG
S
Q
D
K
F
R
M
L
L
F
M
I
R
K
L
Y
S
---
L
V
A
G
E
C
S
-
P
D
N
P
D
A
T
Q
H
Q
E
V
L
L
G
G
F
L
--
Y
G
M
I
L
K
E
K
I
D
E
Y
L
Q
N
I
I
A
Q
V
R
M
D
I
N
R
G
M
-----
A
I
N
F
K
D
K
R
Y
M
S
----
R
V
-
L
M
R
V
N
E
N
-----------
I
-
G
S
K
M
Q
Y
F
L
S
-----
T
G
N
L
V
S
Q
S
G
L
-
D
L
Q
Q
V
S
G
Y
T
V
V
A
--
E
K
I
N
F
Y
R
F
---
I
S
H
--
F
R
M
V
H
R
G
S
F
F
A
--
Q
L
K
---
T
T
T
V
RKLLPESWG
F
L
C
P
V
H
T
P
D
G
S
P
C
G
L
L
N
H
F
A
H
K
-----
C
R
I
S
T
Q
Q
S
D
V
S
R
--
I
P
S
I
L
Y
S
L
GVAPAS
H
T
F
A
A
G
P
S
L
C
C
V
Q
I
DGKII
G
W
V
S
H
E
Q
G
K
I
I
A
D
T
L
R
Y
W
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
K
T
P
G
L
P
I
D
L
E
I
G
Y
V
P
P
S
-----
T
R
G
Q
Y
P
G
L
Y
L
F
G
G
H
S
------------
R
---
M
------------
L
R
P
V
R
-----------
Y
L
P
L
--
D
K
E
D
I
V
G
P
F
E
Q
V
Y
M
N
I
A
V
T
P
Q
E
I
Q
--
N
N
V
H
--------------------
T
H
V
E
F
T
PTNILS
I
L
A
N
L
TPFSDFNQ
S
P
R
N
M
Y
Q
C
Q
M
G
K
Q
TMGTPGVALCHRSDN
K
L
Y
R
L
Q
T
G
Q
T
P
IVKA
N
L
Y
D
D
Y
GMDNFPN
G
F
N
A
VVAVISYTGYDMDD
A
M
I
I
N
K
S
A
D
E
R
GFG
Y
G
T
M
Y
K
T
E
K
V
D
LALNRNRGDPITQHFGFGNDEWPKEWLEKLDEDGLPYIG
T
Y
V
E
EGDPI
C
A
Y
F
D
DTLN
K
T
K
I
K
T
Y
H
S
S
E
P
A
Y
I
E
E
V
N
L
IGDESNKFQELQ
T
V
S
I
K
Y
R
I
R
R
T
PQIG
D
K
F
S
S
RHGQKGVCSRKWPTIDMPFSETGIQPD
I
I
I
N
PHAFPSRMT
I
G
M
F
V
E
S
L
A
G
K
A
G
A
L
HG
I
A
Q
D
STPWIFNEDDT
P
A
D
Y
F
G
E
Q
L
A
K
A
GYNYHG
N
E
P
M
Y
S
GATGEELR
A
D
I
Y
V
G
V
V
Y
Y
Q
R
L
R
HMVND
K
F
Q
V
R
STGPVNSLTMQPVKGRKRH
G
G
I
R
VG
E
M
E
R
D
A
L
I
G
H
GT
S
F
L
L
Q
D
R
LLNSSDYTQASVCRECGSILT
T
Q
Q
S
V
P
R
IG
S
I
S
T
V
C
C
RRCSMR
F
E
D
A
K
K
LIFIDDSQ
I
W
E
D
GQ
G
N
K
F
V
G
GNE
T
T
T
V
A
I
P
F
V
L
K
Y
L
D
S
E
L
S
A
M
G
I
R
L
R
Y
N
V
E
PK
15
PsiBlast_PDB
56.00
23%
-144
- C5 -
4BVN
8
ADRB1_MELGA
A:
[9-125]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
--
L
-
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
----
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
-
L
C
E
L
W
T
S
L
D
-----
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
--
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
--
S
A
L
---
V
S
F
L
---------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
---
C
C
D
F
V
T
N
R
A
Y
A
I
-
A
--
S
S
I
I
S
F
--------
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
-------
Y
R
E
A
K
E
Q
I
R
K
R
K
T
S
R
V
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
-----
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
------------
R
---
D
------------
L
V
P
K
W
-----------
L
F
V
A
--
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
R
S
P
D
F
R
K
A
F
K
R
L
L
--------------------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
55.98
20%
-154
- C5 -
4DAJ
2
ACM3_RAT (first)
A:
[13-138]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
I
A
F
L
T
G
F
-
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
----
I
S
-
M
N
L
F
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
L
-
A
C
D
L
W
L
S
I
D
-----
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
--
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
--
S
F
V
---
L
W
A
P
---------
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
E
C
F
I
Q
---
F
L
S
E
P
T
I
T
F
G
T
A
-
I
--
A
A
F
Y
M
P
--------
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
-------
T
E
K
M
N
I
F
E
M
L
R
I
D
E
G
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
-----
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
------------
I
---
G
------------
R
N
T
N
G
-----------
V
I
T
K
--
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
--------------------
L
D
A
V
R
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
55.70
25%
-166
- C5 -
2ZIY
1
OPSD_TODPA
A:
[65-170]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
----
V
N
-
G
F
P
L
M
T
I
S
C
-
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
-----
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
--
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
--
S
V
L
W
A
I
G
P
I
F
---------
G
W
G
A
Y
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
---
S
T
T
R
S
N
I
L
C
M
F
I
-
L
--
G
F
F
G
P
I
--------
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-------
S
N
H
E
K
E
M
A
A
M
A
K
R
L
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
-----
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
------------
V
---
A
------------
L
L
A
Q
F
-----------
G
P
L
E
--
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
--------------------
K
F
R
E
A
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------