@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5G3_HUMAN: (2016-01-13 )
MEDKNQTVVTEFLLLGLTDHPYQKIVLFFMFLFVYLITLGGNLGMITLIWIDPRLHTPMYFFLRHLSFVDICSSSSVVPKMLCNIFAEKKDITFLGCAAQMWFFGLFEAAECFLLAAMAYDRYVAICKPLLYTLIMSQQVCMQLVVGPYAMALISTMTHTIFTFCLPFCGSNIINHFFCDIFPLLSLACADTWVNKFVLFVLAGAIGVLSGLIIMVSYICILMTILKIQTADGKQKAFFTCFSHLAAVSILYGTLFLIYVRPSSSSSLGIYKVISLFYTVVIPMVNPLIYSLRNKEVKDAFRRKIERKKFIIGR
Atome Classification :
(20 SA)
-------------------------------.........-----10...--.....20--.........30....---------....40--...---......50.......-------.60...---------.....70......-.---------------.-----80.....-...90----...-.....100--.......110------........-----.-120.......130...---....140.....--..150....----...160.......170..----------------------.....180..-.....190-----...--.....--.200--.......210..----.....220.......230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------........240.......250---------.......260..---.------------.---.------------..-------270-----------.......280----------.......290....---...300.......310..------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------MEDK
N
Q
T
V
V
-----
T
E
F
L
L
--LGLTDH---
P
Y
Q
K
I
V
L
F
F
M
F
L
F
V
Y
---------
L
I
TLG---GNL---
G
M
I
T
L
I
W
IDPRLH
T
P
-------
M
Y
F
F
L
R
---------
H
L
S
F
V
D
ICSSS
S
V
-
V
---------------
P
-----
K
M
L
C
N
I
F
-AEKK
D
----
I
T
F
-
L
G
C
A
A
Q
M
W
--
F
F
G
L
F
E
A
A
--------
E
C
F
L
L
A
A
M
-----
A
-
Y
D
R
Y
V
A
I
C
K
P
L
L
Y
T
L
I
---
M
S
Q
Q
V
C
M
Q
L
VV
G
--
P
Y
A
M
A
L
I
S
T
----
M
T
H
T
I
F
T
F
C
L
P
F
C
G
S
N
I
I
----------------------
N
H
F
F
C
D
I
F
P
L
-
L
S
L
A
C
A
-------
D
T
W
--
V
N
K
F
V
--
L
F
V
L
--
A
G
A
I
G
V
L
S
G
L
I
I
----
M
V
S
Y
I
C
I
L
M
T
I
L
K
I
QT------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------DGK
Q
K
A
F
F
T
C
F
S
H
L
A
A
V
S
I
L
Y
---------G
T
L
F
L
I
Y
VRPSS---S------------S---S------------
L
G
-------
I
Y
K
-----------
V
I
S
L
F
Y
T
V
V
I
----------
P
M
V
N
P
L
I
Y
S
LRN
K
E
---
V
K
D
A
F
R
R
K
I
E
R
K
KFIIGR------------------------
27
HHSearch
86.72
17%
-149
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
---------
L
V
T
V
G
---
L
N
L
---
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
-------
G
N
L
Y
I
V
---------
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
---------------
P
-----
M
N
I
L
Y
L
L
-
M
S
K
W
S
----
L
G
R
-
P
L
C
L
F
W
L
S
--
M
D
Y
V
A
S
T
A
--------
S
I
F
S
V
F
I
L
-----
C
-
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
--
A
W
F
L
S
F
L
W
V
----
I
P
I
L
G
-
W
N
H
--------
R
----------------------
R
E
D
K
C
E
T
D
F
Y
-
D
------------------
V
T
W
F
--
K
V
M
T
--
A
I
I
N
F
Y
L
P
T
L
L
M
----
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
---------
I
P
Y
F
I
F
F
M
V
I
A
F
---
C
------------
K
NC-
C
------------
N
E
-------
H
L
H
-----------
M
F
T
I
W
L
G
Y
I
N
----------
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
---
F
K
K
T
F
K
R
I
L
H
I
-------------------------------
28
HHSearch
83.69
17%
-152
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
-----------------------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
---------
L
A
I
V
F
---
G
N
V
---
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
-------
T
N
Y
F
I
T
---------
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
---------------
P
-----
F
G
A
A
H
I
L
-
M
K
M
W
T
----
F
G
N
-
F
W
C
E
F
W
T
S
--
I
D
V
L
C
V
T
A
--------
S
I
E
T
L
C
V
I
-----
A
-
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
--
V
W
I
V
S
G
L
T
S
----
F
L
P
I
Q
M
H
W
Y
R
A
----
T
H
Q
----------------------
E
A
I
N
C
Y
A
E
E
-----
T
C
C
-------
D
F
F
--
T
N
Q
A
Y
--
A
I
A
S
--
S
I
V
S
F
Y
V
P
L
V
I
M
----
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
---------
L
P
F
F
I
V
N
I
V
H
V
I
---
Q
------------
D
NL-
I
------------
R
K
-------
E
V
Y
-----------
I
L
L
N
W
I
G
Y
V
N
----------
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
---
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------
24
HHSearch
80.76
18%
-146
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-----------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
---------
L
V
T
I
I
---
G
N
I
---
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
-------
N
N
Y
F
L
F
---------
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
---------------
N
-----
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
----
L
G
P
-
V
V
C
D
L
W
L
A
--
L
D
Y
V
V
S
N
A
--------
S
V
M
N
L
L
I
I
-----
S
-
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
--
A
W
V
L
S
F
I
L
W
----
A
P
A
I
L
F
W
Q
F
I
V
--
G
V
R
T
V
----------------------
E
D
G
E
C
Y
I
Q
F
F
-------------------
S
N
A
A
V
--
T
F
G
T
--
A
I
A
A
F
Y
L
P
V
I
I
M
----
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
---------
A
P
Y
N
V
M
V
L
I
N
T
F
---
C
------------
A
PC-
I
------------
P
N
-------
T
V
W
-----------
T
I
G
Y
W
L
C
Y
I
N
----------
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
---
F
K
K
T
F
K
H
L
L
M
--------------------------------
31
HHSearch
80.66
16%
-144
* C3 *
2Z73
5
OPSD_TODPA
A:
[32-333]
--------------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
---------
I
I
G
C
G
---
G
N
G
---
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
-------
A
N
M
F
I
I
---------
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
---------------
P
-----
L
M
T
I
S
C
F
-
L
K
K
W
I
----
F
G
F
-
A
A
C
K
V
Y
G
F
--
I
G
G
I
F
G
F
M
--------
S
I
M
T
M
A
M
I
-----
S
-
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
--
V
W
L
W
S
V
L
W
A
----
I
G
P
I
F
G
W
G
A
----
Y
T
L
E
G
----------------------
V
L
C
N
C
S
F
D
Y
I
-
S
R
------------
D
S
--
T
T
R
S
N
--
I
L
C
M
--
F
I
L
G
F
F
G
P
I
L
I
I
----
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
---------
S
P
Y
A
V
V
A
L
L
A
Q
F
---
G
------------
P
LEW
V
------------
T
P
-------
Y
A
A
-----------
Q
L
P
V
M
F
A
K
A
S
----------
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
---
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
------------------------
30
HHSearch
79.01
17%
-153
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-471]
----------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
---------
V
L
A
I
L
---
G
N
V
---
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
-------
T
N
Y
F
V
V
---------
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
---------------
P
-----
F
A
I
T
I
S
T
---
G
F
C
----
A
A
C
-
H
G
C
L
F
I
A
C
--
F
V
L
V
L
T
Q
S
--------
S
I
F
S
L
L
A
I
-----
A
-
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
--
C
W
V
L
S
F
A
I
G
----
L
T
P
M
L
G
W
N
N
C
G
Q
-----------------------------
S
Q
G
C
G
E
G
Q
V
----
A
C
L
-------
F
E
D
VV
P
M
N
Y
M
--
V
Y
F
N
--
F
F
A
C
V
L
V
P
L
L
L
M
----
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
---------
L
P
L
H
I
I
N
C
F
T
F
F
---
C
PDCS--------
H
---
A
------------
P
L
-------
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
----------
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
---
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------------
35
HHSearch
78.69
16%
-149
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
---------
L
A
I
V
F
---
G
N
G
---
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
-------
T
N
Y
L
V
V
---------
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
---------------
P
-----
W
V
V
Y
L
E
V
T
G
G
V
W
N
----
F
S
R
-
I
C
C
D
V
F
V
T
--
L
D
V
M
M
C
T
A
--------
S
I
W
N
L
C
A
I
-----
S
-
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
--
V
W
V
L
A
F
A
V
S
----
C
P
L
L
F
G
F
N
T
-------
T
G
----------------------
D
P
T
V
C
S
I
S
N
--------------------
P
D
--
F
--
V
I
Y
S
--
S
V
V
S
F
Y
L
P
F
G
V
T
----
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
---------
L
P
F
F
L
T
H
V
L
N
T
H
---
C
------------
Q
TCH
V
------------
S
P
-------
E
L
Y
-----------
S
A
T
T
W
L
G
Y
V
N
----------
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
---
F
R
K
A
F
L
K
I
L
S
C
-------------------------------
25
HHSearch
78.06
18%
-148
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-497]
--------------------------------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
---------
L
T
G
I
V
---
G
N
G
---
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
-------
T
D
K
Y
R
L
---------
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
---------------
P
-----
F
W
A
V
D
A
V
--
A
N
W
Y
----
F
G
N
-
F
L
C
K
A
V
H
V
--
I
Y
T
V
N
L
Y
S
--------
S
V
W
I
L
A
F
I
-----
S
-
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
--
V
W
I
P
A
L
L
L
T
----
I
P
D
F
I
F
A
N
V
-----
S
E
A
D
----------------------
D
R
Y
I
C
D
R
F
Y
P
-
N
D
-------------
L
--
W
V
V
V
F
--
Q
F
Q
H
--
I
M
V
G
L
I
L
P
G
I
V
I
----
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
---------
L
P
Y
Y
I
G
I
S
I
D
S
F
---
I
L
L
EI
I
K
Q
G
C
E
F
E
N
---
T
------------
V
H
-------
K
W
I
-----------
S
I
T
E
A
L
A
F
F
H
----------
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
---
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
------------------------
48
Fugue
77.82
19%
-153
- C2 -
4KPP
4
?
A:
[2-396]
--------DF
T
K
E
K
F
Q
L
L
A
I
S
S
L
T
L
P
W
L
I
S
L
A
F
N
Y
H
H
P
A
L
-----
T
Q
T
L
L
--
S
G
L
A
V
V
---
S
A
S
F
L
I
S
W
A
A
E
T
A
E
M
---------
D
V
P
R
S
---
F
S
L
---
A
I
V
A
L
L
A
V
L
P
E
Y
A
V
D
-------
G
Y
F
A
W
K
A
G
S
VGGE
Y
V
H
Y
A
T
A
N
M
T
G
A
N
R
L
-
L
---------------
I
G
I
G
W
S
L
V
A
F
I
A
F
-
R
T
L
K
S
----
K
E
V
E
L
D
D
G
I
R
L
E
--
I
F
F
L
F
L
A
T
--------
L
Y
A
F
T
L
P
L
K
GHIS
P
-
F
D
A
L
V
F
V
S
L
Y
A
I
Y
I
Y
L
---
S
T
K
A
E
R
E
E
V
E
V
G
G
V
P
A
Y
L
C
S
L
K
T
----
E
T
R
R
L
S
V
V
V
L
F
L
F
A
G
F
T
I
L
M
S
V
E
A
F
S
E
G
L
L
E
T
A
R
I
A
GID
E
F
L
A
V
Q
W
I
A
P
L
-
A
S
E
S
P
E
-------
L
I
V
--
A
I
Y
F
V
R
R
F
R
V
S
--
A
S
M
N
A
L
I
S
S
K
V
N
Q
W
T
L
L
I
G
T
I
A
I
I
Y
S
I
S
A
F
K
L
Q
S
L
P
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
S
E
E
V
L
L
T
A
A
Q
S
L
F
A
V
A
I
L
L
DLKIS
W
K
E
A
S
A
L
F
L
L
F
I
V
Q
L
L
---
F
------------
P
---
G
------------
V
E
-------
V
R
Y
-----------
I
I
S
A
I
Y
---
I
----------
I
L
S
L
P
I
L
F
A
-
K
R
K
E
---
I
V
E
S
F
R
T
V
K
R
L
I
S
L
E
---------------------------
34
HHSearch
76.92
16%
-153
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
-----------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
---------
V
T
S
V
V
---
G
N
V
---
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
-------
T
N
Y
F
L
V
---------
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
---------------
V
-----
V
N
F
T
Y
A
V
-
H
N
E
W
Y
----
Y
G
L
-
F
Y
C
K
F
H
N
F
--
F
P
I
A
A
V
F
A
--------
S
I
Y
S
M
T
A
V
-----
A
-
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
--
I
W
V
L
A
L
L
L
A
----
F
P
Q
G
Y
Y
S
-
T
----
T
E
T
M
P
----------------------
S
R
V
V
C
M
I
E
W
P
-
E
H
P
N
----------
K
I
--
Y
E
K
V
Y
--
H
I
C
V
--
T
V
L
I
Y
F
L
P
L
L
V
I
----
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
---------
L
P
F
H
I
F
F
L
L
P
Y
I
---
N
------------
P
---
D
LYLKKF------
I
Q
-------
Q
V
Y
-----------
L
A
I
M
W
L
A
M
S
S
----------
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
---
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
------------------------
43
Fugue
75.43
16%
-129
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
-----
V
R
S
P
F
--
E
A
P
Q
Y
Y
LAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
---------
M
L
G
F
P
---
I
N
F
---
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
-------
L
N
Y
I
L
L
---------
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
---------------
T
-----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
-
T
G
C
N
L
E
G
F
--
F
A
T
L
G
G
E
I
--------
A
L
W
S
L
V
V
L
-----
A
-
I
E
R
Y
V
V
V
C
K
P
M
-------------------
S
--
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
----------------------
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
--
N
N
E
S
F
--
V
I
Y
M
--
F
V
V
H
F
I
I
P
L
I
V
I
----
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
---------
L
I
C
W
L
P
Y
A
G
V
A
F
---
Y
------------
I
---
F
------------
T
H
QGSDFGP
I
F
M
-----------
T
I
P
A
F
F
A
K
T
S
----------
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A------------
42
Fugue
75.15
17%
-133
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------------MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
-----
S
P
F
E
A
PQ
Y
Y
L
A
E
P
---
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
----------
M
L
G
F
P
---
I
N
F
---
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
-------
L
N
Y
I
L
L
---------
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
---------------
T
-----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
-
T
G
C
N
L
E
G
F
--
F
A
T
L
G
G
E
I
--------
A
L
W
S
L
V
V
L
-----
A
-
I
E
R
Y
V
V
V
C
K
P
M
-------------------
S
--
N
F
R
F
G
E
N
H
A
----
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
----------------------
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
--
N
N
E
S
F
--
V
I
Y
M
--
F
V
V
H
F
I
I
P
L
I
V
I
----
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
---------
V
I
A
F
L
I
C
W
L
P
Y
A
---
G
------------
V
---
A
------------
F
Y
-------
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
----------
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA------
33
HHSearch
73.10
19%
-144
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
-------------------------------------------------------------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
---------
C
F
I
I
L
---
E
N
I
---
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
-------
M
Y
Y
F
I
G
---------
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
---------------
A
-----
N
L
L
L
S
G
A
--
T
T
Y
K
----
L
T
P
-
A
Q
W
F
L
R
E
G
--
S
M
F
V
A
L
S
A
--------
S
V
F
S
L
L
A
I
-----
A
-
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
--
C
W
V
I
S
L
I
L
G
----
G
L
P
I
M
G
W
N
C
-------
I
S
----------------------
A
L
S
S
C
S
T
V
L
P
-
L
------------------
Y
H
K
H
--
Y
I
L
F
--
C
T
T
V
F
T
L
L
L
L
S
I
----
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
--
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
---------
A
P
L
F
I
L
L
L
L
D
V
G
---
C
------------
K
---
V
KTC
D
--------
I
L
-------
F
R
A
-----------
E
Y
F
L
V
L
A
V
L
N
----------
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
---
M
R
R
A
F
I
R
I
M
G
R
P
L
-----------------------------
32
HHSearch
71.50
16%
-145
- C3 -
1U19
14
OPSD_BOVIN
A:
[38-328]
--------------------------------------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
---------
M
L
G
F
P
---
I
N
F
---
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
-------
L
N
Y
I
L
L
---------
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
---------------
T
-----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
-
T
G
C
N
L
E
G
F
--
F
A
T
L
G
G
E
I
--------
A
L
W
S
L
V
V
L
-----
A
-
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
--
T
W
V
M
A
L
A
C
A
----
A
P
P
L
V
G
W
S
R
--
Y
--
I
P
E
G
----------------------
M
Q
C
S
C
G
I
D
Y
Y
-
T
P
H
----------
E
E
T
--
N
N
E
S
F
--
V
I
Y
M
--
F
V
V
H
F
I
I
P
L
I
V
I
----
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
---------
L
P
Y
A
G
V
A
F
Y
I
F
T
---
H
QGS---------
D
---
F
------------
G
P
-------
I
F
M
-----------
T
I
P
A
F
F
A
K
T
S
----------
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
---
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
------------------------
36
HHSearch
66.19
14%
-145
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
--------------------------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
---------
L
L
S
L
L
---
G
N
S
---
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
-------
T
D
V
Y
L
L
---------
N
L
A
L
A
D
L
L
F
A
L
T
--
L
---------------
P
-----
I
W
A
A
S
K
--
V
N
G
W
I
----
F
G
T
-
F
L
C
K
V
V
S
L
--
L
K
E
V
N
F
Y
S
--------
G
I
L
L
L
A
C
I
-----
S
-
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
--
C
W
G
L
S
M
N
L
S
----
L
P
F
F
L
F
R
Q
A
--
Y
--
H
P
N
N
----------------------
S
S
P
V
C
Y
E
V
L
G
-
N
D
-----------
T
A
K
--
W
R
M
V
L
--
R
I
L
P
--
H
T
F
G
F
I
V
P
L
F
V
M
----
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
---------
L
P
Y
N
L
V
L
L
A
D
T
L
---
M
------------
R
---
T
QVIQE
S
C
E
R
R
N
N
I
G
-------
R
A
L
-----------
D
A
T
E
I
L
G
F
L
H
----------
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
---
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------------
51
Fugue
61.60
19%
-153
- C1 -
4XGC
-
?
D:
[5-457]
D
R
E
L
V
S
I
R
R
F
L
K
E
R
L
Q
RDYTTLRGY
A
K
E
R
S
N
V
R
L
L
L
Q
R
T
A
E
MG
E
S
N
S
L
L
L
--
L
G
P
R
G
S
---
G
K
T
T
L
I
N
S
V
L
A
D
L
L
P
NK
S
F
G
E
N
T
L
I
V
H
L
D
---
G
N
L
HTD
D
R
V
A
L
K
S
I
T
V
Q
M
Q
L
E
NAADGKV
F
G
S
F
A
E
---------
N
L
A
F
L
L
Q
C
L
K
S
K
S
-
V
I
F
I
L
E
E
F
D
L
F
C
A
HHN
Q
-----
T
L
L
Y
N
L
F
-
D
V
S
Q
S
AQ
A
P
I
C
V
-
L
G
V
T
C
R
L
D
--
V
I
E
L
L
E
K
R
V
K
S
R
FSHR
Q
V
F
L
F
P
S
L
-----
R
R
F
E
D
Y
V
D
L
C
R
D
L
L
S
--
L
---
P
T
G
N
S
L
L
L
A
A
E
K
--
I
Y
N
L
Q
N
I
Q
S
GALY
F
S
R
N
H
F
D
P
G
E
Y
G
F
S
P
R
L
R
----------------------
D
A
W
N
K
Q
I
C
K
V
-
L
A
T
Q
Q
A
-------
R
S
T
--
L
Q
A
L
H
--
D
F
D
I
S
E
A
Y
L
K
N
F
L
F
R
L
V
A
----
H
L
R
P
Q
S
P
H
I
T
A
E
K
M
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
S
Q
F
E
G
D
D
K
I
E
L
L
C
G
L
S
V
L
E
---------
L
C
L
I
I
A
I
K
H
H
S
Q
I
Y
D
R
------------
D
---
S
------------
F
N
-------
F
E
I
-----------
I
Y
A
R
F
S
K
F
A
K
V
STTMQAVER
S
I
V
L
K
A
F
E
H
L
R
I
A
E
L
I
M
P
L
T
K
V
Q
K
E
F
E
M
H
K
L
A
L
T
Y
S
Q
I
H
H
C
M
Q
R
YQALPT
E
V
A
Q
W
A
QSS
8
PsiBlast_PDB
53.70
26%
-151
- C3 -
4LDO
3
ENLYS_BPT4
A:
[158-297]
---------------------------------
N
R
A
K
R
V
I
-----
T
T
F
R
T
--
G
T
W
D
A
Y
---
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
---------
L
I
V
L
A
I
V
F
G
N
V
---
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
-------
T
N
Y
F
I
T
---------
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
---------------
P
-----
F
G
A
A
H
I
L
-
T
--
K
T
----
W
T
F
-
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
--------
S
I
E
T
L
C
V
I
-----
A
-
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
--
V
W
I
V
S
G
L
T
S
----
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
----------------------
C
Y
A
E
E
T
C
C
D
F
-
F
T
N
Q
A
Y
-------
A
I
A
--
S
S
I
V
S
--
F
Y
V
P
--
L
V
I
M
V
F
V
Y
S
R
V
F
----
Q
E
A
K
R
Q
L
Q
K
F
A
L
K
E
H
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
---------
N
I
V
H
V
I
Q
D
N
L
I
R
---
K
------------
E
---
V
------------
Y
I
-------
L
L
N
-----------
W
I
G
Y
V
N
S
G
F
N
----------
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
---
Q
E
L
L
C
L
------------------------------------
7
PsiBlast_PDB
52.96
26%
-150
- C3 -
4LDL
3
ADRB2_HUMAN (first)
A:
[158-297]
---------------------------------
N
R
A
K
R
V
I
-----
T
T
F
R
T
--
G
T
W
D
A
Y
---
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
---------
L
I
V
L
A
I
V
F
G
N
V
---
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
-------
T
N
Y
F
I
T
---------
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
---------------
P
-----
F
G
A
A
H
I
L
-
T
--
K
T
----
W
T
F
-
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
--------
S
I
E
T
L
C
V
I
-----
A
-
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
--
V
W
I
V
S
G
L
T
S
----
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
----------------------
C
Y
A
E
E
T
C
C
D
F
-
F
T
N
Q
A
Y
-------
A
I
A
--
S
S
I
V
S
--
F
Y
V
P
--
L
V
I
M
V
F
V
Y
S
R
V
F
----
Q
E
A
K
R
Q
L
Q
K
F
A
L
K
E
H
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
---------
N
I
V
H
V
I
Q
D
N
L
I
R
---
K
------------
E
---
V
------------
Y
I
-------
L
L
N
-----------
W
I
G
Y
V
N
S
G
F
N
----------
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
---
Q
E
L
L
C
L
------------------------------------
9
PsiBlast_PDB
52.50
26%
-151
- C3 -
3SN6
1
ENLYS_BPT4
R:
[158-297]
---------------------------------
N
R
A
K
R
V
I
-----
T
T
F
R
T
--
G
T
W
D
A
-------
E
V
W
V
V
G
M
G
I
V
M
S
---------
L
I
V
L
A
IVF
G
N
V
---
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
-------
T
N
Y
F
I
T
---------
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
---------------
P
-----
F
G
A
A
H
I
L
-
T
--
K
T
----
W
T
F
-
G
N
F
W
C
E
F
W
TS
I
D
V
L
C
V
T
A
--------
S
I
E
T
L
C
V
I
-----
A
-
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
--
V
W
I
V
S
G
L
T
S
----
F
L
P
I
Q
M
H
W
Y
R
Q
E
A
I
N
C
Y
A
----------------------
E
E
T
C
C
D
F
F
T
N
-
Q
A
Y
A
I
A
-------
S
S
I
--
V
S
F
Y
V
--
P
L
V
I
--
M
V
F
V
Y
S
R
V
F
Q
E
A
----
K
R
Q
L
Q
K
I
D
K
S
E
G
R
C
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
---------
F
I
V
N
I
V
H
V
I
Q
D
N
---
L
------------
I
---
R
------------
K
E
-------
V
Y
I
-----------
L
L
N
W
I
G
Y
V
N
S
----------
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
---
I
A
F
Q
E
L
L
C
----------------------------------
6
PsiBlast_PDB
51.47
26%
-147
- C3 -
4LDE
3
ENLYS_BPT4
A:
[158-297]
---------------------------------
N
R
A
K
R
V
I
-----
T
T
F
R
T
--
G
T
W
D
A
Y
---
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
---------
L
I
V
L
A
I
V
F
G
N
V
---
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
-------
T
N
Y
F
I
T
---------
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
---------------
P
-----
F
G
A
A
H
I
L
-
T
--
K
T
----
W
T
F
-
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
--------
S
I
E
T
L
C
V
I
-----
A
-
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
--
V
W
I
V
S
G
L
T
S
----
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
----------------------
C
Y
A
E
E
T
C
C
D
F
-
F
T
N
Q
A
Y
-------
A
I
A
--
S
S
I
V
S
--
F
Y
V
P
--
L
V
I
M
V
F
V
Y
S
R
V
F
----
Q
E
A
K
R
Q
L
Q
K
F
A
L
K
E
H
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
---------
N
I
V
H
V
I
Q
D
N
L
I
R
---
K
------------
E
---
V
------------
Y
I
-------
L
L
N
-----------
W
I
G
Y
V
N
S
G
F
N
----------
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
---
Q
E
L
L
C
L
------------------------------------
17
PsiBlast_PDB
48.99
23%
-156
- C3 -
4U14
1
ENLYS_BPT4
A:
[10-120]
--------------------------------------------------------------
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
---------
L
V
T
I
I
---
G
N
I
---
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
-------
N
N
Y
F
L
L
---------
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
---------------
N
-----
L
F
T
T
Y
I
I
-
M
N
R
W
A
----
L
G
N
-
L
A
C
D
L
W
L
S
--
I
D
Y
V
A
S
N
A
--------
S
V
M
N
L
L
V
I
-----
S
-
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
G
V
M
I
G
L
--
A
W
V
I
S
F
V
L
W
----
A
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
----------------------
G
E
C
F
I
Q
F
L
S
E
-
P
T
I
T
F
G
-------
T
A
I
--
A
A
F
Y
M
--
P
V
T
I
--
M
T
I
L
Y
W
R
I
Y
K
E
T
----
E
K
M
N
C
F
E
M
L
R
I
D
E
G
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
Y
K
D
C
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
---------
P
S
L
N
A
A
K
S
E
L
D
K
---
A
------------
I
---
G
------------
R
N
-------
T
N
G
-----------
V
I
T
K
D
E
A
E
K
L
----------
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
---
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
C
A
------------------------