@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5L2_HUMAN: (2016-01-13 )
MGKENCTTVAEFILLGLSDVPELRVCLFLLFLLIYGVTLLANLGMTALIQVSSRLHTPVYFFLSHLSFVDFCYSSIIVPKMLANIFNKDKAISFLGCMVQFYLFCTCGVTEVFLLAVMAYDRFVAICNPLLYMVTMSQKLRVELTSCCYFCGTVCSLIHSSLALRILFYRSNVINHFFCDLPPLLSLACSDVTVNETLLFLVATLNESVTIMIILTSYLLILTTILKIHSAESRHKAFSTCASHLTAITVSHGTILYIYCRPSSGNSGDVDKVATVFYTVVIPMLNPLIYSLRNKDVNKALRKVMGSKIHS
Atome Classification :
(20 SA)
------------------------------.........10------.-.....-..20...----------------.....30.------....---------..-.40..---......-50........--60-------........70....----..-.-----------.80.....-...90----....-....100...--------....110....-...120-------------------.........130...---.-...140....----------..--------.150.......160...-....170......------.180.---......-------190-----...--.---------.....200---..-----------.---------------------....210.......220...-...-.230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.----.-------------...-...240.......250.......260..------.------------.------------.-------..270...-..---..280.---......-.290....--...300.......310--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------MGK
E
N
C
T
T
V
A
E
------
F
-
I
L
LGL-SD
V
P
E
L
R
----------------
V
C
L
F
L
L
F
L
------
L
I
Y
G
---------
V
T
-
L
L
A
N
L
---
G
M
T
A
L
I
-
Q
V
S
SRLH
T
P
V
--
Y
F
-------
F
L
S
H
L
S
F
V
D
F
C
Y
S
S----
I
I
-
V
-----------
P
K
M
L
A
N
I
F-NK
D
K
A
----
I
S
F
L
-
G
C
M
V
Q
F
Y
L
F
C--------TC
G
V
T
E
V
F
L
L
A
-
V
M
A
Y
---------------------
D
R
F
V
A
I
C
N
P
L
L
Y
M
V
T---M-S
Q
K
L
R
V
E
L
T
S
----------
C
C
--------
Y
F
C
G
T
V
C
S
L
I
H
S
S
L
A
L
R
-
I
L
F
Y
R
S
N
V
I
N
H
F
F------CDL
P
P
---
L
L
S
L
AC-------S-------DVT--V---------
N
E
T
L
L
F
L
V
---
A
T-----------L---------------------NE
S
V
T
I
M
I
I
L
T
S
Y
L
L
I
L
T
T
I
-
L
K
I-HS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
S
-------------
R
H
K
-
A
F
S
T
C
A
S
H
L
T
A
I
T
VSHG
T
I
L
Y
I
Y
C
RPSS------G------------N------------S-------G
D
V
D
K
V
A
T
-
V
F
---
Y
T
V
V
-
I
---
P
M
L
N
P
L
-
I
Y
S
L
RNK
D
--
V
N
K
A
L
R
K
V
M
GSKIHS---------------------
27
HHSearch
87.29
18%
-148
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
------------------------------------------------------------------------------
V
G
M
G
I
V
M
S
------
L
I
V
L
---------
A
I
-
V
F
G
N
V
---
L
V
I
T
A
I
-
A
K
F
E
R
L
Q
T
V
T
--
N
Y
-------
F
I
T
S
L
A
C
A
D
L
V
M
G
L
----
A
V
-
V
-----------
P
F
G
A
A
H
I
L
-
M
K
M
W
T
----
F
G
N
F
-
W
C
E
F
W
T
S
I
D
V
--------
L
C
V
T
A
S
I
E
T
L
C
-
V
I
A
V
---------------------
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
-
T
K
N
K
A
R
V
I
I
L
----------
M
V
--------
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-
R
A
T
----
H
Q
E
A
I
N
------
C
Y
A
E
E
-------
T
C
-------
C
-------
D
F
F
--
T
---------
N
Q
A
Y
A
I
A
S
---
S
I
-----------
V
---------------------
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-
K
R
Q
-
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
----
K
-------------
E
H
K
-
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
------
Q
DN----------
L
------------
I
-------
R
K
E
V
Y
I
L
L
-
N
W
---
I
G
Y
V
-
N
---
S
G
F
N
P
L
-
I
Y
C
-
R
S
P
D
--
F
R
I
A
F
Q
E
L
L
C
L
-------------------------
45
Fugue
85.83
15%
-147
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------------------
M
N
G
T
E
G
P
N
------
F
-
Y
V
P
F
S
-
N
K
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
------
L
L
I
M
---------
L
G
-
F
P
I
N
F
---
L
T
L
Y
V
T
-
V
Q
H
K
K
L
R
T
P
L
--
N
Y
-------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
----
G
G
-
F
-----------
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
T
-
G
C
N
L
E
G
F
F
A
T
--------
L
G
G
E
I
A
L
W
S
L
V
-
V
L
A
I
---------------------
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-------------------------------------
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
-
A
L
A
C
A
A
P
P
L
V
G
W
S
------
R
Y
I
P
E
---
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
--
N
---------
N
E
S
F
V
I
Y
M
---
F
V
-----------
V
---------------------
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-
K
E
A
-
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
T
-------------
T
Q
K
-
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
------------
S
------------
D
-------
F
G
P
I
F
M
T
I
P
A
F
---
F
A
K
T
-
S
---
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
--
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A------
25
HHSearch
83.31
15%
-145
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
------
S
L
S
L
---------
V
T
-
I
I
G
N
I
---
L
V
M
V
S
I
-
K
V
N
R
H
L
Q
T
V
N
--
N
Y
-------
F
L
F
S
L
A
C
A
D
L
I
I
G
V
----
F
S
-
M
-----------
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
----
L
G
P
V
-
V
C
D
L
W
L
A
L
D
Y
--------
V
V
S
N
A
S
V
M
N
L
L
-
I
I
S
F
---------------------
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
-
T
T
K
M
A
G
M
M
I
A
----------
A
A
--------
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
-
I
V
--
G
V
R
T
V
E
D
G
E
------
C
Y
I
Q
F
---
F
S
----------------------------------
N
A
A
V
T
F
G
T
---
A
I
-----------
A
---------------------
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
-
K
S
R
-
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
R
-------------
E
K
K
-
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
------
C
AP----------
C
------------
I
-------
P
N
T
V
W
T
I
G
-
Y
W
---
L
C
Y
I
-
N
---
S
T
I
N
P
A
-
C
Y
A
L
C
N
A
T
--
F
K
K
T
F
K
H
L
L
M
--------------------------
35
HHSearch
83.23
16%
-144
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-333]
-----------------------------------------------------------
A
V
Y
----------------
Y
S
L
G
I
F
I
G
------
I
C
G
I
---------
I
G
-
C
G
G
N
G
---
I
V
I
Y
L
F
-
T
K
T
K
S
L
Q
T
P
A
--
N
M
-------
F
I
I
N
L
A
F
S
D
F
T
F
S
L
----
V
N
G
F
-----------
P
L
M
T
I
S
C
F
-
L
K
K
W
I
----
F
G
F
A
-
A
C
K
V
Y
G
F
I
G
G
--------
I
F
G
F
M
S
I
M
T
M
A
-
M
I
S
I
---------------------
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
-
S
H
R
R
A
F
I
M
I
I
----------
F
V
--------
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
-----
Y
T
L
E
G
V
L
C
N
------
C
S
F
D
Y
---
I
S
R
-------------------
D
S
--
T
---------
T
R
S
N
I
L
C
M
---
F
I
-----------
L
---------------------
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-
S
N
H
-
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----
A
-------------
E
M
R
-
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
------
G
------------
P
LEW---------
V
-------
T
P
Y
A
A
Q
L
P
-
V
M
---
F
A
K
A
-
S
---
A
I
H
N
P
M
-
I
Y
S
V
S
H
P
K
--
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
---------------------
28
HHSearch
82.75
15%
-148
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------------------------------------------
P
L
V
V
V
L
S
------
T
I
C
L
---------
V
T
-
V
G
L
N
L
---
L
V
L
Y
A
V
-
R
S
E
R
K
L
H
T
V
G
--
N
L
-------
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
----
V
V
-
M
-----------
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
----
L
G
R
P
-
L
C
L
F
W
L
S
M
D
Y
--------
V
A
S
T
A
S
I
F
S
V
F
-
I
L
C
I
---------------------
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
-
T
K
T
R
A
S
A
T
I
L
----------
G
A
--------
W
F
L
S
F
L
W
V
I
P
I
L
G
-
W
N
H
---------
R
R
E
D
K
------
C
E
T
D
F
---
Y
D
----------------------------------
V
T
W
F
K
V
M
T
---
A
I
-----------
I
---------------------
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
-
R
Q
H
-
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----
R
-------------
E
R
K
-
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
------
C
------------
K
NC----------
C
-------
N
E
H
L
H
M
F
T
-
I
W
---
L
G
Y
I
-
N
---
S
T
L
N
P
L
-
I
Y
P
L
C
N
E
N
--
F
K
K
T
F
K
R
I
L
H
I
-------------------------
31
HHSearch
81.15
16%
-156
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-469]
-------------------------------------------------------------
S
----------------
S
V
Y
I
T
V
E
L
------
A
I
A
V
---------
L
A
-
I
L
G
N
V
---
L
V
C
W
A
V
-
W
L
N
S
N
L
Q
N
V
T
--
N
Y
-------
F
V
V
S
L
A
A
A
D
I
A
V
G
V
----
L
A
-
I
-----------
P
F
A
I
T
I
S
T
---
G
F
C
----
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
--------
V
L
T
Q
S
S
I
F
S
L
L
-
A
I
A
I
---------------------
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
-
T
G
T
R
A
K
G
I
I
A
----------
I
C
--------
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
-
C
G
Q
-------
S
Q
G
------
C
G
E
G
Q
---
V
---
A
C
-------
L
-------
F
E
D
VV
P
---------
M
N
Y
M
V
Y
F
N
---
F
F
-----------
A
---------------------
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-
R
R
Q
-
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
-------------
E
V
H
-
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
------
C
PDCS--------
H
------------
A
-------
P
L
W
L
M
Y
L
A
-
I
V
---
L
S
H
T
-
N
---
S
V
V
N
P
F
-
I
Y
A
Y
R
I
R
E
--
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------------
46
Fugue
77.78
15%
-122
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------------MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
------
A
-
P
Q
Y
Y
L
-
A
E
P
W
Q
F
S
----------------
M
L
A
A
Y
M
F
L
------
L
I
M
L
---------
G
F
-
P
I
N
F
L
---
T
L
Y
V
T
V
-
Q
H
K
-
K
L
R
T
P
L
--
N
Y
-------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
----
G
G
-
F
-----------
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
T
-
G
C
N
L
E
G
F
F
A
T
--------
L
G
G
E
I
A
L
W
S
L
V
-
V
L
A
I
---------------------
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
---
F
-
G
E
N
H
A
I
M
G
V
A
----------
F
T
--------
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-
Y
--------------------
I
P
E
---
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
--
N
---------
N
E
S
F
V
I
Y
M
---
F
V
-----------
V
---------------------
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-
K
E
A
-
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QESA
T
-------------
T
Q
K
-
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
------
Y
------------
I
------------
F
T
H
QGSDF
G
P
I
F
M
T
I
P
-
A
F
---
F
A
K
T
-
S
---
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
--
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
LGDDEA
S
T
T
V
S
K
TETSQVAPA
32
HHSearch
75.47
14%
-121
- C3 -
1U19
14
OPSD_BOVIN
A:
[39-327]
------------------------------------------------------------
Q
F
----------------
S
M
L
A
A
Y
M
F
------
L
L
I
M
---------
L
G
-
F
P
I
N
F
---
L
T
L
Y
V
T
-
V
Q
H
K
K
L
R
T
P
L
--
N
Y
-------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
----
G
G
-
F
-----------
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
T
-
G
C
N
L
E
G
F
F
A
T
--------
L
G
G
E
I
A
L
W
S
L
V
-
V
L
A
I
---------------------
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-----
G
E
N
H
A
I
M
G
V
A
----------
F
T
--------
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-----
Y
I
P
E
G
M
Q
C
S
------
C
G
I
D
Y
---
Y
T
P
H
-----------------
E
E
T
--
N
---------
N
E
S
F
V
I
Y
M
---
F
V
-----------
V
---------------------
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-
K
E
A
-
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
----
A
-------------
E
K
E
-
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QG---
S
------------
D
------------
F
-------
G
P
I
F
M
T
I
P
-
A
F
---
F
A
K
T
-
S
---
A
V
Y
N
P
V
-
I
Y
I
M
M
N
K
Q
--
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
---------------------
34
HHSearch
75.17
15%
-150
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------------------------------
Y
A
L
S
Y
C
------
A
L
I
L
---------
A
I
-
V
F
G
N
G
---
L
V
C
M
A
V
-
L
K
E
R
A
L
Q
T
T
T
--
N
Y
-------
L
V
V
S
L
A
V
A
D
L
L
V
A
T
----
L
V
-
M
-----------
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
----
F
S
R
I
-
C
C
D
V
F
V
T
L
D
V
--------
M
M
C
T
A
S
I
W
N
L
C
-
A
I
S
I
---------------------
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
-
S
C
R
R
V
A
L
M
I
T
----------
A
V
--------
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
--------
T
G
D
P
T
V
------
C
S
I
S
N
-----------------------------
P
---------
D
--
F
V
I
Y
S
---
S
V
-----------
V
---------------------
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
-
K
Q
R
-
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
----
R
-------------
E
K
K
-
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
------
C
QTC---------
H
------------
V
-------
S
P
E
L
Y
S
A
T
-
T
W
---
L
G
Y
V
-
N
---
S
A
L
N
P
V
-
I
Y
T
T
F
N
I
E
--
F
R
K
A
F
L
K
I
L
S
C
-------------------------
36
HHSearch
74.34
12%
-148
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
-------------------------------------------------------------------------------
L
W
A
A
A
Y
T
------
V
I
V
V
---------
T
S
-
V
V
G
N
V
---
V
V
M
W
I
I
-
L
A
H
K
R
M
R
T
V
T
--
N
Y
-------
F
L
V
N
L
A
F
A
E
A
S
M
A
A
----
F
N
-
T
-----------
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
----
Y
G
L
F
-
Y
C
K
F
H
N
F
F
P
I
--------
A
A
V
F
A
S
I
Y
S
M
T
-
A
V
A
F
---------------------
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
------
S
A
T
A
T
K
V
V
I
C
----------
V
I
--------
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
------
E
T
M
P
S
R
V
V
------
C
M
I
E
W
---
P
E
H
P
N
-----------------
K
I
--
Y
---------
E
K
V
Y
H
I
C
V
---
T
V
-----------
L
---------------------
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
-
W
A
S
-
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
A
-------------
K
R
K
-
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
------
N
------------
P
------------
D
LYLKKF-
I
Q
Q
V
Y
L
A
I
-
M
W
---
L
A
M
S
-
S
---
T
M
Y
N
P
I
-
I
Y
C
C
L
N
D
R
--
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
---------------------
26
HHSearch
74.31
14%
-143
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-496]
-----------------------------------------------------------
F
N
K
----------------
I
F
L
P
T
I
Y
S
------
I
I
F
L
---------
T
G
-
I
V
G
N
G
---
L
V
I
L
V
M
-
G
Y
Q
K
K
L
R
S
M
T
--
D
K
-------
Y
R
L
H
L
S
V
A
D
L
L
F
V
-----
I
T
-
L
-----------
P
F
W
A
V
D
A
V
--
A
N
W
Y
----
F
G
N
F
-
L
C
K
A
V
H
V
I
Y
T
--------
V
N
L
Y
S
S
V
W
I
L
A
-
F
I
S
L
---------------------
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
-
K
L
L
A
E
K
V
V
Y
V
----------
G
V
--------
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
------
S
E
A
D
D
R
Y
I
------
C
D
R
F
Y
---
P
N
D
--------------------
L
--
W
---------
V
V
V
F
Q
F
Q
H
---
I
M
-----------
V
---------------------
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
-
S
H
S
-
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
----
Q
-------------
K
R
K
-
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
------
I
L
L
EI
I
K
Q
G
C
E
F
E
N
------------
T
-------
V
H
K
W
I
S
I
T
-
E
A
---
L
A
F
F
-
H
---
C
C
L
N
P
I
-
L
Y
A
F
L
G
A
K
--
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
---------------------
37
HHSearch
73.43
17%
-118
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
-----------------------------------------------------------
L
N
K
----------------
Y
V
V
I
I
A
Y
A
------
L
V
F
L
---------
L
S
-
L
L
G
N
S
---
L
V
M
L
V
I
-
L
Y
S
R
V
G
R
S
V
T
--
D
V
-------
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
----
T
--
L
-----------
P
I
W
A
A
S
K
--
V
N
G
W
I
----
F
G
T
F
-
L
C
K
V
V
S
L
L
K
E
--------
V
N
F
Y
S
G
I
L
L
L
A
-
C
I
S
V
---------------------
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
-
K
R
H
L
V
K
F
V
C
L
----------
G
C
--------
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
-----
Y
H
P
N
N
S
S
P
V
------
C
Y
E
V
L
---
G
N
D
------------------
T
A
K
--
W
---------
R
M
V
L
R
I
L
P
---
H
T
-----------
F
---------------------
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
-
F
K
A
-
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----
Q
-------------
K
H
R
-
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
------
M
------------
R
TQVIQE
S
C
E
R
R
N
N
-------
I
G
R
A
L
D
A
T
-
E
I
---
L
G
F
L
-
H
---
S
C
L
N
P
I
-
I
Y
A
F
I
G
Q
N
--
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------
54
Fugue
71.74
17%
-157
- C2 -
1YT3
11
RND_ECOLI
A:
[1-375]
------------------------------
M
N
Y
Q
M
I
T
T
D
D
A
------
L
-
A
S
L
C
E
-
A
V
R
A
F
P
A
----------------
I
A
L
D
T
E
F
V
R
T
RTYY
P
Q
L
G
---------
L
I
-
Q
L
F
D
G
---
E
H
L
A
L
I
D
P
L
G
I
T
D
W
S
P
L
--
K
A
-------
I
L
R
D
P
S
I
T
K
F
L
H
A
G
----
S
E
-
D
-----------
L
E
V
F
L
N
V
F
-
G
E
--
L
----
P
Q
P
L
-
I
D
T
Q
I
L
A
A
F
C
--------
G
R
P
M
S
W
G
F
A
S
M
-
V
E
E
Y
SG
V
T
L
D
KSESRTDWLARPLT
E
R
Q
C
E
Y
A
A
A
D
V
W
Y
L
L
P
---
I
-
T
A
K
L
M
V
E
T
E
A
S
GW
L
P
A
A
L
D
E
C
R
--------
L
M
Q
M
R
R
Q
E
V
V
A
P
E
D
A
W
R
-
D
I
T
N
A
W
Q
L
R
T
R
Q
L
------
A
C
L
Q
L
---
L
A
D
W
R
L
-------
R
-------
K
A
R
--
E
R
DLAVNFVV
R
E
E
H
L
W
S
V
---
A
R
Y
MPGS
L
G
E
L
D
S
L
---------------------
G
L
S
G
S
E
I
R
F
H
G
K
T
L
L
A
L
V
E
K
-
A
Q
T
-
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
A
LPQPMLNLMDMPG
Y
R
K
-
A
F
K
A
I
K
S
L
I
T
D
V
S
E
T
H
K
I
S
A
E
L
L
A
-----------------------
S
------------
R
-------
R
Q
I
N
Q
L
L
N
-
W
H
---
W
K
L
K
P
Q
---
N
N
L
P
E
L
-
I
S
G
W
R
G
E
L
--
M
A
E
A
L
H
N
L
L
Q
E
Y
P
Q
----------------------
33
HHSearch
69.62
15%
-141
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
-----------------------------------------------------------
N
S
I
----------------
K
L
T
S
V
V
F
I
------
L
I
C
C
---------
F
I
-
I
L
E
N
I
---
F
V
L
L
T
I
-
W
K
T
K
K
F
H
R
P
M
--
Y
Y
-------
F
I
G
N
L
A
L
S
D
L
L
A
G
V
----
A
Y
-
T
-----------
A
N
L
L
L
S
G
A
--
T
T
Y
K
----
L
T
P
A
-
Q
W
F
L
R
E
G
S
M
F
--------
V
A
L
S
A
S
V
F
S
L
L
-
A
I
A
I
---------------------
E
R
Y
I
T
M
L
K
------------
N
N
F
R
L
F
L
L
I
S
----------
A
C
--------
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
C
--------
I
S
A
L
S
S
------
C
S
T
V
L
---
P
L
----------------------------------
Y
H
K
H
Y
I
L
F
---
C
T
-----------
T
---------------------
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
-
R
T
R
-
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
E
-------------
N
V
A
-
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
------
C
------------
K
VKTC--------
D
-------
I
L
F
R
A
E
Y
F
-
L
V
---
L
A
V
L
-
N
---
S
G
T
N
P
I
-
I
Y
T
L
T
N
K
E
--
M
R
R
A
F
I
R
I
M
G
R
P
L
-----------------------
48
Fugue
63.82
14%
-162
- C3 -
3EA0
3
?
A:
[3-242]
--------------------AK
R
V
F
G
F
V
S
A
K
G
G
D
G
G
S
C
I
A
A
------
N
-
F
A
F
A
L
-
S
Q
E
P
D
I
H
----------------
V
L
A
V
D
I
S
L
------
P
F
G
D
---------
L
D
M
Y
L
S
G
N
---
T
------------------------------------------------
H
-----------
S
Q
D
L
A
D
I
S
-
N
A
S
D
R
----
L
D
------------------------------
K
S
-
L
L
D
T
M
--------------------
V
Q
H
I
S
---
P
S
L
D
L
I
P
---
S
-
P
A
T
F
E
K
I
V
N
------------------------------
I
E
P
E
R
V
S
D
-
L
I
H
I
A
A
S
F
Y
D
Y
I
I
------
V
D
F
G
A
--------------------------
S
--
I
---------
D
H
V
G
V
W
V
L
---
E
H
-----------
L
---------------------
D
E
L
C
I
V
T
T
P
S
L
Q
S
L
R
R
A
G
Q
L
-
L
K
L
-
C
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
----
E
-------------
K
P
I
-----------------
S
R
I
E
I
I
L
N
R
A
D
T
------
N
------------
S
------------
R
-------
I
T
S
D
E
I
E
K
-
V
I
GRP
I
S
K
R
-
I
---
P
Q
D
E
D
A
M
Q
E
S
L
L
S
G
Q
SV
L
K
V
A
P
K
S
Q
L
S
K
T
I
V
D
W
A
L
H
L----------------
51
Fugue
63.07
12%
-158
- C3 -
1ZKP
3
?
A:
[18-268]
----------------------------------
L
Y
F
Q
S
N
A
M
-----
K
M
T
V
V
G
F
W
G
G
F
P
E
A
G
----------------
E
A
T
S
G
Y
L
F
------
E
H
D
G
---------
F
R
-
L
L
V
D
C
---
G
S
G
V
L
A
-
Q
L
Q
K
Y
I
T
P
S
D
ID
A
V
-------
V
L
S
H
Y
H
-------
H
----
D
H
-
V
-----------
A
D
I
G
V
L
Q
Y
-
A
R
L
I
T
----
S
A
T
K
-
G
Q
L
P
E
L
P
I
Y
G
--------
H
T
F
D
E
N
G
F
H
S
L
-
T
H
E
P
---------------------
H
---------
T
K
G
I
P
---
Y
-
N
P
E
E
T
L
Q
I
G
P
---------------------
F
S
I
S
F
L
K
T
V
H
P
V
T
C
F
A
M
R
I
T
A
G
----------------------------------------------------------
N
D
I
V
V
Y
S
A
---
D
S
-----------
S
---------------------
Y
I
P
E
F
I
P
F
T
K
D
A
D
L
F
I
C
E
C
N
M
Y
A
H
-
Q
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
K
-------------
A
G
H
M
N
S
T
E
V
A
S
I
A
K
D
A
N
V
K
--
E
L
L
L
T
H
L
P
H
T
G
------
N
------------
P
------------
A
-------
D
L
V
T
E
A
K
Q
-
I
F
---
S
G
H
I
-
T
---
L
A
H
S
----------------------
G
Y
V
W
N
S
---------------------
49
Fugue
62.00
21%
-158
- C3 -
4XGC
-
?
D:
[5-457]
D
R
E
L
V
S
I
R
R
F
L
K
E
R
L
Q
RDYTTLRGY
A
K
E
R
S
N
V
R
L
L
L
Q
R
T
A
E
MG
E
S
N
S
L
-
L
L
L
G
P
-
R
G
S
G
K
T
T
----------------
L
I
N
S
V
L
A
D
------
L
L
P
N
K
S
F
G
E
N
T
L
I
V
H
-
L
D
G
N
L
HTD
D
R
V
A
L
K
-
S
I
T
V
Q
M
Q
L
E
N
--
A
A
DGKVFGS
F
A
E
N
L
A
F
L
L
Q
C
L
K
S
K
S
V
I
F
I
-
L
E
E
F
D
L
F
C
A
HHN
Q
T
L
L
Y
N
L
F
-
D
V
S
Q
S
AQ
A
P
I
C
V
L
-
G
V
T
C
R
L
D
V
I
E
LLE
K
R
V
K
S
R
F
S
H
R
Q
V
F
L
F
P
S
L
R
R
F
---------------------
E
D
Y
V
D
L
C
R
D
L
L
S
L
P
T
---
G
N
S
L
L
L
A
A
E
K
I
Y
----------
N
L
Q
N
IQSGAL
Y
F
S
R
N
H
F
D
P
G
E
Y
G
F
S
P
R
-
L
R
D
A
W
N
K
Q
I
C
K
V
L
A
T
Q
Q
A
R
S
T
L
Q
A
---
L
H
D
F
D
I
-------
S
-------
E
A
Y
--
L
---------
K
N
F
L
F
R
L
V
---
A
H
-----------
L
RPQSPHIT
A
E
K
M
A
A
V
G
S
Q
F
E
G
D
D
K
I
E
L
L
C
G
L
S
V
L
E
L
C
L
I
I
A
-
I
K
H
-
H
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
Y
DRDSFN
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
E
----
I
-------------
I
Y
A
-
R
F
S
K
F
A
K
V
S
T
T
M
Q
A
V
E
R
S
I
V
L
K
A
F
E
H
L
R
------
I
------------
A
------------
E
L
I
-----
M
P
L
T
K
V
Q
K
-
E
F
---
E
M
H
K
-
L
---
A
L
T
Y
S
Q
-
I
H
H
C
M
Q
R
----
Y
Q
A
L
P
T
E
V
A
Q
W
A
Q
S
S--------------------
50
Fugue
57.75
11%
-152
- C3 -
2QTH
9
HFLX_SULSO
A:
[1-355]
------------------------------
M
K
T
A
A
L
F
V
S
K
E
------
F
-
E
E
E
A
I
-
A
L
V
E
G
A
N
----------------
Y
K
V
T
S
I
Y
K
------
L
P
K
S
---------
P
N
-
V
K
F
Y
I
---
Q
Y
D
K
L
Q
-
Q
I
K
N
D
E
E
I
S
T
--
L
I
-------
I
F
E
Q
L
K
---------------------------
P
R
H
F
I
N
I
R
-
R
E
L
K
G
----
K
E
V
L
D
K
I
L
L
L
L
E
I
F
A
--------
L
H
A
G
S
K
E
A
K
M
Q
-
I
E
L
A
---------------------
R
L
--
K
Y
E
L
P
I
I
K
E
T
S
---
T
-
I
K
F
Y
K
R
R
I
N
K
----------
L
M
--------
K
E
L
E
S
I
K
I
I
P
S
I
G
I
V
G
Y
-
T
N
S
G
K
T
S
L
F
N
S
L
T
------
G
L
M
S
P
K
R
Y
A
I
P
I
N
N
-------
R
-------
K
I
M
--
L
---------
V
D
T
V
G
F
I
R
GIP
P
Q
-----------
I
---------------------
V
D
A
F
F
V
T
L
S
E
A
K
Y
S
D
A
L
I
L
V
-
I
D
S
T
F
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----
L
-------------
L
I
E
-
T
L
Q
S
S
F
E
I
L
R
E
I
G
V
S
G
K
P
I
L
V
T
L
N
K
I
D
K
------
I
------------
N
------------
G
-------
D
L
Y
K
K
L
D
L
-
V
E
---
K
L
S
K
-
E
L
YS
P
I
F
D
V
I
-
P
I
S
A
L
K
R
T
--
N
L
E
L
L
R
D
K
I
Y
Q
L
A
T
Q
L
--------------------
1
PsiBlast_PDB
53.28
25%
-157
- C3 -
4IAQ
1
5HT1B_HUMAN (first)
A:
[19-135]
------------------------------------------------------------
W
K
----------------
V
L
L
V
M
L
L
A
------
L
I
T
L
---------
A
T
-
T
L
S
N
A
---
F
V
I
A
T
V
-
Y
R
T
R
K
L
H
T
P
A
--
N
Y
-------
L
I
A
S
L
A
V
T
D
L
L
V
S
I
----
L
V
-
M
-----------
P
--
I
S
T
M
Y
-
T
V
T
G
R
----
W
T
L
G
-
Q
V
V
C
D
F
W
L
S
S
D
I
------
T
C
C
T
A
S
I
W
H
L
C
-
V
I
A
L
---------------------
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
---
R
-
T
P
K
R
A
A
V
M
I
A
----------
L
V
--------
W
V
F
S
I
S
I
S
L
P
P
F
F
W
R
Q
A
-
S
E
C
V
V
N
T
D
H
I
L
Y
T
------
V
Y
S
T
V
---
G
A
F
Y
F
P
-------
T
-------
L
L
L
--
I
---------
A
L
Y
G
R
I
Y
V
---
E
A
-----------
R
---------------------
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
-
N
A
A
-
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
A
-------------
L
T
K
-
M
R
A
A
A
L
D
A
Q
K
A
T
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
L
------
V
------------
G
------------
Q
-------
I
D
D
A
L
K
L
A
-
N
E
---
G
K
V
K
-
E
---
A
Q
A
A
A
E
-
Q
L
K
T
T
R
N
A
--
Y
I
Q
K
Y
L
L
M
A
A
R
E
R
K
A
---------------------
2
PsiBlast_PDB
52.72
25%
-162
- C3 -
4IAR
1
C562_ECOLX
A:
[19-135]
------------------------------------------------------------
W
K
----------------
V
L
L
V
M
L
L
A
------
L
I
T
L
---------
A
T
-
T
L
S
N
A
---
F
V
I
A
T
V
-
Y
R
T
R
K
L
H
T
P
A
--
N
Y
-------
L
I
A
S
L
A
V
T
D
L
L
V
S
I
----
L
V
-
M
-----------
P
--
I
S
T
M
Y
-
T
V
T
G
R
----
W
T
L
G
-
Q
V
V
C
D
F
W
L
S
S
D
I
------
T
C
C
T
A
S
I
W
H
L
C
-
V
I
A
L
---------------------
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
---
R
-
T
P
K
R
A
A
V
M
I
A
----------
L
V
--------
W
V
F
S
I
S
I
S
L
P
P
F
F
W
R
Q
A
-
S
E
C
V
V
N
T
D
H
I
L
Y
T
------
V
Y
S
T
V
---
G
A
F
Y
F
P
-------
T
-------
L
L
L
--
I
---------
A
L
Y
G
R
I
Y
V
---
E
A
-----------
R
---------------------
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
-
E
K
A
-
D
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
Q
-------------
V
K
D
-
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
P
------
E
------------
M
------------
K
-------
D
F
R
H
G
F
D
I
-
L
V
---
G
Q
I
D
-
D
---
A
L
K
L
A
N
-
E
G
K
V
K
E
A
Q
--
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
---------------------