@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5M1_HUMAN: (2016-01-13 )
MFSPNHTIVTEFILLGLTDDPVLEKILFGVFLAIYLITLAGNLCMILLIRTNSHLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVITEFYILASMALDRYVAICSPLHYSSRMSKNICVCLVTIPYMYGFLSGFSQSLLTFHLSFCGSLEINHFYCADPPLIMLACSDTRVKKMAMFVVAGFNLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEKSVEESKITAVFYTFLSPMLNPLIYSLRNTDVILAMQQMIRGKSFHKIAV
Atome Classification :
(20 SA)
---.......--..10........----------20...----------------..-...30........40--.........50........60........70......-..80.....-...90......-..-100....---...110..--.....120.......130....---....140.......150.----..------....160-------........170..----------------.....180.....--------..190.--......200.......210--.....----...220...-----------..-------..230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.---------.-......240.......250.......260...----.--.------.--.270-------.......280.......290.......300...-....310...----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MFSP
N
H
T
--
I
V
T
E
F
I
LLGLTD----------
D
P
V
L
E
----------------
K
I
-
L
F
G
V
F
L
A
I
Y
L
I
T
L
A---G
N
L
C
M
I
L
L
I
RTNSHLQ
T
P
M
Y
F
F
L
G
H
L
S
F
V
D
I
CYSSNV-
T
P
N
M
L
H
N
F
L
-
S
EQKT
I
S
Y
A
G
C
-
F
T
-
Q
C
L
L
F
I
A
---
L
V
I
T
E
F
Y
I
--
L
A
S
M
A
L
D
R
Y
V
A
I
CSPL-
H
Y
S
SR---MSKN
I
C
V
C
L
V
T
I
P
Y
M
Y
G
F
----
L
S
------
G
F
S
Q
S
L
--------
L
T
F
H
L
S
FCGS
L
E
I
----------------
N
H
F
YCADP
P
L
I
M
L
--------ACSDTR--
V
K
K
M
A
M
F
V
V
AGFNL
S
S
S
L
---
F
I
I
L
L
----
S
Y
L
F
I
F
A
A
I
-----------
F
R
-------IRS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------E---------G-
R
H
K
A
F
S
T
C
A
S
H
L
T
I
V
T
L
F
Y
G
T
L
F
C
M
Y
VRPPSE----K--S------V--
E
E
S
K
-------
I
T
A
V
F
Y
T
F
L
S
P
M
L
N
P
L
I
Y
S
LRN
T
D
V
I
L
A
M
Q
Q
M
I
-RGKS
F
H
KIAV----------------
27
HHSearch
91.29
19%
-151
- C4 -
3EML
13
ENLYS_BPT4
A:
[21-471]
--------------------------------------
S
----------------
S
V
-
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
-
L
F
-
I
A
C
F
V
L
V
---
L
T
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
----
A
I
------
G
L
T
P
M
L
--------
G
W
N
N
C
G
Q
-----------------------
S
Q
G
C
G
E
G
Q
V
-----------
A
C
L
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
---
L
L
M
L
G
----
V
Y
L
R
I
F
L
A
A
-----------
R
R
-------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---------
K
-
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
PDCS
H
--
A
------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
H
V
L
R
Q
-------------------
14
PsiBlast_PDB
90.25
21%
-137
- C4 -
3PWH
1
?
A:
[12-304]
-------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
-
A
C
F
V
L
V
----
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
----
A
I
------
G
L
T
P
M
L
GWNNCGQP------
G
C
G
E
G
Q
V
ACLFEDVVP
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
--
L
K
Q
M
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
-----------------
Q
K
E
V
-----------
H
A
-------
A
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------
I
-
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
--
T
F
F
C
----
P
D
C
S
----
H
--
A
------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
------------------------
17
PsiBlast_PDB
89.89
21%
-137
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
-
A
C
F
V
L
V
----
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
----
A
I
------
G
L
T
P
M
L
GWNNCGQP------
G
C
G
E
G
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
--
L
K
Q
M
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
-----------------
Q
K
E
V
-----------
H
A
-------
A
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------
I
-
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
--
T
F
F
C
----
P
D
C
S
----
H
--
A
------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
------------------------
16
PsiBlast_PDB
89.46
21%
-138
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
-
A
C
F
V
L
V
----
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
----
A
I
------
G
L
T
P
M
L
GWNNCGQP------
G
C
G
E
G
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
--
L
K
Q
M
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
-----------------
Q
K
E
V
-----------
H
A
-------
A
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------
I
-
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
--
T
F
F
C
----
P
D
C
S
----
H
--
A
------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
------------------------
23
HHSearch
89.36
22%
-140
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------------------------
V
----------------
V
G
-
M
G
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
-
E
F
-
W
T
S
I
D
V
L
---
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
----
L
T
------
S
F
L
P
I
Q
--------
M
H
W
Y
R
A
T
----
H
Q
----------------
E
A
I
N
C
Y
A
E
E
------------
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
---
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
-----------
K
R
-------
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
---------
K
-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
DN--
L
--
I
------
R
--
K
E
V
Y
-------
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
-
C
L
------------------------
18
PsiBlast_PDB
88.96
21%
-138
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
-
A
C
F
V
L
V
----
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
----
A
I
------
G
L
T
P
M
L
GWNNCGQP------
G
C
G
E
G
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
--
L
K
Q
M
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
-----------------
Q
K
E
V
-----------
H
A
-------
A
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------
I
-
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
--
T
F
F
C
----
P
D
C
S
----
H
--
A
------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
------------------------
15
PsiBlast_PDB
88.91
21%
-139
- C4 -
3REY
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
-
A
C
F
V
L
V
----
L
A
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
----
A
I
------
G
L
T
P
M
L
GWNNCGQP------
G
C
G
E
G
Q
V
ACL
F
E
D
V
V
P
M
N
Y
M
V
YF
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
--
L
K
Q
M
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
-----------------
Q
K
E
V
-----------
H
A
-------
A
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------
I
-
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
--
T
F
F
C
----
P
D
C
S
----
H
--
A
------
P
--
L
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
S
------------------------
2
PsiBlast_PDB
87.44
22%
-153
- C4 -
4GBR
1
ADRB2_HUMAN
A:
[2-284]
--------------------------------------
E
----------------
V
W
-
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
-
E
F
-
W
T
S
I
D
V
L
---
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
----
L
T
------
S
F
L
P
----------
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----------------
I
N
C
Y
A
E
E
--------------
T
C
C
D
---------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
----
I
M
V
F
V
Y
S
R
V
-----------
F
Q
-------
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
Q
KIDKFC
L
K
-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
----
D
--
N
------
L
IR
K
E
V
Y
-------
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
-
C
L
------------------------
10
PsiBlast_PDB
86.08
21%
-151
- C4 -
4QKX
2
ADRB2_HUMAN
A:
[156-461]
-----
T
P
N
R
A
K
R
V
I
T
T
F
-
R
T
G
T
W
D
----------
A
Y
A
A
D
----------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
-
T
K
T
W
T
F
G
N
F
W
C
-
E
F
-
W
T
S
I
D
V
L
---
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
----
L
T
------
S
F
L
P
----------
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----------------
I
N
C
Y
A
E
E
--------------
T
C
C
D
---------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
----
I
M
V
F
V
Y
S
R
V
-----------
F
Q
-------
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
LQKFAL---
K
-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
----
D
--
N
------
L
IR
K
E
V
Y
-------
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
-
C
L
------------------------
39
Fugue
84.96
15%
-145
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------
M
N
G
T
--
E
G
P
N
F
Y
V
P
F
S
N
K
----------
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
-
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
-
N
L
-
E
G
F
F
A
T
L
---
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
----
A
C
AAPPLV
G
W
S
R
Y
I
--------
P
E
G
M
Q
C
S
C
G
I
--------------------
D
Y
Y
T
P
H
E
E
T
----------------
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
---
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
-----------
K
E
-------
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------
T
-
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
----
I
--
F
------
T
--
H
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-
C
C
G
K
N
P
S
T
T
V
SKTETS
Q
V
A
P
A-----
3
PsiBlast_PDB
84.81
21%
-149
- C4 -
4LDE
3
ENLYS_BPT4
A:
[156-461]
-----
T
P
N
R
A
K
R
V
I
T
T
F
-
R
T
G
T
W
D
----------
A
Y
A
A
D
----------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
-
E
F
-
W
T
S
I
D
V
L
---
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
----
L
T
------
S
F
L
P
----------
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----------------
I
N
C
Y
A
E
E
--------------
T
C
C
D
---------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
----
I
M
V
F
V
Y
S
R
V
-----------
F
Q
-------
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
LQKFAL---
K
-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
----
D
--
N
------
L
IR
K
E
V
Y
-------
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
-
C
L
------------------------
5
PsiBlast_PDB
84.26
21%
-149
- C4 -
4LDO
3
ENLYS_BPT4
A:
[156-461]
-----
T
P
N
R
A
K
R
V
I
T
T
F
-
R
T
G
T
W
D
----------
A
Y
A
A
D
----------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
-
E
F
-
W
T
S
I
D
V
L
---
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
----
L
T
------
S
F
L
P
----------
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----------------
I
N
C
Y
A
E
E
--------------
T
C
C
D
---------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
----
I
M
V
F
V
Y
S
R
V
-----------
F
Q
-------
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
LQKFAL---
K
-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
----
D
--
N
------
L
IR
K
E
V
Y
-------
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
-
C
L
------------------------
4
PsiBlast_PDB
84.21
21%
-150
- C4 -
4LDL
3
ADRB2_HUMAN (first)
A:
[156-461]
-----
T
P
N
R
A
K
R
V
I
T
T
F
-
R
T
G
T
W
D
----------
A
Y
A
A
D
----------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
-
E
F
-
W
T
S
I
D
V
L
---
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
----
L
T
------
S
F
L
P
----------
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
----------------
I
N
C
Y
A
E
E
--------------
T
C
C
D
---------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
----
I
M
V
F
V
Y
S
R
V
-----------
F
Q
-------
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
LQKFA
L
---
K
-
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
----
D
--
N
------
L
IR
K
E
V
Y
-------
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
-
C
L
------------------------
30
HHSearch
83.23
17%
-141
* C4 *
2Z73
5
OPSD_TODPA
A:
[32-333]
------------------------------------
A
V
Y
----------------
Y
S
-
L
G
I
F
I
G
I
C
G
I
I
G
C
G
---
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
-
K
V
-
Y
G
F
I
G
G
I
---
F
G
F
M
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
-
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
----
L
W
------
A
I
G
P
I
F
--------
G
W
G
A
Y
----
T
L
E
G
----------------
V
L
C
N
C
S
F
D
Y
I
S
R
-------------
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
---
L
I
I
F
F
----
C
Y
F
N
I
V
M
S
V
-----------
S
N
-------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---------
A
-
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
PLE-
W
--
V
------
T
--
P
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
-
P
W
V
L
T
C
C
Q
F
D
----------------
24
HHSearch
82.22
18%
-147
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
--------------------------------------------------------
P
-
L
V
V
V
L
S
T
I
C
L
V
T
V
G
---
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
-
L
F
-
W
L
S
M
D
Y
V
---
A
S
T
A
S
I
F
S
--
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
-
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
----
L
W
------
V
I
P
I
L
G
---------
W
N
H
--------
R
----------------
R
E
D
K
C
E
T
D
F
Y
D
-------------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
---
L
L
M
L
W
----
F
Y
A
K
I
Y
K
A
V
-----------
R
Q
-------
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---------
R
-
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
----
K
NC
C
------
N
--
E
H
L
H
-------
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
-
H
I
------------------------
20
PsiBlast_PDB
81.68
24%
-131
- C4 -
3EML
9
ENLYS_BPT4
A:
[27-309]
-------------------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
---
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
---------
T
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
----
A
I
------
G
L
T
P
M
L
-----------
G
W
N
N
C
G
Q
-----------------------
S
Q
G
C
G
E
G
Q
V
--------
A
C
L
F
E
D
--
V
V
P
M
N
Y
M
V
Y
--
F
N
F
F
A
C
V
---
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
QLN
I
F
E
M
L
R
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
------
G
I
G
H
L
L
T
K
S
P
S
L
----
N
--
A
------
A
--
K
S
E
L
-------
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
-
R
N
A
K
L
K
P
V
Y
D
----------------
32
HHSearch
80.00
16%
-139
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
---
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
-
D
V
-
F
V
T
L
D
V
M
---
M
C
T
A
S
I
W
N
--
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
-
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
----
A
V
------
S
C
P
L
L
F
--------
G
F
N
T
-------
T
G
----------------
D
P
T
V
C
S
I
S
N
--------------------
P
D
--
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
---
G
V
T
V
L
----
V
Y
A
R
I
Y
V
V
L
-----------
K
Q
-------
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
---------
R
-
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
QTC-
H
--
V
------
S
--
P
E
L
Y
-------
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
-
S
C
------------------------
21
HHSearch
79.35
15%
-141
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-------------------------------------------------------
V
F
-
I
V
L
V
A
G
S
L
S
L
V
T
I
I
---
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
-
D
L
-
W
L
A
L
D
Y
V
---
V
S
N
A
S
V
M
N
--
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
----
I
L
------
W
A
P
A
I
L
--------
F
W
Q
F
I
V
G
--
V
R
T
V
----------------
E
D
G
E
C
Y
I
Q
F
F
S
-------------------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
---
I
I
M
T
V
----
L
Y
W
H
I
S
R
A
S
-----------
K
S
-------
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------
R
-
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
AP--
C
--
I
------
P
--
N
T
V
W
-------
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
-
M
-------------------------
42
Fugue
76.84
15%
-104
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
P
N
F
Y
--
V
P
F
S
N
K
T
G
V
V
R
S
PFEAPQYYLA
E
P
W
Q
F
----------------
S
M
-
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
-
N
L
-
E
G
F
F
A
T
L
---
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
------
G
W
S
R
Y
I
--------
P
E
G
M
Q
C
S
C
G
I
--------------------
D
Y
Y
T
P
H
E
E
T
----------------
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
-
I
I
P
L
---
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
KEAAAQQQESA
T
T
-------
Q
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------
E
-
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
----
D
--
F
------
G
--
P
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA
31
HHSearch
74.19
16%
-141
- C4 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
-------------------------------------------------------
V
L
-
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
---
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
-
K
F
-
H
N
F
F
P
I
A
---
A
V
F
A
S
I
Y
S
--
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
-
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
----
L
L
------
A
F
P
Q
G
Y
--------
Y
S
T
T
-----
E
T
M
P
----------------
S
R
V
V
C
M
I
E
W
P
E
H
P
--------
N
---
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
---
L
V
I
G
Y
----
A
Y
T
V
V
G
I
T
L
-----------
W
A
-------
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------
A
-
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
----
P
--
D
LYLKKF
I
--
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
-
R
C
C
P
F
I
S
A
G
D
----------------