@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR6A2_HUMAN: (2016-01-13 )
MEWRNHSGRVSEFVLLGFPAPAPLQVLLFALLLLAYVLVLTENTLIIMAIRNHSTLHKPMYFFLANMSFLEIWYVTVTIPKMLAGFVGSKQDHGQLISFEGCMTQLYFFLGLGCTECVLLAVMAYDRYMAICYPLHYPVIVSGRLCVQMAAGSWAGGFGISMVKVFLISGLSYCGPNIINHFFCDVSPLLNLSCTDMSTAELTDFILAIFILLGPLSVTGASYVAITGAVMHIPSAAGRYKAFSTCASHLTVVIIFYAASIFIYARPKALSAFDTNKLVSVLYAVIVPLLNPIIYCLRNQEVKRALCCTLHLYQHQDPDPKKASRNV
Atome Classification :
(20 SA)
------------.........------10........---20-.........30.--------------...--------------------....40........50........60-----..--......70.....-----------..-.80......-..90........100.......110---.........120..------.....130..-----------..--...-140-...-......150.......160...-----..----..170.-.----------......180-..-----......190......--.200.......210--.-..--....-----------220---.......-230------....------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------...--240.......250......--------.260.......270----------.----.------.......--------280....---...290..--------..-------------...300.......310.....---....320.....-------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MEWRNHSGR------
V
S
E
F
V
L
L
GFP---A--PA
P
L
Q
V
L
L
F
A
L
L
--------------
L
L
A
--------------------
Y
V
L
V
LTEN
T
L
I
I
M
A
IRNHST
L
H
K
P
M
Y
-----
F
F
--
L
ANM
S
F
L
E
I
W
Y
V
T
-----------
V
T
-
I
P
K
M
L
A
G
F
V-GSKQDHG
Q
L
I
S
F
E
G
C
M
T
Q
L
Y
F
F
L-----GL
G
C
T
E
C
V
L
L
A
V
M
A
------
Y
D
R
Y
M
A
I
C
YP-----------LH--Y
P
V
-
I
---VS
G
-
R
L
C
V
Q
MAAGSWAG
G
F
G
I
S
M
V
K
V
-----
F
L
----
I
S
G
L
-
S
-Y----------C
G
P
N
I
I
N
H
--
F
F-----CDV
S
P
L
L
N
LSCTDM
S
--
T
A
E
L
T
D
F
I
L
A
I
F
I
L
--L-GP--LSVT-----------GA
S
---
Y
V
A
I
T
G
A
-
V
M-------HIPS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------AGR--
Y
K
A
F
S
T
C
A
S
H
L
T
V
V
I
I
F
YA--------
A
S
I
F
I
Y
ARPKAL------------S----A------F
D
T
N
K
L
V
--------
S
V
L
Y
A
V
I
---
V
P
L
L
N
P
I
I
--------
Y
C
-------------LR
N
Q
E
V
K
R
A
L
C
C
T
L
--
H
LYQH---QDP
D
P
K
KASRNV-------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.92
19%
-136
- C5 -
2YDO
3
?
A:
[18-322]
---------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
-----
Y
F
--
V
V
S
A
A
A
A
D
I
L
V
G
V
-----------
L
A
-
I
P
F
A
I
A
-------
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
------
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
--
Y
N
G
-
L
---
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
----
W
N
N
C
-
G
-
Q
PK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
--
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
--
L
-
R
I
--
F
L
A
A
-----------
R
R
Q
---
L
K
Q
M
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
------------
H
----
A
------
P
L
W
L
M
Y
L
--------
A
I
V
L
S
H
T
---
N
S
V
V
N
P
F
I
--------
Y
A
-------------
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---
Q
E
P
F
K
A
A
A
A
E
N
L
-------------------------------------------------------------------------------------------------------------------------
29
HHSearch
86.34
18%
-152
- C5 -
3EML
13
ENLYS_BPT4
A:
[20-472]
----------------------------------------------
G
S
S
V
Y
I
T
V
E
--------------
L
A
I
--------------------
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
-----
Y
F
--
V
V
S
L
A
A
A
D
I
A
V
G
V
-----------
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
----
A
A
C
H
G
C
L
F
I
A
C
F
V
L
-----
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
------
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
--
Y
N
G
-
L
---
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
----
W
N
N
C
-
G
-
Q
-----------------
S
--
Q
G
-----
C
G
E
G
Q
V
---
A
C
L
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
-
V
P
--
L
L
L
M
-----------
L
G
V
---
Y
L
R
I
F
L
A
-
A
R
-------
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
--
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
--------
P
L
H
I
I
N
C
F
T
F
F
C
------------
P
DCSH
A
------
P
L
W
L
M
Y
L
--------
A
I
V
L
S
H
T
---
N
S
V
V
N
P
F
I
--------
Y
A
-------------
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
---
R
Q
-----------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.97
19%
-135
- C5 -
2YDV
6
?
A:
[18-322]
---------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
-----
Y
F
--
V
V
S
A
A
A
A
D
I
L
V
G
V
-----------
L
A
-
I
P
F
A
I
A
-------
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
------
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
--
Y
N
G
-
L
---
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
----
W
N
N
C
-
G
-
Q
PK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
--
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
--
L
-
R
I
--
F
L
A
A
-----------
R
R
Q
---
L
K
Q
M
E
S
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
--
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
------------
H
----
A
------
P
L
W
L
M
Y
L
--------
A
I
V
L
S
H
T
---
N
S
V
V
N
P
F
I
--------
Y
A
-------------
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---
Q
E
P
F
K
A
A
A
A
E
N
L
-------------------------------------------------------------------------------------------------------------------------
47
Fugue
84.44
22%
-149
- C2 -
4RNZ
9
?
A:
[1-369]
---------M
E
R
L
V
W
D
K
L
T
-------------
L
L
G
F
L
---
E
--
K
N
H
I
P
Q
K
L
Y
Y
N
L
S
S
Q
D
K
E
L
S
A
E
IQSN
V
T
Y
--------------------
Y
T
L
R
D
A
N
N
T
L
I
Q
A
L
I
P
I
S
Q
D
L
Q
I
H
I
Y
-----
K
K
GE
D
Y
F
L
D
F
I
P
I
I
F
T
R
-----------
K
E
-
K
T
L
L
L
S
L
Q
T
-
S
P
Y
Q
D
I
I
K
A
T
N
D
P
L
L
A
N
Q
L
M
N
A
Y
-----
K
K
S
----
V
P
F
K
R
L
V
------
K
N
D
K
I
A
I
V
Y
T
-----------
R
D
--
Y
R
V
G
Q
---
A
F
G
-
Q
P
T
I
K
M
A
M
V
S
S
R
S
------
N
Q
Y
-----
Y
L
----
F
S
H
S
-
N
------------------
G
H
--
Y
Y
-----------------
D
S
K
--
A
Q
E
V
A
G
F
L
L
E
T
P
V
K
--
Y
-
T
R
--
I
S
S
P
FSYGRFHRPHY
G
V
D
---
Y
A
A
K
H
G
S
-
L
I
-------
H
S
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
--
V
G
F
M
G
V
K
A
G
Y
G
K
V
V
E
I
H
L
N
--------
E
L
R
L
V
Y
A
H
M
S
A
F
ANGLKKG-----
S
----
F
------
V
K
K
G
Q
I
I
G
R
V
G
STG
P
H
L
H
F
G
V
Y
K
NS
R
P
I
-
N
P
L
G
--------
Y
I
RT
A
K
S
K
L
H
G
K
Q
R
E
V
F
L
E
K
A
Q
R
S
K
Q
K
L
E
--
E
L
L
K
T
---
H
S
F
E
K
N
S
F
Y
L
L
E
GFLEHHHH-----------------------------------------------------------------------------------------------------------------
42
Fugue
84.40
15%
-119
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
------
V
R
S
P
F
E
A
P
Q
Y
---
Y
LA
E
P
W
Q
F
S
M
L
A
A
Y
M
--------------
F
L
L
--------------------
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
-----
Y
I
--
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
----
P
T
G
C
N
L
E
G
F
F
A
T
-----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
------
I
E
R
Y
V
V
V
C
K
P
-----------
M
S
---
N
F
-
R
---
F
G
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
VGW
S
R
Y
I
----
P
E
G
M
Q
C
-
S
----------
C
G
I
D
------
Y
Y
-----
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
--
F
V
V
H
F
I
I
P
L
I
V
I
F
F
--
C
-
Y
G
--
Q
L
V
F
-----------
T
V
K
---
E
A
A
A
S
A
T
-
T
Q
---------
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
--
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
--------
G
V
A
F
Y
I
F
T
H
Q
G
S
------------
D
----
F
------
G
P
I
F
M
T
I
--------
P
A
F
F
A
K
T
---
S
A
V
Y
N
P
V
I
--------
Y
I
-------------
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
---
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
83.01
19%
-144
- C5 -
4UG2
3
?
A:
[18-309]
---------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
-----
Y
F
--
V
V
S
A
A
A
A
D
I
L
V
G
V
-----------
L
A
-
I
P
F
A
I
A
-------
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
------
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
--
Y
N
G
-
L
---
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
----
W
N
N
C
-
G
-
Q
PK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
--
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
--
L
-
R
I
--
F
L
A
A
-----------
R
R
Q
---
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
T
--
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
------------
H
----
A
------
P
L
W
L
M
Y
L
--------
A
I
V
L
S
H
T
---
N
S
V
V
N
P
F
I
--------
Y
A
-------------
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.80
19%
-137
- C5 -
4UHR
1
AA2AR_HUMAN
A:
[18-319]
---------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
-----
Y
F
--
V
V
S
A
A
A
A
D
I
L
V
G
V
-----------
L
A
-
I
P
F
A
I
A
-------
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
-----
V
L
T
A
S
S
I
F
S
L
L
A
I
A
------
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
--
Y
N
G
-
L
---
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-----
L
G
----
W
N
N
C
-
G
-
Q
PKEGKAG---
C
G
E
G
Q
V
A
C
--
L
F
-----
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
--
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
--
L
-
R
I
--
F
L
A
A
-----------
R
R
Q
---
L
K
Q
M
E
S
Q
-
P
L
-------
P
G
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
T
--
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-------------
H
----
A
------
P
L
W
L
M
Y
L
--------
A
I
V
L
S
H
T
---
N
S
V
V
N
P
F
I
--------
Y
A
-------------
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---
Q
E
P
F
K
A
A
A
A
----------------------------------------------------------------------------------------------------------------------------
25
HHSearch
81.89
17%
-148
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------------
P
L
V
V
V
L
--------------
S
T
I
--------------------
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
-----
L
Y
--
I
V
S
L
S
V
A
D
L
I
V
G
A
-----------
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
----
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
-----
V
A
S
T
A
S
I
F
S
V
F
I
L
C
------
I
D
R
Y
R
S
V
Q
Q
P
-----------
L
R
--
Y
L
K
-
Y
---
R
T
K
-
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
-----
G
-----
W
N
H
--------------------
R
R
E
--
D
K
-----
C
E
T
D
F
Y
D
-----------
V
T
W
F
K
V
M
T
A
I
I
N
F
--
Y
-
L
P
--
T
L
L
M
-----------
L
W
F
---
Y
A
K
I
Y
K
A
-
V
R
-------
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
--
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
--------
P
Y
F
I
F
F
M
V
I
A
F
C
------------
K
----
N
CC----
N
E
H
L
H
M
F
--------
T
I
W
L
G
Y
I
---
N
S
T
L
N
P
L
I
--------
Y
P
-------------
L
C
N
E
N
F
K
K
T
F
K
R
I
L
--
H
I
-------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
81.82
16%
-152
- C5 -
2Z73
5
OPSD_TODPA
A:
[31-334]
--------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
--------------
G
I
C
--------------------
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
-----
M
F
--
I
I
N
L
A
F
S
D
F
T
F
S
L
-----------
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
----
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
-----
I
F
G
F
M
S
I
M
T
M
A
M
I
S
------
I
D
R
Y
N
V
I
G
R
P
-----------
M
A
--
A
S
K
-
K
---
M
S
H
-
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
-----
F
G
----
W
G
A
Y
-
T
-
L
--------------
E
G
V
L
--
C
N
-----
C
S
F
D
Y
I
S
R
-----
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
--
F
-
G
P
--
I
L
I
I
-----------
F
F
C
---
Y
F
N
I
V
M
S
-
V
S
-------
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
--
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
--------
P
Y
A
V
V
A
L
L
A
Q
F
G
------------
P
LEW-
V
------
T
P
Y
A
A
Q
L
--------
P
V
M
F
A
K
A
---
S
A
I
H
N
P
M
I
--------
Y
S
-------------
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
W
V
L
T
---
C
C
Q
F
D
D
K
E
T
E
D
D
-------------------------------------------------------------------------------------------------------------------------
27
HHSearch
80.99
16%
-146
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-----------------------------------------------
V
V
G
M
G
I
V
M
--------------
S
L
I
--------------------
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
-----
Y
F
--
I
T
S
L
A
C
A
D
L
V
M
G
L
-----------
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
-----
L
C
V
T
A
S
I
E
T
L
C
V
I
A
------
V
D
R
Y
F
A
I
T
S
P
-----------
F
K
--
Y
Q
S
-
L
---
L
T
K
-
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-----
Q
M
----
H
W
Y
R
-
A
-
T
----------
H
----
Q
E
A
--
I
N
-----
C
Y
A
E
----
E
T
C
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
--
Y
-
V
P
--
L
V
I
M
-----------
V
F
V
---
Y
S
R
V
F
Q
E
-
A
K
-------
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
--
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
--------
P
F
F
I
V
N
I
V
H
V
I
Q
------------
D
NL--
I
------
R
K
E
V
Y
I
L
--------
L
N
W
I
G
Y
V
---
N
S
G
F
N
P
L
I
--------
Y
C
--------------
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
-------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
79.47
17%
-148
* C5 *
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
-----------------------------------------------
V
V
F
I
V
L
V
A
--------------
G
S
L
--------------------
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
-----
Y
F
--
L
F
S
L
A
C
A
D
L
I
I
G
V
-----------
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
----
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
-----
V
V
S
N
A
S
V
M
N
L
L
I
I
S
------
F
D
R
Y
F
C
V
T
K
P
-----------
L
T
--
Y
P
V
-
K
---
R
T
T
-
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
-----
L
F
----
W
Q
F
I
-
V
-
G
----------
V
--
R
T
V
E
D
--
G
E
-----
C
Y
I
Q
F
F
-----------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
--
Y
-
L
P
--
V
I
I
M
-----------
T
V
L
---
Y
W
H
I
S
R
A
-
S
K
-------
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
--
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
--------
P
Y
N
V
M
V
L
I
N
T
F
C
------------
A
PC--
I
------
P
N
T
V
W
T
I
--------
G
Y
W
L
C
Y
I
---
N
S
T
I
N
P
A
C
--------
Y
A
-------------
L
C
N
A
T
F
K
K
T
F
K
H
L
L
--
M
--------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
78.95
18%
-150
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------
Y
A
L
S
Y
--------------
C
A
L
--------------------
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
-----
Y
L
--
V
V
S
L
A
V
A
D
L
L
V
A
T
-----------
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
----
F
S
R
I
C
C
D
V
F
V
T
L
D
V
-----
M
M
C
T
A
S
I
W
N
L
C
A
I
S
------
I
D
R
Y
T
A
V
V
M
P
-----------
V
H
--
Y
Q
H
-
G
T
G
Q
S
S
C
-
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
-----
F
G
----
F
N
T
T
-------------------
G
D
P
--
T
V
-----
C
S
I
S
N
--------------
P
D
F
V
I
Y
S
S
V
V
S
F
--
Y
-
L
P
--
F
G
V
T
-----------
V
L
V
---
Y
A
R
I
Y
V
V
-
L
K
-------
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
--
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
--------
P
F
F
L
T
H
V
L
N
T
H
C
------------
Q
TCH-
V
------
S
P
E
L
Y
S
A
--------
T
T
W
L
G
Y
V
---
N
S
A
L
N
P
V
I
--------
Y
T
-------------
T
F
N
I
E
F
R
K
A
F
L
K
I
L
--
S
C
-------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
78.33
16%
-147
- C5 -
2KS9
1
NK1R_HUMAN
A:
[33-325]
------------------------------------------------
V
L
W
A
A
A
Y
--------------
T
V
I
--------------------
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
-----
Y
F
--
L
V
N
L
A
F
A
E
A
S
M
A
A
-----------
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
----
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
-----
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
------
F
D
R
Y
M
A
I
I
H
P
-----------
L
Q
--
P
R
L
------
S
A
-
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
-----
Y
Y
----
S
T
T
E
-----------------
T
M
P
S
R
--
V
V
-----
C
M
I
E
W
P
E
H
P
---
N
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
--
F
-
L
P
--
L
L
V
I
-----------
G
Y
A
---
Y
T
V
V
G
I
T
-
L
W
-------
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
--
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
--------
P
F
H
I
F
F
L
L
P
Y
I
N
------------
P
----
D
LYLKKF
I
Q
Q
V
Y
L
A
--------
I
M
W
L
A
M
S
---
S
T
M
Y
N
P
I
I
--------
Y
C
-------------
C
L
N
D
R
F
R
L
G
F
K
H
A
F
--
R
C
C
P
F
---
I
S
A
G
D
Y
E
G
L
E
M
K
-------------------------------------------------------------------------------------------------------------------------
44
Fugue
74.12
16%
-103
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
------
S
P
F
E
A
P
Q
Y
Y
L
---
A
--
E
P
W
Q
F
S
M
L
A
A
Y
M
--------------
F
L
L
--------------------
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
-----
Y
I
--
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
----
P
T
G
C
N
L
E
G
F
F
A
T
-----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
------
I
E
R
Y
V
V
V
C
K
P
-----------
M
S
--
N
F
R
-
F
----
G
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
----
P
E
G
M
-
Q
C
S
----------
C
G
I
D
------
Y
Y
-----
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
--
F
V
V
H
F
I
I
P
L
I
V
I
F
F
--
C
Y
G
Q
--
L
V
F
T
-----------
V
K
E
---
A
A
A
Q
Q
Q
E
S
A
T
-------
T
Q
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
--
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
--------
G
V
A
F
Y
I
F
T
H
Q
G
S
------------
D
----
F
------
G
P
I
F
M
T
I
--------
P
A
F
F
A
K
T
---
S
A
V
Y
N
P
V
I
--------
Y
I
-------------
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
PLG
D
D
E
A
S
T
T
V
S
K
T
E
TSQVAPA------------------------------------------------------------------------------------------------------------------
45
Fugue
73.94
19%
-154
- C4 -
4U6D
22
?
A:
[28-409]
------EGFPFI
L
P
K
E
K
P
N
R
P
------
L
S
A
A
M
Q
R
N
Y
D
N
YM
A
--
P
R
P
E
N
N
E
L
Y
T
Q
F
--------------
K
Y
T
E
L
K
GFDYNGHDGTISRRDPS
K
V
I
Y
E
N
G
K
Y
Y
V
W
Y
T
Y
R
N
T
P
T
P
P
Q
G
A
K
NSNDT
I
P
--
S
A
D
W
D
L
A
E
I
W
Y
A
T
S
KDGF
T
W
E
E
QG
V
A
-
V
P
R
P
P
K
P
N
V
-
G
W
R
S
V
T
T
T
D
I
L
K
W
K
G
K
F
Y
L
Y
Y
Q
G
F
MEAS
G
T
R
G
D
D
C
P
V
A
V
S
Y
A
DSPDGP
W
T
P
H
T
E
V
V
I
P
N
G
K
KGEWDQYS
I
H
D
P
Y
P
I
-
V
---
Y
K
D
-
K
I
Y
L
Y
Y
K
S
-
D
F
D
G
D
P
N
L
V
R
M
Q
G
-----
L
A
----
I
A
D
--
N
-
P
----------
L
G
P
F
K
K
S
-----------
P
L
N
P
V
I
N
-
S
G
H
E
T
T
--
L
F
P
F
K
E
G
M
A
A
L
V
I
R
--
D
-
G
T
EH
N
T
V
Q
-----------
Y
A
E
DGV
N
F
N
I
A
S
I
-
V
E
-------
F
M
P
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
P
--
Y
V
A
D
A
F
T
N
T
K
Y
G
R
G
I
S
W
-----------
G
I
S
H
F
T
N
A
---------------
T
----
T
------
W
D
Q
N
H
A
V
--------
L
A
R
F
D
C
D
---
L
S
L
--------------
D
-------------
V
D
D
P
H
M
K
R
L
G
T
Y
F
K
--
P
E
F
Y
Y
---
Q
M
G
L
S
K
K
Q
R
E
R
I
-------------------------------------------------------------------------------------------------------------------------
31
HHSearch
73.77
15%
-132
- C5 -
1U19
14
OPSD_BOVIN
A:
[38-328]
---------------------------------------------
W
Q
F
S
M
L
A
A
Y
M
--------------
F
L
L
--------------------
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
-----
Y
I
--
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
T
G
C
N
L
E
G
F
F
A
T
-----
L
G
G
E
I
A
L
W
S
L
V
V
L
A
------
I
E
R
Y
V
V
V
C
K
P
-----------
M
S
--
N
F
R
-
F
----
G
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-----
V
G
----
W
S
R
Y
-
I
-
P
--------------
E
G
M
Q
--
C
S
-----
C
G
I
D
Y
Y
T
P
---
H
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
-
I
P
--
L
I
V
I
-----------
F
F
C
---
Y
G
Q
L
V
F
T
-
V
K
-------
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
--
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
--------
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS---------
D
----
F
------
G
P
I
F
M
T
I
--------
P
A
F
F
A
K
T
---
S
A
V
Y
N
P
V
I
--------
Y
I
-------------
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
---
P
L
G
D
D
E
A
S
T
T
V
S
-------------------------------------------------------------------------------------------------------------------------
24
HHSearch
72.59
15%
-148
- C5 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-498]
---------------------------------------------
F
N
K
I
F
L
P
T
I
Y
--------------
S
I
I
--------------------
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
-----
K
Y
--
R
L
H
L
S
V
A
D
L
L
F
V
------------
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
----
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
-----
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
------
L
D
R
Y
L
A
I
V
H
A
-----------
T
N
--
S
Q
R
-
P
---
R
K
L
-
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
-----
I
F
----
A
N
V
S
-
E
----------------
A
D
D
R
--
Y
I
-----
C
D
R
F
Y
P
N
------
D
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
--
I
-
L
P
--
G
I
V
I
-----------
L
S
C
---
Y
C
I
I
I
S
K
-
L
S
-------
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
--
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
--------
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
----
T
------
V
H
K
W
I
S
I
--------
T
E
A
L
A
F
F
---
H
C
C
L
N
P
I
L
--------
Y
A
-------------
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
--
T
S
G
R
P
---
L
E
V
L
F
Q
-------------------------------------------------------------------------------------------------------------------------------
48
Fugue
72.01
19%
-168
- C4 -
4INO
-
?
A:
[1-302]
----------Q
E
V
K
V
K
D
Y
F
G
E
Q
T
I
K
L
P
V
S
K
I
I
Y
L
G
S
F
---
A
--
E
V
P
A
M
F
H
T
W
D
R
---------------
V
V
G
--------------------
I
S
D
Y
A
F
K
S
D
I
V
K
A
T
L
K
D
P
E
R
I
-
K
P
M
S
---------
S
D
H
A
A
A
L
N
V
E
L
L
K
-----------
K
L
-
S
P
D
L
V
V
T
F
V
-
G
N
P
K
A
V
E
H
A
K
K
F
G
--
I
S
F
L
S
F
-----------
Q
E
K
T
I
A
E
V
M
E
------
D
I
D
T
Q
A
K
A
L
E
-----------
V
D
--
A
S
K
-
K
---
L
A
K
M
Q
E
T
L
D
F
I
A
E
R
L
K
G
V
K
K
K
K
G
V
E
L
-----
F
H
KAN
K
I
S
G
H
-
Q
-
A
----------
L
D
S
D
I
L
E
K
G
G
I
D
-----
N
F
G
L
K
Y
V
K
F
G
R
A
D
I
S
--
V
E
K
I
V
K
E
N
P
E
I
I
F
I
W
W
I
-
S
P
--
L
S
--------------
P
E
---
D
V
L
N
N
P
K
-
F
A
-------
T
I
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
K
Q
V
Y
K
L
P
T
M
D
I
G
G
P
R
A
P
L
I
--
S
--------
L
F
I
A
L
K
A
H
P
E
A
F
------------
K
----
G
------
V
D
I
N
A
I
V
--------
K
D
Y
Y
K
V
V
---
F
D
L
-----------------------------
N
D
A
E
V
E
P
F
L
---------
W
H
----------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
68.17
11%
-131
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
--------------
S
L
I
--------------------
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
-----
Y
F
--
I
T
S
L
A
C
A
D
L
V
M
G
L
-----------
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
----
N
F
W
C
E
F
W
T
S
I
D
V
-----
L
C
V
T
A
S
I
E
T
L
C
V
I
A
------
V
D
R
Y
F
A
I
T
S
P
-----------
F
K
--
Y
Q
S
-
L
---
L
T
K
-
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-----
Q
M
------
H
W
-
Y
-
R
----------
A
T
H
Q
E
A
I
N
--
C
Y
A
EETC
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
--
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
--
S
-
R
V
--
F
Q
E
A
-----------
K
R
Q
---
L
N
I
F
E
M
L
-
R
I
D
E
G
L
R
L
K
I
Y
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
Y
--
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
--------
S
E
L
D
K
A
I
G
R
N
T
N
------------
G
----
V
------
I
T
K
D
E
A
E
--------
K
L
F
N
Q
D
V
---
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-------------
S
L
D
A
V
R
R
A
A
L
I
N
M
V
--
F
Q
M
G
E
---
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
32
HHSearch
66.86
14%
-136
- C5 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
--------------------------------------------
E
N
S
I
K
L
T
S
V
V
F
--------------
I
L
I
--------------------
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
-----
Y
F
--
I
G
N
L
A
L
S
D
L
L
A
G
V
-----------
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
----
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
-----
V
A
L
S
A
S
V
F
S
L
L
A
I
A
------
I
E
R
Y
I
T
M
L
K
-------------------------
N
N
-
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
-----
M
G
----
W
N
C
I
-------------------
S
A
L
--
S
S
-----
C
S
T
V
L
P
L
-----------
Y
H
K
H
Y
I
L
F
C
T
T
V
F
--
T
-
L
L
--
L
L
S
I
-----------
V
I
L
---
Y
C
R
I
Y
S
L
-
V
R
-------
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
--
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
--------
P
L
F
I
L
L
L
L
D
V
G
C
------------
K
----
V
KTC
D
--
I
L
F
R
A
E
Y
--------
F
L
V
L
A
V
L
---
N
S
G
T
N
P
I
I
--------
Y
T
-------------
L
T
N
K
E
M
R
R
A
F
I
R
I
M
--
G
R
P
L
-----------------------------------------------------------------------------------------------------------------------------------------