@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR6C3_HUMAN: (2016-01-14 )
MNHTMVTEFVLLGLSDDPDLQIVIFLFLFITYILSVTGNLTIITLTFVDSHLQTPMYFFLRNFSFLEISFTTVCIPRFLGAIITRNKTISYNNCAAQLFFFIFMGVTEFYILTAMSYDRYVAICKPLHYTSIMNRKLCTLLVLCAWLSGFLTIFPPLMLLLQLDYCASNVIDHFACDYFPLLQLSCSDTWLLEVIGFYFALVTLLFTLALVILSYMYIIRTILRIPSASQRKKAFSTCSSHMIVISISYGSCIFMYANPSAKEKASLTKGIAILNTSVAPMLNPFIYTLRNQQVKQAFKNVVHKVVFYANQ
Atome Classification :
(20 SA)
.........10........20----------------........30........40........50........60........70...-.....80........90..--....---..---100.......110.......120.......130.......140.......150.......160.......--170--....----....180.....-------.-------..190.......200.......210.......220..---------...-.-----------.--------------------230--.---........240.......250--------.......260.---.---.-------.-------.--..270.......280.......290.......300.------------------......310----------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
H
T
M
V
T
E
F
V
LLGLSDDPD
L
Q
----------------
I
V
I
F
L
F
L
F
I
T
Y
I
L
SVTG
N
L
T
I
I
T
L
T
F
V
D
S
H
LQ
T
P
M
Y
F
F
L
RNF
S
F
L
E
I
S
F
T
T
V
C
-
I
P
R
F
L
G
A
I
I
TRNKTISY
N
N
--
C
A
A
Q
---
L
F
---
F
F
I
F
M
G
V
T
E
F
Y
I
L
T
AMSYD
R
Y
V
A
I
CKP
L
H
Y
T
S
I
M
N
R
K
L
C
T
L
L
V
L
C
A
W
L
S
G
F
L
T
I
F
P
P
L
M
L
L
L
Q
L
D
Y
C
A
S
N
--
V
I
---
D
H
F
A----C
D
Y
F
P
L
-
L
Q
LSC-------S-------
D
T
W
L
L
E
V
I
G
F
Y
F
A
L
V
T
L
L
F
T
L
A
L
V
I
L
S
Y
M
Y
I
I
R
T
I
L
R---------IPS-
A
-----------
S
--------------------
Q
----
R
---
K
K
A
F
S
TCSS
H
M
I
V
I
S
ISYG
S
C
--------
I
F
M
YANPS
A
K
E
---
K
---
A
-------
S
-------L--TK
G
I
A
I
LNT
S
V
A
P
M
L
N
P
F
I
Y
T
L
R
N
Q
Q
V
K
Q
A
F
K
N
V
V
H
------------------
K
V
V
FYANQ-----------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
92.97
18%
-146
- C3 -
2YDV
6
?
A:
[18-312]
------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
--
C
L
F
I
---
A
C
---
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
--
K
E
---
G
K
A
H
----
S
Q
G
C
G
E
-
G
Q
V
A
C
LF-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ--------------------------------------------S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
---
P
-------
L
-------
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
------------------
S
H
V
L
R
Q
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
92.61
18%
-144
- C3 -
2YDO
3
?
A:
[18-312]
------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
--
C
L
F
I
---
A
C
---
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
--
K
E
---
G
K
A
H
----
S
Q
G
C
G
E
-
G
Q
V
A
C
LF-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S---------------------------------------------T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
---
P
-------
L
-------
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
------------------
S
H
V
L
R
Q
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
90.05
20%
-148
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[18-305]
------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
-----------------
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
-
E
-----------
R
--------------------
A
----
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
---
P
-------
L
-------
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
90.03
20%
-148
- C3 -
3PWH
1
?
A:
[18-305]
------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
-----------------
G
C
G
E
-
G
Q
V
A
C
LF-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
-
E
-----------
R
--------------------
A
----
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
---
P
-------
L
-------
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
89.25
20%
-146
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[18-305]
------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
-----------------
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
-
E
-----------
R
--------------------
A
----
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
---
P
-------
L
-------
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
88.64
20%
-144
- C3 -
3REY
1
AA2AR_HUMAN
A:
[18-305]
------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
-----------------
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
-
E
-----------
R
--------------------
A
----
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
---
P
-------
L
-------
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.59
20%
-150
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[18-308]
------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
----------------
S
Q
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
-
E
-----------
R
--------------------
A
----
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
---
P
-------
L
-------
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
------------------
S
H
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
88.47
20%
-147
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[18-305]
------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
P
-----------------
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
-
E
-----------
R
--------------------
A
----
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
---
P
-------
L
-------
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
88.37
18%
-137
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
---
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
------------------------
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
-
S
-----------
A
--------------------
T
----
T
---
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
---
F
---
T
-------
H
QGSDFGP
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
------------------
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A-----------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.62
20%
-153
- C3 -
3VG9
8
?
A:
[18-309]
------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
G
W
N
N
C
G
Q
----------------
S
Q
G
C
G
E
-
G
Q
V
A
C
L
F
-----
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
-
E
-----------
R
--------------------
A
----
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
---
P
-------
L
-------
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
------------------
S
H
V
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
86.97
19%
-119
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
---
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
------------------------
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
-
Q
-----------
Q
--------------------
Q
ESA
T
T
---
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
---
F
---
T
H
QGSDFG
P
-------
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
84.51
15%
-142
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-------------------
V
Y
----------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
--
C
K
V
Y
---
G
F
---
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
------
G
---
V
L
C
N
----
C
S
F
D
Y
I
-------------
S
-------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
---------
H
E
K
-
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
----
E
---
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
--------
A
V
V
A
L
L
A
Q
F
G
P
LEW
V
---
T
-------
P
-------
Y
--
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
------------------
W
V
L
T
C
C
Q
F
-----------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
84.05
17%
-141
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
--------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
--
C
K
F
H
---
N
F
---
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-
E
T
M
------
P
---
S
R
V
V
----
C
M
I
E
W
P
-
E
H
----------
P
-------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
---------
S
E
I
-
P
GDSSDRYH
E
Q
V
S
--------------------
A
----
K
---
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
--------
H
I
F
F
L
L
P
Y
I
N
P
---
D
LYL
K
-------
K
F------
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
------------------
C
C
P
F
I
S
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
76.15
15%
-123
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-327]
-------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
--
C
N
L
E
---
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
------
E
G
---
M
Q
C
S
----
C
G
I
D
Y
Y
-
T
P
----------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
-
Q
-----------
Q
QESA
T
T
Q
K
------------
A
----
E
---
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
--------
A
G
V
A
F
Y
I
F
T
H
Q
G--
S
DF-
G
-------
P
-------
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
------------------
C
G
K
N
P
L
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
75.78
15%
-116
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------
D
E
V
W
V
----------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
--
C
E
F
W
---
T
S
---
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-
R
A
T
H
Q
E
--
A
I
---
N
C
Y
A
----
E
E
T
C
C
D
-
F
F
T
N
Q
-------
A
-------
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
---------
L
R
I
-
D
-----------
E
--------------------
G
----
L
---
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
-
H
L
L
--------
T
K
S
P
S
L
N
A
A
K
S
---
E
---
L
-------
D
-------
K
--
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
------------------
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
17
PsiBlast_PDB
75.62
22%
-157
- C3 -
4LDO
3
A:
[197-395]
---------------------------------------------------
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
--
C
E
F
W
---
T
S
---
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
---
Y
R
A
T
H
Q
E
A
I
---
N
C
Y
A
EETC
C
D
F
F
T
N
-
Q
A
Y
A
I
-------
A
-------
S
S
----
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
---
F
Q
E
A
K
R
Q
L
Q
------------
K
F
A
-----------
L
--------------------
K
----
E
---
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
--------
F
I
V
N
I
V
H
V
I
Q
D
---
N
---
L
-------
I
-------
R
--
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
------------------
C
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.56
23%
-167
- C3 -
4QKX
2
ADRB2_HUMAN
A:
[197-395]
---------------------------------------------------
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
C
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
---
T
S
---
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
---
Y
R
A
T
H
Q
E
A
I
---
N
C
Y
A
EETC
C
D
F
F
T
N
-
Q
A
Y
A
I
-------
A
-------
S
S
----
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
---
F
Q
E
A
K
R
Q
L
Q
------------
K
F
A
-----------
L
--------------------
K
----
E
---
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
--------
F
I
V
N
I
V
H
V
I
Q
D
---
N
---
L
-------
I
-------
R
--
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
------------------
C
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.32
22%
-160
- C3 -
4LDL
3
ADRB2_HUMAN
A:
[197-395]
---------------------------------------------------
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
--
C
E
F
W
---
T
S
---
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
---
Y
R
A
T
H
Q
E
A
I
---
N
C
Y
A
EETC
C
D
F
F
T
N
-
Q
A
Y
A
I
-------
A
-------
S
S
----
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
---
F
Q
E
A
K
R
Q
L
Q
------------
K
F
A
-----------
L
--------------------
K
----
E
---
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
--------
F
I
V
N
I
V
H
V
I
Q
D
---
N
---
L
-------
I
-------
R
--
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
------------------
C
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.26
22%
-155
- C3 -
2YCZ
2
ADRB1_MELGA
A:
[16-219]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
--
F
L
C
E
---
L
W
T
S
-
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
--
L
K
C
Y
Q
D
P
G
C
----
C
D
F
V
T
N
-
R
A
Y
A
I
-------
A
-------
S
S
----
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
---
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
-
A
-----------
S
--------------------
K
----
R
---
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
--------
F
T
L
C
W
L
P
F
F
L
V
---
N
---
I
-------
V
-------
N
--
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
------------------
R
K
A
F
K
R
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.02
22%
-153
- C3 -
2YCW
7
ADRB1_MELGA
A:
[16-219]
-----------------------------------------
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
--
F
L
C
E
---
L
W
T
S
-
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
--
L
K
C
Y
Q
D
P
G
C
----
C
D
F
V
T
N
-
R
A
Y
A
I
-------
A
-------
S
S
----
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
---
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
-
A
-----------
S
--------------------
K
----
R
---
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
--------
F
T
L
C
W
L
P
F
F
L
V
---
N
---
I
-------
V
-------
N
--
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
------------------
R
K
A
F
K
R
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------