@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR6N2_HUMAN: (2016-01-14 )
MDQYNHSSLAEFVFLGFASVGYVRGWLFVLLLLAYLFTICGNMLIFSVIRLDAALHTPMYHFVSVLSFLELWYTATTIPKMLSNILSEKKTISFAGCLLQTYFFHSLGASECYLLTAMAYDRYLAICRPLHYPIIMTTTLCAKMAAACWTCGFLCPISEVILASQLPFCAYNEIQHIFCDFPPLLSLACKDTSANILVDFAINAFIILITFFFIMISYARIIGAVLKIKTASGRKKAFSTCASHLAVVLIFFGSIIFMYVRLKKSYSLTLDRTLAIVYSVLTPMVNPIIYSLRNKEIIKAIKRTIFQKGDKASLAHL
Atome Classification :
(20 SA)
------------------------------------------------------------------.........10.--.....---------..20....----------------....30.------------------.......40........50.........60..--..----....70......-..80.......---.90.--.......100.......110.....-----------..120--.....---..130-----.........140.......150.---....---------..160-...--.-...170.......180--.........------190..--...------..200.....--..210.---......220.---......--------------.---230----------.--------------------..----.....240----.........250.------...-----...260...-------.---.---..-270--.........280...---....290..----------------.....300....---------------...310.....-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------MDQY
N
H
S
S
L
A
E
F
--
V
F
L
G
F
---------
A
S
V
G
Y
V
R
G
----------------
W
L
F
V
L
L
L
------------------
L
A
Y
L
F
T
I
C
G
N
M
L
I
F
S
V
I
R
-
L
D
A
A
LH
T
P
M
Y
H
F
V
--
S
V
----
L
S
F
L
E
L
W
Y
T
AT
T
-
I
P
K
M
L
S
N
I
L
SE---KK
T
I
--
S
F
A
G
C
L
L
Q
T
Y
F
F
HSLGAS
E
C
Y
L
L
T
A
-----------
M
A
Y
D
R
--
Y
L
A
I
C
---RPL-------HY
P
I
I
M
T
T
T
L
C
A
K
M
A
A
A
C
W
TCGF---LC
P
I
---------
S
E
V
I
L
-
A
SQ--L-P
F
C
A
Y
N
E
I
Q
H
I
F
CD----FP
P
L
L
S
L
AC------KDTSA--
N
I
L
------
V
D
F
A
I
N
A
F
I
I
--
L
I
T
F
F
F
---
I
M
I
S
Y
A
R
I
-
I
---
G
A
V
L
K
I
--------------K---TA-----------S--------------------G
R
----
K
K
A
F
S
T
------
C
A
S
H
L
A
V
V
L
I
F
F
G
------
S
I
I
-----
F
M
Y
V
R
L
KKS-------Y---S---L
T
-
L
----
D
R
T
L
A
I
V
Y
S
V
L
T
P
M
V
---
N
P
I
I
Y
S
LR
N
----------------
K
E
I
I
K
A
I
K
R
T
I
F---------------QKGDKASLAHL-----------------
3
PsiBlast_PDB
89.87
25%
-159
- C5 -
2YDO
3
?
A:
[18-303]
--------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
V
T
N
Y
F
V
--
V
S
----
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
---
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
-----------
I
A
I
D
R
--
Y
I
A
I
R
---
I
P
L
-------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
LGWNNCGQP
K
E
G
K
A
-
H
S
Q
-----
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------------------
N
Y
M
------
V
Y
F
N
F
F
A
-
C
V
--
L
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
L
---
A
A
R
R
Q
L
--------------
K
---
Q
M
-----------
E
--------------------
S
----------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
S
-------
H
---
A
---
P
L
-
W
----
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
----------------
R
E
F
R
Q
T
F
R
K
I
I
R
---------------
S
H
V
L
R
Q
Q
E
P
F
K
-----------------
2
PsiBlast_PDB
89.55
25%
-160
- C5 -
3VGA
1
AA2AR_HUMAN
A:
[18-303]
--------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
V
T
N
Y
F
V
--
V
S
----
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
---
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-----------
I
A
I
D
R
--
Y
I
A
I
R
---
I
P
L
-------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
LGWNNCGQ--------
S
Q
-----
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------------------
N
Y
M
------
V
Y
F
N
F
F
A
-
C
V
--
L
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
L
---
A
A
R
R
Q
L
--------------
K
---
Q
M
-----------
E
--------------------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
S
-------
H
---
A
---
P
L
-
W
----
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
----------------
R
E
F
R
Q
T
F
R
K
I
I
R
---------------
S
H
V
L
------------------------
4
PsiBlast_PDB
89.03
25%
-160
- C5 -
2YDV
6
?
A:
[18-303]
--------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
V
T
N
Y
F
V
--
V
S
----
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
---
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
-----------
I
A
I
D
R
--
Y
I
A
I
R
---
I
P
L
-------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
LGWNNCGQP
K
E
G
K
A
-
H
S
Q
-----
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------------------
N
Y
M
------
V
Y
F
N
F
F
A
-
C
V
--
L
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
L
---
A
A
R
R
Q
L
--------------
K
---
Q
M
-----------
E
--------------------
S
Q
--------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
S
-------
H
---
A
---
P
L
-
W
----
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
----------------
R
E
F
R
Q
T
F
R
K
I
I
R
---------------
S
H
V
L
R
Q
Q
E
P
F
K
-----------------
1
PsiBlast_PDB
87.75
25%
-160
- C5 -
3VG9
8
?
A:
[18-303]
--------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
V
T
N
Y
F
V
--
V
S
----
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
---
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-----------
I
A
I
D
R
--
Y
I
A
I
R
---
I
P
L
-------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
LGWNNCGQ--------
S
Q
-----
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------------------
N
Y
M
------
V
Y
F
N
F
F
A
-
C
V
--
L
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
L
---
A
A
R
R
Q
L
--------------
K
---
Q
M
-----------
E
--------------------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
S
-------
H
---
A
---
P
L
-
W
----
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
----------------
R
E
F
R
Q
T
F
R
K
I
I
R
---------------
S
H
V
L
R
-----------------------
5
PsiBlast_PDB
87.14
25%
-163
- C5 -
4UG2
3
?
A:
[18-303]
--------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
V
T
N
Y
F
V
--
V
S
----
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
---
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
-----------
I
A
I
D
R
--
Y
I
A
I
R
---
I
P
L
-------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
LGWNNCGQP
K
E
G
K
A
-
H
S
Q
-----
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------------------
N
Y
M
------
V
Y
F
N
F
F
A
-
C
V
--
L
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
L
---
A
A
R
R
Q
L
------------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
S
-------
H
---
A
---
P
L
-
W
----
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
----------------
R
E
F
R
Q
T
F
R
K
I
I
R
---------------
S
H
V
L
R
-----------------------
6
PsiBlast_PDB
86.86
25%
-161
- C5 -
4UHR
1
AA2AR_HUMAN
A:
[18-303]
--------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
V
T
N
Y
F
V
--
V
S
----
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
---
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
-----------
I
A
I
D
R
--
Y
I
A
I
R
---
I
P
L
-------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
LGWNNCGQP
K
E
G
K
A
---------
G
C
G
E
G
Q
V
A
C
L
F
E
D
----
V
V
P
M
------------------
N
Y
M
------
V
Y
F
N
F
F
A
-
C
V
--
L
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
F
L
---
A
A
R
R
Q
L
--------------
K
---
Q
M
-----------
E
--------------------
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
---
F
T
F
F
C
P
D
C
--------
H
---
A
---
P
L
-
W
----
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
----------------
R
E
F
R
Q
T
F
R
K
I
I
R
---------------
S
H
V
L
R
Q
Q
E
P
F
K
-----------------
40
Fugue
84.22
16%
-120
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------------------------------------------------------
M
N
G
T
E
G
P
N
F
--
Y
V
P
F
S
---------
N
K
T
G
V
V
R
S
PFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
------------------
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
-
Q
H
K
K
L
R
T
P
L
N
Y
I
L
--
L
N
----
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
---
Y
F
V
F
--
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-----------
L
A
I
E
R
--
Y
V
V
V
C
---
K
P
M
-------
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
---
A
C
A
A
---------
P
P
L
V
G
-
W
S
R
-----------------
Y
----
I
P
E
G
M
Q
C
S
C
------
G
I
D
Y
Y
--
T
P
H
------
E
E
T
N
N
E
S
F
V
I
--
Y
M
F
V
V
H
---
F
I
I
P
L
I
V
I
-
F
---
F
C
Y
G
Q
L
VFTVKEAAASATTQ
K
---
A
E
-----------
K
--------------------
E
V
----
T
R
M
V
I
I
------
M
V
I
A
F
L
I
C
W
L
P
Y
A
------
G
V
A
-----
F
Y
I
F
T
H
Q
G
S
-------
D
---
F
---
G
P
-
I
----
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
---
N
P
V
I
Y
I
M
M
N
----------------
K
Q
F
R
N
C
M
V
T
T
L
C
---------------
C
G
K
N
P
S
T
T
V
S
K
TETS
Q
V
A
P
A--------
41
Fugue
80.39
17%
-132
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------------------------------------------------MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
--
P
Q
Y
Y
L
---------
A
E
P
W
Q
F
S
M
----------------
L
A
A
Y
M
F
L
------------------
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
-
Q
H
K
K
L
R
T
P
L
N
Y
I
L
--
L
N
----
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
---
Y
F
V
F
--
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-----------
L
A
I
E
R
--
Y
V
V
V
C
---
K
P
M
-------
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
---
A
C
A
--------------
A
-
P
P
L
--
V
-
G
W
S
R
Y
-------------
I
P
E
G
M
Q
C
S
C
G
I
DYYT
P
H
E
E
T
--
N
-
N
------
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
---
I
F
F
C
Y
G
Q
L
-
V
---
F
T
V
K
E
A
AAQQQESA------
T
---
T
Q
-----------
K
--------------------
A
E
----
K
E
V
T
R
M
------
V
I
I
M
V
I
A
F
L
I
C
W
L
------
P
Y
A
-----
G
V
A
F
Y
I
F
T
H
-------
Q
---
G
---
S
D
-
F
----
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
AV
Y
N
P
V
I
Y
I
M
M
N
----------------
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------
34
HHSearch
80.02
16%
-140
- C5 -
2Z73
5
OPSD_TODPA
A:
[32-335]
--------------------------------------------------------------------------------------------------
A
V
Y
Y
----------------
S
L
G
I
F
I
G
------------------
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
-
K
T
K
S
L
Q
T
P
A
N
M
F
I
--
I
N
----
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
---
K
W
I
F
--
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-----------
I
S
I
D
R
--
Y
N
V
I
G
---
R
P
M
-------
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
---
L
W
A
I
---------
G
P
I
F
G
-
W
G
A
--
Y
-
T
L
----
E
G
V
L
C
N
C
S
----
F
D
Y
I
S
-----------
R
D
S
T
--
T
R
S
------
N
I
L
C
M
F
I
L
G
F
--
F
G
P
I
L
I
---
I
F
F
C
Y
F
N
I
-
V
---
M
S
V
S
N
H
--------------
E
---
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
----
M
R
L
A
K
I
------
S
I
V
I
V
S
Q
F
L
L
S
W
S
------
P
Y
A
-----
V
V
A
L
L
A
Q
F
G
-------
P
LEW
V
---
T
P
-
Y
----
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
---
N
P
M
I
Y
S
V
S
H
----------------
P
K
F
R
E
A
I
S
Q
T
F
P
---------------
W
V
L
T
C
C
Q
F
D
D
K
-----------------
31
HHSearch
77.52
14%
-144
- C5 -
2KS9
1
NK1R_HUMAN
A:
[33-325]
-----------------------------------------------------------------------------------------------------
V
----------------
L
W
A
A
A
Y
T
------------------
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
-
A
H
K
R
M
R
T
V
T
N
Y
F
L
--
V
N
----
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
---
E
W
Y
Y
--
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
-----------
V
A
F
D
R
--
Y
M
A
I
I
---
H
P
L
-------
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
---
L
L
A
F
---------
P
Q
G
Y
Y
-
S
T
T
--
E
--
T
----
M
P
S
R
V
V
C
M
----
I
E
W
P
E
H
---------
P
N
K
I
Y
--
E
K
V
------
Y
H
I
C
V
T
V
L
I
Y
--
F
L
P
L
L
V
---
I
G
Y
A
Y
T
V
V
-
G
---
I
T
L
W
A
S
--------------
E
---
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
----
R
K
V
V
K
M
------
M
I
V
V
V
C
T
F
A
I
C
W
L
------
P
F
H
-----
I
F
F
L
L
P
Y
I
N
-------
P
---
D
LYL
K
K
F
I
Q
Q
--
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
---
N
P
I
I
Y
C
C
L
N
----------------
D
R
F
R
L
G
F
K
H
A
F
R
---------------
C
C
P
F
I
S
A
G
D
Y
E
-----------------
32
HHSearch
77.45
16%
-123
- C5 -
1U19
14
OPSD_BOVIN
A:
[40-328]
----------------------------------------------------------------------------------------------------
F
S
----------------
M
L
A
A
Y
M
F
------------------
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
-
Q
H
K
K
L
R
T
P
L
N
Y
I
L
--
L
N
----
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
---
Y
F
V
F
--
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-----------
L
A
I
E
R
--
Y
V
V
V
C
---
K
P
M
-------
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
---
A
C
A
A
---------
P
P
L
V
G
-
W
S
R
--
Y
-
I
P
--
E
--
G
M
Q
C
S
C
G
----
I
D
Y
Y
T
P
---------
H
E
E
T
N
--
N
E
S
------
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
---
I
F
F
C
Y
G
Q
L
-
V
---
F
T
V
K
E
A
--------------
A
---
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
----
K
E
V
T
R
M
------
V
I
I
M
V
I
A
F
L
I
C
W
L
------
P
Y
A
-----
G
V
A
F
Y
I
F
T
H
-------
Q
GSD
F
---
G
P
-
I
----
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
---
N
P
V
I
Y
I
M
M
N
----------------
K
Q
F
R
N
C
M
V
T
T
L
C
---------------
C
G
K
N
P
L
G
D
D
E
A
-----------------
48
Fugue
73.63
20%
-152
- C4 -
4QTZ
-
?
A:
[1-321]
--------------------------------------------------------------------------
L
G
N
V
--
V
C
V
T
G
---------
A
S
-
G
Y
I
A
S
----------------
W
L
V
R
L
L
L
H
R
GYTVKATVRDPNDPKK
V
D
H
L
V
K
L
D
G
A
K
E
R
L
Q
L
F
K
-
A
N
---
L
L
E
E
G
A
F
D
--
S
V
----
V
Q
G
C
H
G
V
F
H
--
T
-
A
S
P
F
Y
H
D
V
K
D
P
---
Q
A
E
L
--
I
D
P
A
L
K
G
T
L
N
V
L
N
S
C
A
K
S
P
-
S
L
K
R
V
-----------
V
L
T
S
S
--
I
A
A
V
A
YNG
K
P
R
-------
T
P
D
V
V
V
D
E
T
W
F
T
D
-
A
D
F
C
A
K
S
N
L
---
W
Y
V
V
---------
S
K
T
L
A
-
E
E
A
--
A
W
K
F
V
K
E
N
N
I
D
M
V
T
I
N
P
A
MV
I
G
P
L
L
Q
P
V
L
------
N
T
S
A
A
--
A
I
L
--------
N
L
I
N
G
A
Q
T
--
F
P
N
A
S
F
---
G
W
V
N
V
K
D
V
-
A
---
N
A
H
I
L
A
--------------
Y
E
NA
S
A
-----------
S
--------------------
G
R
----
H
C
L
V
E
R
------
V
A
H
Y
S
E
V
V
R
I
L
R
E
------
L
---------
Y
P
S
L
Q
L
P
-------
E
---
K
---
C
A
-
D
----
D
K
P
Y
V
P
I
Y
Q
V
S
K
E
K
A
---
K
S
L
--
G
L
E
Y
----------------
T
P
L
E
V
S
I
K
E
T
V
E
---------------
S
L
K
E
K
-
K
F
A
N
L
-----------------
44
Fugue
72.74
17%
-163
* C3 *
4PO6
4
TYK2_HUMAN
A:
[6-546]
G
G
L
K
V
L
L
HWAGPGGGEP
W
V
T
F
SESSLT
A
E
E
V
C
I
H
I
A
H
K
V
GITPPCFNL
F
A
L
F
DAQAQ
V
W
L
P
PN
H
I
L
E
I
P
R
D
A
S
L
M
L
Y
F
--
R
I
R
F
Y
F
R
NWHGMNP
R
E
P
A
V
Y
R
C
GPPGQGM---------
Q
L
L
D
P
A
S
------------------
F
E
Y
L
F
E
Q
G
K
H
E
F
V
N
D
V
A
S
-
L
W
E
L
S
T
E
E
E
I
H
H
F
--
K
N
E
S
L
G
M
A
F
L
H
L
C
H
L
A
L
R
-
H
G
I
P
L
E
E
V
A
K
K
T
S
F
K
D
C
I
P
R
S
F
R
R
H
I
R
Q
H
S
A
L
T
R
L
R
L
R
N
V
F
R
R
F
L
R
D
FQPGRLS
Q
Q
M
V
M
V
K
--
Y
L
A
T
L
---
E
R
L
A
P
RFG
T
E
R
V
P
V
C
H
L
R
L
L
A
Q
A
E
G
E
P
C
Y
I
R
D
A
---
G
P
P
T
---------
H
E
V
L
V
-
T
G
T
G
G
I
-
Q
W
W
P
V
E
P
L
W
A
Y
F
C
D
----
F
R
D
I
T
H
V
V
L
------
K
E
H
C
V
--
S
I
H
R
QDNKC
L
E
L
S
L
P
S
R
A
A
--
A
L
S
F
V
S
---
L
V
D
G
Y
F
R
L
-
T
ADS
S
H
Y
L
C
H
--------------
E
---
V
A
-----------
P
--------------------
P
R
----
L
V
M
S
I
R
------
D
G
I
H
G
P
L
L
E
P
F
V
Q
------
A
K
L
RPEDG
L
Y
L
I
H
W
S
T
S
-------
H
---
P
---
Y
R
-
L
----
I
L
T
V
A
Q
R
S
Q
A
P
D
G
M
Q
---
S
L
R
L
R
K
F
P
I
E
QAFVLEGWGRSFPS
V
R
E
L
G
A
A
L
Q
G
C
L
L
---------------
R
A
G
D
D
C
F
S
L
R
R
C
C
L
PQPGETSNL
I
I
M
R
G
29
HHSearch
69.75
14%
-125
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
---------------------------------------------------------------------------------------------------
N
K
Y
----------------
V
V
I
I
A
Y
A
------------------
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
-
Y
S
R
V
G
R
S
V
T
D
V
Y
L
--
L
N
----
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
---
G
W
I
F
--
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
-----------
I
S
V
D
R
--
Y
L
A
I
V
---
H
A
T
-------
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
---
N
L
S
L
---------
P
F
F
L
F
-
R
Q
A
--
Y
-
H
---
P
-
N
N
S
S
P
V
C
Y
----
E
V
L
G
N
----------
D
T
A
K
W
--
R
M
V
------
L
R
I
L
P
H
T
F
G
F
--
I
V
P
L
F
V
---
M
L
F
C
Y
G
F
T
-
L
---
R
T
L
F
K
A
--------------
H
---
M
------------
G
--------------------
Q
K
----
H
R
A
M
R
V
------
I
F
A
V
V
L
I
F
L
L
C
W
L
------
P
Y
N
-----
L
V
L
L
A
D
T
L
M
RTQVIQE
S
C
E
R
R
---
N
N
-
I
G
R
--
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
---
N
P
I
I
Y
A
F
I
G
----------------
Q
N
F
R
H
G
F
L
K
I
L
A
---------------
M
H
G
-------------------------
43
Fugue
65.35
18%
-146
- C2 -
4Y7L
5
?
A:
[2-240]
-----------------------------------------------------------T
P
A
A
E
S
L
N
A
R
W
R
T
A
V
V
D
G
W
N
N
A
F
S
G
R
---------
Y
P
F
K
N
V
S
S
----------------
D
A
S
L
P
L
L
------------------
A
K
Y
L
N
T
D
T
G
R
I
A
R
F
L
Q
N
N
-
L
S
G
V
L
H
R
E
G
S
R
W
V
P
D
T
G
----
L
T
F
N
P
A
F
L
K
A
I
N
-
T
L
S
E
I
A
D
V
A
----------------------
F
T
T
G
N
A
G
------------------------------------------------
L
H
F
E
L
R
P
G
T
A
A
G
V
M
Q
T
T
L
---
I
T
D
N
---------
Q
K
L
I
Y
-
V
N
Q
--
M
-
P
-------
V
W
K
R
F
T
----
W
P
A
-------------
D
T
E
A
--
P
------------------------------------------
G
A
S
L
S
W
--------------
V
---
S
T
-----------
Q
--------------------
A
G
----
T
R
Q
Y
A
D
------
L
P
G
S
W
G
L
I
R
L
L
E
M
------
A
R
R
-----
K
A
A
P
G
V
A
S
G
-------
W
---
S
---
L
S
-
W
Q
A
QD
G
R
M
L
N
Y
T
L
R
T
E
A
G
E
G
---
P
L
V
L
L
K
L
R
N
----------------
F
V
L
----
P
E
T
V
F
---------------
E
---------------------------
26
HHSearch
62.60
22%
-155
- C5 -
3EML
8
ENLYS_BPT4
A:
[22-222]
-----------------------------------------------------------------------------------------------------
S
----------------
V
Y
I
T
V
E
L
------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
V
T
N
Y
F
V
--
V
S
----
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
-----
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-----------
I
A
I
D
R
--
Y
I
A
I
R
---
I
P
L
-------
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
---------
T
P
M
L
G
-
W
N
N
--
C
-
G
Q
-------
S
Q
G
C
G
----
E
G
Q
---
V
A
C
------
L
F
E
D
V
VP
M
N
Y
------
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
---
M
L
G
V
Y
L
R
I
-
F
---
L
A
A
R
R
Q
--------------
L
---
N
I
-----------
F
--------------------
E
M
----
L
R
I
D
E
G
------
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
------
T
I
G
-----
I
G
H
L
L
T
K
S
P
-------
S
---
L
---
N
A
-
A
----
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
---
I
T
K
D
E
A
E
K
L
----------------
F
N
Q
D
V
D
A
A
V
R
G
I
---------------
L
R
N
A
K
L
K
P
V
Y
D
-----------------
23
HHSearch
61.99
20%
-148
- C5 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-201]
----------------------------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
------------------
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
-
S
E
R
K
L
H
T
V
G
N
L
Y
I
--
V
S
----
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
---
K
W
S
L
--
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
-----------
L
C
I
D
R
--
Y
R
S
V
Q
---
Q
P
L
-------
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
---
L
W
V
I
---------
P
I
L
-
G
-
W
N
H
-----------
R
R
E
D
K
C
E
----
T
----------------
D
F
Y
D-
V
T
W
------
F
K
V
M
T
A
I
I
N
F
--
Y
L
P
T
L
L
---
M
L
W
F
Y
A
K
I
-
Y
---
K
A
V
R
Q
H
--------------
C
---
N
I
-----------
F
--------------------
E
M
----
L
R
I
D
E
G
------
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
------
T
I
G
-----
I
G
H
L
L
T
K
S
P
-------
S
---
L
---
N
A
-
A
----
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
---
I
T
K
D
E
A
E
K
L
----------------
F
N
Q
D
V
D
A
A
V
R
G
I
---------------
L
R
N
A
K
L
K
P
V
Y
D
-----------------
45
Fugue
61.82
15%
-129
- C3 -
3PVT
2
PAAA_ECOLI
A:
[1-304]
------------------------------------------------------------------
M
R
S
T
Q
E
E
R
F
E
Q
R
--
I
A
Q
E
T
---------
A
I
E
P
--
Q
D
----------------
W
M
-------------------------------
P
D
A
Y
R
K
T
L
I
R
Q
I
G
Q
H
A
H
S
E
I
V
G
M
L
--
P
E
----
G
N
W
I
T
R
A
P
T
L
R
R
-
K
A
I
L
L
A
K
V
Q
D
E
---
A
G
H
G
--
L
Y
L
Y
S
A
A
E
T
-----
L
G
C
A
R
E
D
I
Y
Q
K
-----------
M
L
D
G
R
MK
Y
S
S
I
F
NY-
P
T
L
-------
S
W
A
D
I
G
V
I
G
W
L
V
D
G
A
A
I
V
N
Q
V
A
----
L
C
R
T
---------
S
Y
G
P
Y
-
A
R
A
--
M
-
V
K
I
C
K
E
E
S
F
H
Q
R
Q
G
----
F
E
A
C
M
A
L
A
Q
------
G
S
E
A
Q
--
K
Q
M
------
L
Q
D
A
I
N
R
F
W
W
--
P
A
L
M
M
F
GPN
D
D
N
S
P
N
S
A
-
R
---
S
L
T
W
K
I
--------------
K
RFT
N
D
-----------
E
--------------------
L
R
----
Q
R
F
V
D
N
------
T
V
P
Q
V
E
M
L
G
M
T
V
P
------
D
P
D
-----
L
H
F
D
T
E
S
G
H
-------
Y
---
R
---
F
G
------
E
I
D
W
Q
E
F
N
E
V
I
N
G
-----
R
G
I
C
N
Q
E
R
L
----------------
D
A
K
R
K
A
W
E
E
G
T
W
---------------
V
R
E
A
A
L
A
H
A
Q
K
-----------------
24
HHSearch
61.31
19%
-145
* C5 *
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
----------------------------------------------------------------------------------------------------
V
V
----------------
G
M
G
I
V
M
S
------------------
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
-
K
F
E
R
L
Q
T
V
T
N
Y
F
I
--
T
S
----
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
---
M
W
T
F
--
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
-----------
I
A
V
D
R
--
Y
F
A
I
T
---
S
P
F
-------
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
---
L
T
S
F
---------
L
P
I
Q
M
H
W
Y
R
--
A
-
T
H
-----
Q
E
A
I
N
C
Y
----
A
E
----
E
T
C
------
C
D
F
F
T
--
N
Q
A
------
Y
A
I
A
S
S
I
V
S
F
--
Y
V
P
L
V
I
---
M
V
F
V
Y
S
R
V
-
F
---
Q
E
A
K
R
Q
--------------
L
---
N
I
-----------
F
--------------------
E
M
----
L
R
I
D
E
G
------
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
------
T
I
G
-----
I
G
H
L
L
T
K
S
P
-------
S
---
L
---
N
A
-
A
----
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
---
I
T
K
D
E
A
E
K
L
----------------
F
N
Q
D
V
D
A
A
V
R
G
I
---------------
L
R
N
A
K
L
K
P
V
Y
D
-----------------
22
HHSearch
59.71
19%
-151
- C5 -
3UON
2
ACM2_HUMAN (first)
A:
[25-215]
----------------------------------------------------------------------------------------------------------------------
F
I
V
L
V
A
G
------------------
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
-
V
N
R
H
L
Q
T
V
N
N
Y
F
L
--
F
S
----
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
---
Y
W
P
L
--
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
-----------
I
S
F
D
R
--
Y
F
C
V
T
---
K
P
L
-------
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
---
I
L
W
A
---------
P
A
I
L
F
-
W
Q
F
--
I
-
V
G
V
-
R
-
T
V
E
D
G
E
--------------
C
------
Y
I
Q
F
F
S-
N
A
A
------
V
T
F
G
T
A
I
A
A
F
--
Y
L
P
V
I
I
---
M
T
V
L
Y
W
H
I
-
S
---
R
A
S
K
S
R
--------------
I
---
N
I
-----------
F
--------------------
E
M
----
L
R
I
D
E
G
------
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
------
T
I
G
-----
I
G
H
L
L
T
K
S
P
-------
S
---
L
---
N
A
-
A
----
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
---
I
T
K
D
E
A
E
K
L
----------------
F
N
Q
D
V
D
A
A
V
R
G
I
---------------
L
R
N
A
K
L
K
P
V
Y
D
-----------------