@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR6P1_HUMAN: (2016-01-14 )
MRNLSGGHVEEFVLVGFPTTPPLQLLLFVLFFAIYLLTLLENALIVFTIWLAPSLHRPMYFFLGHLSFLELWYINVTIPRLLAAFLTQDGRVSYVGCMTQLYFFIALACTECVLLAVMAYDRYLAICGPLLYPSLMPSSLATRLAAASWGSGFFSSMMKLLFISQLSYCGPNIINHFFCDISPLLNLTCSDKEQAELVDFLLALVMILLPLLAVVSSYTAIIAAILRIPTSRGRHKAFSTCAAHLAVVVIYYSSTLFTYARPRAMYTFNHNKIISVLYTIIVPFFNPAIYCLRNKEVKEAFRKTVMGRCHYPRDVQD
Atome Classification :
(20 SA)
.........10...--------.....---------------20.....--------...30........40........50......---..60........70......-..80........90........100.......110.....--..120.......130.......140.......150.......160---.---...--..-----.----------.170.......180.......190-.........200.......210---.........220....------.-------------..230--------------------.--------......240....-----...250--------...--------......260.--.------.--.---.----.-.-270.-----.-------.......280...-------------....290.......300..---------.....310.....---------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRNLSGGH
V
E
E
F
V
L
--------
V
GFPT---------------T
P
P
L
Q
L
L
--------
L
F
V
L
F
F
A
I
Y
L
L
T
L
LEN
A
L
I
V
F
T
I
WLAPSLHR---
P
M
Y
F
F
L
G
H
L
S
F
L
E
L
W
Y
I
NV
T
-
I
P
R
L
L
A
A
F
LTQDGR
V
S
Y
V
G
C
M
T
Q
L
Y
F
F
I
A
L
A
C
T
E
C
V
L
L
A
V
--
M
A
Y
D
R
Y
L
A
I
C
G
P
L
L
Y
P
SL
M
P
S
S
L
A
T
R
L
A
AASWG
S
G
F
F
S
S
M
M
K
L
L
----
F
---
I
S
Q
--
L
S-----Y----------C
G
P
N
I
I
N
H
F
F
CD
I
S
P
L
LNLTCS---
D
K
E
Q
A
E
L
V
D
F
L
L
A
L
V
M
I
L
L
P
-----
L
L
A
V
V
S
S
Y
T
A
I
I
A
A
I
L
------R-------------IPTSR--------------------G--------R
H
K
A
F
S
T
C
A
A
H
L
A
-----
V
V
V
I
----------
Y
YS--------S
T
L
F
TYAR
P
R
--
A
------
M
--
Y
---
T
----F-N-H--
N
-----
K
-------
I
I
S
V
L
Y
T
I
I
V
P
FF-------------NP
A
I
Y
C
LR
N
K
E
V
K
E
A
F
R
K
T
---------
V
MGRCHYPRDVQD---------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
94.87
22%
-148
- C2 -
2YDO
3
?
A:
[15-312]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
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P
F
A
I
A
--
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S
T
G
F
C
A
A
C
H
G
C
L
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I
A
C
F
V
L
V
L
T
A
S
S
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S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
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L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
PK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-----
F
L
A
A
R
R
Q
L
K
Q
M
E
S
---------------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
-----
I
I
V
G
----------
L
F
A
L
C
W
L
P
L
H
I
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N
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F
T
F
F
C
P
D
--
C
------
S
--
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
H
V
L
R
Q
Q
E
P
---------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
94.83
22%
-148
- C2 -
2YDV
6
?
A:
[15-312]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
PK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-----
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
-----------------------------------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
A
-----
I
I
V
G
----------
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
--
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
H
V
L
R
Q
Q
E
P
---------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.68
22%
-167
- C2 -
3REY
1
AA2AR_HUMAN
A:
[15-305]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
PG--------
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
------
R
Q
L
K
Q
M
E
S
QP----
L
P
G
E
R
--------------------
A
--------
R
S
T
L
Q
K
E
V
H
A
A
K
S
-----
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
--------
I
N
C
F
T
F
F
C
P
D
--
C
------
S
--
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
94.34
22%
-142
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[15-312]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
PKEGKAG---
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-----
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------
P
-------------
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
A
-----
I
I
V
G
----------
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
---------
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
H
V
L
R
Q
Q
E
P
---------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
94.21
22%
-165
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[15-305]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
PG--------
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
------
R
Q
L
K
Q
M
E
S
QP----
L
P
G
E
R
--------------------
A
--------
R
S
T
L
Q
K
E
V
H
A
A
K
S
-----
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
--------
I
N
C
F
T
F
F
C
P
D
--
C
------
S
--
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.91
22%
-163
- C2 -
3PWH
1
?
A:
[15-305]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
PG--------
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
------
R
Q
L
K
Q
M
E
S
QP----
L
P
G
E
R
--------------------
A
--------
R
S
T
L
Q
K
E
V
H
A
A
K
S
-----
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
--------
I
N
C
F
T
F
F
C
P
D
--
C
------
S
--
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.43
22%
-165
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[15-305]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
PG--------
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
------
R
Q
L
K
Q
M
E
S
QP----
L
P
G
E
R
--------------------
A
--------
R
S
T
L
Q
K
E
V
H
A
A
K
S
-----
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
--------
I
N
C
F
T
F
F
C
P
D
--
C
------
S
--
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.13
22%
-164
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[15-305]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
PG--------
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
--------------
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-----
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
------
R
Q
L
K
Q
M
E
S
QP----
L
P
G
E
R
--------------------
A
--------
R
S
T
L
Q
K
E
V
H
A
A
K
S
-----
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
--------
I
N
C
F
T
F
F
C
P
D
--
C
------
S
--
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
A
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.93
22%
-148
- C2 -
3VG9
8
?
A:
[15-309]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
SQG-------
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-----
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------
P
-------------
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
A
-----
I
I
V
G
----------
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
--
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
H
V
L
R
-------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
91.70
22%
-150
- C2 -
4UG2
3
?
A:
[15-309]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
PK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-----
F
L
A
A
R
R
Q
L
-------------------------------
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
A
-----
I
I
V
G
----------
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
--
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
H
V
L
R
-------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.51
22%
-144
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[15-308]
---------------------------------------------------------------
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
--
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----
G
---
W
N
N
--
C
G
-----
Q
SQG-------
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-----
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
------
P
-------------
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
A
-----
I
I
V
G
----------
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
------
S
--
H
---
A
----
P
-
L
-
W
--
L
-----
M
-------
Y
L
A
I
V
L
S
H
T
N
S
V
V
-------------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---------
I
--
R
S
H
V
L
--------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
87.74
22%
-176
* C2 *
3ZEV
6
NTR1_RAT
A:
[19-325]
----------------------------------------------
K
V
L
--------
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
V
D
Y
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
-
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
------
A
L
L
----
A
---
I
P
M
--
L
F
-----
T
----------
M
G
---
L
Q
N
L
S
G
D
G
T
H
P
G
G
L
V
C
T
PIV
D
T
A
T
L
K
V
V
I
Q
V
N
T
F
M
S
F
L
F
P
-----
M
L
-
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V
HQ------------------
P
--------------------
G
--------
R
V
Q
A
L
R
R
G
V
L
V
L
R
-----
A
V
V
I
----------
A
F
V
--------
V
C
W
L
P
Y
H
V
R
R
--
L
------
M
--
F
---
C
----
Y
I
S
-
D
--
E
-----
Q
-------
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
---------
L
A
C
-------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
86.51
18%
-141
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---
M
N
G
T
E
G
P
N
F
Y
V
PFSNKTGV
V
R
S
P
F
---------------
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
---
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
---
I
P
E
GM
Q
C
-----
S
----------
C
G
I
D
Y
Y
T
------------
P
H
E
---
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
-
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
-------------
A
A
A
S
A
--------------------
T
--------
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
----------
A
F
L
--------
I
C
W
L
P
Y
A
G
V
A
--
F
------
Y
--
I
---
F
----
T
-
H
-
Q
--
G
-----
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
-------------
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---------
L
C
C
G
K
N
P
S
T
T
V
S
K
TETS
Q
V
A
P
A------------------------------------------------------------------------------------------------------------------------------
42
Fugue
80.75
17%
-127
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
--
N
F
Y
V
P
--------
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
--------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
---
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
---
I
P
E
GM
Q
C
-----
S
----------
C
G
I
D
----
Y
Y
T
--------
P
H
E
---
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
-
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
-------------
A
A
A
Q
Q
--------------------
Q
ESA
T
----
T
Q
K
A
E
K
E
V
T
R
M
V
I
-----
I
M
V
I
----------
A
F
L
--------
I
C
W
L
P
Y
A
G
V
A
--
F
------
Y
--
I
---
F
----
T
-
H
-
Q
--
G
-----
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
-------------
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---------
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA------------------------------------------------------------------------------------------------------------------------
32
HHSearch
80.38
15%
-157
- C2 -
2KS9
1
NK1R_HUMAN
A:
[33-325]
-----------------------------------------------
V
L
--------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
---
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
--
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
----
Y
---
S
T
T
--
E
--------------------
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
-----
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
------
A
-------------
S
E
I
P
G
DSSDRYH
E
Q
V
S
---------
A
--------
K
R
K
V
V
K
M
M
I
V
V
V
C
-----
T
F
A
I
----------
C
W
L
--------
P
F
H
I
F
F
L
L
P
Y
--
I
------
N
PD
L
Y--
L
----
K
-
K
F
I
Q
Q
V
-----
Y
-------
L
A
I
M
W
L
A
M
S
S
T
M
Y
-------------
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
---------
F
R
C
C
P
F
I
S
A
G
D
Y
E
---------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
77.17
12%
-153
- C2 -
2Z73
5
OPSD_TODPA
A:
[32-333]
--------------------------------------------
A
V
Y
Y
S
--------
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
---
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
--
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
----
G
---
W
G
A
--
Y
T
-------------------
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
--------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
-----
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
------
N
-------------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
--------
E
M
R
L
A
K
I
S
I
V
I
V
S
-----
Q
F
L
L
----------
S
W
S
--------
P
Y
A
V
V
A
L
L
A
Q
--
F
------
G
--
P
LEW
V
----
T
-
P
-
Y
--
A
-----
A
-------
Q
L
P
V
M
F
A
K
A
S
A
I
H
-------------
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
---------
F
P
W
V
L
T
C
C
Q
F
D
D
K
---------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
76.87
16%
-141
- C2 -
1U19
14
OPSD_BOVIN
A:
[40-330]
----------------------------------------------
F
S
M
--------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
---
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
--
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
----
G
---
W
S
R
--
Y
------------------
I
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
---
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
------
E
-------------
A
A
A
Q
Q
--------------------
Q
ESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
-----
A
F
L
I
----------
C
W
L
--------
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
------
G
--
S
D--
F
----
G
-
P
-
I
--
F
-----
M
-------
T
I
P
A
F
F
A
K
T
S
A
V
Y
-------------
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---------
L
C
C
G
K
N
P
L
G
D
D
E
A
---------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
75.21
16%
-150
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
---------------------------------------------
N
K
Y
V
--------
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
---
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
--
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
----
F
---
R
Q
A
--
Y
------------------
H
-
P
N
N
S
S
P
V
C
Y
E
V
L
G
N
----
D
---
T
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
-----
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
------
K
-------------
A
H
M
G
---------------------
Q
--------
K
H
R
A
M
R
V
I
F
A
V
V
L
-----
I
F
L
L
----------
C
W
L
--------
P
Y
N
L
V
L
L
A
D
T
--
L
M
RTQVI
Q
--
E
---
S
C
E
R
R
N
-
N
-
I
G
R
A
-----
L
-------
D
A
T
E
I
L
G
F
L
H
S
C
L
-------------
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
---------
L
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
71.46
14%
-142
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------------
D
E
V
W
V
V
G
--------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
--
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
----
M
HWY
R
A
T
--
H
Q
-----
E
----------
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
---
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
-----
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
------
I
-------------
D
E
G
L
R
--------------------
L
--------
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
-----
I
G
H
L
----------
L
T
K
--------
S
P
S
L
N
A
A
K
S
E
--
L
------
D
--
K
---
A
----
I
-
G
-
R
--
N
TNGVI
T
-------
K
D
E
A
E
K
L
F
N
Q
D
V
D
-------------
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL-------
44
Fugue
68.40
12%
-142
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
P
C
F
R
E
--------------------
E
N
---------------
A
N
F
N
K
I
F
--------
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
---
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
---
L
P
F
W
A
V
D
A
V
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
--
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
----
F
---
A
N
V
--
S
E
A
DD
R
Y
I
----------
C
D
R
F
Y
P
N
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
---
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
HSGSN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
------
K
D
TEG
Y
Y
T
I
GIGHL
L
T
K
S
P
--------------------
S
--------
L
N
A
A
K
S
E
L
D
K
A
I
G
RNTNG
V
I
T
K
----------
D
E
A
--------
E
K
L
F
N
Q
D
V
D
A
--
A
------
V
--
R
---
G
----
I
-
L
-
R
--
N
-----
A
-------
K
L
K
P
V
Y
D
S
L
D
A
V
R
-------------
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
---------
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ