@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR7C2_HUMAN: (2016-01-14 )
MERGNQTEVGNFLLLGFAEDSDMQLLLHGLFLSMYLVTIIGNLLIILTISSDSHLHTPMYFFLSNLSFADICFTSTTVPKMLVNIQTQSKMITFAGCLTQIFFFIAFGCLDNLLLTMTAYDRFVAICYPLHYTVIMNPRLCGLLVLGSWCISVMGSLLETLTILRLSFCTNMEIPHFFCDPSEVLKLACSDTFINNIVMYFVTIVLGVFPLCGILFSYSQIFSSVLRVSARGQHKAFSTCGSHLSVVSLFYGTGLGVYLSSAVTPPSRTSLAASVMYTMVTPMLNPFIYSLRNKDMKGSLGRLLLRATSLKEGTIAKLS
Atome Classification :
(20 SA)
--------------.........10.....----------------...20........30........40--.........50........60........70......-..80........90.........100.......110.....--.-------.120.......130.......140.......150.......160.......170....---...--180.......-------190-----......--------...200.......210.......220.......230-----------.---------------------.......-240-----------------........250.......---------260.-------..------.------.--.-------.270.......------280.......290.......300..-.------..------------..310.......-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MERGNQTEVG
N
F
L
L
L
G
----------------FAEDS
D
M
Q
L
L
L
H
G
L
F
L
S
M
Y
L
V
T
I
I---G
N
L
L
I
I
L
T
ISSDSHLH
T
P
M
Y
F
F
L
SNLS
F
A
D
I
CFTSTT-VP
K
M
L
V
N
I
QTQS
K
-
M
I
T
F
A
G
C
L
T
Q
I
F
F
F
I
A
F
G
C
L
D
N
L
L
L
T
M
--
T
-------
A
Y
D
R
F
V
A
I
C
Y
P
L
H
Y
T
V
I
MNPR
L
C
G
L
L
V
L
G
S
W
C
I
S
V
M
G
S
L
L
E
T
L
T
I
L
R
L
S
FCTNMEI
P
H
---
F
FC--
D
P
S
E
V
L
K
L
AC-------
S
-------
D
T
F
I
N
N
--------
I
V
M
Y
F
V
T
I
V
L
G
V
F
P
L
C
G
I
L
F
S
Y
S
Q
I
F
S
S
V
L
R
V
SAR------------G---------------------Q
H
K
A
F
S
T
-
C
G------------------
S
H
L
S
V
V
S
L
F
Y
GT
G
L
G
V
Y
L
---------
S
SAV-------TP------P------
S
--
R
-------
T
S
L
A
A
S
V
M
Y
T
M
------
V
T
P
M
L
N
P
F
I
Y
S
L
RNKDMK
G
S
L
G
R
L
L
-
L
------
R
A------------TSLKEGTIAKLS-----------------
4
PsiBlast_PDB
91.39
24%
-131
- C6 -
4GBR
1
ADRB2_HUMAN
A:
[9-286]
----------------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
-------
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
---
C
Y
A
--
E
E
T
------
C
-------
C
-------
D
F
F
T
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
K
IDKFC
L
------
K
---------------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
---------
V
H
V
I
-------------------------
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------
1
PsiBlast_PDB
90.28
24%
-136
- C6 -
4LDE
3
A:
[186-463]
----------------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
-------
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
---
C
Y
A
--
E
E
T
------
C
-------
C
-------
D
F
F
T
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
-KFAL--------
K
---------------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
---------
V
H
V
I
-------------------------
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------
3
PsiBlast_PDB
89.84
24%
-139
- C6 -
4LDO
3
A:
[186-463]
----------------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
-------
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
---
C
Y
A
--
E
E
T
------
C
-------
C
-------
D
F
F
T
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
-KFAL--------
K
---------------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
---------
V
H
V
I
-------------------------
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------
2
PsiBlast_PDB
89.50
24%
-138
- C6 -
4LDL
3
ADRB2_HUMAN
A:
[186-463]
----------------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
-------
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
---
C
Y
A
--
E
E
T
------
C
-------
C
-------
D
F
F
T
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
-KFA
L
--------
K
---------------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
---------
V
H
V
I
-------------------------
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------
5
PsiBlast_PDB
89.19
24%
-139
- C6 -
4QKX
2
ADRB2_HUMAN
A:
[186-463]
----------------------------------------------------------
G
I
V
M
S
L
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
-------
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
---
C
Y
A
--
E
E
T
------
C
-------
C
-------
D
F
F
T
N
Q
--------
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
-KFAL--------
K
---------------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
---------
V
H
V
I
-------------------------
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------
43
Fugue
85.56
18%
-112
- C6 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
SNKTGVVRSPFEAPQY
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
--
L
-------
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
-------
Y
I
P
E
---
G
---------
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
--------
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
------------
A
T--------------------
T
Q
K
A
E
K
E
-
V
T
------------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
---------
G
V
A
F
-------
Y
I
------
F
------
T
--
H
QGSDFGP
I
F
M
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-
C
CGKNPS
T
T
------------
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------
36
HHSearch
84.85
19%
-126
- C6 -
2Z73
5
OPSD_TODPA
A:
[33-332]
----------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
---
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
--
I
-------
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
---
C
N
C
--
S
F
D
Y
I
S
-------------------
R
D
S
T
T
R
--------
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
-
S
I
------------------
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
---------
L
A
Q
F
-------
G
P
LEW---
V
------
T
--
P
-------
Y
A
A
Q
L
P
V
M
F
A
K
------
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
-
P
------
W
V
------------
L
T
C
C
Q
F
D
D
K
E
T
E
-----------------
42
Fugue
83.25
18%
-121
- C6 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
----------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
-
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
--
L
-------
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
-------
I
P
E
---
G
---------
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
--------
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
QQESA-------
T
---------------------
T
Q
K
A
E
K
E
-
V
T
------------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
---------
G
V
A
F
Y
I
F
T
H
QG
S
D
------
F
------
G
--
P
-------
I
F
M
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-
C
------
C
G
KNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------
48
Fugue
81.58
18%
-119
- C6 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------
S
F
K
C
A
L
T
K
T
G
F
---------------------------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
---
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
-
L
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
--
I
-------
S
A
H
R
Y
S
G
V
V
Y
P
--------
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
K
NKT
I
T
C
--
Y
D
T
------
T
-------
S
-------
D
E
Y
L
R
S
--------
Y
F
I
Y
S
M
C
T
T
V
A
M
F
--
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
------------
K
---------------------
M
K
K
Y
T
C
T
V
C
G
Y
I
Y
N
PEDGDPDNGVNPGT
D
F
K
D
I
V
C
P
L
C
G
V
G
K
D
Q
F
E
E
V
EE
P
L
R
R
K
S
I
Y
L
-------
V
I
------
I
------
V
--
L
-------
T
V
F
A
V
S
Y
I
P
F
H
------
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
-
Y
------
A
T
------------
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR
32
HHSearch
79.70
16%
-117
- C6 -
2KS9
1
NK1R_HUMAN
A:
[34-328]
-------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
---
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
--
V
-------
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
-----
M
P
S
R
---
V
V
C
--
M
I
E
W
P
E
H
P
-----------------
N
K
I
Y
E
K
--------
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
S
A
---------------------
K
R
K
V
V
K
M
-
M
I
------------------
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
---------
L
P
Y
I
-------
N
P
------
D
LYLKKF
I
--
Q
-------
Q
V
Y
L
A
I
M
W
L
A
M
------
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
-
R
------
C
C
------------
P
F
I
S
A
G
D
Y
E
G
L
E
-----------------
34
HHSearch
79.39
17%
-125
* C6 *
1U19
14
OPSD_BOVIN
A:
[40-330]
-----------------------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
--
L
-------
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
----
E
G
M
Q
---
C
S
C
--
G
I
D
Y
Y
T
P
----------
H
-------
E
E
T
N
N
E
--------
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
QESA
T
T
Q
K
A
------------
E
K
E
V
T
R
M
-
V
I
------------------
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
---------
Y
I
F
T
H
------
Q
G
SD----
F
------
G
--
P
-------
I
F
M
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-
C
------
C
G
------------
K
N
P
L
G
D
D
E
A
S
T
T
-----------------
14
PsiBlast_PDB
78.28
23%
-124
- C6 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
-------
C
-------
D
-
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
R
------------
K
R
V
M
L
M
R
---------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
V
F
T
L
C
W
---
L
P
F
F
L
---------
V
N
I
V
-------
N
V
------
F
------
N
--
R
--------
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
------------------------------------------------------
13
PsiBlast_PDB
77.59
23%
-132
- C6 -
2YCW
7
ADRB1_MELGA
A:
[8-297]
-----------------------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
-------
C
-------
D
-
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
R
------------
K
R
V
M
L
M
R
---------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
V
F
T
L
C
W
---
L
P
F
F
L
---------
V
N
I
V
-------
N
V
------
F
------
N
--
R
--------
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
------
F
------------------------------------------
15
PsiBlast_PDB
76.87
23%
-130
- C6 -
2YCZ
2
ADRB1_MELGA
A:
[9-297]
------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
-------
C
-------
D
-
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
R
------------
K
R
V
M
L
M
R
---------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
V
F
T
L
C
W
---
L
P
F
F
L
---------
V
N
I
V
-------
N
V
------
F
------
N
--
R
--------
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
------
F
------------------------------------------
20
PsiBlast_PDB
76.58
22%
-139
- C6 -
2Y03
9
ADRB1_MELGA
A:
[8-299]
-----------------------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
-------
C
-------
D
-
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---------------------S
R
V
M
L
M
R
--------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
V
F
T
L
C
W
---
L
P
F
F
L
---------
V
N
I
V
-------
N
V
------
F
------
N
--
R
--------
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
-------------------------------------------------
30
HHSearch
76.51
18%
-116
- C6 -
2LNL
-
CXCR1_HUMAN
A:
[36-323]
--------------------------------------------------
T
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
---
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
-
V
N
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
--
I
-------
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
P
----
N
N
S
S
---
P
V
C
--
Y
E
V
L
G
N
D
------------------
T
A
K
W
R
M
--------
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
M
G
------------
Q
---------------------
K
H
R
A
M
R
V
-
I
F
------------------
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
---------
A
D
T
L
-------
M
R
TQVIQE
S
C
E
R
R
--
N
N
I
G
-------
R
A
L
D
A
T
E
I
L
G
F
------
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
-
A
------
M
H
------------
G
----------------------------
18
PsiBlast_PDB
76.09
22%
-136
- C6 -
2Y01
12
ADRB1_MELGA
A:
[8-299]
-----------------------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
-------
C
-------
D
-
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------S
R
V
M
L
M
R
--------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
V
F
T
L
C
W
---
L
P
F
F
L
---------
V
N
I
V
-------
N
V
------
F
------
N
--
R
--------
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
-------------------------------------------------
19
PsiBlast_PDB
76.00
22%
-138
- C6 -
2Y02
13
ADRB1_MELGA
A:
[8-299]
-----------------------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
-------
C
-------
D
-
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------S
R
V
M
L
M
R
--------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
V
F
T
L
C
W
---
L
P
F
F
L
---------
V
N
I
V
-------
N
V
------
F
------
N
--
R
--------
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
-------------------------------------------------
17
PsiBlast_PDB
75.83
22%
-139
- C6 -
2Y00
13
ADRB1_MELGA
A:
[8-299]
-----------------------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
-------
C
-------
D
-
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------S
R
V
M
L
M
R
--------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
V
F
T
L
C
W
---
L
P
F
F
L
---------
V
N
I
V
-------
N
V
------
F
------
N
--
R
--------
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
-------------------------------------------------
16
PsiBlast_PDB
75.60
23%
-131
- C6 -
2YCY
6
ADRB1_MELGA
A:
[10-297]
-------------------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
W
W
R
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
------
G
C
-------
C
-------
D
-
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--
D
R
A
S
K
R
------------
K
R
V
M
L
M
R
---------------
E
H
K
A
L
K
T
-
L
G
------------------
I
I
M
G
V
F
T
L
C
W
---
L
P
F
F
L
---------
V
N
I
V
-------
N
V
------
F
------
N
--
R
--------
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
------
F
------------------------------------------