@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR7D2_HUMAN: (2016-01-14 )
MEAGNQTGFLEFILLGLSEDPELQPFIFGLFLSMYLVTVLGNLLIILAISSDSHLHTPMYFFLSNLSWVDICFSTCIVPKMLVNIQTENKAISYMDCLTQVYFSMFFPILDTLLLTVMAYDRFVAVCHPLHYMIIMNPHLCGLLVFVTWLIGVMTSLLHISLMMHLIFCKDFEIPHFFCELTYILQLACSDTFLNSTLIYFMTGVLGVFPLLGIIFSYSRIASSIRKMSSSGGKQKALSTCGSHLSVVSLFYGTGIGVHFTSAVTHSSQKISVASVMYTVVTPMLNPFIYSLRNKDVKGALGSLLSRAASCL
Atome Classification :
(20 SA)
--------------.........10........20--.........30.......---.40--.........50........60........70......-..--80........90........100.......110....-------...120.......130.......140.......150.......160.......170.......180.......-------190-----.........200.......210....----...220.......230--.--------------------.--------..-----.---------....240.......250.......260...---.------------.-------..-------270.......280----.........290.......300.......310---------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MEAGNQ
T
G
F
L
E
F
I
L
L
GLSED---PE
L
Q
P
F
I
F
G
L
F
L
S
M
Y
L
V
T
---
V
L
---G
N
L
L
I
I
L
A
ISSDSHLH
T
P
M
Y
F
F
L
SNL
S
W
V
D
I
C
F
S
T
C
I
-
V
P
--
K
M
L
V
N
I
QTENK
A
I
S
Y
M
D
C
L
T
Q
V
Y
F
S
M
F
F
P
I
L
D
T
L
L
L
T
-------
V
M
A
Y
D
R
F
V
A
V
CHP
L
H
Y
M
I
I
MNP
H
L
C
G
L
L
V
F
V
T
W
L
I
G
V
M
T
S
L
L
H
I
S
L
M
M
H
L
I
F
CKDFE
I
P
H
F
F
C
E
L
T
Y
I
L
Q
L
AC-------S-------D
T
F
L
N
S
T
L
I
Y
F
M
T
G
V
L
G
V
F
P
L
L
G
I
I
F
----
S
Y
S
R
I
A
S
S
I
R
K
M
S
S----S--------------------G--------G
K
-----
Q
---------
K
A
L
S
T
C
G
S
H
L
S
V
V
S
L
F
YGTGI
G
V
H
F
T
S
AVT---H------------S-------SQ-------K
I
S
V
A
S
V
M
Y
T
V
------
V
T
P
M
L
N
P
F
I
Y
S
L
RNK
D
V
K
G
A
L
G
S
L
L
S
R
A
A
SCL---------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
86.85
16%
-132
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
LAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
---
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
--
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
-------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-----------
V
G
W
S
R
Y
I
P
E
G
---
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
----
S
--------------------
A
--------
T
T
-----
Q
---------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
------------
F
-------
T
H
QGSDFGP
I
F
M
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
86.69
25%
-143
- C4 -
2YCW
7
ADRB1_MELGA
A:
[8-298]
----------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
---
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
---------
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
--
M
M
H
--
W
W
R
D
-
E
D
P
Q
---
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
----
A
--------------------
S
--------
K
R
-----
K
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
---
R
------------
D
LV-----
P
D
-------
W
L
F
V
A
F
N
W
L
G
Y
------
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.68
24%
-151
- C4 -
4LDL
3
ADRB2_HUMAN
A:
[179-463]
----------------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
-------
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
------
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
-----------------------------------
K
FA
L
K
E
H
---------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
----
F
F
I
V
N
I
V
---
H
------------
V
-------
I
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.96
24%
-153
- C4 -
4LDO
3
A:
[179-463]
----------------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
-------
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
------
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
-----------------------------------
K
FAL
K
E
H
---------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
----
F
F
I
V
N
I
V
---
H
------------
V
-------
I
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.81
25%
-143
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[9-298]
-----------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
---
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
---------
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
--
M
M
H
--
W
W
R
D
-
E
D
P
Q
---
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
----
A
--------------------
S
--------
K
R
-----
K
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
---
R
------------
D
LV-----
P
D
-------
W
L
F
V
A
F
N
W
L
G
Y
------
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
85.79
25%
-140
- C4 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
-----------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
---
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
---------
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
--
M
M
H
--
W
W
R
D
-
E
D
P
Q
---
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
----
A
--------------------
S
--------
K
R
-----
K
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
---
R
------------
D
LV-----
P
D
-------
W
L
F
V
A
F
N
W
L
G
Y
------
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.78
24%
-149
- C4 -
4LDE
3
A:
[179-463]
----------------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
-------
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
------
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
-----------------------------------
K
FAL
K
E
H
---------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
----
F
F
I
V
N
I
V
---
H
------------
V
-------
I
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
85.77
17%
-144
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-334]
--------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
---
C
G
---
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
--
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
-------
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
-------------------
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
----
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
----
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
E
-----
M
---------
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
---
P
LEW---------
V
-------
T
P
-------
Y
A
A
Q
L
P
V
M
F
A
K
------
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.12
24%
-139
- C4 -
4GBR
1
ADRB2_HUMAN
A:
[17-286]
----------------------------------------------------
L
A
I
---
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
-------
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
------
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
----
K
--------------------
I
--------
D
K
FC
L
K
E
H
---------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
----
F
F
I
V
N
I
V
---
H
------------
V
-------
I
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
84.95
25%
-148
- C4 -
2Y00
13
ADRB1_MELGA
A:
[8-300]
----------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
---
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
---------
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
--
M
M
H
--
W
W
R
D
-
E
D
P
Q
---
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
---
R
------------
D
LV-----
P
D
-------
W
L
F
V
A
F
N
W
L
G
Y
------
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.77
24%
-156
- C4 -
4QKX
2
ADRB2_HUMAN
A:
[179-461]
----------------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
C
I
L
T
K
T
W
T
F
G
N
F
W
C
-------
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
------
C
-------
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
-----------------------------------
K
FAL
K
E
H
---------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
----
F
F
I
V
N
I
V
---
H
------------
V
-------
I
Q
-------
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
84.54
25%
-152
- C4 -
2Y02
13
ADRB1_MELGA
A:
[8-300]
----------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
---
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
---------
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
--
M
M
H
--
W
W
R
D
-
E
D
P
Q
---
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
---
R
------------
D
LV-----
P
D
-------
W
L
F
V
A
F
N
W
L
G
Y
------
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
84.15
25%
-149
- C4 -
2Y01
12
ADRB1_MELGA
A:
[8-300]
----------------------------------------
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
---
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
---------
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
--
M
M
H
--
W
W
R
D
-
E
D
P
Q
---
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
---
R
------------
D
LV-----
P
D
-------
W
L
F
V
A
F
N
W
L
G
Y
------
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.51
25%
-144
- C4 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
---
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
---------
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
--
M
M
H
--
W
W
R
D
-
E
D
P
Q
---
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
----------------------------------------------
E
H
-------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
---
R
------------
D
LV-----
P
D
-------
W
L
F
V
A
F
N
W
L
G
Y
------
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
82.94
25%
-144
- C4 -
2YCY
6
ADRB1_MELGA
A:
[10-298]
------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
---
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
---------
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
--
M
M
H
--
W
W
R
D
-
E
D
P
Q
---
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--
D
R
----
A
--------------------
S
--------
K
R
-----
K
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
---
R
------------
D
LV-----
P
D
-------
W
L
F
V
A
F
N
W
L
G
Y
------
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
81.15
17%
-120
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
----
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
---
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
--
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
-------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
-
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
-----------
V
G
W
S
R
Y
I
P
E
G
---
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
QQQE
S
--------------------
A
--------
T
T
-----
Q
---------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
---
I
------------
F
T
H
QGSDF
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA-------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
79.66
16%
-132
- C4 -
1U19
14
OPSD_BOVIN
A:
[36-327]
---------------------------------
E
---
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
---
F
P
---
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
--
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
-------
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
----------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
----
Q
--------------------
Q
QESA
T
T
Q
K
A
E
-----
K
---------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS
D
------------
F
-------
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
77.52
14%
-143
- C4 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
-------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
---
V
V
---
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
--
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
-------
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
E
T
----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----------------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
----
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
----
P
GDSSDRYH
E
Q
V
---------
S
--------
A
K
-----
R
---------
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
---
P
DLYLKK------
F
-------
I
Q
-------
Q
V
Y
L
A
I
M
W
L
A
M
------
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
76.77
16%
-128
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------
D
---
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
---
V
F
---
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
-------
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-------
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
-------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
-
Y
V
P
L
V
I
M
V
F
----
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
----------------------------------
I
F
-----
E
---------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
---
S
------------
P
-------
S
L
-------
N
A
A
K
S
E
L
D
K
A
I
------
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
31
HHSearch
74.73
16%
-115
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
----------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
---
L
L
---
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
--
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
-------
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
----
P
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
----------
T
--------
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
----
C
Y
G
F
T
L
R
T
L
F
K
A
H
M
----
G
-----------------------------
Q
K
-----
H
---------
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
---
R
TQVIQE
S
C
E
R
R
N
N
-------
I
G
-------
R
A
L
D
A
T
E
I
L
G
F
------
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------