@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR8G2_HUMAN: (2016-01-14 )
MVFLSSVETDQRKMSAGNHSSVTEFILAGLSEQPELQLRLFLLFLGIYVVTVVGNLSMITLIGLSSHLHTPMYYFLSGLSFIDLCHSTIITPKMLVNFVTEKNIISYPECMTQLYFFLIFAIAECHMLAVTAYDRYVAICSPLLYNVIMSYHHCFWLTVGVYVLGILGSTIHTGFMLRLFLCKTNVINHYFCDLFPLLGLSCSSTYINELLVLVLSAFNILTPALTILASYIFIIASILRIRSTEGRSKAFSTCSSHILAVAVFFGSAAFMYLQPSSVSSMDQRKVSSVFYTTIVPMLNPQSIA
Atome Classification :
(20 SA)
-------------------------.........10........20---...----------.....-.30.-.---.....-.40........50..-...-...60........70........-80...-------------.....90.------........100..-......110.......120..-----....-------------.130.......140......---.150---.......160...-------------....170.......180-.......---190.----------....-..200-------.-------...--...210-------.........220..--------------.....230....---..-----------.240.--------------------......250..--.....260.......270.--------..-..----.---.------280.......290.......300..------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------
M
V
F
LSSVET
D
Q
R
KMSAGN
H
S
----
S
V
T
----------
E
F
I
L
A-GLSE-Q---P
E
L
Q
L
-
R
L
F
L
L
F
L
G
I
Y
V
V
T
V
V-GN
L
-
S
M
I
T
L
I
GLSSHL
H
T
P
M
Y
Y
F
L
S
G
L
-
S
F
I
D
L
-------------
C
H
S
TII-
T
------
P
K
M
L
V
N
F
VT-EKN-II
S
Y
P
E
C
M
T
Q
L
Y
F
F
L
I
F
A
I
A
E
-----
C
H
M
L
-------------
A
V
TAY
D
R
Y
V
A
I
C
S
P
L
L
Y
N
V
I
---
M
S
YH---
H
C
F
W
L
T
V
G
V
Y
V
L
G
-------------
I
L
G
S
T
I
H
T
G
F
M
L
R
L
F
L
C-KTN
V
I
N
H
---
Y
F
C
D
----------
L
F
P
L
-LGLSC-------
S
-------
S
T
Y
--
I
N
E
L
---------
L
V
L
V
L
S
A
F
N
I
L
T
P
A
--------------
L
T
I
L
A
S
Y
I
F
I
I
A
---
S
I
-----------
L
R
I
RS--------------------TEGR
S
K
A
F
S
T
C
--
S
S
H
I
L
A
V
A
V
F
FG
S
A
A
F
M
Y
L--------QP-SS----V---
S
------
S
M
D
Q
R
K
V
S
S
V
F
Y
T
T
I
VPMLNPQSIA------------------------------------------
27
HHSearch
85.39
17%
-152
* C3 *
2Z73
5
OPSD_TODPA
A:
[32-316]
------------------------------------------------------------------------------
A
V
Y
Y
-
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
-
G
N
G
-
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
-
A
F
S
D
F
-------------
T
F
S
L
V
N
G
F
------
P
L
M
T
I
S
C
F
L
-
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
-----
I
M
T
M
-------------
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
---
R
A
F
I
M
I
I
F
V
W
L
W
S
-------------
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
-----
E
G
V
L
---
C
N
C
S
----------
F
D
Y
I
-
S
-------------------
R
D
S
--
T
T
R
S
---------
N
I
L
C
M
F
I
L
G
F
F
G
P
I
--------------
L
I
I
F
F
C
Y
F
N
I
V
M
---
S
V
-----------
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
--
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
--------
L
A
-
Q
F
----
G
PLE
W
------
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
------------------------------------------
42
Fugue
84.23
23%
-148
- C2 -
4HU8
3
?
A:
[3-452]
N
E
I
T
L
T
IG
Q
Q
K
D
LASMVPAKFAG
Q
E
L
S
W
T
S
S
---
D
P
E
T
A
S
V
T
D
K
G
----
I
V
T
A
L
K
FSSGGAN
L
F
L
K
A
-
P
A
T
G
-
E
---
A
I
I
T
V
-
T
A
G
K
Q
S
H
S
V
K
V
I
T
T
V
K
G
K
E
-
D
I
E
K
L
P
P
L
K
D
H
F
K
D
---
Y
F
L
I
G
N
-
I
F
N
N
R
DVSGSMMDNDWLA
H
H
Y
A
I
L
-
T
PENHMK
P
S
N
L
T
N
N
R
N
-
E
T
T
G
E
I
T
Y
T
--
F
S
T
A
D
R
M
V
N
A
A
I
A
E
G
L
K
I
H
G
H
T
L
LWHQQIP
P
W
Q
R
S
M
E
S
A
A
K
D
A
A
L
S
V
M
K
K
Y
I
T
E
V
M
---
T
H
Y
K
GKI
Y
S
W
D
V
L
N
E
I
F
P
D
G
RGDNWTTAMRPEN
P
W
F
K
S
I
G
S
D
F
V
Y
E
A
Y
L
A
-
A
R
Q
A
D
P
N
A
I
L
Y
Y
N
D
Y
NMDQ
A
G
K
A
A
L
I
A
A
-
M
V
R
D
V
-------
N
-------
A
K
Y
--
K
Q
A
Y
PRETRLLIE
G
I
G
M
Q
S
H
H
N
M
D
V
P
A
S
N
I
R
N
T
I
N
R
Y
R
E
L
G
V
K
I
S
V
S
E
L
D
I
L
C
MG
W
S
A
-----------
F
R
G
S
T
--------------------
G
Q
G
A
D
K
D
D
M
T
I
AT
N
R
N
I
L
D
Q
A
Y
K
F
N
E
Y
M
K
L
Y
L
--------
E
N
-
S
D
IIE
R
V
---
S
------
M
W
G
V
S
D
R
Y
S
W
R
S
G
G
L
P
L
L
F
D
A
D
N
K
A
K
P
A
Y
Y
S
F
V
R
A
R
E
D
Y
E
A
A
K
A-----------------------
32
HHSearch
79.51
17%
-148
- C3 -
2KS9
1
NK1R_HUMAN
A:
[32-306]
--------------------------------------------------------------------------------
I
V
-
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
-
G
N
V
-
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
-
A
F
A
E
A
-------------
S
M
A
A
F
N
-
T
------
V
V
N
F
T
Y
A
V
H
-
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
-----
I
Y
S
M
-------------
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
---
A
T
K
V
V
I
C
V
I
W
V
L
A
-------------
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
------
M
P
S
R
---
V
V
C
M
----------
I
E
W
P
-
E
H
P
-----------------
N
K
I
--
Y
E
K
V
---------
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
--------------
L
V
I
G
Y
A
Y
T
V
V
G
I
---
T
L
-----------
W
A
S
E
I
PGDSSDRYH
E
Q
---------
V
S
A
K
R
K
V
V
K
M
M
--
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
--------
L
P
-
Y
I
----
N
---
P
DLYLKK
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
------------------------------------------
40
Fugue
79.23
17%
-105
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVR
S
P
F
----------
E
A
P
Q
Y
-
Y
L
A
E
-
P
---
W
Q
F
S
M
-
L
A
A
Y
M
F
L
-
L
I
M
L
G
F
P
-
I
N
F
-
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
L
-------------
F
M
V
F
G
G
-
F
------
T
T
T
L
Y
T
S
L
H
-
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
-------------
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
---
A
I
M
G
V
A
F
T
W
V
M
A
L
-------------
A
C
A
A
P
P
L
V
G
W
-------------
S
R
---
Y
I
P
E
----------
G
----
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
--
N
N
E
S
---------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
--------------
I
V
I
F
F
C
Y
G
Q
L
V
F
---
T
V
KEAAAQQQESA
T
T
Q
K
A
--------------------
E
K
E
V
T
R
M
V
I
I
M
--
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGSDFG
P
I
-
F
M
----
T
---
I
------
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
TETSQVAPA---------
39
Fugue
76.45
15%
-118
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
----
G
V
V
----------
R
S
P
F
E
-
A
P
Q
Y
-
Y
LAE
P
W
Q
F
S
-
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
-
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
L
-------------
F
M
V
F
G
G
-
F
------
T
T
T
L
Y
T
S
L
H
-
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
-------------
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
----------------------
S
N
F
R
F
G
-------------
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
---
G
W
S
R
----------
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
--
N
N
E
S
---------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
--------------
I
V
I
F
F
C
Y
G
Q
L
V
F
---
T
V
-----------
K
E
A
A
A
--------------------
S
A
T
T
Q
K
A
E
K
E
V
--
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
--------
G
V
-
A
F
----
Y
---
I
------
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
MN
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPSTTVSKTETS
Q
V
A
P
A
30
HHSearch
71.71
14%
-140
- C3 -
1U19
11
OPSD_BOVIN
A:
[39-308]
-------------------------------------------------------------------------------
Q
F
S
-
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
-
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
L
-------------
F
M
V
F
G
G
-
F
------
T
T
T
L
Y
T
S
L
H
-
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-----
L
W
S
L
-------------
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
---
H
A
I
M
G
V
A
F
T
W
V
M
A
-------------
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-----
E
G
M
Q
---
C
S
C
G
----------
I
D
Y
Y
-
T
P
----------
H
-------
E
E
T
--
N
N
E
S
---------
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
--------------
I
V
I
F
F
C
Y
G
Q
L
V
F
---
T
V
-----------
K
E
A
A
A
QQQESA
T
T
------------
Q
K
A
E
K
E
V
T
R
M
V
--
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
--------
Y
I
-
F
T
H
QG-
S
---
D
------
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
------------------------------------------
43
Fugue
70.12
19%
-144
* C2 *
4G3A
-
CLASP_DROME
A:
[5-231]
------------------------------------------
K
P
S
----
D
L
D
----------
G
F
I
Q
Q
M
P
K
A
D
M
R
---
V
K
V
Q
L
A
E
D
L
V
T
F
L
S
D
D
T
N
S
I
V
-
C
T
D
M
G
----------------
F
L
I
D
G
L
M
P
W
L
T
G
-------------
S
H
-----------------
F
K
I
A
-
Q
K
S
-
L
E
A
F
S
E
L
I
K
R
L
G
------------------------------------
S
D
F
N
A
Y
T
A
T
V
L
P
H
V
I
---
D
R
----------------
L
G
-------------
D
S
R
D
T
V
R
E
K
A
Q
L
L
L
R
D
L
M
E
H
R
V
L
P
-----
P
Q
A
----------
L
I
D
K
-
L
A
T
S
C
F
KHK---
N
-------
A
K
V
--
R
E
E
F
---------
L
Q
T
I
V
N
A
L
H
E
Y
G
T
Q
--------------
Q
L
S
V
R
V
Y
I
P
P
V
C
---
A
L
-----------
L
G
D
P
T
--------------------
V
N
V
R
E
A
A
I
Q
T
L
--
V
E
I
Y
K
H
V
----
G
D
R
L
R
P
D
L
--------
R
R
M
D
D
----
V
---
P
------
A
S
K
L
A
M
--------
L
E
Q
K
F
D
Q
V
K
L
E
------------------------------------------
23
HHSearch
67.35
19%
-144
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
--------------------------------------------------------------------------------
V
V
-
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
-
G
N
V
-
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
L
-------------
V
M
G
L
A
V
-
V
------
P
F
G
A
A
H
I
L
M
-
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
-------------
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
---
K
A
R
V
I
I
L
M
V
W
I
V
S
-------------
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
-----
H
Q
E
A
---
I
N
C
Y
----------
A
E
-----
E
T
C
-------
C
-------
D
F
F
--
T
N
Q
A
---------
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
--------------
V
I
M
V
F
V
Y
S
R
V
F
Q
---
E
A
-----------
K
R
Q
L
N
--------------------
I
F
E
M
L
R
I
D
E
G
L
--
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
--------
L
T
-
K
S
----
P
---
S
------
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
------------------------------------------
28
HHSearch
67.23
20%
-161
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-222]
---------------------------------------------------------------------------------
S
-
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
-
G
N
V
-
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
-
A
A
A
D
I
-------------
A
V
G
V
L
A
-
I
------
P
F
A
I
T
I
S
T
---
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-----
I
F
S
L
-------------
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
---
R
A
K
G
I
I
A
I
C
W
V
L
S
-------------
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
--------
S
---
Q
G
C
G
----------
E
G
Q
V
----
A
C
-------
L
-------
F
E
D
VV
P
M
N
Y
---------
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
--------------
L
L
M
L
G
V
Y
L
R
I
F
L
---
A
A
-----------
R
R
Q
L
N
--------------------
I
F
E
M
L
R
I
D
E
G
L
--
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
--------
L
T
-
K
S
----
P
---
S
------
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
------------------------------------------
22
HHSearch
66.24
20%
-163
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-241]
------------------------------------------------------------------------------
F
N
K
I
-
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
-
G
N
G
-
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
-
S
V
A
D
L
-------------
L
F
V
-
I
T
-
L
------
P
F
W
A
V
D
A
V
--
A
N
W
-
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
-----
V
W
I
L
-------------
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
---
A
E
K
V
V
Y
V
G
V
W
I
P
A
-------------
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
------
A
D
D
R
---
Y
I
C
D
----------
R
F
Y
P
-
N
--------------------
D
L
--
W
V
V
V
---------
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
--------------
I
V
I
L
S
C
Y
C
I
I
I
S
---
K
L
-----------
S
H
S
G
S
--------------------
N
I
F
E
M
L
R
I
D
E
G
--
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
--------
L
L
-
T
K
----
S
---
P
------
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
------------------------------------------
29
HHSearch
65.93
19%
-161
- C3 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-227]
------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
-
G
N
G
-
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
-
A
V
A
D
L
-------------
L
V
A
T
L
V
-
M
------
P
W
V
V
Y
L
E
V
T
G
G
V
W
-
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
-----
I
W
N
L
-------------
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
---
R
V
A
L
M
I
T
A
V
W
V
L
A
-------------
F
A
V
S
C
P
L
L
F
G
F
N
T
T
--------
G
D
P
---
T
V
C
S
----------
I
S
N
-----------------------------
P
D
---------
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
--------------
G
V
T
V
L
V
Y
A
R
I
Y
V
---
V
L
-----------
K
Q
R
R
R
--------------------
K
N
I
F
E
M
L
R
I
D
E
--
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
--------
H
L
-
L
T
----
K
---
S
------
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
------------------------------------------
21
HHSearch
65.59
18%
-162
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[24-216]
---------------------------------------------------------------------------------
V
-
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
-
G
N
I
-
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
-
A
C
A
D
L
-------------
I
I
G
V
F
S
-
M
------
N
L
Y
T
L
Y
T
V
I
-
G
Y
W
-
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
-----
V
M
N
L
-------------
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
---
M
A
G
M
M
I
A
A
A
W
V
L
S
-------------
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
V
---
R
T
V
E
D
---
G
E
C
Y
----------
I
Q
F
F
--------------------------
S
N
A
A
---------
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
--------------
I
I
M
T
V
L
Y
W
H
I
S
R
---
A
S
-----------
K
S
R
I
N
--------------------
I
F
E
M
L
R
I
D
E
G
L
--
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
--------
L
T
-
K
S
----
P
---
S
------
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
------------------------------------------
24
HHSearch
64.58
20%
-153
- C3 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-201]
-----------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
-
L
N
L
-
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
-
S
V
A
D
L
-------------
I
V
G
A
V
V
-
M
------
P
M
N
I
L
Y
L
L
M
-
S
K
W
-
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
-----
I
F
S
V
-------------
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
---
R
A
S
A
T
I
L
G
A
W
F
L
S
-------------
F
L
W
V
I
P
I
L
G
W
-
N
H
---------
R
R
E
---
D
K
C
E
----------
T
D
F
Y
--------------------------
D
V
T
W
---------
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
--------------
L
L
M
L
W
F
Y
A
K
I
Y
K
---
A
V
-----------
R
Q
H
C
N
--------------------
I
F
E
M
L
R
I
D
E
G
L
--
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
--------
L
T
-
K
S
----
P
---
S
------
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
------------------------------------------
10
PsiBlast_PDB
62.79
26%
-145
- C3 -
4AMJ
4
ADRB1_MELGA
A:
[6-127]
---------------------------------------------------------------------
L
S
Q
-
Q
---
W
E
A
G
M
-
S
L
L
M
A
L
--
V
V
L
L
I
V
A
-
G
N
V
-
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
D
L
-------------
V
V
G
L
L
V
-
V
------
P
F
G
A
T
L
V
V
R
-
G
T
W
-
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
-----
I
E
T
L
-------------
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
---
R
A
K
V
I
I
C
T
V
W
A
I
S
-------------
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
---
Q
D
P
G
----------
C
C
D
F
-
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
---------
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
--------------
R
V
Y
R
E
A
K
E
Q
S
R
V
---
M
L
-----------
M
R
E
H
K
--------------------
A
L
K
T
L
G
I
I
M
G
V
--
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
--------
D
L
-
V
P
----
D
---
W
------
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
------------------------------------------
20
PsiBlast_PDB
62.56
26%
-139
- C3 -
4LDL
3
ADRB2_HUMAN
A:
[192-314]
-------------------------------------------------------------------------------------------
I
V
L
A
I
V
F
-
G
N
V
-
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
L
-------------
V
M
G
L
A
V
-
V
------
P
F
G
A
A
H
I
L
T
-
K
T
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
-------------
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
---
K
A
R
V
I
I
L
M
V
W
I
V
S
-------------
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
-
Q
E
A
I
N
C
Y
---
A
E
E
T
----------
C
C
D
F
-
F
T
N
Q
A
-------
Y
-------
A
I
A
--
S
S
I
V
---------
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
--------------
R
V
F
Q
E
A
K
R
Q
L
Q
K
---
F
A
-----------
L
K
E
H
K
--------------------
A
L
K
T
L
G
I
I
M
G
T
--
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
--------
N
L
-
I
R
----
K
---
E
------
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
------------------------------------------
19
PsiBlast_PDB
62.20
26%
-138
- C3 -
4LDE
3
A:
[192-314]
-------------------------------------------------------------------------------------------
I
V
L
A
I
V
F
-
G
N
V
-
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
L
-------------
V
M
G
L
A
V
-
V
------
P
F
G
A
A
H
I
L
T
-
K
T
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-----
I
E
T
L
-------------
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
---
K
A
R
V
I
I
L
M
V
W
I
V
S
-------------
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
-
Q
E
A
I
N
C
Y
---
A
E
E
T
----------
C
C
D
F
-
F
T
N
Q
A
-------
Y
-------
A
I
A
--
S
S
I
V
---------
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
--------------
R
V
F
Q
E
A
K
R
Q
L
Q
K
---
F
A
-----------
L
K
E
H
K
--------------------
A
L
K
T
L
G
I
I
M
G
T
--
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
--------
N
L
-
I
R
----
K
---
E
------
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
------------------------------------------
6
PsiBlast_PDB
61.89
26%
-143
- C3 -
2Y02
5
ADRB1_MELGA
A:
[6-127]
---------------------------------------------------------------------
L
S
Q
-
Q
---
W
E
A
G
M
-
S
L
L
M
A
L
--
V
V
L
L
I
V
A
-
G
N
V
-
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
D
L
-------------
V
V
G
L
L
V
-
V
------
P
F
G
A
T
L
V
V
R
-
G
T
W
-
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
-----
I
E
T
L
-------------
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
---
R
A
K
V
I
I
C
T
V
W
A
I
S
-------------
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
---
Q
D
P
G
----------
C
C
D
F
-
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
---------
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
--------------
R
V
Y
R
E
A
K
E
Q
S
R
V
---
M
L
-----------
M
R
E
H
K
--------------------
A
L
K
T
L
G
I
I
M
G
V
--
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
--------
D
L
-
V
P
----
D
---
W
------
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
------------------------------------------
9
PsiBlast_PDB
61.54
26%
-139
- C3 -
4AMI
2
ADRB1_MELGA
A:
[6-127]
---------------------------------------------------------------------
L
S
Q
-
Q
---
W
E
A
G
M
-
S
L
L
M
A
L
--
V
V
L
L
I
V
A
-
G
N
V
-
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
D
L
-------------
V
V
G
L
L
V
-
V
------
P
F
G
A
T
L
V
V
R
-
G
T
W
-
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
-----
I
E
T
L
-------------
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
---
R
A
K
V
I
I
C
T
V
W
A
I
S
-------------
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
---
Q
D
P
G
----------
C
C
D
F
-
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
---------
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
--------------
R
V
Y
R
E
A
K
E
Q
L
M
R
---
E
H
-----------
K
A
L
K
T
--------------------
L
G
I
I
M
G
V
F
T
L
C
--
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
--------
D
W
-
L
F
----
V
---
A
------
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
------------------------------------------
14
PsiBlast_PDB
61.52
26%
-145
- C3 -
2YCW
4
ADRB1_MELGA
A:
[6-127]
---------------------------------------------------------------------
L
S
Q
-
Q
---
W
E
A
G
M
-
S
L
L
M
A
L
--
V
V
L
L
I
V
A
-
G
N
V
-
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
D
L
-------------
V
V
G
L
L
V
-
V
------
P
F
G
A
T
L
V
V
R
-
G
T
W
-
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
-----
I
E
T
L
-------------
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
---
R
A
K
V
I
I
C
T
V
W
A
I
S
-------------
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
---
Q
D
P
G
----------
C
C
D
F
-
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
---------
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
--------------
R
V
Y
R
E
A
K
E
Q
I
R
K
---
I
D
-----------
R
A
S
K
R
--------------------
K
R
V
M
L
M
R
E
H
K
A
--
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
--------
L
V
-
N
I
----
V
---
N
------
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
------------------------------------------
7
PsiBlast_PDB
61.47
26%
-143
- C3 -
2Y03
3
ADRB1_MELGA
A:
[6-127]
---------------------------------------------------------------------
L
S
Q
-
Q
---
W
E
A
G
M
-
S
L
L
M
A
L
--
V
V
L
L
I
V
A
-
G
N
V
-
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
D
L
-------------
V
V
G
L
L
V
-
V
------
P
F
G
A
T
L
V
V
R
-
G
T
W
-
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
-----
I
E
T
L
-------------
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
---
R
A
K
V
I
I
C
T
V
W
A
I
S
-------------
A
L
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
-
P
Q
A
L
K
C
Y
---
Q
D
P
G
----------
C
C
D
F
-
V
T
N
R
A
-------
Y
-------
A
I
A
--
S
S
I
I
---------
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
--------------
R
V
Y
R
E
A
K
E
Q
I
R
S
---
R
V
-----------
M
L
M
R
E
--------------------
H
K
A
L
K
T
L
G
I
I
M
--
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
--------
N
R
-
D
L
----
V
---
P
------
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
------------------------------------------