@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR8S1_HUMAN: (2016-01-14 )
MALGNHSTITEFLLLGLSADPNIRALLFVLFLGIYLLTIMENLMLLLMIRADSCLHKPMYFFLSHLSFVDLCFSSVIVPKMLENLLSQRKTISVEGCLAQVFFVFVTAGTEACLLSGMAYDRHAAICRPLLYGQIMGKQLYMHLVWGSWGLGFLDALINVLLAVNMVFCEAKIIHHYSYEMPSLLPLSCSDISRSLIALLCSTLLHGLGNFLLVFLSYTRIISTILSISSTSGRSKAFSTCSAHLTAVTLYYGSGLLRHLMPNSGSPIELIFSVQYTVVTPMLNSLIYSLKNKEVKGERSLRDSSHLPQLHKGQARWKRPAFTEGRREPGHPELSIPVTPQPQGACACSALRAAPTALP
Atome Classification :
(20 SA)
--------------.........10-........20...----------------.....--------30........40...------.....50----------.........60........70.--.....-..-------80.....-...90........100--.----......---110.......120.......130.---..---....140.......150-----....-....160.-----------......170....---...180.......-------190.--------.--......200------.........210.......220------------------------------.......230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------....--------....240.......250-----.......----260...-----------.--------------...270----------.........280.--------......290----.......-----..300.......310-----........320--------------......-----...330...-------....340.......350-----------........------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MALG
N
H
S
T
I
T
E
-
F
L
L
LGLSADP
N
I
R
----------------
A
L
L
F
V
--------
L
F
L
G
I
Y
L
L
T
I
M
E
N
L
M
------
L
L
L
M
IR-----------
A
D
S
C
L
H
K
P
M
Y
F
F
L
S
H
L
S
F
V
D
L
C
--
F
S
S
V
I
-
V
P
-------
K
M
L
E
N
L
L
-SQR
K
T
I
S
V
E
G
C
L
A
Q
V
F
--
F
----
V
F
VTAG---
T
E
A
C
L
L
SGMAYD
R
H
A
A
I
C
R
P
L
L
Y
G
---
Q
I
---
M
G
K
Q
L
Y
M
H
L
V
WGSW
G
L
------
G
F
L
D
-
A
L
I
N
V
L
L
A
-----------
V
N
M
V
F
C
E
A
K
I
I
H
H
---YSYEMPSLLPL
S
C
-------
S
-
D
I
--------
S
--
R
S
L
I
A
L
L
--------
C
S
T
L
L
H
G
L
G
N
F
L
L
V
F
L
S
Y
T
R
I
I
------------------------------
S
T
I
L
S
ISS------------------------------------------------------------------------------------------------------------------------------------------------------------------T-------------------------------------------------------------------------------------------------------------------------------------------------------------------SGRS--------
K
A
F
S
T
CS
A
H
L
T
A
V
T
L
Y
Y
-----
G
S
G
L
L
R
H
----LMPNSG-----------S--------------
P
I
E
L
------------
I
F
S
V
Q
Y
T
V
V
T
P
M
L
--------
N
S
L
I
Y
S
L------KNKEVKG-----ERSLRDSSHL
P
Q
L
H------KGQARWKRP----------------AFTEGR-----REPGHPELS-------IPVTPQPQG
A
C
A
C
S
A
L
------------RAAPTALP------------------------------------------------------------------------------------
28
HHSearch
86.43
17%
-132
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-472]
--------------------------------------
S
----------------
S
V
Y
I
T
--------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
------
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
-------
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--
F
----
V
L
V
L
T
Q
---
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
---
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
------
S
F
A
I
-
G
L
T
P
M
L
G
W
-----------
N
N
C
G
Q
-------
S
---
Q
G
C
G
E
G
Q
V
---
A
C
-------
L
-
F
E
--------
D
VV
P
M
N
Y
M
V
Y
--------
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
------------------------------
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
--------
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
-----
L
P
L
H
I
I
N
----
C
F
T
F
F
C
-----------
P
DCSHAP--------
L
W
L
M
------------
Y
L
A
I
V
L
S
H
T
N
S
V
V
--------
N
P
F
I
Y
A
Y
------
R
I
R
E
F
R
Q
-----
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
85.35
19%
-123
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
--------------------------------------------------------
P
L
V
V
--------
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
------
V
L
Y
A
V
R
-----------
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
--
V
G
A
V
V
-
M
P
-------
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
--
M
----
D
Y
V
A
S
T
---
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
---
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
------
S
F
L
W
-
V
I
P
I
L
G
W
N
------------
H
--------
R
R
E
---
D
K
C
E
T
D
F
Y
D
---------------------------
V
T
W
F
K
V
--------
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
------------------------------
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
--------
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
-----
I
P
Y
F
I
F
F
----
M
V
I
A
F
C
-----------
K
NCCN----------
E
H
L
H
------------
M
F
T
I
W
L
G
Y
I
N
S
T
L
--------
N
P
L
I
Y
P
L
------
C
N
E
N
F
K
K
-----
T
F
K
R
I
L
H
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
80.66
18%
-124
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
-----------------------------------
E
N
S
I
----------------
K
L
T
S
V
--------
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
------
V
L
L
T
I
W
-----------
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
--
A
G
V
A
Y
-
T
A
-------
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
--
S
----
M
F
V
A
L
S
---
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
--------------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
------
S
L
I
L
-
G
G
L
P
I
M
G
W
-----------
N
C
I
-------
S
A
L
---
S
S
C
S
T
V
L
P
L
---------------------------
Y
H
K
H
Y
I
--------
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
------------------------------
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
--------
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
-----
A
P
L
F
I
L
L
----
L
L
D
V
G
C
-----------
K
VKTC
D
I
--------
L
F
R
A
------------
E
Y
F
L
V
L
A
V
L
N
S
G
T
--------
N
P
I
I
Y
T
L
------
T
N
K
E
M
R
R
-----
A
F
I
R
I
M
G
R
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
80.65
15%
-128
* C3 *
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------------------------
V
----------------
V
G
M
G
I
--------
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
------
V
I
T
A
I
A
-----------
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
-------
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
--
I
----
D
V
L
C
V
T
---
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
---
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
------
S
G
L
T
-
S
F
L
P
I
Q
M
H
-----------
W
Y
R
A
T
H
----
Q
E
A
---
I
N
C
Y
A
E
E
----
T
C
-------
C
-
D
F
--------
F
--
T
N
Q
A
Y
A
I
--------
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
------------------------------
Q
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
--------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
-----
L
P
F
F
I
V
N
----
I
V
H
V
I
Q
-----------
D
NLIR----------
K
E
V
Y
------------
I
L
L
N
W
I
G
Y
V
N
S
G
F
--------
N
P
L
I
Y
C
-------
R
S
P
D
F
R
I
-----
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
79.67
15%
-83
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------
M
N
G
T
E
G
P
N
-
F
Y
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
--------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
------
T
L
Y
V
T
V
-----------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
-------
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--
F
----
A
T
L
G
G
E
---
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
---
R
F
---
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
------
A
L
A
C
-
A
-------------------------
A
P
P
L
V
G
---
W
S
R
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
D
Y
YTPHEETN
N
--
E
S
F
V
I
Y
M
--------
F
V
V
--
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
------------------------------
F
T
V
----
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
A
S
--------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
-----
V
I
A
F
L
I
C
----
W
L
P
Y
A
G
-----------
V
--------------
A
F
Y
I
------------
F
T
H
Q
G
S
---------------
D
F
G
P
I
F
M
------
T
I
P
A
F
F
A
-----
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
------
N
K
Q
F
R
N
C
M
V
----------------
T
T
L
C
C
G
-----
K
N
P
S
T
T
V
S
K
-------
T
E
T
S
Q
V
A
P
A
---------------------------------------------------------------------------------------------------------------
30
HHSearch
78.34
14%
-112
- C3 -
2KS9
1
NK1R_HUMAN
A:
[31-327]
-------------------------------------
Q
I
----------------
V
L
W
A
A
--------
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
------
V
M
W
I
I
L
-----------
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
--
M
A
A
F
N
-
T
V
-------
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
--
F
----
P
I
A
A
V
F
---
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
---
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
------
A
L
L
L
-
A
F
P
Q
G
Y
Y
S
-----------
T
T
E
T
-----
M
P
S
R
---
V
V
C
M
I
E
W
P
E
H
P
-----------
N
K
--------
I
--
Y
E
K
V
Y
H
I
--------
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
------------------------------
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
--------
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
-----
L
P
F
H
I
F
F
----
L
L
P
Y
I
N
-----------
P
DLYLKKFI------
Q
Q
V
Y
------------
L
A
I
M
W
L
A
M
S
S
T
M
Y
--------
N
P
I
I
Y
C
C
------
L
N
D
R
F
R
L
-----
G
F
K
H
A
F
R
C
C
P
F
I
S
A
------
G
D
Y
E
G
L
E
M
K
----------------
S
T
R
Y
L
Q
-----
T
Q
G
S
V
Y
K
V
S
-------
R
L
E
T
T
I
S
T
V
V
G
A
------------------------------------------------------------------------------------------------------------
32
HHSearch
78.17
16%
-124
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------------------------
Y
A
L
--------
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
------
V
C
M
A
V
L
-----------
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
--
V
A
T
L
V
-
M
P
-------
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
--
L
----
D
V
M
M
C
T
---
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
---
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
------
A
F
A
V
-
S
C
P
L
L
F
G
F
-----------
N
T
T
-------
G
D
P
---
T
V
C
S
I
S
N
------------------------------
P
D
F
V
I
--------
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
------------------------------
V
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
--------
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
-----
L
P
F
F
L
T
H
----
V
L
N
T
H
C
-----------
Q
TCHVS---------
P
E
L
Y
------------
S
A
T
T
W
L
G
Y
V
N
S
A
L
--------
N
P
V
I
Y
T
T
------
F
N
I
E
F
R
K
-----
A
F
L
K
I
L
S
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
77.28
14%
-78
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
-
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
----------------
M
L
A
A
Y
--------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
------
L
Y
V
T
V
Q
-----------
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
-------
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--
F
----
A
T
L
G
G
E
---
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
---
R
F
---
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
------
A
L
A
C
-
A
A
-------------------------
P
P
L
V
G
---
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-
E
E
--------
T
--
N
N
E
S
F
V
I
--------
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
------------------------------
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
S
--------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
-----
V
I
A
F
L
I
C
----
W
L
P
Y
A
G
-----------
V
--------------
A
F
Y
I
------------
F
T
H
Q
G
S
D
F
G
P
I
F
M
--------
T
I
P
A
F
F
A
------
K
T
S
A
V
------------
Y
N
P
V
I
Y
I
M
M
------
N
K
Q
F
R
N
C
M
V
----------------
T
T
L
C
C
G
-----
K
N
P
L
G
D
D
E
A
-------
S
T
T
V
S
K
T
E
---------------------
T
S
Q
V
A
P
A
------------------------------------------------------------------------------------
23
HHSearch
76.38
16%
-118
- C3 -
2Z73
5
OPSD_TODPA
A:
[31-335]
-----------------------------------
D
A
V
Y
----------------
Y
S
L
G
I
--------
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
------
V
I
Y
L
F
T
-----------
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
--
F
S
L
V
N
G
F
P
-------
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
--
I
----
G
G
I
F
G
F
---
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
---
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
------
S
V
L
W
-
A
I
G
P
I
F
G
W
-----------
G
A
Y
T
L
----
E
G
V
L
---
C
N
C
S
F
D
Y
I
S
-------------
R
D
--------
S
--
T
T
R
S
N
I
L
--------
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
------------------------------
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
--------
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
-----
S
P
Y
A
V
V
A
----
L
L
A
Q
F
G
-----------
P
LEWVT---------
P
Y
A
A
------------
Q
L
P
V
M
F
A
K
A
S
A
I
H
--------
N
P
M
I
Y
S
V
------
S
H
P
K
F
R
E
-----
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
------
F
D
D
K
E
T
E
D
D
----------------
K
D
A
E
T
E
-----
I
P
A
G
E
-----------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
75.47
15%
-128
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-------------------------------------------------------
V
F
I
V
L
--------
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
------
V
M
V
S
I
K
-----------
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
--
I
G
V
F
S
-
M
N
-------
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
--
L
----
D
Y
V
V
S
N
---
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
---
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
------
S
F
I
L
-
W
A
P
A
I
L
F
W
-----------
Q
F
I
V
G
V
R
--
T
V
E
D
---
G
E
C
Y
I
Q
F
F
---------------------------
S
N
A
A
V
T
F
--------
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
------------------------------
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
--------
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
-----
A
P
Y
N
V
M
V
----
L
I
N
T
F
C
-----------
A
PCIP----------
N
T
V
W
------------
T
I
G
Y
W
L
C
Y
I
N
S
T
I
--------
N
P
A
C
Y
A
L
------
C
N
A
T
F
K
K
-----
T
F
K
H
L
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
73.48
19%
-113
- C2 -
2I3O
-
?
D:
[2-516]
---------FRSRP
N
A
L
S
Q
R
S
V
I
A
S
S
S
E
L
A
S
L
A
G
R
D
I
L
K
RG--------------
G
N
I
F
D
--------
A
A
L
A
V
S
A
L
C
V
T
Q
N
N
L
CGLGGD
L
F
A
L
I
R
DENGQIDLNGS
G
Q
A
S
R
A
V
S
I
D
Y
Y
E
S
G
L
T
K
I
P
E
R
GP
Y
A
A
I
T
-
V
P
GIAGSWD
E
I
F
R
K
F
A
-
T
D
I
A
D
I
-
L
E
P
A
I
R
T
A
S
AG
F
----
P
I
T
Q
N
Y
---
S
D
S
I
A
R
S
A
P
V
I
G
Q
Y
R
G
W
S
S
I
F
P
N
G
---
S
V
PV-
A
G
E
I
L
K
Q
P
D
L
A
E
S
F
R
L
SEEGFR
S
F
Y
D
G
S
L
A
D
I
I
I
A
GLEGTGSPLSD
R
D
L
R
V
Y
R
P
L
I
G
K
P
---
V
F
T
D
L
D
E
F
R
I
Y
E
T
-------
S
-
P
N
--------
S
QG
I
T
V
I
E
W
I
RGESHGYD
S
R
T
W
E
A
K
I
E
D
I
F
E
T
E
E
A
Y
D
K
R
R
KITDPSYNIAQHDSANGKGLPKRDHNDIGD
T
T
Y
F
S
I
S
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
R
---------------
S
V
S
I
I
Q
S
N
Y
G
F
-----
G
S
G
I
V
P
K
GTGF
V
L
Q
N
R
G
-----------
S
--------------
Y
F
T
L
QRDHPNALPGKR
T
F
H
T
L
A
A
C
V
E
K
E
---------
H
D
L
Y
A
S
L
GSGGDI
Q
P
Q
V
Q
Q
I
-----
L
E
I
L
K
D
N
T
D
-
P
Q
A
I
------
L
D
K
P
R
W
T
E
P
YTIYEAPGAVYVESEE
L
Y
R
N
V
S
-----
K
Q
I
S
G
R
K
V
V
-------
L
R
D
V
S
Q
E
F
G
T
A
Q
I
T
T
L
IRGDVVVGAADP
R
G
D
G
I
A
I
P
YS----------------------------------------------------------------------------------
22
HHSearch
73.46
15%
-119
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-498]
----------------------------------
A
N
F
N
K
----------------
I
F
L
P
T
--------
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
------
V
I
L
V
M
G
-----------
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
--
F
V
-
I
T
-
L
P
-------
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
--
I
----
Y
T
V
N
L
Y
---
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
---
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
------
A
L
L
L
-
T
I
P
D
F
I
F
A
-----------
N
V
S
E
-----
A
D
D
R
---
Y
I
C
D
R
F
Y
P
N
--------------
D
--------
L
--
W
V
V
V
F
Q
F
--------
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
------------------------------
S
K
L
S
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
--------
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
-----
L
P
Y
Y
I
G
I
----
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
-----------
H
K
W
I
------------
S
I
T
E
A
L
A
F
F
H
C
C
L
--------
N
P
I
L
Y
A
F
------
L
G
A
K
F
K
T
-----
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
------
L
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
73.30
14%
-123
- C3 -
1U19
14
OPSD_BOVIN
A:
[37-328]
-----------------------------------
P
W
Q
F
----------------
S
M
L
A
A
--------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
------
T
L
Y
V
T
V
-----------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
-------
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--
F
----
A
T
L
G
G
E
---
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
---
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
------
A
L
A
C
-
A
A
P
P
L
V
G
W
-----------
S
R
Y
I
P
----
E
G
M
Q
---
C
S
C
G
I
D
Y
Y
T
P
H
-----------
E
E
--------
T
--
N
N
E
S
F
V
I
--------
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
------------------------------
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
--------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
-----
L
P
Y
A
G
V
A
----
F
Y
I
F
T
H
-----------
Q
GSDFG---------
P
I
F
M
------------
T
I
P
A
F
F
A
K
T
S
A
V
Y
--------
N
P
V
I
Y
I
M
------
M
N
K
Q
F
R
N
-----
C
M
V
T
T
L
C
C
G
K
N
P
L
G
------
D
D
E
A
S
T
T
V
S
----------------
K
T
E
T
S
Q
-----
V
A
P
A
------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
67.53
14%
-124
- C1 -
4PQG
2
?
A:
[6-511]
-----------HH
H
M
T
I
Y
N
I
N
L
G
I
G
-
W
A
S
S
G
V
E
Y
A
Q
A
Y
R
----------------
A
G
V
F
R
K
L
N
L
S
S
K
F
I
F
T
D
M
I
L
A
D
N
I
Q
H
L
T
------
A
N
I
G
F
D
-----------
D
N
Q
-----
V
I
W
L
Y
N
H
F
T
D
I
K
I
A
--
P
T
S
V
T
-
V
D
-------
D
V
L
A
Y
F
G
-
G
E
E
S
H
R
E
K
N
G
K
V
L
R
V
F
--
F
FDQD
K
F
V
T
C
Y
L
VD
E
N
K
D
L
V
Q
H
A
E
Y
V
F
K
G
N
L
I
R
K
D
Y
F
S
YTR
Y
C
---
S
E
Y
F
A
P
K
D
N
V
A
V
L
Y
Q
R
------
T
F
Y
N
-
E
D
G
T
P
V
Y
D
-----------
I
L
M
N
Q
G
K
E
E
V
Y
H
F
KD
K
I
F
Y
G
K
Q
A
F
V
R
A
F
M
-------
K
-
S
L
--------
N
--
L
N
K
S
D
L
V
--------
I
L
D
R
E
T
G
I
G
Q
V
V
F
E
E
A
Q
T
A
H
L
A
------------------------------
V
V
V
H
A
E
H
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
A
T
NED
Y
I
L
W
N
N
Y
Y
D
Y
Q
F
T
N
A
D
K
V
D
F
F
I
V
ST
D
R
Q
N
E
V
L
Q
E
----
Q
F
A
K
Y
T
-----------
Q
--------------
H
Q
P
K
------------
I
V
T
I
P
V
G
S
I
D
S
L
T
D
SSQGRKP
F
S
L
I
T
A
S
------
R
L
A
K
E
K
H
I
D
W
L
V
K
A
V
I
E
A
H
K
E
L
P
E
L
T
F
D
I
Y
G
S
G
G
E
D
S
L
L
R
E
----------------
I
I
A
N
H
Q
AEDYI
Q
L
K
G
H
A
E
L
S
QIYSQYE
V
Y
L
T
A
S
T
S
E
G
F
G
L
T
L
M
------------
E
A
I
G
S
G
L
P
L
I
G
F
DVPY
G
N
Q
T
F
IEDGQN
G
Y
L
I
PSSSDHV
E
D
Q
I
K
Q
A
Y
A
A
K
I
C
Q
L
Y
Q
E
NR
L
E
A
M
R
A
Y
S
Y
Q
I
A
E
G
F
L
T
K
E
I
L
E
K
W
K
K
T
V
E
E
V
L
HD
33
HHSearch
65.82
14%
-106
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[36-323]
-----------------------------------
T
L
N
K
----------------
Y
V
V
I
I
--------
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
------
V
M
L
V
I
L
-----------
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
--
F
A
L
T
--
L
P
-------
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
--
L
----
K
E
V
N
F
Y
---
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
---
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
------
S
M
N
L
-
S
L
P
F
F
L
F
R
-----------
Q
A
Y
H
P
----
N
N
S
S
---
P
V
C
Y
E
V
L
G
N
D
------------
T
A
--------
K
--
W
R
M
V
L
R
I
--------
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
------------------------------
R
T
L
F
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
--------
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
-----
L
P
Y
N
L
V
L
----
L
A
D
T
L
M
-----------
R
TQVIQE
S
C
E
R
R
N
N
I
G
R
A
L
------------
D
A
T
E
I
L
G
F
L
H
S
C
L
--------
N
P
I
I
Y
A
F
------
I
G
Q
N
F
R
H
-----
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.15
24%
-156
- C3 -
3EML
8
ENLYS_BPT4
A:
[29-148]
----------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
------
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
-------
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--
F
----
V
L
V
L
T
Q
---
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
---
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
------
S
F
A
I
-
G
L
T
P
M
L
G
W
-----------
N
N
C
G
Q
S
Q
G
C
G
E
G
Q
---
V
A
C
L
F
E
D
V
V
P
M
N
Y
-------
M
-
V
Y
--------
F
--
N
F
F
A
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
------------------------------
I
F
E
M
L
R
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
R
L
--------
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
-----
L
T
K
S
P
S
L
----
N
A
A
K
S
E
-----------
L
--------------
D
K
A
I
------------
G
R
N
T
N
G
V
I
T
K
D
E
A
--------
E
K
L
F
N
Q
D
------
V
D
A
A
V
R
G
-----
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
------
D
A
V
R
R
A
A
L
I
----------------
N
M
V
F
Q
M
-----
G
E
T
G
V
A
G
F
T
-------
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
------------
N
L
A
K
S
R
W
Y
------------------------------------------------------------------------------------
9
PsiBlast_PDB
60.07
24%
-153
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[14-133]
----------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
------
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
-------
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--
F
----
V
L
V
L
T
Q
---
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
---
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
------
S
F
A
I
-
G
L
T
P
M
L
G
W
-----------
N
N
C
G
Q
S
Q
G
C
G
E
G
Q
---
V
A
C
L
F
E
D
V
V
P
M
N
Y
-------
M
-
V
Y
--------
F
--
N
F
F
A
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
------------------------------
Q
M
E
S
Q
P
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
--------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
-----
G
L
F
A
L
C
W
----
L
P
L
H
I
I
-----------
N
--------------
C
F
T
F
------------
F
C
P
D
C
S
H
A
P
L
W
L
M
--------
Y
L
A
I
V
L
S
------
H
T
N
S
V
V
N
-----
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
------
F
R
K
I
I
R
S
H
V
----------------
L
--------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
59.73
25%
-154
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[14-133]
----------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
------
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
-------
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--
F
----
V
L
V
L
A
Q
---
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
---
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
------
S
F
A
I
-
G
L
T
P
M
L
G
W
-----------
N
N
C
G
Q
P
G
C
G
E
G
Q
V
---
A
C
L
F
E
D
V
V
P
M
N
Y
M
-------
V
-
Y
F
--------
N
--
F
F
A
C
V
L
V
--------
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
------------------------------
M
E
S
Q
P
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
-----
L
F
A
L
C
W
L
----
P
L
H
I
I
N
-----------
C
--------------
F
T
F
F
------------
C
P
D
C
S
H
A
P
L
W
L
M
Y
--------
L
A
I
V
L
A
H
------
T
N
S
V
V
N
P
-----
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
------
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.70
24%
-152
- C3 -
3VG9
4
?
A:
[14-133]
----------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
------
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
-------
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--
F
----
V
L
V
L
T
Q
---
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
---
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
------
S
F
A
I
-
G
L
T
P
M
L
G
W
-----------
N
N
C
G
Q
S
Q
G
C
G
E
G
Q
---
V
A
C
L
F
E
D
V
V
P
M
N
Y
-------
M
-
V
Y
--------
F
--
N
F
F
A
C
V
L
--------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
------------------------------
Q
M
E
S
Q
P
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
--------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
-----
G
L
F
A
L
C
W
----
L
P
L
H
I
I
-----------
N
--------------
C
F
T
F
------------
F
C
P
D
C
S
H
A
P
L
W
L
M
--------
Y
L
A
I
V
L
S
------
H
T
N
S
V
V
N
-----
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
------
F
R
K
I
I
R
S
H
V
----------------
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
59.46
25%
-154
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[14-133]
----------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
------
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
-------
F
A
I
T
--
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--
F
----
V
L
V
L
A
Q
---
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
---
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
------
S
F
A
I
-
G
L
T
P
M
L
G
W
-----------
N
N
C
G
Q
P
G
C
G
E
G
Q
V
---
A
C
L
F
E
D
V
V
P
M
N
Y
M
-------
V
-
Y
F
--------
N
--
F
F
A
C
V
L
V
--------
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
------------------------------
M
E
S
Q
P
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
-----
L
F
A
L
C
W
L
----
P
L
H
I
I
N
-----------
C
--------------
F
T
F
F
------------
C
P
D
C
S
H
A
P
L
W
L
M
Y
--------
L
A
I
V
L
A
H
------
T
N
S
V
V
N
P
-----
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
------
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------