@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR8U9_HUMAN: (2016-01-14 )
MTQINCTQVTEFILVGLTDRQELKMPLFVLFLSIYLFTVVGNLGLILLIRTDEKLNTPMYFFLSNLAFVDFCYSSVITPKMLGNFLYKQNSISFNACAAQLGCFLAFMTAECLLLASMAYDRYVAICNPLMYMVVMSPGICIQLVAAPHSYSILVALFHTILTFRLSYCHSNIVNHFYCDDMPLLRLTCSDTRFKQLWIFACAGIMFISSLLIVFVSYMFIISAILRMHSAEGRQKAFSTCGSHMLAVTIFYGTLIFMYLQPSSSHALDTDKMASVFYTVIIPMLNPLIYSLQNKEVKEALKKIIINKN
Atome Classification :
(20 SA)
--------------.........10........20.....----------------...30........40.-.......50........60........70......-..80.....-...-90.........100...--....110..--.....120......-------.130...---....140.......150.......160.......170.......180..-.....-------190--...--.-....200.......210.......220.......230-------------------.--------.......240.......250.......260--.--.----.---.---...-270..-----------.......280-......--------.290.......300.......--------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MTQI
N
C
T
Q
V
T
E
F
I
LVGLT
D
R
Q
E
LK
M
P
----------------
L
F
V
L
F
L
S
I
Y
L
F
T
V
VGN-L
G
L
I
L
L
I
RTDEKLNT
P
M
Y
F
F
L
S
N
L
A
F
V
D
F
C
Y
S
SVI-
T
P
K
M
L
G
N
F
L
-
Y
KQ-N-SI
S
F
N
A
C
A
A
Q
L
G
C
F
L
--
A
F
M
T
A
E
C
L
L
--
L
A
S
M
A
Y
D
R
Y
V
A
I
C
N
-------
P
L
M
Y
M
V
V---MSPG
I
C
I
Q
L
V
AAPH
S
Y
S
I
L
V
A
L
F
H
T
I
L
T
F
R
L
S
Y
C
H
S
N
I
V
N
H
FYCDDM
P
L
-
L
R
L
TC-------S-D--TR
F
--
K
-
Q
L
W
I
F
A
C
A
G
I
M
F
I
S
S
L
L
I
V
F
V
S
Y
M
F
I
I
S
A
I
L
R
M
HSA--------------------E--------
G
R
Q
K
A
F
S
T
CGS
H
M
L
A
V
T
I
F
Y
G
T
L
I
F
M
Y
LQP--S--S----S---H---AL
D
-
T
--
D
K
-----------
M
A
S
V
F
Y
T
V
I
I
-
P
M
L
N
P
L
--------
I
Y
SLQ
N
K
E
V
K
E
A
L
K
K
I
IINKN--------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
86.61
19%
-152
- C3 -
2Z73
5
OPSD_TODPA
A:
[34-332]
-------------------------------------
Y
Y
S
----------------
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
-
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
-
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
--
I
F
G
F
M
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
--
Y
-
T
-
L
E
G
V
L
C
N
C
S
F
D
Y
I
-
S
-------------
R
--
D
S
T
--
T
-
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
--
Q
--
F
----
G
PLE
W
---
V
T
P
-
Y
--
A
A
-----------
Q
L
P
V
M
F
A
K
A
S
-
A
I
H
N
P
M
--------
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
83.91
16%
-142
- C3 -
2KS9
1
NK1R_HUMAN
A:
[36-323]
---------------------------------------------------------
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
-
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
-
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
--
A
A
V
F
A
S
I
Y
S
--
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
-------
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
--
S
-
T
T
-
E
-
T
M
P
S
R
V
V
C
M
I
E
W
P
-
E
H
P
-----------
N
--
K
I
Y
--
E
-
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
--
Y
--
I
NPD-
L
---
Y
---
L
K
K
F
I
Q
Q
V
Y
-----------
L
A
I
M
W
L
A
M
S
S
-
T
M
Y
N
P
I
--------
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
78.53
17%
-134
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------
D
E
V
W
V
V
G
----------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
-
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
-
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
--
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-------
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
-------
T
H
Q
E
A
I
N
C
Y
A
-
E
E
T
C
C
-------
D
-
F
--
F
T
N
--
Q
-
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
--------------------
E
--------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
--
P
----
S
---
L
---
N
A
A
-
K
--
S
E
-----------
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
--------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
48
Fugue
76.66
16%
-132
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
----------------
A
A
Y
M
F
L
-
L
I
M
L
G
F
P
I
N
-
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
--
V
F
-
G
G
F
T
T
T
L
Y
T
-
S
L
H
-
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------
P
M
-------------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTP
H
-
E
--
E
T
N
--
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
--------------------
Q
--------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
--
Y
--
A
----
G
---
V
---
A
F
Y
-
I
--
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
--------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
NPLGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
75.88
15%
-136
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
FEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
-
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------
P
M
-------------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
D
YY
T
P
H
--
E
-
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
--------------------
A
--------
A
A
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
--
Y
--
A
----
G
---
V
---
A
F
Y
-
I
--
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
--------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
NPSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
75.07
15%
-132
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[40-323]
--------------------------------------
Y
V
----------------
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
-
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
--
V
N
G
-
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
--
V
N
F
Y
S
G
I
L
L
--
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
-------
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
--
A
Y
H
P
--
N
N
S
S
P
V
C
Y
E
V
L
G
-
N
D
------------
T
--
A
K
W
--
R
-
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
-
M
--------------------
G
--------
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
--
R
TQVI
Q
E--
S
C
E
R
R
N
N
-
I
--
G
R
A
L
---------
D
A
T
E
I
L
G
F
L
H
-
S
C
L
N
P
I
--------
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
72.30
22%
-155
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[42-235]
---------------------------------------
G
----------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
-
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
-
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
--
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-------
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-
R
A
---
T
H
Q
E
A
I
N
C
Y
A
E
-----
E
T
C
-------
C
-
D
--
F
F
T
--
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
--
K
--
S
----
P
---
S
---
L
N
A
-
A
--
K
S
-----------
E
L
D
K
A
I
G
R
N
T
-
N
G
V
I
T
K
--------
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
67.86
21%
-156
- C3 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-200]
---------------------------------------
P
----------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
-
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
-
W
-
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
--
V
A
S
T
A
S
I
F
S
--
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
-------
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
--
W
N
-
H
------
R
R
E
D
K
C
E
T
---------------------
D
F
Y
--
D
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
--
K
--
S
----
P
---
S
---
L
N
A
-
A
--
K
S
-----------
E
L
D
K
A
I
G
R
N
T
-
N
G
V
I
T
K
--------
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
67.61
15%
-129
- C3 -
1U19
14
OPSD_BOVIN
A:
[42-325]
---------------------------------------
M
----------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
-
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
--
Y
-
I
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
-
T
P
----------
H
-
E
--
E
T
N
--
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
--------------------
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
--
F
T
H
Q
----
G
S--
D
---
F
G
P
-
I
--
F
M
-----------
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
--------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
65.42
17%
-172
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-221]
--------------------------------------
S
V
----------------
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
-
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
-
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
--
V
L
T
Q
S
S
I
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-------
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
----
V
A
C
-------
L
-
F
--
E
D
V
VP
M
-
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
--
K
--
S
----
P
---
S
---
L
N
A
-
A
--
K
S
-----------
E
L
D
K
A
I
G
R
N
T
-
N
G
V
I
T
K
--------
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
64.35
19%
-156
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[25-215]
---------------------------------------
F
----------------
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
-
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
-
W
-
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
--
V
V
S
N
A
S
V
M
N
--
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
-------
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
--
I
V
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
--------------------
F
S
--
N
-
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
--
K
--
S
----
P
---
S
---
L
N
A
-
A
--
K
S
-----------
E
L
D
K
A
I
G
R
N
T
-
N
G
V
I
T
K
--------
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
63.06
15%
-169
- C1 -
4TQG
1
?
A:
[1-319]
---------------
S
Q
I
N
D
K
---
T
I
M
I
F
G
G
S
G
---------------------------
S
L
G
N
R
L
I
E
T
Y
I
N
-
N
N
I
I
V
N
Y
S
R
D
E
S
K
H
W
S
M
E
L
K
Y
K
S
-
D
K
L
K
N
I
I
G
D
I
R
-
D
F
E
K
V
Q
Q
S
I
-
M
R
I
-
N
P
D
I
I
I
I
A
A
A
L
K
H
I
D
R
C
--
E
Y
E
I
N
E
C
L
D
--
T
N
I
K
G
L
Q
N
V
L
K
V
T
E
I
NRSNLS
N
L
K
A
V
C
F
---
V
S
T
---
D
K
A
C
S
P
V
N
S
Y
G
M
S
K
A
I
C
E
T
L
V
V
E
K
S
K
Y
I
K
D
I
K
Y
V
C
V
R
Y
G
N
--
V
-
L
N
F
T
L
-------
T
-
H
--
T
S
M
--
T
-
R
F
I
M
T
L
D
D
S
V
K
L
I
E
Y
A
I
I
N
G
N
S
G
E
I
V
I
P
K
L
N
S
M
Y
I
K
--------------------
D
--------
M
I
E
L
F
A
D
K
Y
P
I
V
I
T
G
L
R
S
G
E
R
M
Y
E
S
L
I
N
D
T
--
Q
--
S
----
M
---
K
---
T
V
P
-
K
--
G
D
----------------
Y
Y
H
I
L
-
P
T
Y
D
P
T
IVTEE
F
Y
E
Y
S
S
K
Q
N
I
L
S
K
Q
E
L
E
N
Y
L
N
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.40
25%
-144
- C3 -
4IAQ
1
5HT1B_HUMAN (first)
A:
[20-153]
-------------------------------------
K
V
L
----------------
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
-
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
-
M
P
I
S
T
M
Y
T
V
-
T
G
R
-
W
-
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
--
T
C
C
T
A
S
I
W
H
--
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
-------
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
P
F
F
W
R
Q
A
S
E
C
V
V
N
T
D
H
I
L
Y
T
V
Y
S
T
V
G
-
A
F
Y
F
P
-------
T
-
L
--
L
L
I
--
A
-
L
Y
G
R
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
N
A
A
Q
V
K
--------------------
D
--------
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
D
S
P
E
M
K
D
F
R
H
G
F
D
--
I
--
L
----
V
---
G
---
Q
I
D
-
D
--
A
L
-----------
K
L
A
N
E
G
K
V
K
E
-
A
Q
A
A
A
E
--------
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
L
M
A
A
R
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.63
25%
-149
- C3 -
4IAR
1
C562_ECOLX
A:
[20-153]
-------------------------------------
K
V
L
----------------
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
-
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
-
M
P
I
S
T
M
Y
T
V
-
T
G
R
-
W
-
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
--
T
C
C
T
A
S
I
W
H
--
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
-------
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
P
F
F
W
R
Q
A
S
E
C
V
V
N
T
D
H
I
L
Y
T
V
Y
S
T
V
G
-
A
F
Y
F
P
-------
T
-
L
--
L
L
I
--
A
-
L
Y
G
R
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
--------------------
A
--------
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
--
S
--
P
----
E
---
M
---
K
D
F
-
R
--
H
G
-----------
F
D
I
L
V
G
Q
I
D
D
-
A
L
K
L
A
N
--------
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.28
26%
-141
- C3 -
4XEE
1
?
A:
[32-170]
-------------------------------------
K
V
L
----------------
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
-----
S
T
V
H
Y
H
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
-
M
P
V
E
L
Y
N
F
I
-
W
V
H
-
H
-
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
--
V
A
S
L
S
V
E
R
Y
L
A
I
C
H
-------
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
R
S
A
D
G
T
H
P
G
G
L
V
C
T
P
I
V
-
D
T
A
T
V
-------
K
-
V
--
V
I
Q
--
V
-
N
T
F
M
S
F
L
F
P
M
L
V
I
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V
P
G
R
V
Q
A
L
R
--------------------
H
--------
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
I
S
--
D
--
E
----
Q
---
W
---
T
T
F
-
L
--
F
D
-----------
F
Y
H
Y
F
Y
M
L
T
N
-
A
L
F
Y
A
S
--------
S
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
58.30
15%
-157
- C3 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-226]
--------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
-
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
-
W
-
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
--
M
M
C
T
A
S
I
W
N
--
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
-------
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
-
N
--
T
----
T
G
D
P
T
V
C
S
I
---------------------
S
N
P
--
D
--
F
V
-
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
--------------------
N
--------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
--
L
--
T
----
K
---
S
---
P
S
L
-
N
--
A
A
-----------
K
S
E
L
D
K
A
I
G
R
-
N
T
N
G
V
I
--------
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
57.92
17%
-142
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[49-239]
--------------------------------------
I
F
----------------
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
-
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
-
W
-
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
--
V
N
L
Y
S
S
V
W
I
--
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
-------
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
-
N
--
V
S
--
E
A
D
D
R
Y
I
C
D
R
F
Y
P
-
N
----------------
D
L
W
--
V
-
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
--------------------
I
--------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
--
T
--
K
----
S
---
P
---
S
L
N
-
A
--
A
K
-----------
S
E
L
D
K
A
I
G
R
N
-
T
N
G
V
I
T
--------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
57.04
19%
-149
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[63-249]
-------------------------------------
I
K
L
----------------
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
-
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
-
Y
-
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
--
V
A
L
S
A
S
V
F
S
--
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
------------------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
W
N
-------
C
I
S
A
L
S
S
C
S
T
V
L
P
------------------
L
-
Y
--
H
-
K
H
Y
I
L
F
-
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
--------------------
E
--------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
--
S
--
P
----
S
---
L
---
N
A
A
-
K
--
S
E
-----------
L
D
K
A
I
G
R
N
T
N
-
G
V
I
T
K
D
--------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
56.31
27%
-159
- C3 -
3RZE
2
ENLYS_BPT4 (first)
A:
[9-117]
--------------------------------------
M
P
----------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
-
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
-
W
-
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
--
V
A
S
T
A
S
I
F
S
--
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
-------
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
H
R
R
E
D
K
C
E
T
D
F
Y
D
V
T
W
F
K
V
M
T
-
A
I
I
N
F
-------
Y
-
L
--
P
T
L
--
L
-
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
--------------------
E
--------
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
--
N
--
T
----
N
---
G
---
V
I
T
-
K
--
D
E
-----------
A
E
K
L
F
N
Q
D
V
D
-
A
A
V
R
G
I
--------
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
55.48
28%
-156
- C3 -
4IB4
7
5HT2B_HUMAN (first)
A:
[34-136]
----------------------------------------------------------
L
L
I
L
M
V
I
I
P
T
I
G
G
N
-
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
I
A
L
L
T
I
M
-
F
E
A
M
W
-
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
--
L
F
S
T
A
S
I
W
H
--
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
-------
P
I
Q
A
N
Q
Y
---
N
S
R
A
T
A
F
I
K
I
T
V
V
W
L
I
S
I
G
I
A
I
P
V
P
I
K
G
I
E
T
N
P
N
N
I
T
C
V
L
T
K
E
R
F
G
D
F
M
-
L
F
G
S
L
-------
A
-
A
--
F
F
T
--
P
-
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
K
A
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
--------------------
E
--------
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
K
D
F
R
H
G
--
F
--
D
----
I
---
L
---
V
G
Q
-
I
--
D
D
-----------
A
L
K
L
A
N
E
G
K
V
-
K
E
A
Q
A
A
--------
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
Q
T
I
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------