@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR9A2_HUMAN: (2016-01-14 )
MMDNHSSATEFHLLGFPGSQGLHHILFAIFFFFYLVTLMGNTVIIVIVCVDKRLQSPMYFFLSHLSTLEILVTTIIVPMMLWGLLFLGCRQYLSLHVSLNFSCGTMEFALLGVMAVDRYVAVCNPLRYNIIMNSSTCIWVVIVSWVFGFLSEIWPIYATFQFTFRKSNSLDHFYCDRGQLLKLSCDNTLLTEFILFLMAVFILIGSLIPTIVSYTYIISTILKIPSASGRRKAFSTFASHFTCVVIGYGSCLFLYVKPKQTQGVEYNKIVSLLVSVLTPFLNPFIFTLRNDKVKEALRDGMKRCCQLLKD
Atome Classification :
(20 SA)
-------------.........10....----------------..--..20-------........30...------------.....40-........50...-...--------..60........70....-------.-..---------.80-----.----------.-------------...-------....--90........-100.......110......-------.120.---------------------.....--.130...--....140.----------......150.---------......------160..---.....------170.......180...-------....-190-.....------...200.......210..---------------.....220......--------------------.--------230..---.....240....-.-..250--------.....-.--------.----.260--.---.---.--.---..---...270.....---..---280.......290---------.........300------------........310---------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MMDNHSSA
T
E
F
H
L
LG----------------FP--GSQ
G
-------
L
H
H
I
L
F
A
I
F
F
F
F
Y
------------
L
V
T
LMGN-
T
V
I
I
V
I
V
C
V
D
K
R
L-QS
P
--------
M
Y
F
F
L
S
H
L
S
T
L
E
I
L
V
T
T
I
-------
I
-
V
P
---------
M
M
------
L
----------
W
-------------
G
L
L
-------
F
L
G
C
--
R
Q
Y
L
S
L
H
V
S
L
-
N
FSC
G
T
M
E
F
A
L
L
G
V
M
A
V
D
R
-------
Y
V
A
VC---------------------N
P
L
R
Y
--
N
I
I
MNSS--
T
C
I
W
V
V
I
V
----------
S
W
V
F
G
F
L
S
E
I
---------
W
P
I
Y
A
T
------
F
Q
F
T
F
---RKSNS------LD
H
F
YCDRG
Q
L
L
K
LSC-------D
N
T
L
-
L
-
T
-
E
F
I
L
F
------
L
M
A
V
F
I
L
I
G
S
L
I
P
T
I
V
S
Y
---------------
T
Y
I
I
S
T
I
L
KIPSAS--------------------G--------
R
R
K
A
F
---
S
T
F
AS
H
F
T
C
V
V
I
-G-YG
S
-
C
--------
L
F
L
Y
V-K--------P----KQ----T---Q---G--V---
E
Y
---
N
K
I
V
S
L
L
V
S
V
L
---
T
P
---
F
L
N
P
F
I
F
TLR
N
-----------
D
K
V
K
E
A
L
R
D
G
M
-------------
K
R
C
C
Q
L
LKD-----------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
86.11
18%
-149
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[18-301]
------------------------------------------------------------------------------------
V
L
A
I
L
G
N
-
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
--------
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
-------
A
-
I
P
---------
F
A
------
I
T
I
S
T
G
F
C
A
A
C
H
-------------
G
C
L
-------
F
I
A
C
--
F
V
L
V
L
A
Q
S
S
I
---------
F
S
L
L
A
I
-
A
I
D
R
-------
Y
I
A
I
A
---------------------
I
P
L
R
Y
--
N
G
L
V
T
G
T
--
R
A
A
G
I
I
A
I
----------
C
W
V
L
S
F
A
I
G
L
---------
T
P
M
L
G
W
------
N
N
C
G
Q
---
P
--------------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
-
M
-
N
-
Y
M
V
Y
F
NFFACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
---------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
--------------------
E
--------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
-
G
L
F
A
L
-
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
--------
P
----
D
C
----
S
---
H
---
A
--
P
---
L
W
---
L
M
Y
L
A
I
V
L
A
H
T
---
N
S
---
V
V
N
P
F
I
Y
A
Y
R
I
-----------
R
E
F
R
Q
T
F
R
K
I
I
-------------
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
85.69
18%
-148
- C5 -
3REY
1
AA2AR_HUMAN
A:
[18-301]
------------------------------------------------------------------------------------
V
L
A
I
L
G
N
-
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
--------
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
-------
A
-
I
P
---------
F
A
------
I
T
I
S
T
G
F
C
A
A
C
H
-------------
G
C
L
-------
F
I
A
C
--
F
V
L
V
L
A
Q
S
S
I
---------
F
S
L
L
A
I
-
A
I
D
R
-------
Y
I
A
I
A
---------------------
I
P
L
R
Y
--
N
G
L
V
T
G
T
--
R
A
A
G
I
I
A
I
----------
C
W
V
L
S
F
A
I
G
L
---------
T
P
M
L
G
W
------
N
N
C
G
Q
---
P
--------------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
-
M
-
N
-
Y
M
V
Y
F
NFFACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
---------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
--------------------
E
--------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
-
G
L
F
A
L
-
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
--------
P
----
D
C
----
S
---
H
---
A
--
P
---
L
W
---
L
M
Y
L
A
I
V
L
A
H
T
---
N
S
---
V
V
N
P
F
I
Y
A
Y
R
I
-----------
R
E
F
R
Q
T
F
R
K
I
I
-------------
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
85.42
18%
-147
- C5 -
3PWH
1
?
A:
[18-301]
------------------------------------------------------------------------------------
V
L
A
I
L
G
N
-
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
--------
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
-------
A
-
I
P
---------
F
A
------
I
T
I
ST
G
F
C
A
A
C
H
-------------
G
C
L
-------
F
I
A
C
--
F
V
L
V
L
A
Q
S
S
I
---------
F
S
L
L
A
I
-
A
I
D
R
-------
Y
I
A
I
A
---------------------
I
P
L
R
Y
--
N
G
L
V
T
G
T
--
R
A
A
G
I
I
A
I
----------
C
W
V
L
S
F
A
I
G
L
---------
T
P
M
L
G
W
------
N
N
C
G
Q
---
P
--------------
G
C
G
E
G
Q
V
A
C
L
F
E
-------
D
V
V
P
-
M
-
N
-
Y
M
V
Y
F
NFFACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
---------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
--------------------
E
--------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
-
G
L
F
A
L
-
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
--------
P
----
D
C
----
S
---
H
---
A
--
P
---
L
W
---
L
M
Y
L
A
I
V
L
A
H
T
---
N
S
---
V
V
N
P
F
I
Y
A
Y
R
I
-----------
R
E
F
R
Q
T
F
R
K
I
I
-------------
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
84.34
17%
-132
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
SNKTGVVRSPFEAPQY
Y
L
--
A
E
P
W
-------
Q
F
S
M
L
A
A
Y
M
F
L
L
I
------------
M
L
G
F
P
I
N
-
F
L
T
L
Y
V
T
V
Q
H
K
K
L
-
R
T
P
--------
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
-------
G
-
F
T
---------
T
T
------
L
----------
Y
-------------
T
S
L
H
GY----
F
V
F
G
--
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
-------
Y
V
V
V
C
---------------------
K
P
M
S
---
N
F
R
F
G
E
N
--
H
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
---------
P
P
L
V
G
W
------
S
R
Y
I
P
E
GM
Q
C
S
C
G
------
I
D
Y
Y
----------
T
P
-------
H
E
E
T
-
N
-
N
-
E
S
F
V
I
------
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
--------------------
T
--------
T
Q
K
A
E
---
K
E
V
T
R
M
V
I
I
M
V
I
-
A
-
F
L
I
-
C
--------
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
----
G
S
----
D
---
F
---
G
--
P
---
I
F
---
M
T
I
P
A
F
F
A
K
T
S
---
A
V
----
Y
N
P
V
I
Y
I
M
M
N
-----------
K
Q
F
R
N
C
M
V
T
T
L
-------------
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A-----------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
79.93
18%
-124
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
----------------
Q
Y
YL
A
E
P
W
-------
Q
F
S
M
L
A
A
Y
M
F
L
L
I
------------
M
L
G
F
P
I
N
-
F
L
T
L
Y
V
T
V
Q
H
K
K
L
-
R
T
P
--------
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
-------
G
-
F
T
---------
T
T
------
L
----------
Y
-------------
T
S
L
H
GY----
F
V
F
G
--
P
T
G
C
N
L
E
G
F
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
-------
Y
V
V
V
C
---------------------
K
P
M
S
---
N
F
R
F
G
E
N
--
H
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
---------
P
P
L
V
--------------------
G
------
W
S
R
Y
I
P
E
G
---
M
Q
C
S
C
G
I
DYYTP
H
E
E
T
-
N
-
N
-
E
S
F
V
I
------
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
--------------------
Q
ESA
T
----
T
Q
K
A
E
---
K
E
V
T
R
M
V
I
I
M
V
I
-
A
-
F
L
I
-
C
--------
W
L
P
Y
A
-
G
--------
V
A
F
Y
I
F
T
----
H
---
Q
---
G
--
S
---
D
F
---
G
P
I
F
M
T
I
P
A
F
F
A
KT
S
A
---
V
Y
N
P
V
I
Y
I
M
M
N
-----------
K
Q
F
R
N
C
M
V
T
T
L
-------------
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA-----------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
78.98
16%
-150
- C5 -
2Z73
5
OPSD_TODPA
A:
[32-332]
---------------------------------------------------
A
-------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
------------
I
I
G
C
G
G
N
-
G
I
V
I
Y
L
F
T
K
T
K
S
L
-
Q
T
P
--------
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
-------
N
G
F
P
---------
L
M
------
T
----------
I
-------------
S
C
F
L
KKWIFG
F
A
A
C
--
K
V
Y
G
F
----
I
-
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
-------
Y
N
V
I
G
---------------------
R
P
M
A
A
--
S
K
K
M
S
H
R
--
R
A
F
I
M
I
I
F
----------
V
W
L
W
S
V
L
W
A
I
---------
G
P
I
F
G
W
------
G
A
Y
T
L
-------
E
------
G
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
S
-
T
-
T
-
R
S
N
I
L
------
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
---------------
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
--------
E
M
R
L
A
---
K
I
S
I
V
I
V
S
Q
F
L
L
-
S
-
W
S
P
-
Y
--------
A
V
V
A
L
-
L
--------
A
----
Q
F
----
G
---
P
LEW
V
--
T
---
P
Y
---
A
A
Q
L
P
V
M
F
A
K
A
---
S
A
---
I
H
N
P
M
I
Y
S
V
S
H
-----------
P
K
F
R
E
A
I
S
Q
T
F
-------------
P
W
V
L
T
C
C
Q
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
78.34
16%
-145
- C5 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
-------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
------------
V
T
S
V
V
G
N
-
V
V
V
M
W
I
I
L
A
H
K
R
M
-
R
T
V
--------
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
-------
N
-
T
V
---------
V
N
------
F
----------
T
-------------
Y
A
V
H
NEWYYG
L
F
Y
C
--
K
F
H
N
F
----
F
-
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
-------
Y
M
A
I
I
---------------------
H
P
L
Q
P
--
R
L
--
S
A
T
--
A
T
K
V
V
I
C
V
----------
I
W
V
L
A
L
L
L
A
F
---------
P
Q
G
Y
Y
S
------
T
T
-
E
T
-------
M
------
P
S
R
V
V
C
M
I
E
W
P
E
H
P
----------
N
K
I
-
Y
-
E
-
K
V
Y
H
I
------
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
---------------
T
V
V
G
I
T
L
W
A
S
E
I
P
G
DSSDRYH
E
Q
V
S
---------
A
--------
K
R
K
V
V
---
K
M
M
I
V
V
V
C
T
F
A
I
-
C
-
W
L
P
-
F
--------
H
I
F
F
L
-
L
--------
P
----
Y
I
----
N
---
P
---
D
--
L
YLK
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
---
S
T
---
M
Y
N
P
I
I
Y
C
C
L
N
-----------
D
R
F
R
L
G
F
K
H
A
F
-------------
R
C
C
P
F
I
S
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
74.55
14%
-145
- C2 -
1EI1
6
GYRB_ECOLI
A:
[1-391]
SNSSDSSS
I
K
V
L
K
G
L
D
A
V
R
K
R
P
G
M
Y
I
G
D
----------------
T
D
--
D
G
T
G
-------
L
H
H
M
V
F
E
V
V
D
N
A
I
------------
D
E
A
L
A
G
H
C
K
E
I
I
V
T
I
H
A
D
N
S
V
-
S
V
Q
D
DGRGIPT
G
I
H
P
E
E
G
V
S
A
A
E
V
I
M
T
V
L
-------
H
-
A
G
---------
G
K
------
F
----------
D
DNSYKVSGGLHGV
G
V
S
-------
V
V
N
A
L
-
S
Q
K
L
E
L
V
I
Q
R
-
E
G
K
I
H
R
Q
I
Y
E
H
G
V
P
Q
A
P
L
A
-------
V
T
G
E
T
-----------------------
E
K
T
G
T
M
V
R
F
W
P
S
--
L
E
T
F
T
N
V
T
----------
E
F
E
Y
E
I
L
A
K
R
---------
L
R
E
L
S
F
L
D
SG
V
S
I
R
L
R
D
---
K
R
D
G
K
------
E
D
H
F
H
Y
E
G
G
I
K
A
F
V
E
Y
-------
L
N
K
N
-
K
-
T
-
P
I
H
P
N
------
I
F
Y
F
S
T
E
K
D
G
I
G
V
E
V
A
L
Q
W
N
DGF
Q
---------
E
N
I
Y
C
F
T
N
N
I
P
Q
R
D
--------------------
G
--------
G
-
T
H
L
---
A
G
F
R
A
A
M
T
R
T
L
N
-
A
-
Y
M
D
K
E
--------
G
Y
S
K
K
-
A
--------
K
----
V
S
----
A
---
T
---
G
--
D
---
D
A
---
R
E
G
L
I
A
V
V
S
V
K
---
V
P
D
P
K
F
S
S
Q
T
K
D
K
L
V
S
-----------
S
E
V
K
S
A
V
E
Q
Q
M
-------------
N
E
L
L
A
E
Y
L
L
E
N
P
T
D
A
K
I
V
V
G
K
I
I
D
A
A
R
A
R
E
A
A
R
R
A
R
E
MT-----------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
73.42
15%
-130
- C5 -
1U19
14
OPSD_BOVIN
A:
[40-327]
------------------------------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
------------
M
L
G
F
P
I
N
-
F
L
T
L
Y
V
T
V
Q
H
K
K
L
-
R
T
P
--------
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
-------
G
-
F
T
---------
T
T
------
L
----------
Y
-------------
T
S
L
H
GYFVFG
P
T
G
C
--
N
L
E
G
F
----
F
-
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
-------
Y
V
V
V
C
---------------------
K
P
M
S
N
--
F
R
-
F
G
E
N
--
H
A
I
M
G
V
A
F
----------
T
W
V
M
A
L
A
C
A
A
---------
P
P
L
V
G
W
------
S
R
Y
I
------
P
-
E
------
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
----------
H
E
E
T
-
N
-
N
-
E
S
F
V
I
------
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------------
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
--------------------
Q
ESA
T
T
Q
K
A
E
K
E
V
T
---
R
M
V
I
I
M
V
I
A
F
L
I
-
C
-
W
L
P
-
Y
--------
A
G
V
A
F
-
Y
--------
I
----
F
T
H
---
Q
---
G
---
S
DF
G
---
P
I
---
F
M
T
I
P
A
F
F
A
K
T
---
S
A
---
V
Y
N
P
V
I
Y
I
M
M
N
-----------
K
Q
F
R
N
C
M
V
T
T
L
-------------
C
C
G
K
N
P
L
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
71.20
13%
-125
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------------------------
D
E
V
-------
W
V
V
G
M
G
I
V
M
S
L
I
V
------------
L
A
I
V
F
G
N
-
V
L
V
I
T
A
I
A
K
F
E
R
L
-
Q
T
V
--------
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
-------
V
-
V
P
---------
F
G
------
A
----------
A
-------------
H
I
L
M
KM----
W
T
F
G
--
N
F
W
C
E
F
W
T
S
I
-
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
-------
Y
F
A
I
T
---------------------
S
P
F
K
Y
--
Q
S
L
L
T
K
N
--
K
A
R
V
I
I
L
M
----------
V
W
I
V
S
G
L
T
S
F
---------
L
P
I
Q
----------
M
H
W
---
Y
R
A
T
H
------
Q
E
A
I
N
C
Y
A
E
---
E
T
C
C
-------
D
F
F
T
-
N
-
Q
-
A
Y
A
I
A
------
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
---------------
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
--------------------
M
--------
L
R
I
D
E
---
G
L
R
L
K
I
Y
K
D
T
E
G
-
Y
-
Y
T
I
-
G
--------
I
G
H
L
L
-
T
--------
K
----
S
P
----
S
---
L
---
N
--
A
---
A
K
---
S
E
L
D
K
A
I
G
R
N
T
---
N
G
----------
V
I
T
K
-----------
D
E
A
E
K
L
F
N
Q
D
V
-------------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
3
PsiBlast_PDB
68.94
23%
-145
- C5 -
2YCZ
2
ADRB1_MELGA
A:
[23-219]
------------------------------------------------------------------------------------
L
L
I
V
A
G
N
-
V
L
V
I
A
A
I
G
S
T
Q
R
L
-
Q
T
L
--------
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-------
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
------
L
----------
W
-------------
G
S
F
-------
L
C
--------
E
L
W
T
S
L
-
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
-------
Y
L
A
I
T
---------------------
S
P
F
R
Y
--
Q
S
L
M
T
R
A
--
R
A
K
V
I
I
C
T
----------
V
W
A
I
S
A
L
V
S
F
---------
L
P
I
M
M
H
------
W
---
W
---
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
-------
A
S
S
I
-
I
-
S
-
F
Y
I
P
L
------
L
I
M
I
F
V
-------
A
L
R
V
Y
---------------
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
--------------------
K
--------
R
K
R
V
M
---
L
M
R
E
H
K
A
L
K
T
L
G
-
I
-
I
M
G
-
V
--------
F
T
L
C
W
-
L
--------
P
----
F
F
----
L
---
V
---
N
--
I
---
V
N
---
V
F
N
R
D
L
V
P
D
W
L
---
F
V
---
A
F
N
W
L
G
Y
A
N
S
A
-----------
M
N
P
I
I
Y
C
R
S
P
D
-------------
F
R
K
A
F
K
R
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
68.91
23%
-144
- C5 -
2YCW
7
ADRB1_MELGA
A:
[23-219]
------------------------------------------------------------------------------------
L
L
I
V
A
G
N
-
V
L
V
I
A
A
I
G
S
T
Q
R
L
-
Q
T
L
--------
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-------
V
-
V
P
F
G
A
T
L
V
V
RG
T
W
------
L
----------
W
-------------
G
S
F
-------
L
C
--------
E
L
W
T
S
L
-
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
-------
Y
L
A
I
T
---------------------
S
P
F
R
Y
--
Q
S
L
M
T
R
A
--
R
A
K
V
I
I
C
T
----------
V
W
A
I
S
A
L
V
S
F
---------
L
P
I
M
M
H
------
W
---
W
---
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
-------
A
S
S
I
-
I
-
S
-
F
Y
I
P
L
------
L
I
M
I
F
V
-------
A
L
R
V
Y
---------------
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
--------------------
K
--------
R
K
R
V
M
---
L
M
R
E
H
K
A
L
K
T
L
G
-
I
-
I
M
G
-
V
--------
F
T
L
C
W
-
L
--------
P
----
F
F
----
L
---
V
---
N
--
I
---
V
N
---
V
F
N
R
D
L
V
P
D
W
L
---
F
V
---
A
F
N
W
L
G
Y
A
N
S
A
-----------
M
N
P
I
I
Y
C
R
S
P
D
-------------
F
R
K
A
F
K
R
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
68.51
12%
-174
- C4 -
3UO9
4
GLSK_HUMAN
A:
[67-489]
---PS
L
E
D
L
L
F
Y
T
I
A
E
G
Q
E
K
I
P
V
H
K
F
I
T
----------------
A
L
--
K
S
T
G
LRTSDPR
L
K
E
C
M
D
M
L
R
L
T
L
Q
T
TSDGV
M
L
D
K
D
L
F
K
K
C
V
Q
S
-
N
I
V
L
L
T
Q
A
F
R
R
K
F
-
V
I
P
D-------
F
M
S
F
T
S
H
I
D
E
L
Y
E
S
A
K
K
Q
S
G
G
K
V
AD
Y
-
I
P
---------
Q
L
A
K
FSPD
L
----------
W
-------------
G
V
S
-------
V
C
T
V
DG
Q
R
H
S
T
G
D
T
K
V
-
P
F
C
L
Q
S
C
V
K
P
L
K
Y
A
I
A
V
N
D
-------
L
G
T
E
Y
V
H
R
Y
VGKEPSGLRFNKLFLNE
D
D
K
P
H
--
N
P
M
V
N
A
G
--
A
I
V
V
T
S
L
I
KQGVN
N
A
E
K
F
D
Y
V
M
Q
F
L
N
K
M
A
G
N
E
Y
V
G
F
S
N
A
T
F
Q
S
------
E
R
E
S
G
---
D
R
N
F
A
------
I
G
Y
Y
L
K
E
K
K
C
F
P
E
-
G
T
-------
D
M
V
G
-
I
-
L
-
D
F
Y
F
Q
------
L
C
S
I
E
V
T
C
E
S
A
S
V
M
A
A
T
L
A
N
GGFCPITGERVLS
P
E
A
V
R
N
T
L
S
L
M
H
S
C
--------------------
G
--------
M
Y
D
F
S
---
G
Q
F
A
F
H
V
G
L
P
A
K
S
G
-
V
A
G
-
G
--------
I
L
L
V
V
-
P
--------
N
----
V
------------------------------
M
G
M
M
C
W
---
S
P
---
P
L
D
K
M
G
N
S
V
K
G
-----------
I
H
F
C
H
D
L
V
S
L
C
NFHNYDNLRHFAK
K
L
D
P
R
R
E
G
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
68.31
23%
-134
- C5 -
2YCX
3
ADRB1_MELGA
A:
[23-219]
------------------------------------------------------------------------------------
L
L
I
V
A
G
N
-
V
L
V
I
A
A
I
G
S
T
Q
R
L
-
Q
T
L
--------
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-------
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
------
L
----------
W
-------------
G
S
F
-------
L
C
--------
E
L
W
T
S
L
-
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
-------
Y
L
A
I
T
---------------------
S
P
F
R
Y
--
Q
S
L
M
T
R
A
--
R
A
K
V
I
I
C
T
----------
V
W
A
I
S
A
L
V
S
F
---------
L
P
I
M
M
H
------
W
---
W
---
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
-------
A
S
S
I
-
I
-
S
-
F
Y
I
P
L
------
L
I
M
I
F
V
-------
A
L
R
V
Y
---------------
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
--------------------
K
--------
R
K
R
V
M
---
L
M
R
E
H
K
A
L
K
T
L
G
-
I
-
I
M
G
-
V
--------
F
T
L
C
W
-
L
--------
P
----
F
F
----
L
---
V
---
N
--
I
---
V
N
---
V
F
N
R
D
L
V
P
D
W
L
---
F
V
---
A
F
N
W
L
G
Y
A
N
S
A
-----------
M
N
P
I
I
Y
C
R
S
P
D
-------------
F
R
K
A
F
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.35
23%
-146
- C5 -
2YCY
6
ADRB1_MELGA
A:
[23-219]
------------------------------------------------------------------------------------
L
L
I
V
A
G
N
-
V
L
V
I
A
A
I
G
S
T
Q
R
L
-
Q
T
L
--------
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
-------
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
------
L
----------
W
-------------
G
S
F
-------
L
C
--------
E
L
W
T
S
L
-
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
-------
Y
L
A
I
T
---------------------
S
P
F
R
Y
--
Q
S
L
M
T
R
A
--
R
A
K
V
I
I
C
T
----------
V
W
A
I
S
A
L
V
S
F
---------
L
P
I
M
M
H
------
W
---
W
---
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
-------
A
S
S
I
-
I
-
S
-
F
Y
I
P
L
------
L
I
M
I
F
V
-------
A
L
R
V
Y
---------------
R
E
A
K
E
Q
I
R
--
D
R
A
S
--------------------
K
--------
R
K
R
V
M
---
L
M
R
E
H
K
A
L
K
T
L
G
-
I
-
I
M
G
-
V
--------
F
T
L
C
W
-
L
--------
P
----
F
F
----
L
---
V
---
N
--
I
---
V
N
---
V
F
N
R
D
L
V
P
D
W
L
---
F
V
---
A
F
N
W
L
G
Y
A
N
S
A
-----------
M
N
P
I
I
Y
C
R
S
P
D
-------------
F
R
K
A
F
K
R
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
65.96
13%
-133
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
------------------------------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
------------
L
L
S
L
L
G
N
-
S
L
V
M
L
V
I
L
Y
S
R
V
G
-
R
S
V
--------
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
---------
L
P
---------
I
W
------
A
----------
A
-------------
S
K
V
N
GWIFG-
T
F
L
C
--
K
V
V
S
L
----
L
-
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
-------
Y
L
A
I
V
---------------------
H
A
T
R
T
--
L
T
-
Q
K
R
H
--
L
V
K
F
V
C
L
G
----------
C
W
G
L
S
M
N
L
S
L
---------
P
F
F
L
F
R
------
Q
A
Y
------
H
P
-
N
------
N
S
S
P
V
C
Y
E
V
L
G
N
---
D
--------
T
A
K
-
W
-
R
-
M
V
L
R
I
------
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
---------------
G
F
T
L
R
T
L
F
K
A
H
M
G
---------------------
Q
--------
K
H
R
A
M
---
R
V
I
F
A
V
V
L
I
F
L
L
-
C
-
W
L
P
-
Y
--------
N
L
V
L
L
-
A
--------
D
----
T
L
M
RTQ
V
IQE
S
C
E
R
R
--
N
---
N
I
G
R
-
A
L
D
A
T
E
I
L
G
F
L
---
H
S
---
C
L
N
P
I
I
Y
A
F
I
G
-----------
Q
N
F
R
H
G
F
L
K
I
L
-------------
A
M
H
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
64.76
18%
-152
- C5 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
------------
L
A
I
V
F
G
N
-
V
L
V
I
T
A
I
A
K
F
E
R
L
-
Q
T
V
--------
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
-------
V
-
V
P
---------
F
G
------
A
----------
A
-------------
H
I
L
M
KMWTFG
N
F
W
C
--
E
F
W
T
S
----
I
-
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
-------
Y
F
A
I
T
---------------------
S
P
F
K
Y
--
Q
S
L
L
T
K
N
--
K
A
R
V
I
I
L
M
----------
V
W
I
V
S
G
L
T
S
F
---------
L
P
I
Q
M
H
------
W
Y
R
A
-----
T
H
--------
Q
E
A
I
N
C
Y
A
----
E
E
T
C
-------
C
D
F
F
-
T
-
N
-
Q
A
Y
A
I
------
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
---------------
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
--------------------
E
--------
M
L
R
I
D
---
E
G
L
R
L
K
I
Y
K
D
T
E
-
G
-
Y
Y
T
-
I
--------
G
I
G
H
L
-
L
--------
T
----
K
S
----
P
---
S
---
L
--
N
---
A
A
---
K
S
E
L
D
K
A
I
G
R
N
---
T
N
---
G
V
I
T
K
D
E
A
E
K
L
-----------
F
N
Q
D
V
D
A
A
V
R
G
-------------
I
L
R
N
A
K
L
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
63.41
18%
-166
- C5 -
3EML
8
ENLYS_BPT4
A:
[22-222]
-------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
------------
V
L
A
I
L
G
N
-
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
--------
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
-------
A
-
I
P
---------
F
A
------
I
----------
T
-------------
I
S
T
GFCAA--
C
H
G
C
--
L
F
I
A
C
----
F
-
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
-------
Y
I
A
I
R
---------------------
I
P
L
R
Y
--
N
G
L
V
T
G
T
--
R
A
K
G
I
I
A
I
----------
C
W
V
L
S
F
A
I
G
L
---------
T
P
M
L
G
W
------
N
N
C
G
Q
----------------
S
Q
G
C
G
E
G
Q
---
V
A
C
-------
L
F
E
D
V
V
-
P
M
N
Y
M
V
Y
------
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
---------------
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
--------------------
E
--------
M
L
R
I
D
---
E
G
L
R
L
K
I
Y
K
D
T
E
-
G
-
Y
Y
T
-
I
--------
G
I
G
H
L
-
L
--------
T
----
K
S
----
P
---
S
---
L
--
N
---
A
A
---
K
S
E
L
D
K
A
I
G
R
N
---
T
N
---
G
V
I
T
K
D
E
A
E
K
L
-----------
F
N
Q
D
V
D
A
A
V
R
G
-------------
I
L
R
N
A
K
L
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
62.25
12%
-143
- C3 -
4HKA
1
T23O_DROME
A:
[3-347]
-GKI
Y
G
E
Y
L
M
L
D
K
L
L
D
A
Q
C
M
L
S
E
E
D
--
K
----------------
R
P
--
V
H
D
E
-------
H
L
F
I
I
T
H
Q
A
Y
E
L
W
------------
F
K
Q
I
I
F
E
-
F
D
S
I
R
D
M
L
D
A
E
V
I
D
E
T
K
--------
T
L
E
I
V
K
R
L
N
R
V
V
L
I
L
K
L
L
-------
V
-
D
Q
---------
V
P
------
I
----------
L
-------------
E
T
M
T
P
L
D
---
F
M
D
F
--
R
K
Y
L
A
P
A
S
G
F
Q
S
L
Q
F
R
L
I
E
N
K
L
-
G
V
L
T
E
Q
R
VRYNQKY
S
D
V
F
S
---------------------
D
E
E
A
R
--
N
S
I
R
N
S
E
K
D
P
S
L
L
E
L
V
Q
----------
R
W
L
E
R
T
P
------------
G
L
E
E
S
G
------
F
N
F
W
A
---
K
F
Q
E
S
------
V
D
R
F
L
E
A
Q
V
Q
S
A
M
E
E
P
-------
V
E
K
A
-
K
-
N
-
Y
R
L
M
D
------
I
E
K
R
R
E
V
Y
R
S
I
F
--------------------------------
D
P
A
--------------------
V
--------
H
D
A
L
V
---
R
R
G
D
R
R
F
S
H
R
A
L
-
Q
-
G
A
I
-
M
--------
I
T
F
Y
R
D
E
--------
P
----
R
F
----
S
---
Q
---
P
--
H
---
Q
L
---
L
T
L
L
M
D
I
D
S
L
I
---
T
K
---
W
R
Y
N
H
V
I
M
V
Q
R
M
IGSQQLGTGG
S
S
G
Y
Q
Y
L
R
S
T
L
-------------
S
D
R
Y
K
V
F
L
D
L
F
N
LSTFLIPREA
I
P
P
L
D
E----------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
61.07
18%
-153
- C5 -
3UON
2
ACM2_HUMAN (first)
A:
[24-215]
-------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
------------
L
V
T
I
I
G
N
-
I
L
V
M
V
S
I
K
V
N
R
H
L
-
Q
T
V
--------
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
-------
S
-
M
N
---------
L
Y
------
T
----------
L
-------------
Y
T
V
I
GYWPLG
P
V
V
C
--
D
L
W
L
A
----
L
-
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
-------
Y
F
C
V
T
---------------------
K
P
L
T
Y
--
P
V
K
R
T
T
K
--
M
A
G
M
M
I
A
A
----------
A
W
V
L
S
F
I
L
W
A
---------
P
A
I
L
F
W
------
Q
F
I
V
-----
G
V
R
T
------
V
E
D
G
----------
E
C
-------
Y
I
Q
F
-
F
S
N
-
A
A
V
T
F
------
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
---------------
W
H
I
S
R
A
S
K
S
R
I
N
I
F
--------------------
E
--------
M
L
R
I
D
---
E
G
L
R
L
K
I
Y
K
D
T
E
-
G
-
Y
Y
T
-
I
--------
G
I
G
H
L
-
L
--------
T
----
K
S
----
P
---
S
---
L
--
N
---
A
A
---
K
S
E
L
D
K
A
I
G
R
N
---
T
N
---
G
V
I
T
K
D
E
A
E
K
L
-----------
F
N
Q
D
V
D
A
A
V
R
G
-------------
I
L
R
N
A
K
L
K
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------