@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PE2R1_HUMAN: (2016-01-14 )
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
Atome Classification :
(20 SA)
....--.....10......--..20........--30......-..40....---....50....------....60........70........80......--.--.---90---........100.....-..110.....----..120.......130.......140......---.150------........160.......170-...-....180-.......---.190--.----..--.--.-..200..----.....210.......220.......230.....--..240...-..------.------------------.------------250--------------.-----------------------------------------------------------.--------.----------------------.-----------------.--------------------.-----.------.------.---------------------260-----.------------------------------.---------------------------------------.------------------------------.-----.-------------------------------------.----.-------.------------.------270.---------------------.-----------.------------.-------.-----------------.---------.---------..----------280.......290.......300.......310.......320-...---------.---------...330.......340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSPC--GPL
N
L
S
LAGEATT--CAAPWVPNTSAV--PPSGASPA-
L
P
I
F
S
M
T
L
---
G
A
V
S
N
L
L
A
L
A
------
L
L
A
Q
A
A
G
R
L
R
R
R
R
S
A
A
T
F
L
L
F
V
A
S
L
L
A
T
D
LA
G
--
H
--
V
---
I
P
---
G
A
L
V
L
R
LYTAGRAPAG-
G
A
C
H
F
L
G
G
C
M
----
V
F
F
G
L
C
P
L
L
L
G
C
G
M
A
V
E
R
C
V
G
V
T
R
P
L
L
H
A
A
R
---
V
S
V
-------
A
R
A
R
L
A
L
A
A
V
A
A
V
A
L
A
V
A
L
L
P
-
L
A
R
-VG
R
Y
E
L
--QYPG
T
W
C
---
F
I
G
L--G----PP--
G
--
G
-
W
R
Q
A
L
L
A
----
G
L
F
A
S
L
G
L
V
A
L
L
A
A
L
V
C
N
T
L
S
G
L
A
L
L
R
A
R
W
R
RR--SRRPPPAS-G
P
------
D
------------------
S
------------
R
----------------R-----------------------------------------------------------R--------W----------------------G-----------------A--------------------H-----G------P------R---------------------S-------A------------------------------S---------------------------------------A------------------------------S-----
S
-------------------------------------
A
----
S
-------
S
------------I------A--S---------------------
A
-----------
S
------------
T
-------
F
-----------------F---------G---------GS----------RSSGSARRARA
H
D
V
E
M
V
G
Q
L
V
G
I
M
V
V
S
C
I
C
W
S
P
M
L
V
L
V
A
L
AVG-GWS---------S---------TSLQR
P
L
F
L
A
V
R
LA
S
W
N
Q
I
L
D
P
W
V
Y
I
L
L
R
Q
A
V
L
R
Q
L
L
R
LLPPRAGAKGGPAGLGLTPSAW
E
A
S
S
L
R
S
S
R
HSGLSHF
27
HHSearch
76.33
15%
-125
* C4 *
2Z73
5
OPSD_TODPA
A:
[31-334]
--------------------------------
D
--
A
V
Y
Y
S
L
G
I
-
F
I
G
I
C
G
I
I
---
G
C
G
G
N
G
I
V
I
Y
------
L
F
T
K
T
----
K
S
L
Q
T
--
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
--
S
--
L
V
N
G
F
P
---
L
M
T
I
S
-
C
F
L
K
K
W
I
F
G
F
-
A
A
C
K
V
Y
G
F
I
G
----
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
-------
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
-
I
F
G
-
W
G
A
Y
T
L
--
E
G
V
L
C
N
C
---
S
F
D
Y
--
I
----
S
R
--
D
--
S
-
T
T
R
S
N
I
L
----
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
--
A
M
A
K
R
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
K
E
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
-
G
P
L
---------
E
---------
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
--------
28
HHSearch
74.77
16%
-120
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
--------------------------------------
V
G
M
G
I
-
V
M
S
L
I
V
L
A
---
I
V
F
G
N
V
L
V
I
T
------
A
I
A
K
F
----
E
R
L
Q
T
--
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
--
G
L
A
V
---
V
P
---
F
G
A
A
H
I
-
L
M
K
M
W
T
F
G
N
-
F
W
C
E
F
W
T
S
I
D
----
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
-------
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
H
W
Y
R
A
T
H
--
Q
-
E
A
I
N
C
---
Y
A
E
E
--
T
C---
C
D
--
F
--
F
-
T
N
Q
A
Y
A
I
----
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
--
M
L
R
I
D
E
G
L
-
R
L
------
K
I
Y
K
D
TEGYYTIGIGHLLT
K
------------
S
PS
L
N
A
A
K
S
E
L
D
-----
K
A
I
GRN------------------------------------------------------
T
--------
N
----------------------
G
-----------------
V
IT
K
D
E
---------------
A
-----
E
K
L
F
N
Q
D
V
------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
-------
R
R
A
A
L
I
N
------------------------
M
V
F
Q
M-----------------------------------
G
------------------------------
E
T
G
V
A
-
G
F
T
N
S
L
--------------------------------
R
----
M
-------
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
------
K
--
S
R
--------------------
W
-----------
Y
------------
N
-------
Q
-----------------
T
P
N
R
A
K
R
V
I
T
T
---------
F
R
----------
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
-
Q
D
N
-------------------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------
43
Fugue
73.25
16%
-123
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
--
V
R
S
P
F
E
A
P
Q
Y
Y
L
--
A
E
P
W
Q
F
S
M
-
L
A
A
Y
-
M
F
L
---
L
I
M
L
G
F
P
I
N
F
------
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
--
L
N
L
A
V
A
D
L
F
M
--
V
--
F
---
G
G
---
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
----
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
---
F
G
E
-------
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
-
L
V
G
-
W
S
R
Y
I
P
--
E
G
M
Q
C
S
C
---
G
I
D
Y
YT
P
----
H
E
--
E
--
T
-
N
N
E
S
F
V
I
----
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------
E
A
----------
A
A
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
---
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-
H
Q
G
---------
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------
31
HHSearch
72.18
17%
-131
- C4 -
1U19
14
OPSD_BOVIN
A:
[41-328]
--------------------------------------
S
M
L
A
A
-
Y
M
F
L
L
I
M
L
---
G
F
P
I
N
F
L
T
L
Y
------
V
T
V
Q
H
----
K
K
L
R
T
--
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
--
V
F
G
G
---
F
T
---
T
T
L
Y
T
-
S
L
H
G
Y
F
V
F
G
P
-
T
G
C
N
L
E
G
F
F
A
----
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
-------
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
-
L
V
G
-
W
S
R
Y
I
P
--
E
G
M
Q
C
S
C
---
G
I
D
Y
--
Y
----
T
P
HE
E
--
T
-
N
N
E
S
F
V
I
----
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
--
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-
H
Q
G
---------
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------
29
HHSearch
72.02
16%
-117
- C4 -
3EML
13
ENLYS_BPT4
A:
[22-472]
--------------------------------------
S
V
Y
I
T
-
V
E
L
A
I
A
V
L
---
A
I
L
G
N
V
L
V
C
W
------
A
V
W
L
N
----
S
N
L
Q
N
--
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
--
G
V
L
A
---
I
P
---
F
A
I
T
I
S
---
T
G
F
C
A
A
C
-
H
G
C
L
F
I
A
C
F
V
----
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
-------
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-
M
L
G
-
W
N
N
C
G
Q
-----
S
Q
G
C
---
G
E
G
Q
--
V
ACLF
E
D
--
V
--
V
-
P
M
N
Y
M
V
Y
----
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
--
M
L
R
I
D
E
G
L
-
R
L
------
K
------------------
I
Y
K
D
TEGYYTIGI
G
HLLT------------
K
SPS
L
N
------------------------------------------------------
A
--------
A
K
---------------------
S
E
L
D
K
A
I
GRNT-------
N
--------------------
G
VIT
K
D
E
------
A
E
K
L
F
N
Q
D
---------------------
V
-------
D
------------------------------
A
---------------------------------------
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
----
N
M
V
F
Q
M
G
E
T
G
V
A
G
F------------------------------
T
N
S
L
R
M
-------
L
------------
Q
------
Q
--
K
---------------------
R
W
D
E
A
A
V
N
----
L
------------
A
K
S
R
W
Y
N
Q
T
-----------------
P
---------
N
R
A
K
R
V
I
T
T
F
R
T
----------
G
T
W
D
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
---------
C
S--------
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----------------------------
25
HHSearch
70.60
16%
-131
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------
Y
A
L
-
S
Y
C
A
L
I
L
A
---
I
V
F
G
N
G
L
V
C
M
------
A
V
L
K
E
----
R
A
L
Q
T
--
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
--
A
T
L
V
---
M
P
---
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
-
I
C
C
D
V
F
V
T
L
D
----
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
-------
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
-
L
F
G
-
F
N
T
T
G
-----
D
P
T
V
C
---
S
I
S
N
--
P
----------------
D
F
V
I
----
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
--
F
E
M
L
R
I
D
E
-
G
L
RL
K
I
Y
K
D
------------------
T
------------
E
----------------
G
Y
Y
T
I
G
IG----------------------------------------------------
H
L-------
L
TKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN
G
-----------------
V
--------------------
I
-----
T
------
K
------
D
---------------------
E
-------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
---------------------------------------
R
------------------------------
R
-----
A
A
L
I
N
M
V
F
Q
MG---------------------------
E
----
T
G
V
A
G
F
T
N
S
------------
L
R
M
L
Q
Q
-
K
--
R
W
D
E
A
A
V
N
L
A
------------
K
S
R
W
Y
-------
N
------------
Q
-------
T
P
N
R
A
K
R
V
I
---------
T
---------
T
---------
F
R
----------
T
G
T
W
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
-
C
Q
T
---------
C
---------
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------
24
HHSearch
70.40
15%
-120
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------
P
L
V
V
-
V
L
S
T
I
C
L
V
---
T
V
G
L
N
L
L
V
L
Y
------
A
V
R
S
E
----
R
K
L
H
T
--
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
--
G
A
V
V
---
M
P
---
M
N
I
L
Y
L
-
L
M
S
K
W
S
L
G
R
-
P
L
C
L
F
W
L
S
M
D
----
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
-------
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
-
L
-
G
-
W
N
H
------
R
R
E
D
K
C
---
E
T
D
F
--
Y
----
D
V
---------
T
W
F
K
V
----
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
--
M
L
R
I
D
E
G
L
-
R
L
------
K
I
Y
K
D
TE------------
G
Y
Y
T
I
G
IGHLLTK
S
----------------
P
-----------------------------------------------------------
S
--------
L
----------------------
N
-----------------
A
A
K
S
E
L
D
K
A
I
G----------
R
-----
N
------
T
NGVIT
K
D
---------------------
E
-------
A
------------------------------
E
---------------------------------------
K
------------------------------
L
F
N
Q
--
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
--
V
-------
A
------------
G
------
F
--
T
---------------------
N
-----------
S
L
R
M
L
--------
Q
-------
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
---------
T
---------
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
-
C
K
N
-------------------
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------
32
HHSearch
69.14
13%
-139
- C4 -
2KS9
1
NK1R_HUMAN
A:
[34-326]
---------------------------------------
L
W
A
A
-
A
Y
T
V
I
V
V
T
---
S
V
V
G
N
V
V
V
M
W
------
I
I
L
A
H
----
K
R
M
R
T
--
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
--
A
A
F
N
---
T
V
---
V
N
F
T
Y
A
-
V
H
N
E
W
Y
Y
G
L
-
F
Y
C
K
F
H
N
F
F
P
----
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
-------
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
-
G
Y
Y
-
S
T
-
T
E
T
--
M
P
S
R
V
V
C
---
M
I
E
W
--
P
----
E
H
--
P
NK
I
-
Y
E
K
V
Y
H
I
----
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
--
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
-
N
P
D
---------
L
YLK------
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
42
Fugue
68.70
17%
-103
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
--
E
G
P
N
F
Y
V
P
F
S
N
K
T
GV
V
R
S
P
F
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
L
A
-
A
Y
M
F
L
L
I
M
---
L
G
F
P
I
N
F
L
T
L
------
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
--
T
--
T
---
T
L
---
Y
T
S
L
H
G
Y
F
V
F
G
----
P
-
T
G
C
N
L
E
G
F
F
A
----
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
-
R
---
F
G
E
-------
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
-
L
V
G
-
W
S
R
Y
I
P
--
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
--
H
----
E
E
--
T
--
N
--
N
E
S
F
V
I
----
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
---------
G
Q
L
V
F
T
--
V
K
E
A
A
A
Q
Q
-
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
---------
P
---------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
----
V
Y
N
P
V
I
Y
I
M
M
-
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------
51
Fugue
67.44
13%
-111
- C2 -
1AUI
2
PP2BA_HUMAN
A:
[14-486]
----------
T
D
R
V
V
K
A
V
P
--
F
P
P
S
H
R
L
T
A
K
E
V
--
F
D
N
D
G
K
P
R
-
V
D
I
L
K
A
H
L
M
K
E
G
R
L
E
E
S
V
A
L
R
------
I
I
T
E
G
A
S
I
L
R
Q
E
K
N
L
L
D
I
D
A
P
V
T
--
V
C
G
D
I
H
G
--
Q
-----------
F
F
D
L
M
K
L
F
E
V
G
G
S
P
A
N
-
T
R
Y
L
F
L
G
D
Y
V
DRGY
F
S
I
E
C
V
L
Y
L
W
A
L
K
I
L
Y
P
K
T
L
F
L
L
R
G
N
H
E
C
R
H
---
L
T
E
Y
F
T
F
K
Q
E
C
K
I
K
Y
S
E
R
V
Y
D
A
C
M
D
A
F
D
C
L
P
L
A
A
L
-
M
N
Q
Q
F
L
--
C
V
H
G
--------
G
L
--
S
----
P
E
--
I
--
N
-
T
L
D
D
I
R
K
LDRF
K
E
P
P
A
Y
G
P
M
C
D
I
L
W
S
D
P
L
E
D
F
G
N
E
K
T
Q
E
H
F
T
H
N
--
T
V
R
G
C
S
Y
F
Y
S
Y
------
P
------------------
A
------------
V
----------------
C
-----------------------------------------------------------
E
--------
F
----------------------
L
-----------------
Q
--------------------
H
-----
N
------
N
------
L
---------------------
L
-------
S
------------------------------
I
---------------------------------------
L
------------------------------
R
-----
A
-------------------------------------
H
----
E
-------
A
------------
Q
------
D
--
A
---------------------
G
-----------
Y
------------
R
-------
M
-----------------
Y
---------
R
---------
K
S
----------
Q
T
T
G
F
P
------------
S
L
I
T
I
F
S
A
P
N
Y
L
D
V
Y
N
N
K
A
A
V
L
K
Y
E
-
N
N
V
---------
M
---------
N
I
R
Q
F
N
C
S
P
H
P
Y
W
L
P
N
F
M
D
V
F
T
W
S
L
P
F
V
G
E
K
V
T
E
M
L
V
N
V
L
N
I
--------------
C
S
S
F
E
E
A
K
G
L
D
R
I
N
E
R
M
P
P
R
22
HHSearch
66.70
12%
-121
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------
V
F
I
V
L
-
V
A
G
S
L
S
L
V
---
T
I
I
G
N
I
L
V
M
V
------
S
I
K
V
N
----
R
H
L
Q
T
--
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
--
G
V
F
S
---
M
N
---
L
Y
T
L
Y
T
-
V
I
G
Y
W
P
L
G
P
-
V
V
C
D
L
W
L
A
L
D
----
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
-------
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
-
I
L
F
-
W
Q
F
I
V
G
VR
T
V
E
D
G
E
C
---
Y
I
Q
F
--
F
----
S
N
---------
A
A
V
T
F
----
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
--
M
L
R
I
D
E
G
L
-
R
L
------
K
------------------
I
------------
Y
K
D
TEG
Y
Y
T
I
GIGHLLT
K
-----------------------------------------------------------
S
PS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN------------
G
VIT--------------
K
--------------------
D
-----
E
------
A
------
E
---------------------
K
-------
L
------------------------------
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
------------------------------
E
-----
T
-------------------------------------
G
----
V
-------
A
G
F
T
N
S
-------
L
R
M
L
---
Q
--
Q
---------------------
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
--------
Q
-------
T
-----------------
P
N
R
A
K
R
V
I
T
-
T
---------
F
R
----------
T
G
T
W
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
-
C
A
P
-------------------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------
26
HHSearch
65.05
15%
-127
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[62-495]
------------------------------------
S
I
K
L
T
S
V
-
V
F
I
L
I
C
C
F
---
I
I
L
E
N
I
F
V
L
L
------
T
I
W
K
T
----
K
K
F
H
R
--
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
--
G
--
V
A
Y
-
T
A
---
N
L
L
L
S
--
G
A
T
T
Y
K
L
T
P
-
A
Q
W
F
L
R
E
G
S
M
----
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
-------
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
-
I
M
G
-
W
N
C
I
S
-----
A
L
S
S
C
---
S
T
V
L
--
P
----
L
Y
---------
H
K
H
Y
I
----
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
--
L
R
I
D
E
G
L
R
-
L
K
------
I
------------------
Y
------------
K
----------------
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
--------
N
----------------------
A
-----------------
K
--------------------
L
-----
K
------
P
------
V
---------------------
Y
-------
D
------------------------------
S
LD
A
V
R
----------------------------------
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K--
R
-----
W
-------------------------------------
D
----
E
-------
A
A
V
N
---------
L
------
A
--
K
---------------------
S
-----------
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
-------
T
-----------------
T
---------
F
---------
R
T
----------
G
T
W
D
A
Y
A
S
R
S
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
-
C
K
V
---------
K
T--------
C
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
--------------------------------
21
HHSearch
60.64
11%
-103
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-498]
------------------------------------
N
K
I
F
L
P
T
-
I
Y
S
I
I
F
L
T
---
G
I
V
G
N
G
L
V
I
L
------
V
M
G
Y
Q
----
K
K
L
R
S
--
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
--
V
I
-
T
---
L
P
---
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
-
F
L
C
K
A
V
H
V
I
Y
----
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
-------
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
-
F
I
F
-
A
N
V
S
E
---
A
D
D
R
Y
I
C
---
D
R
F
Y
--
P
----
N
D
--
L
----
W
V
V
V
F
Q
F
----
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
--
E
M
L
R
I
D
E
G
-
L
R
------
L
------------------
K
------------
I
----------------
Y
-----------------------------------------------------------
K
--------
D
----------------------
T
EG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
-----
D
------
E
------
A
---------------------
E
K
L
F
N
Q
D
V
D
------------------------------
A
---------------------------------------
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG---
E
-------------------------------------
T
----
G
-------
V
A
G
F
T
--------
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
-----------
V
------------
I
-------
T
-----------------
T
---------
F
---------
R
T
----------
G
T
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
-
I
L
L
EI
I
K
Q
G
C
E
F
E
---------
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-------------------------
33
HHSearch
60.57
15%
-139
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[40-323]
--------------------------------------
Y
V
V
I
I
-
A
Y
A
L
V
F
L
L
---
S
L
L
G
N
S
L
V
M
L
------
V
I
L
Y
S
----
R
V
G
R
S
--
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
--
A
L
-
T
---
L
P
---
I
W
A
A
S
--
K
V
N
G
W
I
F
G
T
-
F
L
C
K
V
V
S
L
L
K
----
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
-------
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
-
F
L
F
-
R
Q
A
Y
H
P
--
N
N
S
S
P
V
C
---
Y
E
V
L
--
G
----
N
D
--
T
--
A
K
W
R
M
V
L
R
I
----
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
-
M
R
T
---------
Q
VIQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------
6
PsiBlast_PDB
53.31
22%
-148
- C4 -
3P0G
1
ENLYS_BPT4
A:
[31-177]
--------------------------------------
D
V
T
Q
Q
R
D
E
V
W
V
V
G
M
---
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
--
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
--
V
---
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
----
N
-
F
W
C
E
F
W
T
S
I
D
----
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
-------
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
Y
R
A
T
--
H
Q
E
A
I
N
C
---
Y
A
E
E
--
T
----
C
C
--
D
--
F
-
F
T
N
Q
A
Y
A
----
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
L
K
E
H
K
A
--
L
K
T
L
G
I
I
M
-
G
T
------
F
------------------
T
------------
L
----------------
C
-----------------------------------------------------------
W
--------
L
----------------------
P
-----------------
F
--------------------
F
-----
I
------
V
------
N
---------------------
I
-------
V
------------------------------
H
---------------------------------------
V
------------------------------
I
-----
Q
-------------------------------------
D
----
N
-------
L
------------
I
------
R
--
K
---------------------
E
-----------
V
------------
Y
-------
I
-----------------
L
---------
L
---------
N
W
----------
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
R
R
---------------------------------------------------------------------------------------------------------------
50
Fugue
52.99
12%
-93
- C3 -
1UG3
-
IF4G1_HUMAN
A:
[1234-1566]
------------------------------------
S
K
A
A
L
S
E
-
E
E
L
E
K
K
S
K
---
A
I
I
E
E
Y
L
H
L
N
------
D
M
K
E
A
V
Q
C
V
Q
E
L
A
S
P
S
L
L
F
I
F
V
R
H
G
V
E
S
T
L
E
R
--
S
--
A
---
I
A
---
R
E
H
M
G
Q
L
L
H
Q
L
L
C
A
--------------------
G
H
L
S
-----
T
A
Q
Y
Y
Q
G
L
Y
E
I
L
E
L
A
E
D
M
E
---
I
D
I
-------
P
H
V
W
L
Y
L
A
E
L
V
T
P
I
L
Q
E
G
G
V
P
-
M
G
E
-
L
F
R
E
I
T
--
K
P
--------------
L
----
R
P
--
L
--
G
-
K
A
A
S
L
L
L
----
E
I
L
G
L
L
C
K
S
M
-----------
G
P
K
K
V
G
T
L
W
R
E
A
GL
S
W
K
E
F
L
P
E
-
G
Q
------
D
------------------
I
------------
G
----------------
A
-----------------------------------------------------------
F
--------
V
----------------------
A
-----------------
E
--------------------
Q
-----
K
------
V
------
E
---------------------
Y
-------
T
------------------------------
L
---------------------------------------
A
------------------------------
L
-----
P
-------------------------------------
S
----
E
-------
E
------------
L
------
N
--
R
---------------------
Q
-----------
L
------------
E
-------
K
-----------------
L
---------
L
---------
K
E
----------
G
S
S
N
Q
R
V
F
D
W
I
E
A
N
L
S
E
Q
Q
I
V
S
---------
N
T
L
V
R
A
L
M
T
A
V
C
-
Y
S
A
---------
I
---------
I
F
E
T
P
L
R
V
D
V
A
V
L
K
A
R
A
K
L
L
Q
K
Y
L
C
D
E
Q
K
E
L
Q
A
L
Y
A
L
Q
A
L
V
V
T
L
E
Q
P
P
N
-
L
L
R
M
F
F
D
A
L
Y
D
E
D
V
V
K
E
D
A
F
Y
S
W
E
S
-
7
PsiBlast_PDB
51.42
22%
-150
- C4 -
3PDS
4
ADRB2_HUMAN (first)
A:
[12-145]
---------------------------------------------------
M
---
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
--
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
--
V
---
V
P
F
G
A
A
C
I
L
M
K
M
W
T
F
G
----
N
-
F
W
C
E
F
W
T
S
I
D
----
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
-------
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
Y
R
A
T
--
H
Q
E
A
I
N
C
---
Y
A
E
E
--
T
----
C
C
--
D
--
F
-
F
T
N
Q
A
Y
A
----
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
--
E
M
L
R
I
D
E
G
-
L
R
------
L
------------------
K
------------
I
----------------
Y
-----------------------------------------------------------
K
--------
D
----------------------
T
-----------------
E
--------------------
G
-----
Y
------
Y
------
T
---------------------
I
-------
G
------------------------------
I
---------------------------------------
G
------------------------------
H
-----
L
-------------------------------------
L
----
T
-------
K
------------
S
------
P
--
S
---------------------
L
-----------
N
------------
A
-------
A
-----------------
K
---------
S
---------
E
L
----------
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-
S
L
D
---------
A
---------
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
5
PsiBlast_PDB
50.52
22%
-152
- C4 -
2RH1
5
ADRB2_HUMAN (first)
A:
[36-176]
--------------------------------------------
D
E
V
W
V
V
G
M
---
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
--
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
--
V
---
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
----
N
-
F
W
C
E
F
W
T
S
I
D
----
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
-------
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
Y
R
A
T
--
H
Q
E
A
I
N
C
---
Y
A
E
E
--
T
----
C
C
--
D
--
F
-
F
T
N
Q
A
Y
A
----
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
--
E
M
L
R
I
D
E
G
-
L
R
------
L
------------------
K
------------
I
----------------
Y
-----------------------------------------------------------
K
--------
D
----------------------
T
-----------------
E
--------------------
G
-----
Y
------
Y
------
T
---------------------
I
-------
G
------------------------------
I
---------------------------------------
G
------------------------------
H
-----
L
-------------------------------------
L
----
T
-------
K
------------
S
------
P
--
S
---------------------
L
-----------
N
------------
A
-------
A
-----------------
K
---------
S
---------
E
L
----------
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-
S
L
D
---------
A
---------
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
3
PsiBlast_PDB
50.49
22%
-157
- C4 -
3NY9
4
ADRB2_HUMAN (first)
A:
[40-177]
-----------------------------------------------
W
V
V
G
M
---
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
--
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
--
V
---
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
----
N
-
F
W
C
E
F
W
T
S
I
D
----
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
-------
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
Y
R
A
T
--
H
Q
E
A
I
N
C
---
Y
A
E
E
--
T
----
C
C
--
D
--
F
-
F
T
N
Q
A
Y
A
----
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
--
E
M
L
R
I
D
E
G
-
L
R
------
L
------------------
K
------------
I
----------------
Y
-----------------------------------------------------------
K
--------
D
----------------------
T
-----------------
E
--------------------
G
-----
Y
------
Y
------
T
---------------------
I
-------
G
------------------------------
I
---------------------------------------
G
------------------------------
H
-----
L
-------------------------------------
L
----
T
-------
K
------------
S
------
P
--
S
---------------------
L
-----------
N
------------
A
-------
A
-----------------
K
---------
S
---------
E
L
----------
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-
S
L
D
---------
A
---------
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
2
PsiBlast_PDB
49.91
22%
-158
- C4 -
3NY8
7
ENLYS_BPT4
A:
[40-177]
-----------------------------------------------
W
V
V
G
M
---
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
--
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
--
V
---
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
----
N
-
F
W
C
E
F
W
T
S
I
D
----
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
-------
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
Q
M
-
H
W
Y
R
A
T
--
H
Q
E
A
I
N
C
---
Y
A
E
E
--
T
----
C
C
--
D
--
F
-
F
T
N
Q
A
Y
A
----
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
--
E
M
L
R
I
D
E
G
-
L
R
------
L
------------------
K
------------
I
----------------
Y
-----------------------------------------------------------
K
--------
D
----------------------
T
-----------------
E
--------------------
G
-----
Y
------
Y
------
T
---------------------
I
-------
G
------------------------------
I
---------------------------------------
G
------------------------------
H
-----
L
-------------------------------------
L
----
T
-------
K
------------
S
------
P
--
S
---------------------
L
-----------
N
------------
A
-------
A
-----------------
K
---------
S
---------
E
L
----------
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-
S
L
D
---------
A
---------
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K