@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PE2R3_HUMAN: (2016-01-14 )
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
Atome Classification :
(20 SA)
-----.........----10.----.......20........30........40----.....----------....50........60---........70........80........90........100....-...110-----........120.......130.......-140.......150.......160......---.170.......180.......190....-....200--......---.210.......220........230--.....-----..----..--240.......-------250.......260---------------....--------.------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------.270.------.-.....280....-...290.---.....--------...300.....-----..310.......320..--------------------------.....330--------...------....340....-------...350.-...------...360--........370.......380--....--.....390------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----MKETRGYGG----DA
P
----
F
C
T
RLNHSYTGMWAPER
S
A
EARGNLTRP-----PGSGE----------DCGS
V
S
V
A
F
P
I
T
M
L
L
T
---
G
F
V
G
N
A
L
A
M
L
L
V
S
R
S
Y
R
R
R
E
S
K
RK
K
S
F
L
L
C
I
G
W
L
A
L
T
D
L
V
G
Q
L
L
T-T
P
V
V
I
------
V
V
Y
LSKQRWEHIDPSG
R
L
C
T
F
F
G
L
T
M
T
V
-
F
G
L
S
S
L
F
I
A
S
A
M
A
V
E
R
A
L
AIRAP
H
W
Y
A
S
H
---
M
K
T
R
A
T
R
A
V
L
L
G
V
W
L
A
V
L
A
F
A
L
-
L
P
V
LG-VG
Q
Y
T
V
Q
--WP
G
T
W
C
---
F
I
STGRGGNGTSS-SHNW
G
N
L
F
F
----
A
S
A
F
A
-----
F
L
----
G
L
--
L
A
L
T
V
T
FSC
N
-------
L
A
T
I
K
A
L
V
S
R
C
RA---------------KATA--------S------------------------------------------------------------------------------------------------------------------------------------------------------Q-------------------------------------------------------------------------------------------------------------------------------------------------------SSAQW------G-R
I
T
T
E
T
A
I
Q
L
M
G
-
I
M
C
V
--
L
---
S
V
C
W
S
--------
P
L
L
I
M
M
L
K
M
I
F-----NQT
S
V
E
H
C
K
T
H
T
E
K
QKE--------------------------C
N
F
F
L
I
A
V
--------
R
L
A
------
S
L
N
Q
I
L
D
P
W
V
Y
-------
L
L
L
R
K
I
L
-
L
R
K
------
F
C
Q
I
R
---
Y
HTNNYASSSTSLPCQCSS----
T
L
M
W
--
S
DHLER--------------------------------------------------------------------
36
HHSearch
92.92
18%
-130
- C3 -
3EML
13
ENLYS_BPT4
A:
[22-472]
----------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
---
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-----
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
------
T
I
S
T
---
G
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
V
L
V
-
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-
T
P
M
L
G
-
W
N
N
C
G
Q
-----
S
Q
G
C
---
G
E
G
Q
V
A
C
L
F
E
----
D
V
V
P
M
N
Y
M
V
----
Y
F
N
F
F
-----
A
C
----
V
L
--
V
P
L
L
L
M
L
G
V
Y
-------
L
R
I
F
L
A
A
R
R
Q
L
N
I
---------------
F
E
M
L
--------
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
R
S
T
------
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
-
I
V
G
L
--
F
---
A
L
C
W
L
--------
P
L
H
I
I
N
C
F
T
F
F
-----
C
P
D
C
S
---------
H
A
P
--------------------------
L
W
L
M
Y
L
A
I
--------
V
L
S
------
H
T
N
S
V
V
N
P
F
I
Y
-------
A
Y
R
I
R
E
F
-
R
Q
T
------
F
R
K
I
I
---
R
S
H
V
L
R
Q
------------------------------------------------------------------------------------------------
35
HHSearch
91.03
18%
-140
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
---
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
-----
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
------
Y
L
E
V
T
G
G
V
W
N
F
S
R
---
I
C
C
D
V
F
V
T
L
D
V
M
-
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
-
P
L
L
F
G
-
F
N
T
T
G
-----
D
P
T
V
C
---
S
I
S
N
P
---------------
D
F
V
----
I
Y
S
S
V
-----
V
S
----
F
Y
--
L
P
F
G
V
T
V
L
V
Y
-------
A
R
I
Y
V
V
L
K
Q
R
R
R
K
---------------
N
I
F
E
--------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
----------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW--------------------------------------------------------------------------------------------------------------------------------------
D
A
Y
G
V
------
P
-
L
R
E
K
K
A
T
Q
M
V
A
I
-
V
L
G
A
--
F
---
I
V
C
W
L
--------
P
F
F
L
T
H
V
L
N
T
H
-----
C
Q
T
C
H
----------
V
S
--------------------------
P
E
L
Y
S
A
T
T
--------
W
L
G
------
Y
V
N
S
A
L
N
P
V
I
Y
-------
T
T
F
N
I
E
F
-
R
K
A
------
F
L
K
I
L
---
S
C
-----------------------------------------------------------------------------------------------------
32
HHSearch
87.49
19%
-142
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-----------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
---
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
-----
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
------
L
Y
L
L
-
M
S
K
W
S
L
G
R
---
P
L
C
L
F
W
L
S
M
D
Y
V
-
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
-
P
I
-
L
G
-
W
N
H
------
R
R
E
D
K
C
---
E
T
D
F
Y
D
V
------------
T
W
F
K
----
V
M
T
A
I
-----
I
N
----
F
Y
--
L
P
T
L
L
M
L
W
F
Y
-------
A
K
I
Y
K
A
V
R
Q
H
C
N
I
---------------
F
E
M
L
--------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-----------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW---------------------------------------------------------------------------------------------------------------------------------------
D
A
Y
L
H
------
M
-
N
R
E
R
K
A
A
K
Q
L
G
F
-
I
M
A
A
--
F
---
I
L
C
W
I
--------
P
Y
F
I
F
F
M
V
I
A
F
-----
C
K
N
C
C
-----------
N
--------------------------
E
H
L
H
M
F
T
I
--------
W
L
G
------
Y
I
N
S
T
L
N
P
L
I
Y
-------
P
L
C
N
E
N
F
-
K
K
T
------
F
K
R
I
L
---
H
I
-----------------------------------------------------------------------------------------------------
30
HHSearch
83.77
16%
-132
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
---------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
---
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
-----
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
------
A
H
I
L
-
M
K
M
W
T
F
G
N
---
F
W
C
E
F
W
T
S
I
D
V
L
-
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
---
E
A
I
N
C
---
Y
A
E
E
T
C
C
D
-------
F
F
T
N
Q
A
Y
A
----
I
A
S
S
I
-----
V
S
----
F
Y
--
V
P
L
V
I
M
V
F
V
Y
-------
S
R
V
F
Q
E
A
K
R
Q
L
N
I
---------------
F
E
M
L
--------
R
------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
A
Y
K
F
------
C
-
L
K
E
H
K
A
L
K
T
L
G
I
-
I
M
G
T
--
F
---
T
L
C
W
L
--------
P
F
F
I
V
N
I
V
H
V
I
-----
Q
D
N
L
-----------
I
R
--------------------------
K
E
V
Y
I
L
L
N
--------
W
I
G
------
Y
V
N
S
G
F
N
P
L
I
Y
-------
C
-
R
S
P
D
F
-
R
I
A
------
F
Q
E
L
L
---
C
L
-----------------------------------------------------------------------------------------------------
27
HHSearch
83.69
18%
-119
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[41-497]
----------------------------------------------------------
E
E
N
A
N
----------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
---
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
-----
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
------
V
D
A
V
--
A
N
W
Y
F
G
N
---
F
L
C
K
A
V
H
V
I
Y
T
V
-
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
-
P
D
F
I
F
-
A
N
V
S
E
-
A
--
D
D
R
Y
I
C
---
D
R
F
Y
P
N
D
---------
L
W
V
V
V
F
Q
----
F
Q
H
I
M
-----
V
G
----
L
I
--
L
P
G
I
V
I
L
S
C
Y
-------
C
I
I
I
S
K
L
S
H
S
G
S
N
---------------
I
F
E
M
--------
L
------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
Y
G
S
K
------
G
-
H
Q
K
R
K
A
L
K
T
T
V
I
-
L
I
L
A
--
F
---
F
A
C
W
L
--------
P
Y
Y
I
G
I
S
I
D
S
F
-----
I
L
L
E
I
I
K
-
Q
G
C
E
F
E
N
T
V
--------------------------
H
K
W
I
S
I
T
E
--------
A
L
A
------
F
F
H
C
C
L
N
P
I
L
Y
-------
A
F
L
G
A
K
F
-
K
T
S
------
A
Q
H
A
L
---
T
S
G
R
P
L
E
V
L
F
Q
--------------------------------------------------------------------------------------------
49
Fugue
83.43
18%
-81
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----
M
N
G
T
E
G
P
N
F
----
Y
V
P
----
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
----------------
A
E
P
----------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
---
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
---
P
L
N
Y
I
L
----
L
N
L
A
V
A
D
L
F
M
V
F
-
G
G
F
T
T
------
T
L
Y
T
S
L
H
G
Y
--
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
-
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
S
R
Y
I
P
E
--
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
---------
N
E
S
F
V
----
I
Y
M
F
V
-----
V
H
----
F
I
--
I
P
L
I
V
I
F
F
C
Y
-----------
G
Q
L
V
F
T
V
K
E
---------------
A
A
A
Q
--------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
------
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
-
M
V
I
A
--
F
---
L
I
C
W
L
--------
P
Y
A
G
V
A
F
Y
I
F
T
---------------
H
Q
G
S
D
F
G
--------------------------
P
I
F
M
T
I
P
A
--------
F
F
A
------
K
T
S
A
V
Y
N
P
V
I
Y
-------
I
M
M
N
K
Q
F
-
R
N
C
------
M
V
T
T
L
---
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
--
V
S
----
K
T
E
T
--
S
Q
V
A
P
A
--------------------------------------------------------------------
48
Fugue
80.59
16%
-99
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----
M
N
G
T
E
G
--------
P
N
----
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
------------
E
P
----------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
---
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
---------
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
G
F
------
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
-
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
S
R
Y
I
P
E
--
G
M
Q
C
S
C
---
G
I
------
D
Y
Y
T
P
-
H
E
E
T
N
N
E
S
F
----
V
I
Y
M
F
-----
V
V
-------------
H
F
I
I
P
-------
L
I
V
I
F
F
C
Y
G
Q
L
V
F
---------------
T
V
K
E
--------
A
------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
A
T
T
------
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
-
M
V
I
A
--
F
---
L
I
C
W
L
--------
P
Y
A
G
V
A
F
Y
I
F
T
-----
H
Q
----------
G
S
D
F
G
--------------------------
P
I
F
M
T
I
P
A
--------
F
F
A
------
K
T
S
A
V
Y
N
P
V
I
Y
-------
I
M
M
N
K
Q
F
-
R
N
C
------
M
V
T
T
L
---
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
----
P
A
------------------------------------------------------------------------------
50
Fugue
79.75
17%
-124
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------
S
F
----
K
C
A
------------------------
L
-----
T
K
T
G
F
----------
Q
F
Y
Y
L
P
A
V
Y
-
I
L
V
F
I
I
---
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
-----
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
L
T
-
L
P
A
L
I
------
F
Y
Y
F
N
K
T
D
W
I
F
---
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
-
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
-
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
-
P
I
L
F
Y
-
S
G
T
G
V
R
K
--
N
K
T
I
T
C
---
Y
--------
D
T
T
S
-
D
E
Y
L
R
S
Y
F
I
----
Y
S
M
C
T
-----
T
V
----
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
-------
G
L
I
V
R
A
L
I
Y
K
M
K
----------------
K
Y
T
C
--------
T
------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
C
G
Y
I
Y
N
PEDGD
P
-
D
N
G
V
N
P
G
T
D
F
K
D
-
I
V
C
P
--
L
---
C
-----------------------------
G
V
G
K
D
Q
F
E
E
V
E
E
P
L
R
R
--------------------------
K
S
I
Y
L
V
I
I
--------
V
L
T
------
V
F
A
V
S
Y
I
P
F
H
V
-------
M
K
T
M
N
L
R
-
A
R
L
DFQTPA
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
----
I
L
Y
F
LA
G
D
T
F
R
R
R-------------------------------------------------------------------
29
HHSearch
79.48
16%
-131
* C3 *
2Z73
5
OPSD_TODPA
A:
[27-333]
----------------------------------------------------------
D
Q
V
P
D
----------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
---
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
-----
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
------
I
S
C
F
-
L
K
K
W
I
F
G
F
---
A
A
C
K
V
Y
G
F
I
G
G
I
-
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
-
G
P
I
F
G
-
W
G
A
Y
T
L
E
--
G
V
L
C
N
C
---
S
F
D
Y
I
S
R
--------
D
S
T
T
R
S
N
I
----
L
C
M
F
I
-----
L
G
----
F
F
--
G
P
I
L
I
I
F
F
C
Y
-------
F
N
I
V
M
S
V
S
N
H
E
K
E
---------------
M
A
A
M
A
K
RLNAKE
L
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
Q
A
G
------
A
-
N
A
E
M
R
L
A
K
I
S
I
V
-
I
V
S
Q
--
F
---
L
L
S
W
S
--------
P
Y
A
V
V
A
L
L
A
Q
F
-----
G
P
L
E
W
----------
V
T
--------------------------
P
Y
A
A
Q
L
P
V
--------
M
F
A
------
K
A
S
A
I
H
N
P
M
I
Y
-------
S
V
S
H
P
K
F
-
R
E
A
------
I
S
Q
T
F
---
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
----
A
E
T
E
--
I
P
A
G
E
---------------------------------------------------------------------
38
HHSearch
79.13
17%
-133
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-326]
----------------------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
---
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
-----
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
------
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
---
F
Y
C
K
F
H
N
F
F
P
I
A
-
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
-
P
Q
G
Y
Y
-
S
-
T
T
E
T
M
--
P
S
R
V
V
C
---
M
I
E
W
P
E
H
P
N
------
K
I
Y
E
K
V
Y
H
----
I
C
V
T
V
-----
L
I
----
Y
F
--
L
P
L
L
V
I
G
Y
A
Y
-------
T
V
V
G
I
T
L
W
A
S
E
I
P
---------------
G
D
S
S
--------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
H
E
Q
------
V
-
S
A
K
R
K
V
V
K
M
M
I
V
-
V
V
C
T
--
F
---
A
I
C
W
L
--------
P
F
H
I
F
F
L
L
P
Y
I
-----
N
P
D
L
Y
L
-------
K
K
F
I
--------------------------
Q
Q
V
Y
L
A
I
M
--------
W
L
A
------
M
S
S
T
M
Y
N
P
I
I
Y
-------
C
C
L
N
D
R
F
-
R
L
G
------
F
K
H
A
F
---
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
----
R
Y
L
Q
--
T
Q
G
S
V
Y
--------------------------------------------------------------------
56
Fugue
77.19
17%
-101
* C1 *
2OCC
-
COX1_BOVIN
A:
[1-514]
-----
M
F
I
N
R
W
L
F
S
TN
H
K
D
I
G
----
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
I
R
A
E
L
G
Q
P
GTLLG-----D
D
Q
I
Y
N
V
V
V
T
A
H
A
F
V
M
I
F
F
M
V
M
P
I
M
I
---
G
G
F
G
N
W
L
V
P
L
M
I
G
A
P
D
M
A
F
P
R
M
N
N
M
S
F
W
L
L
P
P
S
F
L
L
L
L
A
S
S
M
V
E
------
A
GAGTGW
T
V
Y
P
P
L
--
A
G
N
L
A
H
A
G
A
S
V
D
L
T
I
F
S
L
H
L
-
A
G
V
S
S
--
I
L
G
A
I
N
F
I
T
T
I
I
N
M
K
P
P
A
M
S
Q
Y
---
Q
T
P
L
F
V
W
S
V
M
I
T
A
V
L
L
L
L
S
L
P
V
-
L
A
A
G
I
-
T
M
L
L
T
D
R
--
N
L
N
T
-
T
---
F
F
D
P
A
G
G
G
D
P
I
L
Y
-
Q
H
L
F
W
F
F
G
H
----
P
E
V
Y
I
-----
L
I
L
P
G
F
G
M
--
I
S
H
I
V
T
Y
Y
S
G
KKEPFG
Y
M
G
M
V
W
A
M
M
S
I
G
F
L
G
F
I
V
WAHHMFTVGMD
V
D
T
R
--------
A
------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
S
A
T
------
M
-
I
I
A
I
P
T
G
V
K
V
F
S
-
W
L
A
T
--
L
HGG
N
I
K
W
S
--------
P
A
M
M
W
A
L
G
F
I
F
L
F
T
V
G
G
L
T
G
I
V
L
A
N
S
S
L
D
I
V
L
H
--------------------------
D
T
Y
Y
V
V
A
H
F
H
Y
V
L
S
MG
A
V
F
------
A
I
M
G
G
F
V
H
W
F
P
-------
L
F
S
G
Y
T
L
-
N
D
T
------
W
A
K
I
H
---
F
A
I
M
F
V
G
V
N
M
T
F
F
P
Q
H
F
L
G
L
S
G
M
P
R
R
Y
--
S
D
Y
P
D
A
Y
T
M
W
N
T
I
S
S
M
G
S
F
I
S
L
T
A
V
M
L
M
V
F
I
I
W
E
A
F
A
S
KREVLTVDLTTTNLEWLNGCPPPYHTFE
E
P
T
Y
V
N
LK
28
HHSearch
76.52
14%
-140
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
---
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
-----
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
------
L
Y
T
V
-
I
G
Y
W
P
L
G
P
---
V
V
C
D
L
W
L
A
L
D
Y
V
-
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
-
P
A
I
L
F
-
W
Q
F
I
V
G
V
RT
V
E
D
G
E
C
---
Y
I
Q
F
F
S
------------
N
A
A
V
T
----
F
G
T
A
I
-----
A
A
----
F
Y
--
L
P
V
I
I
M
T
V
L
Y
-------
W
H
I
S
R
A
S
K
S
R
I
N
I
---------------
F
E
M
L
--------
R
------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
A
Y
P
P
------
P
-
S
R
E
K
K
V
T
R
T
I
L
A
-
I
L
L
A
--
F
---
I
I
T
W
A
--------
P
Y
N
V
M
V
L
I
N
T
F
-----
C
A
P
C
I
-----------
P
--------------------------
N
T
V
W
T
I
G
Y
--------
W
L
C
------
Y
I
N
S
T
I
N
P
A
C
Y
-------
A
L
C
N
A
T
F
-
K
K
T
------
F
K
H
L
L
---
M
------------------------------------------------------------------------------------------------------
33
HHSearch
76.19
16%
-131
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[59-495]
-------------------------------------------------------------
K
E
----------
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
---
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
-----
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
------
L
S
G
A
--
T
T
Y
K
L
T
---
P
A
Q
W
F
L
R
E
G
S
M
F
V
-
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
-
L
P
I
M
G
-
W
N
C
I
S
-----
A
L
S
S
C
---
S
T
V
L
P
L
Y
------------
H
K
H
Y
----
I
L
F
C
T
-----
T
V
----
F
T
--
L
L
L
L
S
I
V
I
L
Y
-------
C
R
I
Y
S
L
V
R
T
R
N
I
F
---------------
E
M
L
R
--------
I
DEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
A
S
R
------
S
-
S
E
N
V
A
L
L
K
T
V
I
I
-
V
L
S
V
--
F
---
I
A
C
W
A
--------
P
L
F
I
L
L
L
L
D
V
G
-----
C
K
V
K
T
C
---------
D
I
--------------------------
L
F
R
A
E
Y
F
L
--------
V
L
A
------
V
L
N
S
G
T
N
P
I
I
Y
-------
T
L
T
N
K
E
M
-
R
R
A
------
F
I
R
I
M
---
G
R
P
L
---------------------------------------------------------------------------------------------------
53
Fugue
75.72
18%
-86
- C2 -
4LZ6
-
?
A:
[1-446]
-----
Q
K
Q
Q
S
E
R
L
G
----
T
E
A
IPKL
L
R
S
L
S
I
P
A
M
I
G
M
F
V
M
A
L
Y
N
V
V
D
T
I
F
I
S
Y
-----
A
V
G
I
E
----------
G
V
A
G
V
T
I
A
F
P
I
M
M
I
M
M
S
M
A
G
A
L
G
I
G
G
A
S
V
I
S
R
R
L
G
E
R
R
G
E
E
A
N
Q
V
F
G
N
I
L
T
V
I
L
V
L
S
V
I
G
F
I
S
A
-
F
T
------------
L
L
G
P
A
L
Q
L
F
G
A
T
S
V
T
Q
G
Y
A
T
D
Y
L
F
P
-
I
L
L
G
S
I
F
F
F
F
A
F
A
A
N
N
I
I
R
S
E
G
N
A
T
F
A
-----
M
V
T
M
I
V
P
A
V
L
N
I
L
L
D
V
L
F
I
F
G
L
N
M
G
V
L
G
-
A
S
I
A
T
V
I
--
A
Q
A
S
V
T
---
G
L
V
L
R
Y
F
L
T
G
K
S
T
L
S
L
H
W
S
D
L
R
M
KGSV
I
K
E
V
C
-----
L
V
----
G
L
--
P
A
F
V
Q
Q
S
S
A
S
-------
L
M
M
I
A
I
N
S
M
L
L
R
F
---------------
G
S
D
F
--------
Y
------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
F
G
L
------
V
Q
R
I
M
M
F
V
M
M
P
M
M
G
-
I
M
Q
A
--
M
---
Q
P
I
V
G
YNYGAKQ
Y
S
R
L
R
E
T
V
M
L
G
F
-----
K
V
A
T
I
F
S
I
G
I
F
A
L
L
M
L
F
P
E
A
L
L
R
V
F
TAD
R
E
V
I
Q
A
GVSAMHILF
C
V
T
F
L
I
G
A
--------
Q
I
V
A
G
G
L
Y
Q
S
L
G
K
P
K
Q
A
L
I
L
-------
S
L
S
R
Q
I
I
F
L
I
P
------
L
V
L
I
L
---
P
H
I
F
G
L
S
G
V
W
W
A
F
P
I
A
D
V
L
----
S
F
I
L
--
T
V
V
L
L
Y
R
D
RNVFFLK-----------------------------------------------------------
37
HHSearch
74.13
17%
-120
- C3 -
1U19
14
OPSD_BOVIN
A:
[40-328]
---------------------------------------------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
---
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-----
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
------
Y
T
S
L
-
H
G
Y
F
V
F
G
P
---
T
G
C
N
L
E
G
F
F
A
T
L
-
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
-
W
S
R
Y
I
P
E
--
G
M
Q
C
S
C
---
G
I
D
Y
Y
T
P
H
E
------
E
T
N
N
E
S
F
V
----
I
Y
M
F
V
-----
V
H
----
F
I
--
I
P
L
I
V
I
F
F
C
Y
-------
G
Q
L
V
F
T
V
K
E
A
A
A
Q
---------------
Q
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
------
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
-
M
V
I
A
--
F
---
L
I
C
W
L
--------
P
Y
A
G
V
A
F
Y
I
F
T
-----
H
Q
G
S
D
----------
F
G
--------------------------
P
I
F
M
T
I
P
A
--------
F
F
A
------
K
T
S
A
V
Y
N
P
V
I
Y
-------
I
M
M
N
K
Q
F
-
R
N
C
------
M
V
T
T
L
---
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
----
E
T
S
Q
--
V
A
P
A
----------------------------------------------------------------------
39
HHSearch
74.05
20%
-127
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
--------------------------------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
---
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
-----
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
------
A
S
K
--
V
N
G
W
I
F
G
T
---
F
L
C
K
V
V
S
L
L
K
E
V
-
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
-
P
F
F
L
F
-
R
Q
A
Y
H
P
N
--
N
S
S
P
V
C
---
Y
E
V
L
G
N
D
T
-------
A
K
W
R
M
V
L
R
----
I
L
P
H
T
-----
F
G
----
F
I
--
V
P
L
F
V
M
L
F
C
Y
-------
G
F
T
L
R
T
L
F
K
A
H
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
-
V
V
L
I
--
F
---
L
L
C
W
L
--------
P
Y
N
L
V
L
L
A
D
T
L
-----
M
R
T
Q
V
I
Q
E
-
S
C
E
R
R
N
N
I
--------------------------
G
R
A
L
D
A
T
E
--------
I
L
G
------
F
L
H
S
C
L
N
P
I
I
Y
-------
A
F
I
G
Q
N
F
-
R
H
G
------
F
L
K
I
L
---
A
M
H
G
---------------------------------------------------------------------------------------------------
54
Fugue
61.75
12%
-96
* C2 *
2NSY
8
NADE_BACSU
A:
[1-271]
S
M
Q
E
K
I
M
R
E
L
H
V
K
P
----
S
I
D
----
P
K
Q
E
I
E
D
R
V
N
F
L
K
Q
Y
V
K
K
T
G
A
K
G
-----------------------------------
F
V
L
G
I
S
---
G
G
Q
D
S
T
L
A
G
R
L
A
Q
L
A
V
E
S
I
R
E
E
G
G
D
A
----------------------
Q
F
I
------
A
V
R
L
P
H
G
T
Q
Q
D
E
D
D
A
Q
L
A
L
K
F
I
K
P
D
K
S
W
K
F
D
I
K
S
T
V
S
A
F
S
D
Q
Y
Q
Q
E
T
G
D
Q
L
T
D
F
N
K
G
N
---
V
K
A
R
T
R
M
I
A
Q
Y
A
I
G
G
Q
E
G
L
-----
L
V
L
G
-
T
D
H
A
A
E
A
--
V
T
G
F
F
T
--------
K
Y
G
D
G
G
A
D
-
L
L
P
L
T
G
L
T
K
----
R
Q
G
R
T
-----
L
L
----
K
E
--
L
G
A
P
-----------------
E
R
L
Y
L
K
------------------------------
E
------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
L
------
D
-
E
K
P
Q
Q
S
D
E
T
E
L
G
-
I
-------------------------------------------------------------------------------------------------
S
Y
D
------
E
I
D
D
Y
L
E
G
K
E
V
-------
S
A
K
V
S
E
A
-
L
E
K
------
R
Y
S
M
T
---
E
H
K
R
Q
V
P
A
S
M
-------------------
F
D
D
W
W
K
--------------------------------------------------------------------
15
PsiBlast_PDB
60.48
18%
-125
- C3 -
4GBR
1
ADRB2_HUMAN
A:
[98-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-
L
P
I
-------
Q
M
H
--
W
--------
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
-
E
E
T
C
C
D
F
F
T
----
N
Q
A
Y
A
------------
I
--
A
S
S
I
V
S
F
Y
V
P
-------
L
V
I
M
V
F
V
Y
S
R
V
F
Q
---------------
E
A
K
R
--------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
I
D
K
------
F
-
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
--
F
---
T
L
C
W
L
--------
P
F
F
I
V
--------------
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
--------------------------
V
--
Y
I
L
L
N
--------
W
I
G
------
Y
V
N
S
G
F
N
P
L
I
Y
CRS
P
D
F
R
I
A
F
Q
E
L
L
-
C
L
----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
59.94
22%
-100
- C3 -
2Z73
2
OPSD_TODPA
A:
[108-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
K
V
Y
G
F
I
G
G
I
-
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
-
G
P
I
F
G
-
W
G
A
Y
T
L
E
----
G
V
L
C
---
N
C
S
F
D
Y
I
S
R
D
S
T
T
-
R
S
N
I
L
C
M
F
I
----
L
G
F
F
G
P
I
L
I
I
F
F
----
C
Y
--
F
N
I
V
M
S
V
S
N
H
-------
E
K
E
M
A
A
M
A
K
R
L
N
A
---------------
K
-----------
E
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
A
Q
A
------
G
-
A
-
N
A
E
M
R
L
A
K
I
S
-
I
V
I
V
S
Q
F
---
L
L
S
W
S
--------
P
Y
A
V
V
A
L
L
A
Q
F
-----
G
P
L
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
--------------------------
A
K
A
S
A
I
H
N
--------
P
M
I
------
Y
S
V
S
H
P
K
F
R
E
A
-------
I
S
Q
T
F
P
W
-
V
L
T
------
C
C
Q
F
D
---
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-------------------------------------------------------------------------------------
1
PsiBlast_PDB
59.13
22%
-112
- C3 -
2ZIY
1
OPSD_TODPA
A:
[107-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
K
V
Y
G
F
I
G
G
I
-
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
-
G
P
I
F
G
-
W
G
A
Y
T
L
E
----
G
V
L
C
---
N
C
S
F
D
Y
I
S
R
D
S
T
T
-
R
S
N
I
L
C
M
F
I
----
L
G
F
F
G
P
I
L
I
I
F
F
----
C
Y
--
F
N
I
V
M
S
V
S
N
H
-------
E
K
E
M
A
A
M
A
K
R
L
N
A
---------------
K
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
A
Q
A
------
G
-
A
-
N
A
E
M
R
L
A
K
I
S
-
I
V
I
V
S
Q
F
---
L
L
S
W
S
--------
P
Y
A
V
V
A
L
L
A
Q
F
-----
G
P
L
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
--------------------------
A
K
A
S
A
I
H
N
--------
P
M
I
------
Y
S
V
S
H
P
K
F
R
E
A
-------
I
S
Q
T
F
P
W
-
V
L
T
------
C
C
Q
F
D
---
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
S
----
S
D
A
A
--
P
S
A
D
A
A
--------------------------------------------------------------------