@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RL3R1_HUMAN: (2016-01-14 )
MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGAPPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTATTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.....-..110.......120.......130...-....140..-.....150.......160.......170.......180.......190..---.....200.......210.......220.......230...-.-...240---.....-...250.......260.......270...-....280.....-..290......------.---------300----------..-----------------...------------.----------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------310-----------------------------------------------------------------------------.-------------.---------------.---------------.....--.320--------.....---------..---330.......340..-.....350.......360..----------.....370........380.--......390.......400.---......410.......420--------.......430.......440.......450.......460.......----------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQMAD
A
A
T
I
A
T
M
NKAAG
G
D
K
L
A
E
L
F
S
L
V
P
D
L
L
E
A
ANTSGN
A
S
LQL
P
D
L
W
W
E
LGLELPDGAPPGHPPGSGGAESA
D
T
E
A
R
V
R
I
L
I
S
V
V
Y
W
V
V
C
A
L
G
L
A
G
N
L
L
V
L
Y
L
M
K
-
S
M
Q
G
W
R
KSS
I
N
L
F
V
T
NLAL
T
D
F
Q
F
V
L
T
L-
P
F
W
A
VENAL-DFKW
P
F
G
K
A
M
C
K
I
V
S
M
V
T
S
M
N
M
Y
A
S
V
F
F
L
T
A
M
S
V
T
R
Y
H
S
V
A
S
A
L
K
S
H
RTR---GHGRGDCCGRSL
G
D
S
C
C
F
S
A
K
A
L
C
V
W
I
W
A
L
A
A
L
A
S
L
P
S
A
I
F
-
S
-
T
T
V
K
-
V
---
M
G
EE
L
-
C
L
V
RF
P
D
K
L
LGRD
R
Q
F
W
L
G
L
YHS
Q
K
V
L
L
G
-
F
V
L
P
L
G
I
I
I
L
C
Y
-
L
L
L
V
R
F
I
A
DRR------A---------AGT----------KG-----------------GAA------------V----------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------G-------------------------------------------------------------------------------G-------------R---------------P---------------TG
A
S
A
--
R
R
L
S
--------
K
V
T
K
S
---------
V
T
---
I
V
V
L
S
F
F
L
C
WLPNQA-
L
T
T
W
S
I
L
I
K
F
NAVPFSQ
E
Y
F
----------
L
C
Q
V
Y
A
-
F
P
V
S
V
C
L
AHSNS
C
--
L
N
P
V
L
Y
C
L
V
R
R
E
F
R
K
A
L
K
S
L
---
L
W
R
IASPSITSMRPFTATT--------KPEHEDQGLQAPAPPHAAAEP
D
L
L
YYPP
G
V
V
V
YSGGRYDLLPSSSAY----------------------------------------------------
24
HHSearch
84.50
23%
-127
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[41-498]
-------------------------------------------------------------------------
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
-
Y
Q
K
K
-
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
---
K
L
---------------
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
-
N
V
S
E
-
A
---
D
D
R
Y
I
-
C
D
R
F
Y
P
N
D
L
W
-------
V
V
V
F
Q
F
Q
H
I
M
V
G
-
L
I
L
P
G
I
V
I
L
S
C
Y
-
C
I
I
I
S
K
L
S
H
S
G
------
S
---------
N
I
F
----------
E
M
-----------------
L
R
I
------------
D
----------------------------------------------------------------------------------------------------------------------------------
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TG
T
-------------------------------------------------------------------------------
W
-------------
D
---------------
A
---------------
Y
G
S
K
G
--
H
Q
K
R
--------
K
A
L
K
T
---------
T
V
---
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
-
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
----------
N
T
V
H
K
W
-
I
S
I
T
E
A
L
A
F
F
H
C
C
--
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
---
L
T
S
G
R
P
L
E
V
L
F
Q
------------------------------------------------------------------------------------------------------------------
47
Fugue
84.16
29%
-148
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------------------------
S
F
K
C
A
L
T
K
T
G
F
-------------------------------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
--
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-------------------
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
V
R
-
K
---
N
K
T
I
T
-
C
Y
D
T
T
S
D
E
Y
------
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
-
G
L
I
V
R
A
L
I
Y
K
M
------
K
---------
K
Y
T
C
TVCG
Y
I
Y
N
P
E
D
-----------------
G
D
P
------------
D
----------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------
V
-------------
N
---------------
P
GTDFKDIVCPL----
C
G
V
G
K
--
D
Q
F
E
E
V
EE
P
L
R
R
K
S
I
Y
L
---------
V
I
---
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
-
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
----------
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
--
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
-------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
83.08
22%
-104
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------------------------------------------------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
-
Y
Q
K
K
-
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
L
-
P
F
W
A
V
D
A
V
A
---
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
---
K
L
L
A
E
---------------
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
-
N
V
S
E
-
A
---
D
D
R
Y
I
-
C
D
R
F
Y
P
N
-------
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
-
L
I
L
P
G
I
V
I
L
S
C
Y
-
C
I
I
I
S
K
L
S
H
S
G
SN
I
F
E
M
L
---------
R
I
D
----------
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GI
G
H
L
------------
L
----------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------
S
-------------
P
---------------
S
---------------
L
N
A
A
K
--
S
E
L
D
--------
K
A
I
G
R
---------
N
T
NGV
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
-
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
----------
A
V
R
R
A
A
-
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGS
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
21
PsiBlast_CBE
81.09
31%
-141
- C4 -
4EA3
3
C562_ECOLX (first)
B:
[124-407]
-------------------------------------------------------------------------------
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
-
R
H
T
K
M
-
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
L
-
P
F
Q
G
T
D
I
L
L
-
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
I
R
A
L
D
V
R
---
T
S
S
K
---------------
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
-
G
-
S
A
----------
E
I
E
C
L
V
E
I
P
T
P
-----
Q
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
-
F
I
V
P
V
L
V
I
S
V
C
Y
-
S
L
M
I
R
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
K
D
-----
R
N
L
R
--------
R
I
T
R
L
---------
V
L
---
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
-
F
----
V
L
A
Q
G
L
G
V
Q
P
S
S
E
-------------
T
A
V
A
I
-
L
R
F
C
T
A
L
G
Y
V
N
S
C
--
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
K
F
---------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
80.61
26%
-146
- C4 -
4XNV
15
P2RY1_HUMAN
A:
[56-382]
--------------------------------------------------------------------------------------
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
--
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
------------------
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
V
R
-
K
---
N
K
T
I
T
-
C
Y
D
T
T
S
D
E
Y
L
---
R
S
Y
F
--
I
Y
S
M
C
T
T
V
A
M
-
F
C
V
P
L
V
L
I
L
G
C
Y
-
G
L
I
V
R
A
L
I
Y
K
M
------
K
---------
K
Y
T
C
TVCG
Y
I
Y
N
P
E
D
-----------------
G
D
P
------------
D
----------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------
V
-------------
N
---------------
P
GTDFKDIVCPL----
C
G
V
G
K
--
D
Q
F
E
--------
E
V
E
E
P
L
R
R
K
S
I
Y
L
-
V
I
---
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
-
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
----------
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
--
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
----------
R
---------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.88
31%
-142
- C4 -
4EA3
3
C562_ECOLX (first)
A:
[124-405]
-------------------------------------------------------------------------------
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
-
R
H
T
K
M
-
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
L
-
P
F
Q
G
T
D
I
L
L
-
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
---------------
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
-
G
-
S
A
-
Q
-
V
---
E
D
E
E
I
E
C
L
V
E
I
P
T
P
-----
Q
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
-
F
I
V
P
V
L
V
I
S
V
C
Y
-
S
L
M
I
R
R
L
---------------------------------
R
G
-----------------
V
R
L
------------
L
----------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------
S
-------------
R
---------------
E
---------------
K
D
-----
R
N
L
R
--------
R
I
T
R
L
---------
V
L
---
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
-
F
----
V
L
A
Q
G
L
G
V
Q
P
S
S
E
-------------
T
A
V
A
I
-
L
R
F
C
T
A
L
G
Y
V
N
S
C
--
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.13
28%
-127
- C4 -
4RWA
2
C562_ECOLX (first)
A:
[112-405]
---------------------------------------------------------------------
G
A
R
S
A
S
S
L
A
-
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
-
R
Y
T
K
M
-
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
Q
S
A
K
Y
L
M
-
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
---
T
P
A
K
---------------
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
-
V
T
R
P
-
R
---
D
G
A
V
V
-
C
M
L
Q
F
P
S
P
-----
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
-----------------------------
G
L
----------
M
L
-----------------
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
E
K
D
R
S
L
R
--------
R
I
T
R
M
---------
V
L
---
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
-----------------
V
A
A
-
L
H
L
C
I
A
L
G
Y
A
N
S
S
--
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
---
C
-----------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.55
29%
-119
- C4 -
4N6H
23
C562_ECOLX (first)
A:
[112-408]
------------------------------------------------------------------
G
S
P
G
A
R
S
A
S
S
L
A
-
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
-
R
Y
T
K
M
-
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
Q
S
A
K
Y
L
M
-
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
---
T
P
A
K
---------------
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
-
V
T
R
P
-
R
---
D
G
A
V
V
-
C
M
L
Q
F
P
S
P
-----
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
-----------------------------
G
L
----------
M
L
-----------------
L
R
L
------------
R
----------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------
R
-------------
L
---------------
L
---------------
S
G
S
K
E
K
D
R
S
L
R
--------
R
I
T
R
M
---------
V
L
---
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
-----------------
V
A
A
-
L
H
L
C
I
A
L
G
Y
A
N
S
S
--
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
---
C
R
K
P
C
G
------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.27
28%
-121
- C4 -
4RWD
7
C562_ECOLX (first)
A:
[112-405]
---------------------------------------------------------------------
G
A
R
S
A
S
S
L
A
-
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
-
R
Y
T
K
M
-
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
Q
S
A
K
Y
L
M
-
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
---
T
P
A
K
---------------
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
-
V
T
R
P
-
R
---
D
G
A
V
V
-
C
M
L
Q
F
P
S
P
-----
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
-----------------------------
G
L
----------
M
L
-----------------
L
R
L
------------
R
----------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------
R
-------------
L
---------------
L
---------------
S
G
S
K
E
K
D
R
S
L
R
--------
R
I
T
R
M
---------
V
L
---
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
-----------------
V
A
A
-
L
H
L
C
I
A
L
G
Y
A
N
S
S
--
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
---
C
-----------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.22
26%
-141
- C4 -
4XNW
2
RUBR_CLOPA
A:
[56-382]
--------------------------------------------------------------------------------------
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
--
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
------------------
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
G
V
R
-
K
---
N
K
T
I
T
-
C
Y
D
T
T
S
D
E
Y
L
---
R
S
Y
F
--
I
Y
S
M
C
T
T
V
A
M
-
F
C
V
P
L
V
L
I
L
G
C
Y
-
G
L
I
V
R
A
L
I
Y
K
M
------
K
---------
K
Y
T
C
TVCG
Y
I
Y
N
P
E
D
-----------------
G
D
P
------------
D
----------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------
V
-------------
N
---------------
P
GTDFKDIPDDWVCPL
C
G
V
G
K
--
D
Q
F
E
--------
E
V
E
E
P
L
R
R
K
S
I
Y
L
-
V
I
---
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
-
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
----------
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
--
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
----------
R
---------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
76.67
24%
-142
- C4 -
4MBS
8
CCR5_HUMAN (first)
A:
[34-361]
----------------------------------------------------------------------------------
L
L
P
P
L
Y
S
L
V
F
I
F
G
F
V
G
N
M
L
V
I
L
I
L
I
-
N
Y
K
R
L
-
K
S
M
T
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
T
V
-
P
F
W
A
H
Y
A
A
A
---
Q
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
R
---
T
V
T
F
G
---------------
V
V
T
S
V
I
T
W
V
V
A
V
F
A
S
L
P
N
I
I
F
-
T
-
R
S
Q
K
-
E
---
G
L
H
Y
T
-
C
S
S
H
F
P
----
Y
S
Q
Y
Q
F
W
K
N
F
Q
T
L
K
I
V
I
L
G
-
L
V
L
P
L
L
V
M
V
I
C
Y
-
S
G
I
L
K
T
L
L
R
M
K
------
K
Y
T
C
TVCG
Y
I
Y
N
P
----------
E
D
-----------------
G
D
P
------------
D
----------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------
V
-------------
N
---------------
P
GTDFKDIPDDWVCPL
C
G
V
G
K
--
D
Q
F
E
--------
E
V
E
E
E
K
K
R
H
R
D
V
R
L
I
F
---
T
I
M
I
V
Y
F
L
F
W
A
P
-------
Y
N
I
V
L
L
L
N
T
F
---
Q
E
F
F
GLNN
C
S
S
S
N
R
L
D
Q
--
A
-
M
Q
V
T
E
T
L
G
M
T
H
C
C
--
I
N
P
I
I
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
---
F
Q
----------------------------------------------------------------------------------------------------------------------------
29
HHSearch
75.65
22%
-125
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
-
S
E
R
K
-
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
---
T
K
---------------
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-
N
-
H
--------
R
R
E
D
K
-
C
E
T
D
F
Y
D
V
T
----------
W
F
K
V
M
T
A
I
I
N
-
F
Y
L
P
T
L
L
M
L
W
F
Y
-
A
K
I
Y
K
A
V
R
Q
H
C
------
N
---------
I
F
E
----------
M
L
-----------------
R
I
D
------------
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
------------------------------------------------------------------------------------------------------
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
---------------------------------------------
Q
-------------------------------------------------------------------------------
T
-------------
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
---------------
A
Y
L
H
M
--
N
R
E
R
--------
K
A
A
K
Q
---------
L
G
---
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
-
F
F
M
V
I
A
F
C
K
N
C
-
C
N
-------------------
E
H
L
-
H
M
F
T
I
W
L
G
Y
I
N
S
T
--
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
---
L
H
I
---------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.64
30%
-136
- C4 -
5C1M
7
?
A:
[18-296]
---------------------------------------------------------------------------------
I
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
-
R
Y
T
K
-
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
-
P
F
Q
S
V
-
N
Y
L
-
M
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
---
T
P
R
---------------
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
M
-
A
-
T
T
K
Y
-
R
---
Q
G
S
I
D
-
C
T
L
T
F
-----
S
H
P
T
W
Y
W
E
N
L
L
K
I
C
V
F
I
F
A
-
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
K
S
V
R
M
------
L
---------
S
G
S
----------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
--
R
N
L
R
--------
R
I
T
R
M
---------
V
L
---
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
-
Y
V
I
I
K
A
L
I
T
I
P
E
T
T
F
-----------------
Q
T
V
S
-
W
H
F
C
I
A
L
G
Y
T
N
S
C
--
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
74.99
20%
-116
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
-
K
F
E
R
-
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
---
T
K
---------------
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-
Y
R
A
T
-
H
---
Q
E
A
I
N
-
C
Y
A
E
E
T
C
C
D
F
-----
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
------
N
---------
I
F
E
----------
M
L
-----------------
R
I
D
------------
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------
T
-------------
W
---------------
D
---------------
A
Y
K
F
C
--
L
K
E
H
--------
K
A
L
K
T
---------
L
G
---
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
-
V
N
I
V
H
V
I
Q
D
N
L
-
I
R
-------------------
K
E
V
-
Y
I
L
L
N
W
I
G
Y
V
N
S
G
--
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
---
L
C
L
---------------------------------------------------------------------------------------------------------------------------
35
HHSearch
74.75
23%
-125
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
-
K
E
R
A
-
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
---------------
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
-
N
T
T
------
G
D
P
T
V
-
C
S
I
S
N
P
-------------
D
F
V
I
Y
S
S
V
V
S
-
F
Y
L
P
F
G
V
T
V
L
V
Y
-
A
R
I
Y
V
V
L
K
Q
R
R
------
R
---------
K
N
I
----------
F
E
-----------------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
T
EG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
----------
T
P
N
R
----------------------------------------------------------------------------------------------------------------------------------------------
A
K
R
V
I
T
T
F
R
T
G---------------------------------------------------------------------
T
-------------
W
---------------
D
---------------
A
Y
G
V
P
--
L
R
E
K
--------
K
A
T
Q
M
---------
V
A
---
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
-
T
H
V
L
N
T
H
C
Q
T
C
H
V
-------------------
S
P
E
L
-
Y
S
A
T
T
W
L
G
Y
V
N
S
A
--
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
---
L
S
C
---------------------------------------------------------------------------------------------------------------------------
25
HHSearch
71.10
21%
-108
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
---------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
-
V
N
R
H
-
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
---
T
T
---------------
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
-
Q
F
I
V
-
G
VRT
V
E
D
G
E
-
C
Y
I
Q
F
F
S
N
----------
A
A
V
T
F
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
L
Y
-
W
H
I
S
R
A
S
K
S
R
I
------
N
---------
I
F
E
----------
M
L
-----------------
R
I
D
------------
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
--------------------------------------------------------------------------------
E
A
------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
---------------
D
---------------
A
Y
P
P
P
--
S
R
E
K
--------
K
V
T
R
T
---------
I
L
---
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
-
M
V
L
I
N
T
F
C
A
P
C
-
I
P
-------------------
N
T
V
-
W
T
I
G
Y
W
L
C
Y
I
N
S
T
--
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
---
L
M
----------------------------------------------------------------------------------------------------------------------------
45
Fugue
70.37
18%
-106
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
---------
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
-
Q
H
K
K
L
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
-------------------
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
-
S
R
Y
I
-
P
---
E
G
--
M
-
Q
C
S
C
G
I
D
-
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
F
T
V
K
E
A
A
------
A
---------
S
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
--
K
A
E
K
--------
E
V
T
R
M
---------
V
I
---
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
-
V
A
F
Y
I
F
T
---------
H
Q
G
S
----------
D
F
G
P
I
F
-
M
T
I
P
A
F
F
A
K
T
S
A
V
--
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---
L
C
C
G
K
N
P
S
--------------------
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------------------------------------------------------------------------------
26
HHSearch
69.62
20%
-131
* C4 *
2Z73
5
OPSD_TODPA
A:
[29-335]
---------------------------------------------------------------------------
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
-
K
T
K
S
-
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
---
S
H
---------------
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
-
G
A
Y
T
L
E
---
G
V
L
C
N
-
C
S
F
D
Y
I
S
R
D
S
------
T
T
R
S
N
I
L
C
M
F
I
L
G
-
F
F
G
P
I
L
I
I
F
F
C
Y
-
F
N
I
V
M
S
V
S
N
H
E
------
K
---------
E
M
A
----------
A
M
-----------------
A
K
R
------------
L
----------------------------------------------------------------------------------------------------------------------------------
N
AK-----------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------
L
-------------
R
---------------
K
---------------
A
Q
A
G
A
--
N
A
E
M
--------
R
L
A
K
I
---------
S
I
---
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
-
V
A
L
L
A
Q
F
G
P
L
E
W
V
-------------------
T
P
Y
A
-
A
Q
L
P
V
M
F
A
K
A
S
A
I
--
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
---
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
--------
D
A
E
T
E
I
P
A
G
E
-----------------------------------------------------------------------------------------
30
HHSearch
68.85
22%
-126
- C4 -
2KS9
1
NK1R_HUMAN
A:
[32-326]
--------------------------------------------------------------------------------
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
-
A
H
K
R
-
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
S
A
--------------------
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
-
T
T
E
T
-
M
---
P
S
R
V
V
-
C
M
I
E
W
P
E
H
P
N
K
----
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
-
Y
F
L
P
L
L
V
I
G
Y
A
Y
-
T
V
V
G
I
T
L
W
A
S
E
------
I
---------
P
G
D
----------
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---------------
R
---------------
Y
H
E
Q
V
--
S
A
K
R
--------
K
V
V
K
M
---------
M
I
---
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
-
F
F
L
L
P
Y
I
N
P
D
L
Y
L
K
---
K
-------------
F
I
Q
Q
V
-
Y
L
A
I
M
W
L
A
M
S
S
T
M
--
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
---
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
--------
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-------------------------------------------------------------------------
33
HHSearch
68.07
18%
-107
- C4 -
3EML
13
ENLYS_BPT4
A:
[22-472]
---------------------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
---
T
G
---------------
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
-
N
N
C
G
-
Q
-----
S
Q
G
-
C
G
E
G
Q
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
-
L
R
I
F
L
A
A
R
R
Q
L
------
N
---------
I
F
E
----------
M
L
-----------------
R
I
D
------------
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
-------------------------------------------------------------------------------------------------------------------------------------------------
P
N
R
A
K
R
V
I
T
T
F
R
TGT-----------------------------------------------------------------
W
-------------
D
---------------
A
---------------
Y
R
S
T
L
--
Q
K
E
V
--------
H
A
A
K
S
---------
L
A
---
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
-
I
N
C
F
T
F
F
C
P
D
C
S
H
------------------
A
P
L
W
L
-
M
Y
L
A
I
V
L
S
H
T
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---
I
R
S
H
V
L
R
Q
----------------------------------------------------------------------------------------------------------------------