@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RXFP1_HUMAN: (2016-01-14 )
MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100....---..-----.--110.......120-.-.----.....-130-----------------------.........140.......150.......160......--.170.......180.---------------------.-.-....190.......200.......210.........220.......230.......240.......250.......260.......--.270----------------------.........280........290...---------------------------....300------------------------.......310......--.320.......330.......------340.......350--.......360.......370.......380..------.....390.......400.......410.......420.........430.......440.....----..450..----.....460......--.470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTSG
S
V
F
F
Y
I
L
I
F
G
K
Y
F
SHGGGQ
D
V
K
C
SLGYFPCG
N
I
T
K
C
L
P
Q
L
L
HCNGVDDCGNQADEDNCGDNNG
W
S
L
Q
F
D
K
Y
F
A
S
Y
Y
K
M
T
SQYPFEAETP
E
C
LVGSV
P
V
Q
C
L
C---QG-----L--ELDCDETNLRAVP-S-V----SSN
V
T
-
A
-------------------------
M
S
L
Q
W
N
L
I
RKL
P
P
D
C
F
K
N
Y
H
D
L
Q
K
L
Y
LQNNK
I
T
S
I
S
I
Y
--
A
FR
G
L
N
S
L
T
K
L
Y
LSH---------------------N-
R
-
I
T
F
LK
P
G
V
F
E
D
L
H
R
L
E
W
L
I
IEDNHL--SRISP
P
T
F
Y
G
L
N
S
L
I
L
L
V
L
M
N
N
V
L
TRLPD
K
P
L
C
Q
HMPR
L
H
W
L
DLEGNHIH-NLR
N
L
T
F
I
--SC------------------------S
N
L
T
V
L
V
M
RK-NKINHLNENT
F
A
P
L
Q
---------------------------
K
L
D
ELDL------------------------GSNKIENL
P
P
L
I
F
K
D
L
--
K
E
L
S
Q
LNLSYNP
I
Q
KIQANQ
F
------
D
Y
L
V
K
L
KSLSLEG--I
E
I
S
N
I
Q
Q
R
M
F
R
P
L
M
N
L
S
H
I
Y
F
K
K
F
Q
YCGYAP------HVRSCKPNTD
G
I
S
S
L
E
N
L
L
A
S
I
I
Q
R
V
F
V
W
V
V
S
A
V
T
C
--
F
G
N
I
F
V
I
C
M
R
P
Y
IRSENK
L
Y
A
M
S
I
I
S
L
----
C
C
A
D
C
L
M
----
G
I
Y
L
F
V
IGG
F
D
L
K
F
--RGEY
N
K
H
A
Q
L
W
M
EST
H
C
Q
L
V
G
S
L
A
I
L
S
T
E
V
S
V
L
L
L
T
F
L
T
L
E
K
Y
I
C
I
V
Y
P
F
RCVRPGK
C
R
T
I
T
V
L
I
L
I
W
I
T
G
F
I
V
A
F
I
PLS
N
K
E
F
F
K
N
YYGTN
G
V
C
FPLHSE
D
T
E
S
I
G
A
Q
I
Y
S
V
A
I
F
L
G
I
N
L
A
A
F
I
I
I
VFSY
G
S
M
F
Y
S
V
H
Q
S
A
I
T
A
T
E
I
R
N
Q
V
K
K
E
M
I
L
A
K
R
F
F
F
I
V
FTD
A
L
C
W
I
P
I
F
V
V
K
F
L
S
L
L
Q
VEIPGT
I
T
S
W
V
V
I
F
I
L
PINSAL
N
P
I
L
Y
TLTTR
P
F
K
E
M
I
H
R
F
W
Y
N
Y
R
Q
RKSMDSKGQKTYA
P
S
F
I
W
V
E
MW
P
L
QEM
P
P
E
LMKPD
L
F
TYPC
E
M
S
L
I
SQSTRLNSYS
58
Fugue
87.61
23%
-128
- C2 -
2ID5
7
LIGO1_HUMAN
A:
[1-477]
-------------------------------------------------------------------------------------------------
T
G
C
P
P
R
C
E
C
---
S
A
QD---
R
--
A
V
L
C
H
R
K
R
F
V
A
V
P
-
E
G
I
----
P
T
E
T
R
-
L
-------------------------
L
D
L
G
K
N
R
I
K
T
L
N
Q
D
E
F
A
S
F
P
H
L
E
E
L
E
L
N
E
N
I
V
S
A
V
E
P
G
--
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
---------------------
N
-
R
-
L
K
L
I
P
L
G
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
N
K
I
--
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
V
Y
I
S
H
R
A
F
-
S
G
L
N
S
L
E
Q
L
T
L
E
K
C
N
L
T
-
S
I
P
T
E
A
L
S
--
H
L
------------------------
H
G
L
I
V
L
R
L
R
H
-
L
N
I
N
A
I
R
D
Y
S
F
K
R
L
Y
---------------------------
R
L
K
V
L
E
I
S
HWPYLDTMTPNCLYGLNLT
S
L
S
I
T
H
C
N
L
T
A
V
P
Y
L
A
V
R
H
L
--
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
L
------
H
E
L
L
R
L
Q
E
I
Q
L
V
G
--
G
Q
L
A
V
V
E
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
------
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
--
C
D
C
R
L
L
W
V
F
R
R
R
W
R
LN
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
PNYF
T
C
R
R
A
R
I
RDRK
A
Q
Q
V
F
V
D
E
G
H
T
V
Q
F
V
C
R
A
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
L
T
V
F
-
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
----
A
G
G
N
D
S
M
P
A
H
L
H
V
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
HHSearch
76.86
27%
-117
- C2 -
2ID5
6
LIGO1_HUMAN
A:
[35-332]
--------------------------------------------------------------------------------------------------------------------
R
--
L
L
D
L
G
K
N
R
I
K
T
L
N
-
Q
-
D
EFAS
F
P
H
L
E
-
E
-------------------------
L
E
L
N
E
N
I
V
S
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
N
R
L
K
L
I
P
L
G
--
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
---------------------
N
-
K
-
I
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
--
V
Y
I
S
H
R
A
F
S
G
L
N
S
L
E
Q
L
T
L
E
K
C
N
L
T
S
I
P
T
E
A
L
S
-
H
L
H
G
L
I
V
L
R
L
R
H
L
N
I
N
-
A
I
R
D
Y
S
F
K
--
R
L
YRLK
V
L
E
I
S
HWPYLDTMTPNCLYG
L
N
L
T
S
L
S
I
T
H
-
C
N
L
T
A
V
P
Y
L
A
V
R
H
L
V
---------------------------
Y
L
R
F
L
N
L
------------------------
S
Y
N
P
I
S
T
I
E
G
S
M
L
H
E
L
--
L
R
L
Q
E
I
Q
L
V
G
G
Q
L
A
V
V
E
P
Y
A
F
------
R
G
L
N
Y
L
R
V
L
N
V
S
G
--
N
Q
L
T
T
L
E
E
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
C
D
C
R
------
L
L
W
V
F
R
R
R
W
R
L
N
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
--
V
L
L
P
N
Y
F
T
C
R
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
D
E
G
----
H
T
V
Q
F
V
C
----
R
A
D
G
D
P
P
P
A
I
L
W
L
S
--
P
R
K
H
L
V
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.03
31%
-129
- C2 -
2ID5
6
LIGO1_HUMAN
C:
[57-295]
----------------------------------------------------------------------------------------------------------------------------------------------
H
L
E
-
E
-------------------------
L
E
L
N
E
N
I
V
S
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
N
R
L
K
L
I
P
L
G
--
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
---------------------
N
-
K
-
I
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
--
V
Y
I
S
H
R
A
F
S
G
L
N
S
L
E
Q
L
T
L
E
K
C
N
L
T
S
I
P
T
E
A
L
-
S
H
L
H
G
L
I
V
L
R
L
R
H
L
N
I
N
-
A
I
R
D
Y
S
F
K
--
R
L
------------------------
Y
R
L
K
V
L
E
I
S
H
W
P
Y
L
D
T
M
T
P
N
C
L
Y
G
L
N
----------------------------
L
T
S
L
S
I
------------------------
T
H
C
N
L
T
A
V
P
Y
L
A
V
R
H
L
--
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
L
------
H
E
L
L
R
L
Q
E
I
Q
L
V
G
--
G
Q
L
A
V
V
E
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
------
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
C
D
C
R
L
L
W
V
F
R
R
R
W
R
L
N
--
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
----
P
N
Y
F
T
C
R
----
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
--
D
E
G
H
T
V
Q
F
V
C
R
A
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
N
G
R
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
74.94
27%
-129
- C2 -
2ID5
6
LIGO1_HUMAN
A:
[2-308]
--------------------------------------------------------------------------------------------------
G
C
P
P
R
C
E
C
---
S
A
-----
Q
DR
A
V
L
C
H
R
K
R
F
V
A
V
P
-
E
-
G
I---
P
T
E
T
R
-
L
-------------------------
L
D
L
G
K
N
R
I
K
T
L
N
Q
D
E
F
A
S
F
P
H
L
E
E
L
E
L
N
E
N
I
V
S
A
V
E
P
G
--
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
---------------------
N
-
R
-
L
K
L
I
P
L
G
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
N
K
I
--
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
V
Y
I
S
H
R
A
F
S
-
G
L
N
S
L
E
Q
L
T
L
E
K
C
N
L
T
-
S
I
P
T
E
A
L
S
--
H
L
------------------------
H
G
L
I
V
L
R
L
R
H
-
L
N
I
N
A
I
R
D
Y
S
F
K
R
L
Y
RLK
V
L
E
I
S
HWPYLDTMTPNCLYGL---
N
L
T
S
L
S
I
------------------------
T
H
C
N
L
T
A
V
P
Y
L
A
V
R
H
L
--
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
L
------
H
E
L
L
R
L
Q
E
I
Q
L
V
G
--
G
Q
L
A
V
V
E
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
------
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
C
D
C
R
L
L
W
V
F
R
R
R
W
R
L
N
--
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
----
P
N
Y
F
T
C
R
----
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
--
D
E
G
H
T
V
Q
F
V
C
R
A
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
74.33
31%
-126
- C2 -
2ID5
6
LIGO1_HUMAN
B:
[57-295]
----------------------------------------------------------------------------------------------------------------------------------------------
H
L
E
-
E
-------------------------
L
E
L
N
E
N
I
V
S
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
N
R
L
K
L
I
P
L
G
--
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
---------------------
N
-
K
-
I
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
--
V
Y
I
S
H
R
A
F
S
G
L
N
S
L
E
Q
L
T
L
E
K
C
N
L
T
S
I
P
T
E
A
L
-
S
H
L
H
G
L
I
V
L
R
L
R
H
L
N
I
N
-
A
I
R
D
Y
S
F
K
--
R
L
------------------------
Y
R
L
K
V
L
E
I
S
H
W
P
Y
L
D
T
M
T
P
N
C
L
Y
G
L
N
----------------------------
L
T
S
L
S
I
------------------------
T
H
C
N
L
T
A
V
P
Y
L
A
V
R
H
L
--
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
L
------
H
E
L
L
R
L
Q
E
I
Q
L
V
G
--
G
Q
L
A
V
V
E
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
------
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
C
D
C
R
L
L
W
V
F
R
R
R
W
R
L
N
--
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
----
P
N
Y
F
T
C
R
----
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
--
D
E
G
H
T
V
Q
F
V
C
R
A
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
S
A
K
S
N
G
R
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.94
31%
-130
- C2 -
2ID5
6
LIGO1_HUMAN
A:
[57-295]
----------------------------------------------------------------------------------------------------------------------------------------------
H
L
E
-
E
-------------------------
L
E
L
N
E
N
I
V
S
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
N
R
L
K
L
I
P
L
G
--
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
---------------------
N
-
K
-
I
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
--
V
Y
I
S
H
R
A
F
S
G
L
N
S
L
E
Q
L
T
L
E
K
C
N
L
T
S
I
P
T
E
A
L
-
S
H
L
H
G
L
I
V
L
R
L
R
H
L
N
I
N
-
A
I
R
D
Y
S
F
K
--
R
L
------------------------
Y
R
L
K
V
L
E
I
S
H
W
P
Y
L
D
T
M
T
P
N
C
L
Y
G
L
N
----------------------------
L
T
S
L
S
I
------------------------
T
H
C
N
L
T
A
V
P
Y
L
A
V
R
H
L
--
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
L
------
H
E
L
L
R
L
Q
E
I
Q
L
V
G
--
G
Q
L
A
V
V
E
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
------
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
C
D
C
R
L
L
W
V
F
R
R
R
W
R
L
N
--
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
----
P
N
Y
F
T
C
R
----
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
--
D
E
G
H
T
V
Q
F
V
C
R
A
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
73.47
31%
-125
- C2 -
2ID5
3
LIGO1_HUMAN
D:
[57-295]
----------------------------------------------------------------------------------------------------------------------------------------------
H
L
E
-
E
-------------------------
L
E
L
N
E
N
I
V
S
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
N
R
L
K
L
I
P
L
G
--
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
---------------------
N
-
K
-
I
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
--
V
Y
I
S
H
R
A
F
S
G
L
N
S
L
E
Q
L
T
L
E
K
C
N
L
T
S
I
P
T
E
A
L
-
S
H
L
H
G
L
I
V
L
R
L
R
H
L
N
I
N
-
A
I
R
D
Y
S
F
K
--
R
L
------------------------
Y
R
L
K
V
L
E
I
S
H
W
P
Y
L
D
T
M
T
P
N
C
L
Y
G
L
N
----------------------------
L
T
S
L
S
I
------------------------
T
H
C
N
L
T
A
V
P
Y
L
A
V
R
H
L
--
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
L
------
H
E
L
L
R
L
Q
E
I
Q
L
V
G
--
G
Q
L
A
V
V
E
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
------
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
C
D
C
R
L
L
W
V
F
R
R
R
W
R
L
N
--
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
----
P
N
Y
F
T
C
R
----
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
--
D
E
G
H
T
V
Q
F
V
C
R
A
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
S
A
K
S
N
G
R
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
72.53
35%
-117
- C2 -
4R5C
2
?
A:
[89-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
L
S
N
N
Q
L
E
T
L
P
Q
G
V
F
E
K
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
--
V
F
E
R
L
A
S
L
T
T
L
N
L
S
N
---------------------
N
-
Q
-
L
T
S
L
P
Q
G
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
--
T
S
L
P
Q
G
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
-
Q
G
V
F
E
R
L
T
S
L
H
T
L
D
L
S
N
N
G
I
T
-
D
I
S
A
L
K
----
N
L
------------------------
D
N
L
H
T
L
D
L
S
N
-
N
G
I
T
D
I
--
S
A
L
K
N
L
D
---------------------------
N
L
H
T
L
D
L
------------------------
S
N
N
G
I
T
D
I
S
A
L
--
K
N
L
--
T
S
L
H
T
L
D
L
S
N
N
G
I
T
D
I
S
A
--
L
------
K
N
L
D
N
L
E
T
L
D
L
R
N
--
N
G
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.69
30%
-116
- C2 -
4QXE
7
LGR4_HUMAN
A:
[9-314]
-------------------------------------------------------------------------------------------------------
C
S
C
---
D
G
D----
R
--
R
V
D
C
S
G
K
G
L
T
A
V
P
E
G
-
L
----
S
A
F
T
Q
-
A
-------------------------
L
D
I
S
M
N
N
I
T
Q
L
P
E
G
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
--
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
---------------------
N
-
Q
-
L
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
--
T
S
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
V
H
P
L
-
S
N
L
P
T
L
Q
A
L
T
L
A
L
N
K
I
S
-
S
I
P
D
F
A
F
T
--
N
L
------------------------
S
S
L
V
V
L
H
L
H
N
-
N
K
I
R
S
L
S
Q
H
C
F
D
G
L
D
---------------------------
N
L
E
T
L
D
L
------------------------
N
Y
N
N
L
G
E
F
P
Q
A
I
-
K
A
L
--
P
S
L
K
E
L
G
F
H
S
N
S
I
S
V
I
P
D
G
A
F
------
D
G
N
P
L
L
R
T
I
H
L
Y
D
--
N
P
L
S
F
V
G
N
S
A
F
H
N
L
S
D
L
H
S
L
V
I
R
G
A
S
M
V
Q
Q
F
P
NLTGTV
H
L
E
S
L
T
L
T
G
T
K
I
S
S
I
P
N
N
L
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
N
I
--
R
D
L
P
S
F
N
G
C
H
A
L
E
E
I
S
L
Q
R
N
Q
I
Y
Q
I
K
E
----
G
T
F
Q
G
L
I
----
S
L
R
I
L
D
L
A
S
N
Q
L
K
S
--
V
P
D
G
I
F
D
R
L
T
S
L
Q
K
I
W
L
H
T
N
P
W
D
C
S
C
P
R
I
D
Y
L
S
R
W
L
N
K
N
S
Q
K
E
Q
G
S
A
K
C
S
G
S
G
K
P
V
R
S
I
I
C
P
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
71.40
30%
-116
- C2 -
4KT1
2
LGR4_HUMAN
A:
[8-313]
-------------------------------------------------------------------------------------------------------
C
S
C
---
D
G
D----
R
--
R
V
D
C
S
G
K
G
L
T
A
V
P
E
G
-
L
----
S
A
F
T
Q
-
A
-------------------------
L
D
I
S
M
N
N
I
T
Q
L
P
E
D
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
--
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
---------------------
N
-
Q
-
L
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
--
T
S
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
V
H
P
L
-
S
N
L
P
T
L
Q
A
L
T
L
A
L
N
K
I
S
-
S
I
P
D
F
A
F
T
--
N
L
------------------------
S
S
L
V
V
L
H
L
H
N
-
N
K
I
R
S
L
S
Q
H
C
F
D
G
L
D
---------------------------
N
L
E
T
L
D
L
------------------------
N
Y
N
N
L
G
E
F
P
Q
A
I
-
K
A
L
--
P
S
L
K
E
L
G
F
H
S
N
S
I
S
V
I
P
D
G
A
F
------
D
G
N
P
L
L
R
T
I
H
L
Y
D
--
N
P
L
S
F
V
G
N
S
A
F
H
N
L
S
D
L
H
S
L
V
I
R
G
A
S
M
V
Q
Q
F
P
NLTGTV
H
L
E
S
L
T
L
T
G
T
K
I
S
S
I
P
N
N
L
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
N
I
--
R
D
L
P
S
F
N
G
C
H
A
L
E
E
I
S
L
Q
R
N
Q
I
Y
Q
I
K
E
----
G
T
F
Q
G
L
I
----
S
L
R
I
L
D
L
S
R
N
L
I
H
E
--
I
H
S
R
A
F
A
T
L
G
P
I
T
N
L
D
V
S
F
N
E
L
T
S
F
P
T
E
G
L
N
G
L
N
Q
L
K
L
V
G
N
F
K
L
K
E
A
L
A
A
K
D
F
V
N
L
R
S
L
S
V
P
Y
A
Y
Q
C
C
A
F
W
G
C
I
H
C
T
P
S
T
G
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.74
31%
-121
- C2 -
4OQT
6
LIGO1_HUMAN
A:
[57-295]
----------------------------------------------------------------------------------------------------------------------------------------------
H
L
E
-
E
-------------------------
L
E
L
N
E
N
I
V
S
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
N
R
L
K
L
I
P
L
G
--
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
---------------------
N
-
K
-
I
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
--
V
Y
I
S
H
R
A
F
S
G
L
N
S
L
E
Q
L
T
L
E
K
C
N
L
T
S
I
P
T
E
A
L
-
S
H
L
H
G
L
I
V
L
R
L
R
H
L
N
I
N
-
A
I
R
D
Y
S
F
K
--
R
L
------------------------
Y
R
L
K
V
L
E
I
S
H
W
P
Y
L
D
T
M
T
P
N
C
L
Y
G
L
N
----------------------------
L
T
S
L
S
I
------------------------
T
H
C
N
L
T
A
V
P
Y
L
A
V
R
H
L
--
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
L
------
H
E
L
L
R
L
Q
E
I
Q
L
V
G
--
G
Q
L
A
V
V
E
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
------
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
C
D
C
R
L
L
W
V
F
R
R
R
W
R
L
N
--
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
----
P
N
Y
F
T
C
R
----
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
--
D
E
G
H
T
V
Q
F
V
C
R
A
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
S
A
K
S
N
G
R
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
67.05
32%
-106
- C2 -
4QXF
-
LGR4_HUMAN
A:
[9-253]
-------------------------------------------------------------------------------------------------------
C
S
C
---
D
G
D----
R
--
R
V
D
C
S
G
K
G
L
T
A
V
P
E
G
-
L
----
S
A
F
T
Q
-
A
-------------------------
L
D
I
S
M
N
N
I
T
Q
L
P
E
G
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
--
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
---------------------
N
-
Q
-
L
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
--
T
S
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
V
H
P
L
-
S
N
L
P
T
L
Q
A
L
T
L
A
L
N
K
I
S
-
S
I
P
D
F
A
F
T
--
N
L
------------------------
S
S
L
V
V
L
H
L
H
N
-
N
K
I
R
S
L
S
Q
H
C
F
D
G
L
D
---------------------------
N
L
E
T
L
D
L
------------------------
N
Y
N
N
L
G
E
F
P
Q
A
I
-
K
A
L
--
P
S
L
K
E
L
A
L
D
T
N
Q
L
K
S
V
P
D
G
I
F
------
D
R
L
T
S
L
Q
K
I
W
L
H
T
--
N
P
W
D
C
S
C
P
R
I
D
Y
L
S
R
W
L
N
K
N
S
Q
K
E
Q
G
S
A
K
C
S
G
------
S
G
K
P
V
R
S
I
I
C
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
64.77
30%
-100
- C2 -
1XKU
3
PGS2_BOVIN
A:
[22-326]
-------------------------------------------------------------------------------------------
G
P
V
C
-----
P
F
R
C
Q
C
---
H
L
-----
R
--
V
V
Q
C
S
D
L
G
L
E
K
V
P
-
K
D
L
----
P
P
D
T
A
-
L
-------------------------
L
D
L
Q
N
N
K
I
T
E
I
K
D
G
D
F
K
N
L
K
N
L
H
T
L
I
L
I
N
N
K
I
S
K
I
S
P
G
--
A
F
A
P
L
V
K
L
E
R
L
Y
L
S
K
NQLKELPEKMPKTLQELRVHE
N
-
E
-
I
T
K
V
R
K
S
V
F
N
G
L
N
Q
M
I
V
V
E
L
G
T
N
P
L
KS
S
G
I
E
N
G
A
F
Q
G
M
K
K
L
S
Y
I
R
I
A
D
T
N
I
T
T
I
P
Q
G
L
P
----
P
S
L
T
E
L
H
L
D
G
N
K
I
T
-
K
V
D
A
A
S
L
K
--
G
L
------------------------
N
N
L
A
K
L
G
L
S
F
-
N
S
I
S
A
V
D
N
G
S
L
A
N
T
P
---------------------------
H
L
R
E
L
H
L
------------------------
N
N
N
K
L
V
K
V
P
G
G
-
L
A
D
H
--
K
Y
I
Q
V
V
Y
L
H
N
N
N
I
S
A
I
G
S
N
D
F
CPPGYN
T
K
K
A
S
Y
S
G
V
S
L
F
S
NP
V
Q
Y
W
E
I
Q
P
S
T
F
R
C
V
Y
V
R
A
A
V
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.57
30%
-103
- C2 -
4LI1
1
LGR4_XENTR
B:
[22-304]
-------------------------------------------------------------------------------------------------------------------------
D
C
S
G
K
G
L
V
T
V
P
-
D
-
G
----
L
S
V
F
T
H
S
-------------------------
L
D
L
S
M
N
N
I
T
K
L
P
E
G
A
F
K
G
F
P
Y
L
E
E
L
R
L
A
G
N
D
L
S
I
I
H
P
M
--
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
---------------------
N
-
Q
-
L
K
T
V
P
S
E
S
L
K
G
L
V
S
L
Q
S
L
R
L
D
A
N
H
I
--
V
T
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
T
E
V
P
I
R
P
L
S
-
N
L
P
S
L
Q
A
L
T
L
A
L
N
K
I
S
-
H
I
P
D
Y
A
F
S
--
N
L
------------------------
S
S
L
V
V
L
H
L
H
N
-
N
K
I
R
T
L
G
P
H
C
F
H
G
L
D
---------------------------
N
L
E
A
L
D
L
------------------------
N
Y
N
N
L
I
D
F
P
D
S
I
-
R
S
L
--
P
N
L
K
E
L
G
F
H
S
N
S
I
T
I
I
P
D
G
A
F
------
V
K
N
P
L
L
R
T
I
H
L
Y
D
--
N
P
L
S
F
V
G
N
S
A
F
Q
---
N
L
S
D
L
H
F
L
I
I
R
G
A
S
N
V
----------
Q
W
F
P
N
L
T
G
T
N
N
L
E
S
L
T
L
T
G
T
K
I
R
S
I
P
I
K
F
C
Q
E
Q
--
K
M
L
R
T
L
D
L
S
Y
N
E
I
S
A
L
V
G
F
E
G
C
S
S
L
E
E
----
V
Y
L
Q
N
N
Q
----
I
Q
E
V
Q
N
E
T
F
Q
G
L
A
A
--
L
R
M
L
D
L
S
R
N
R
I
H
T
I
H
K
E
A
F
V
T
L
K
A
L
T
N
L
D
L
S
F
N
D
L
T
A
F
P
T
A
G
L
H
G
L
N
Q
L
K
L
T
G
N
P
N
F
K
E
T
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
63.56
32%
-110
- C2 -
4P8S
3
R4RL2_RAT
A:
[2-234]
--------------------------------------------------------------------------------------------------
S
C
P
M
L
C
T
C
---
Y
S
-----
S
PP
T
V
S
C
Q
A
N
N
F
S
S
V
P
L
S
-
L
----
P
P
S
T
Q
-
R
-------------------------
L
F
L
Q
N
N
L
I
R
S
L
R
P
G
T
F
G
P
--
N
L
L
T
L
W
L
F
S
N
N
L
S
T
I
Y
P
G
--
T
F
R
H
L
Q
A
L
E
E
L
D
L
G
D
---------------------
N
-
R
H
L
R
S
L
E
P
D
T
F
Q
G
L
E
R
L
Q
S
L
H
L
Y
R
C
Q
L
--
S
S
L
P
G
N
I
F
R
G
L
V
S
L
Q
Y
L
Y
L
Q
E
N
S
L
L
H
L
Q
D
D
-
L
F
A
D
L
A
N
L
S
H
L
F
L
H
G
N
R
L
R
-
L
L
T
E
H
V
F
R
--
G
L
------------------------
G
S
L
D
R
L
L
L
H
G
-
N
R
L
Q
G
V
H
R
A
A
F
H
G
L
S
---------------------------
R
L
T
I
L
Y
L
------------------------
F
N
N
S
L
A
S
L
P
G
E
A
L
A
D
L
--
P
A
L
E
F
L
R
L
N
A
N
P
W
A
C
D
C
R
A
R
P
------
L
W
A
W
F
Q
R
A
R
V
S
S
S
--
D
V
T
C
A
T
P
P
E
R
Q
G
R
D
L
R
T
L
R
D
T
D
F
Q
A
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
62.56
32%
-110
- C2 -
4P91
4
R4RL2_RAT
A:
[2-234]
--------------------------------------------------------------------------------------------------
S
C
P
M
L
C
T
C
Y
S
-
S
P
-----
P
--
T
V
S
C
Q
A
N
N
F
S
S
V
P
L
S
-
L
----
P
P
S
T
Q
-
R
-------------------------
L
F
L
Q
N
N
L
I
R
S
L
R
P
G
T
F
G
P
--
N
L
L
T
L
W
L
F
S
N
N
L
S
T
I
Y
P
G
--
T
F
R
H
L
Q
A
L
E
E
L
D
L
G
D
---------------------
N
-
R
H
L
R
S
L
E
P
D
T
F
Q
G
L
E
R
L
Q
S
L
H
L
Y
R
C
Q
L
--
S
S
L
P
G
N
I
F
R
G
L
V
S
L
Q
Y
L
Y
L
Q
E
N
S
L
L
H
L
Q
D
D
-
L
F
A
D
L
A
N
L
S
H
L
F
L
H
G
N
R
L
R
-
L
L
T
E
H
V
F
R
--
G
L
------------------------
G
S
L
D
R
L
L
L
H
G
-
N
R
L
Q
G
V
H
R
A
A
F
H
G
L
S
---------------------------
R
L
T
I
L
Y
L
------------------------
F
N
N
S
L
A
S
L
P
G
E
A
L
A
D
L
--
P
A
L
E
F
L
R
L
N
A
N
P
W
A
C
D
C
R
A
R
P
------
L
W
A
W
F
Q
R
A
R
V
S
S
S
--
D
V
T
C
A
T
P
P
E
R
Q
G
R
D
L
R
T
L
R
D
T
D
F
Q
A
C
P
P
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
62.21
33%
-107
- C2 -
5CMP
1
?
B:
[82-282]
-----------------------------------------------------------------------------------------------------------------------------------------------
V
K
-
E
-------------------------
L
H
L
Q
E
N
N
I
R
T
I
T
Y
D
S
L
S
K
I
P
Y
L
E
E
L
H
L
D
D
N
S
V
S
A
V
S
I
E
EG
A
F
R
D
S
N
Y
L
R
L
L
F
L
S
R
---------------------
N
-
H
-
L
S
T
I
P
W
G
L
---
P
R
T
I
E
E
L
R
L
D
D
N
R
I
--
S
T
I
S
S
P
S
L
Q
G
L
T
S
L
K
R
L
V
L
D
G
N
L
L
N
N
-------------
H
G
L
---
G
D
K
V
F
F
N
L
V
N
L
T
E
L
--
S
L
VRNSLTAAPVNLPG----------
T
N
L
R
K
L
Y
L
Q
D
-
N
H
I
N
R
V
P
P
N
A
F
S
Y
L
R
---------------------------
Q
L
Y
R
L
D
M
------------------------
S
N
N
N
L
S
N
L
P
Q
G
I
F
D
D
L
--
D
N
I
T
Q
L
I
L
R
N
N
P
W
Y
C
G
C
K
M
K
W
------
V
R
D
W
L
Q
S
L
P
V
K
V
N
--
V
R
G
L
M
C
Q
A
P
E
K
V
R
G
M
A
I
K
D
L
N
A
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.20
30%
-110
- C2 -
1OZN
3
RTN4R_HUMAN
A:
[3-236]
----------------------------------------------------------------------------------------------------
P
G
A
C
V
C
Y
N
E
P
K
-----
V
--
T
T
S
C
P
Q
Q
G
L
Q
A
V
P
V
G
-
I
----
P
A
A
S
Q
-
R
-------------------------
I
F
L
H
G
N
R
I
S
H
V
P
A
A
S
F
R
A
C
R
N
L
T
I
L
W
L
H
S
N
V
L
A
R
I
D
A
A
--
A
F
T
G
L
A
L
L
E
Q
L
D
L
S
D
---------------------
N
A
Q
-
L
R
S
V
D
P
A
T
F
H
G
L
G
R
L
H
T
L
H
L
D
R
C
G
L
--
Q
E
L
G
P
G
L
F
R
G
L
A
A
L
Q
Y
L
Y
L
Q
D
N
A
L
Q
A
L
P
D
D
T
F
-
R
D
L
G
N
L
T
H
L
F
L
H
G
N
R
I
S
-
S
V
P
E
R
A
F
R
--
G
L
------------------------
H
S
L
D
R
L
L
L
H
Q
-
N
R
V
A
H
V
H
P
H
A
F
R
D
L
G
---------------------------
R
L
M
T
L
Y
L
------------------------
F
A
N
N
L
S
A
L
P
T
E
A
L
A
P
L
--
R
A
L
Q
Y
L
R
L
N
D
N
P
W
V
C
D
C
R
A
R
P
------
L
W
A
W
L
Q
K
F
R
G
S
S
S
--
E
V
P
C
S
L
P
Q
R
L
A
G
R
D
L
K
R
L
A
A
N
D
L
Q
G
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.66
27%
-112
- C2 -
4BSR
3
LGR5_HUMAN
A:
[23-307]
-----------------------------------------------------------------------------------------------
L
L
R
G
C
P
T
H
C
H
C
---
E
P
D
G
RM
L
L
--
R
V
D
C
S
D
L
G
L
S
E
L
P
-
S
-
N
----
L
S
V
F
T
-
S
YLDLSMNNISQLLPNPLPSLRFLE
E
L
R
L
A
G
N
A
L
T
Y
I
P
K
G
A
F
T
G
L
Y
S
L
K
V
L
M
L
Q
N
N
Q
L
R
H
V
P
T
E
--
A
L
Q
N
L
R
S
L
Q
S
L
R
L
D
A
---------------------
N
-
H
-
I
S
Y
V
P
P
S
C
F
S
G
L
H
S
L
R
H
L
W
L
D
D
N
A
L
--
T
E
I
P
V
Q
A
F
R
S
L
S
A
L
Q
A
M
T
L
A
L
N
K
I
H
H
I
P
D
Y
A
F
G
-
N
L
S
S
L
V
V
L
H
L
H
N
N
R
I
H
-
S
L
G
K
K
C
F
D
--
G
L
------------------------
H
S
L
E
T
L
D
L
N
Y
-
N
N
L
D
E
F
-
P
T
A
I
R
T
L
S
---------------------------
N
L
K
E
L
G
F
------------------------
H
S
N
N
I
R
S
I
P
E
K
A
F
V
G
N
--
P
S
L
I
T
I
H
F
Y
D
N
P
I
Q
F
V
G
R
S
A
F
------
Q
H
L
P
E
L
R
T
L
T
L
N
G
--
A
S
Q
I
T
E
F
P
D
L
T
G
T
A
N
L
E
S
L
T
L
T
G
A
Q
I
S
S
L
P
Q
T
------
V
C
N
Q
L
P
N
L
Q
V
L
D
L
S
Y
N
L
L
E
D
L
P
S
F
S
V
C
Q
K
L
Q
K
I
D
L
R
--
H
N
E
I
Y
E
I
K
V
D
T
F
Q
Q
L
L
S
L
R
S
L
N
L
A
W
N
K
----
I
A
I
I
H
P
N
----
A
F
S
T
L
P
S
L
I
K
L
D
L
S
--
S
N
L
L
S
S
F
P
I
T
G
L
H
G
L
T
H
L
K
L
T
G
N
H
A
L
Q
S
L
I
S
S
E
N
F
P
E
L
K
V
I
E
M
P
Y
A
Y
Q
C
C
A
F
G
V
C
E
R
D
L
E
D
F
L
L
D
F
E
E
D
L
K
A
L
H
S
V
Q
C
S
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
HHSearch
61.43
25%
-113
- C2 -
1ZIW
8
TLR3_HUMAN
A:
[4-305]
---------------------------------------------------------------------------------------------------------
V
---
S
H
-----
E
--
V
A
D
C
S
H
L
K
L
T
Q
V
P
-
D
-
D
L---
P
T
N
I
T
-
V
-------------------------
L
N
L
T
H
N
Q
L
R
R
L
P
A
A
N
F
T
R
Y
S
Q
L
T
S
L
D
V
G
F
N
T
I
S
K
L
E
P
E
--
L
C
Q
K
L
P
M
L
K
V
L
N
L
Q
H
---------------------
N
-
E
-
L
S
Q
L
S
D
K
T
F
A
F
C
T
N
L
T
E
L
H
L
M
S
N
S
I
--
Q
K
I
K
N
N
P
F
V
K
Q
K
N
L
I
T
L
D
L
S
H
N
G
L
S
S
T
K
L
G
T
Q
V
-
Q
L
E
N
L
Q
E
L
L
L
S
N
N
K
I
Q
-
A
L
K
S
E
E
L
D
IF
A
N
------------------------
S
S
L
K
K
L
E
L
S
S
-
N
Q
I
K
E
F
S
P
G
C
F
H
A
I
G
RLF
G
L
F
LNNVQLG
P
S
L
T
E
K
L
C
L
E
L
ANT
S
I
R
N
L
S
L
------------------------
S
N
S
Q
L
S
T
T
S
N
T
T
F
L
G
L
KW
T
N
L
T
M
L
D
L
S
Y
N
N
L
N
V
V
G
N
D
S
F
------
A
W
L
P
Q
L
E
Y
F
F
L
E
Y
--
N
N
I
Q
H
L
F
S
H
S
L
H
G
L
F
N
V
R
Y
L
N
L
K
R
S
F
T
K
Q
L
P
K
------
I
D
D
F
S
F
Q
W
L
K
C
L
E
H
L
N
M
E
D
N
D
I
P
G
I
K
S
N
M
F
T
G
L
I
N
L
--
K
Y
L
S
L
S
N
S
F
T
S
L
R
T
L
T
N
E
T
F
V
S
L
A
H
S
P
----
L
H
I
L
N
L
T
----
K
N
K
I
S
K
I
E
S
D
A
F
S
W
--
L
G
H
L
E
V
L
D
L
G
L
N
E
I
G
Q
E
L
T
G
Q
E
W
R
G
L
E
N
I
F
E
I
Y
L
S
Y
N
K
Y
L
Q
L
T
R
N
S
F
A
L
V
P
S
L
Q
R
L
M
L
R
R
V
A
L
K
N
V
D
S
S
P
S
P
F
Q
P
L
R
N
L
T
I
L
D
L
S
N
N
N
I
A
N
I
N
D
D
M
L
E
G
L
E
K
L
E
I
L
D
L
Q
H
N
N
L
A
R
L
W
K
H
A
N
P
G
G
P
I
Y
F
L
K
G
L
S
H
L
H
I
L
N
L
E
S
N
G
F
D
E
I
P
V
E
V
F
K
D
L
F
E
L
K
I
I
D
L
G
L
N
N
L
N
T
L
P
A
S
V
F
N
N
Q
V
S
L
K
S
L
N
L
Q
K
N
L
I
T
S
V
E
K
K
V
F
G
P
A
F
R
N
L
T
E
L
D
M
R
F
N
P
F
D
C
T
C
E
S
I
A
W
F
V
N
W
I
N
E
T
------------------------------------------------------