@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RXFP2_HUMAN: (2016-01-14 )
MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110..---...---.--.--120.....------....130.-.-..--...140.......150.......160.......170.......180.......190....-...200.......210.......220.......230.......240...--....250.....--------..260..-.....270.......------------------------280--------------.........290.......-------------------300-....------------------------.....310.......320---..--------......330.......340.......350.......360.......370.------......380.......390.......400.......410..--.....420.......430.......440.......450.......460.......470.......480.......490.......500-.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
V
F
L
V
F
K
H
L
F
S
L
R
L
I
T
M
F
F
L
L
H
F
I
V
L
I
NVK
D
F
A
LTQGSMITPSCQKGYFPCG
N
L
T
K
C
L
P
R
A
FHCDGKDDCGNGADEENCGDTSG
W
A
T
I
F
G
T
VHGNAN
S
V
A
L
T
Q
E
C
F
L
K
QYPQC---CDC---K--E--T--
E
L
E
CV------NGDLKSVP-M-IS--N
N
V
T
L
L
S
LKKNKIHSL
P
D
K
V
F
I
K
Y
T
K
L
K
K
I
F
L
Q
H
N
C
I
R
H
I
S
R
K
A
F
FGLC
N
L
Q
I
L
Y
LNHN
C
-
I
T
TL
R
P
G
I
F
K
D
L
H
Q
L
T
W
L
I
LDDN
P
I
T
R
I
S
Q
R
L
F
T
G
L
N
S
L
F
F
L
S
M
V
N
N
Y
L
--
E
A
L
P
K
Q
M
C
A
QMP--------Q
L
N
W
V
DL-EG
N
R
I
K
Y
L
TNS
T
F
LS------------------------C----------------D
S
L
T
V
L
F
LPRNQIGFV
P
E
K
-------------------
T
---
F
S
S
L
------------------------
K
N
L
GELDLSSN
T
I
T
EL
S
----
P
H
--------
L
F
K
D
L
K
L
L
Q
K
LNLSSN
P
L
M
Y
L
H
K
N
Q
F
E
S
L
K
Q
L
Q
SLD
L
E
R
IEIPNIN
T
R
M
F
------
Q
P
M
K
N
L
S
H
I
Y
F
KNFRYCSYAPH
V
R
I
C
M
PLT
D
G
I
S
S
F
E
D
L
L
A
--
N
N
I
L
R
I
F
V
W
V
I
A
F
I
T
C
F
G
N
L
F
V
I
G
M
R
S
F
I
KAENT
T
H
A
M
S
I
K
I
L
C
C
A
D
C
L
M
G
V
Y
L
F
F
V
G
I
F
D
I
K
YRG
Q
Y
Q
K
Y
A
L
L
W
M
E
S
V
Q
C
R
L
M
G
F
L
A
-
M
L
S
T
E
V
S
V
L
L
L
T
Y
L
T
L
E
K
F
L
V
I
V
F
PFSNIRPGK
R
Q
T
S
V
I
L
I
C
I
W
M
A
G
F
L
I
A
V
IPFWNKDYFGNFYGKN
G
V
C
F
P
L
YYDQ
T
E
DIGSKGY
S
L
G
I
F
L
G
V
N
L
L
A
F
L
I
I
V
F
S
Y
I
T
M
F
C
S
I
Q
K
T
A
L
Q
T
T
E
V
R
N
C
FGRE
V
A
VA
N
R
F
F
F
I
V
FSDA
I
C
W
I
P
V
F
V
V
K
I
L
S
L
F
RVEIPDTM
T
S
W
I
V
I
F
F
L
PVNSAL
N
P
I
L
Y
T
L
T
T
N
F
F
K
D
K
L
K
Q
L
L
H
K
H
Q
R
K
S
I
F
K
I
K
KKSLS
T
S
I
V
W
IEDSSS
L
K
L
G
V
L
N
K
ITLG
D
S
I
MKPVS
26
PsiBlast_CBE
77.91
35%
-122
- C1 -
4U06
6
?
A:
[15-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
V
L
D
L
S
R
Q
E
L
K
T
L
P
I
E
I
G
-
K
L
K
N
L
Q
R
L
Y
L
H
Y
N
Q
L
T
V
L
P
Q
E
-
I
E
Q
L
K
N
L
Q
L
L
Y
L
R
S
N
R
-
L
T
T
L
-
P
K
E
I
E
Q
L
K
N
L
Q
V
L
D
L
G
S
N
Q
L
T
V
L
P
Q
E
I
-
G
Q
L
K
N
L
Q
L
L
Y
L
H
S
N
R
L
--
T
T
L
S
K
D
I
-
E
Q
L
Q
--------
N
L
K
S
L
D
L
-
S
N
N
Q
L
T
T
L
P
N
E
-
I
E
Q
------------------------
L
----------------
K
N
L
K
S
L
Y
L
S
E
N
Q
F
A
T
F
P
-
K
-------------------
E
---
I
G
Q
L
------------------------
Q
N
L
K
V
L
F
L
N
N
N
Q
I
T
I
L
-----
P
N
--------
E
I
A
K
L
K
K
L
Q
Y
L
Y
L
S
D
N
Q
L
I
T
L
P
K
-
E
I
E
Q
L
K
N
L
Q
T
L
D
L
S
Y
N
Q
L
M
I
L
P
K
E
V
G
------
Q
L
E
N
L
Q
T
L
D
L
R
N
N
Q
L
K
T
L
P
K
E
I
E
Q
L
K
N
L
Q
T
L
F
L
S
N
N
Q
L
T
I
L
--
P
Q
E
I
G
K
L
K
N
L
L
W
L
S
L
V
Y
N
Q
L
T
T
L
P
N
E
I
E
Q
L
K
N
L
Q
T
L
Y
L
N
N
N
Q
F
S
S
Q
E
K
K
R
I
R
K
L
L
P
K
C
Q
I
Y
F
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
74.23
29%
-124
- C1 -
4LI1
1
LGR4_XENTR
B:
[42-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
S
M
N
N
I
T
K
L
P
E
G
A
F
K
G
F
P
Y
L
E
E
L
R
L
A
G
N
D
L
S
I
I
H
P
M
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
-
L
K
T
V
P
S
E
S
L
K
G
L
V
S
L
Q
S
L
R
L
D
A
N
H
I
V
T
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
--
T
E
V
P
I
R
P
L
S
N
L
P
--------
S
L
Q
A
L
T
L
-
A
L
N
K
I
S
H
I
P
D
Y
A
F
S
N
------------------------
L
----------------
S
S
L
V
V
L
H
L
H
N
N
K
I
R
T
L
G
P
H
-------------------
C
---
F
H
G
L
------------------------
D
N
L
E
A
L
D
L
N
Y
N
N
L
I
D
F
-----
P
D
--------
S
I
R
S
L
P
N
L
K
E
L
G
F
H
S
N
S
I
T
I
I
P
D
G
A
F
V
K
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
------
Q
---
N
L
S
D
L
H
F
L
I
I
R
G
A
S
N
V
Q
W
F
P
N
L
T
G
T
N
N
L
E
S
L
T
L
T
G
T
K
--
I
R
S
I
P
I
K
F
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
E
I
S
A
L
V
G
F
E
G
C
S
S
L
E
E
V
Y
L
Q
N
N
Q
I
Q
E
V
Q
N
E
T
F
Q
G
L
A
A
L
R
M
L
D
L
S
R
N
R
I
H
T
I
H
K
E
A
F
V
T
L
K
A
L
T
N
L
-
D
L
S
F
N
D
L
T
A
F
P
T
A
G
L
H
G
L
N
Q
L
K
L
T
G
N
P
N
F
K
E
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
72.34
29%
-122
- C1 -
4LI2
-
LGR4_XENTR
A:
[42-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
S
M
N
N
I
T
K
L
P
E
G
A
F
K
G
F
P
Y
L
E
E
L
R
L
A
G
N
D
L
S
I
I
H
P
M
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
-
L
K
T
V
P
S
E
S
L
K
G
L
V
S
L
Q
S
L
R
L
D
A
N
H
I
V
T
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
--
T
E
V
P
I
R
P
L
S
N
L
P
--------
S
L
Q
A
L
T
L
-
A
L
N
K
I
S
H
I
P
D
Y
A
F
S
N
------------------------
L
----------------
S
S
L
V
V
L
H
L
H
N
N
K
I
R
T
L
G
P
H
-------------------
S
---
F
H
G
L
------------------------
D
N
L
E
A
L
D
L
N
Y
N
N
L
I
D
F
-----
P
D
--------
S
I
R
S
L
P
N
L
K
E
L
G
F
H
S
N
S
I
T
I
I
P
D
G
A
F
V
K
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
------
Q
---
N
L
S
D
L
H
F
L
I
I
R
G
A
S
N
V
Q
W
F
P
N
L
T
G
T
N
N
L
E
S
L
T
L
T
G
T
K
--
I
R
S
I
P
I
K
F
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
E
I
S
A
L
V
G
F
E
G
C
S
S
L
E
E
V
Y
L
Q
N
N
Q
I
Q
E
V
Q
N
E
T
F
Q
G
L
A
A
L
R
M
L
D
L
S
R
N
R
I
H
T
I
H
K
E
A
F
V
T
L
K
A
L
T
N
L
-
D
L
S
F
N
D
L
T
A
F
P
T
A
G
L
H
G
L
N
Q
L
K
L
T
G
N
P
N
F
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.33
29%
-134
- C1 -
3ZYJ
1
LRC4C_HUMAN
A:
[36-286]
---------------------------------------------------------------------------------------------------------------
P
S
V
---
C
S
C
---
S
--
N
QF
S
--
K
V
I
C
V
------
R
K
N
L
R
E
V
P
D
G
-
I
S
--
T
N
T
R
L
L
N
L
H
E
N
Q
I
Q
I
I
K
V
N
S
F
K
H
L
R
H
L
E
I
L
Q
L
S
R
N
H
I
R
T
I
E
I
G
A
F
N
G
L
A
N
L
N
T
L
E
L
F
D
N
R
-
L
T
T
I
P
N
G
A
F
V
Y
L
S
K
L
K
E
L
W
L
R
N
N
P
I
--------------------------
E
S
I
P
S
Y
A
F
N
R
I
P
--------
S
L
R
R
L
D
L
G
E
L
K
R
L
S
Y
I
S
E
G
A
F
E
G
------------------------
L
----------------
S
N
L
R
Y
L
N
L
A
M
C
N
L
R
E
I
P
N
------------------------
L
T
P
L
------------------------
I
K
L
D
E
L
D
L
S
G
N
H
L
S
A
I
R
----
P
G
--------
S
F
Q
G
L
M
H
L
Q
K
L
W
M
I
Q
S
Q
I
Q
V
I
E
R
N
A
F
D
N
L
Q
S
L
V
E
I
N
L
A
H
N
N
L
T
L
L
P
H
D
L
F
------
T
P
L
H
H
L
E
R
I
H
L
H
H
N
P
W
N
C
N
C
D
I
L
W
L
S
W
W
I
K
D
M
A
P
S
N
T
A
C
C
A
--
R
C
N
T
P
P
N
L
K
G
R
Y
I
G
N
Y
F
T
C
Y
A
P
V
I
V
E
P
P
A
D
L
N
V
T
E
G
M
A
A
E
L
K
C
R
A
S
T
S
L
T
S
V
S
W
I
T
P
N
G
T
V
M
T
H
G
A
Y
K
V
R
I
A
V
L
S
D
G
T
L
N
F
T
N
V
T
V
Q
D
-
T
G
M
Y
T
C
M
V
S
N
S
V
G
N
T
T
A
S
A
T
L
N
V
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
70.49
19%
-132
- C1 -
2ID5
7
LIGO1_HUMAN
A:
[1-477]
------------------------------------------------------------------------------------------------------------
T
G
C
P
P
R
---
C
E
C
---
S
--
A
--
Q
DR
A
V
L
C
H
------
R
K
R
F
V
A
V
P
-
E
G
I
P
--
T
E
T
R
L
L
D
L
G
K
N
R
I
K
T
L
N
Q
D
E
F
A
S
F
P
H
L
E
E
L
E
L
N
E
N
I
V
S
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
N
R
-
L
K
L
I
P
L
G
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
N
K
I
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
--
V
Y
I
S
H
R
A
F
S
G
L
N
--------
S
L
E
Q
L
T
L
-
E
K
C
N
L
T
S
I
P
T
E
A
L
S
H
------------------------
L
----------------
H
G
L
I
V
L
R
L
R
H
L
N
I
N
A
I
R
D
Y
-------------------
S
---
F
K
R
L
------------------------
Y
R
L
K
V
L
E
I
S
H
W
P
Y
L
D
T
M
----
T
P
--------
N
C
L
Y
G
L
N
L
T
S
L
S
I
T
H
C
N
L
T
A
V
P
Y
L
A
V
R
H
L
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
L
------
H
E
L
L
R
L
Q
E
I
Q
L
V
G
G
Q
L
A
V
V
E
P
Y
A
------
F
R
G
L
N
Y
L
R
V
L
N
V
SG
N
Q
L
T
T
L
E
E
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
---------------
P
L
A
C
--
D
C
R
L
L
W
V
F
------------
R
R
R
W
R
L
N
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
P
N
Y
F
T
C
R
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
D
E
G
H
T
V
Q
F
V
C
R
-
A
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
70.22
25%
-125
- C1 -
2ID5
6
LIGO1_HUMAN
A:
[56-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
L
E
E
L
E
L
N
E
N
I
V
S
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
N
R
L
K
L
I
P
L
G
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
N
K
-
I
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
V
Y
I
S
H
R
A
F
S
G
L
N
S
L
E
Q
L
T
L
E
K
C
N
L
--
T
S
I
P
T
E
A
L
S
H
L
H
--------
G
L
I
V
L
R
L
-
R
H
L
N
I
N
A
I
R
D
Y
S
F
K
R
LYRLK
V
L
E
I
S
HWPYLDTMTPNCLY
G
----------------
L
N
L
T
S
L
S
I
T
H
C
N
L
T
A
V
P
Y
L
-------------------
A
---
V
R
H
L
------------------------
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
----
G
S
--------
M
L
H
E
L
L
R
L
Q
E
I
Q
L
V
G
G
Q
L
A
V
V
E
P
Y
A
F
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
S
V
F
------
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
C
D
C
R
L
L
W
V
F
R
R
R
W
R
L
N
F
N
R
Q
Q
P
T
C
--
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
P
N
Y
F
T
C
R
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
D
E
G
H
T
V
Q
F
V
C
R
A
D
G
D
P
P
P
A
I
L
W
L
S
P
R
K
H
L
V
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
-
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.11
27%
-126
- C1 -
4KT1
2
LGR4_HUMAN
A:
[7-290]
---------------------------------------------------------------------------------------------------------------
P
C
S
---
C
D
----
G
--
D
--
R
--
R
V
D
C
S
------
G
K
G
L
T
A
V
P
-
E
G
L
S
--
A
F
T
Q
A
L
D
I
S
M
N
N
I
T
Q
L
P
E
D
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
-
L
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
--
T
E
V
P
V
H
P
L
S
N
L
P
--------
T
L
Q
A
L
T
L
-
A
L
N
K
I
S
S
I
P
D
F
A
F
T
N
------------------------
L
----------------
S
S
L
V
V
L
H
L
H
N
N
K
I
R
S
L
S
Q
H
-------------------
C
---
F
D
G
L
------------------------
D
N
L
E
T
L
D
L
N
Y
N
N
L
G
E
F
-----
P
Q
--------
A
I
K
A
L
P
S
L
K
E
L
G
F
H
S
N
S
I
S
V
I
P
D
G
A
F
D
G
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
------
H
N
L
S
D
L
H
S
L
V
I
R
G
A
S
M
V
Q
Q
F
P
N
L
T
G
T
V
H
L
E
S
L
T
L
T
G
T
K
I
S
S
--
I
P
N
N
L
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
N
I
R
D
L
P
S
F
N
G
C
H
A
L
E
E
I
S
L
Q
R
N
Q
I
Y
Q
I
K
E
G
T
F
Q
G
L
I
S
L
R
I
L
D
L
S
R
N
L
I
H
E
I
H
S
R
A
F
A
T
L
G
P
I
T
N
L
D
V
S
-
F
N
E
L
T
S
F
P
T
E
G
L
N
G
L
N
Q
L
K
L
V
G
N
F
K
L
K
E
A
L
A
A
K
D
F
V
N
L
R
S
L
S
V
P
Y
A
Y
Q
C
C
A
F
W
G
C
I
H
C
T
P
S
T
G
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.87
27%
-126
- C1 -
4QXE
6
LGR4_HUMAN
A:
[8-291]
---------------------------------------------------------------------------------------------------------------
P
C
S
---
C
D
----
G
--
D
--
R
--
R
V
D
C
S
------
G
K
G
L
T
A
V
P
-
E
G
L
S
--
A
F
T
Q
A
L
D
I
S
M
N
N
I
T
Q
L
P
E
G
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
-
L
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
--
T
E
V
P
V
H
P
L
S
N
L
P
--------
T
L
Q
A
L
T
L
-
A
L
N
K
I
S
S
I
P
D
F
A
F
T
N
------------------------
L
----------------
S
S
L
V
V
L
H
L
H
N
N
K
I
R
S
L
S
Q
H
-------------------
C
---
F
D
G
L
------------------------
D
N
L
E
T
L
D
L
N
Y
N
N
L
G
E
F
-----
P
Q
--------
A
I
K
A
L
P
S
L
K
E
L
G
F
H
S
N
S
I
S
V
I
P
D
G
A
F
D
G
N
P
L
L
R
T
I
H
L
Y
D
N
P
L
S
F
V
G
N
S
A
F
------
H
N
L
S
D
L
H
S
L
V
I
R
G
A
S
M
V
Q
Q
F
P
N
L
T
G
T
V
H
L
E
S
L
T
L
T
G
T
K
I
S
S
--
I
P
N
N
L
C
Q
E
Q
K
M
L
R
T
L
D
L
S
Y
N
N
I
R
D
L
P
S
F
N
G
C
H
A
L
E
E
I
S
L
Q
R
N
Q
I
Y
Q
I
K
E
G
T
F
Q
G
L
I
S
L
R
I
L
D
L
A
S
N
Q
L
K
S
V
P
D
G
I
F
D
R
L
T
S
L
Q
K
I
W
L
H
-
T
N
P
W
D
C
S
C
P
R
I
D
Y
L
S
R
W
L
N
K
N
S
Q
K
E
Q
G
S
A
K
C
S
G
S
G
K
P
V
R
S
I
I
C
P
T
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
68.93
35%
-123
- C1 -
4PSJ
-
?
A:
[52-262]
------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
A
N
------
N
S
D
I
K
S
V
Q
-
G
-
I
Q
YL
P
N
V
R
Q
L
N
L
G
G
N
K
L
H
D
I
--------------------------
S
A
L
K
E
L
T
N
L
G
W
L
N
L
S
S
N
K
-
I
E
K
L
P
Q
G
L
F
E
S
L
T
T
L
T
Q
L
N
L
S
N
N
Q
I
T
S
L
P
Q
G
L
F
E
S
L
A
S
L
T
Q
L
N
L
S
N
N
Q
I
--
T
S
L
P
Q
G
L
F
E
S
L
T
--------
N
L
T
Q
L
N
L
-
S
N
N
Q
I
T
S
L
P
Q
G
L
F
E
S
------------------------
L
----------------
T
N
L
T
Q
L
N
L
S
N
N
Q
I
T
S
L
P
Q
G
-------------------
L
---
F
E
S
L
------------------------
T
S
L
T
Q
L
N
L
S
N
N
Q
I
T
S
L
P
----
Q
G
--------
L
F
E
S
L
T
N
L
K
Q
L
N
L
S
G
N
Q
I
Q
S
L
P
Q
G
L
H
E
S
L
T
Q
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.54
30%
-119
- C1 -
4R5C
2
?
A:
[18-273]
----------------------------------------------------------------------------------------------------
A
E
T
I
K
A
N
L
K
K
K
S
V
T
---
D
A
V
---
T
--
Q
--
N
--
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
-
G
-
I
Q
YL
P
N
V
R
Y
L
A
L
G
G
N
K
L
H
D
I
--------------------------
S
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
Q
-
L
E
T
L
P
Q
G
V
F
E
K
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
A
S
L
T
T
L
N
L
S
N
N
Q
L
--
T
S
L
P
Q
G
V
F
E
R
L
T
--------
N
L
T
T
L
N
L
-
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
------------------------
L
----------------
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
-------------------
V
---
F
E
R
L
------------------------
T
S
L
H
T
L
D
L
S
N
N
G
I
T
D
I
S
----
A
----------
L
K
N
L
D
N
L
H
T
L
D
L
S
N
N
G
I
T
D
I
S
A
--
L
K
N
L
D
N
L
H
T
L
D
L
S
N
N
G
I
T
D
I
-----------
S
A
L
K
N
L
T
S
L
H
T
L
D
L
S
N
N
G
I
T
D
I
S
A
L
K
N
L
D
N
L
E
T
L
D
L
R
N
N
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
68.51
24%
-131
- C1 -
2ID5
6
LIGO1_HUMAN
A:
[2-310]
-------------------------------------------------------------------------------------------------------------
G
C
P
P
R
---
C
E
C
---
S
--
A
QD
R
--
A
V
L
C
H
------
R
K
R
F
V
A
V
P
-
E
G
I
P
--
T
E
T
R
L
L
D
L
G
K
N
R
I
K
T
L
N
Q
D
E
F
A
S
F
P
H
L
E
E
L
E
L
N
E
N
I
V
S
A
V
E
P
G
A
F
N
N
L
F
N
L
R
T
L
G
L
R
S
N
R
-
L
K
L
I
P
L
G
V
F
T
G
L
S
N
L
T
K
L
D
I
S
E
N
K
I
V
I
L
L
D
Y
M
F
Q
D
L
Y
N
L
K
S
L
E
V
G
D
N
D
L
--
V
Y
I
S
H
R
A
F
S
G
L
N
--------
S
L
E
Q
L
T
L
-
E
K
C
N
L
T
S
I
P
T
E
A
L
S
H
------------------------
L
----------------
H
G
L
I
V
L
R
L
R
H
L
N
I
N
A
I
R
D
Y
-------------------
S
---
F
K
R
L
YRLK
V
L
E
I
S
HWPYLDTMTPNCLYG
L
N
L
T
S
L
S
I
T
H
C
N
L
T
A
V
P
----
Y
L
--------
A
V
R
H
L
V
Y
L
R
F
L
N
L
S
Y
N
P
I
S
T
I
E
G
S
M
L
H
E
L
L
R
L
Q
E
I
Q
L
V
G
G
Q
L
A
V
V
E
P
Y
A
F
------
R
G
L
N
Y
L
R
V
L
N
V
S
G
N
Q
L
T
T
L
E
E
S
V
F
H
S
V
G
N
L
E
T
L
I
L
D
S
N
P
L
A
--
C
D
C
R
L
L
W
V
F
R
R
R
W
R
L
N
F
N
R
Q
Q
P
T
C
A
T
P
E
F
V
Q
G
K
E
F
K
D
F
P
D
V
L
L
P
N
Y
F
T
C
R
R
A
R
I
R
D
R
K
A
Q
Q
V
F
V
D
E
G
H
T
V
Q
F
V
C
R
A
D
G
D
P
P
P
A
I
L
W
L
S
-
P
R
K
H
L
V
L
T
V
F
P
D
G
T
L
E
V
R
Y
A
Q
V
Q
D
N
G
T
Y
L
C
I
A
A
N
A
G
G
N
D
S
M
P
A
H
L
H
V
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
68.49
24%
-114
- C1 -
3OJA
4
?
B:
[54-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
V
T
F
K
N
S
T
M
R
K
L
P
A
A
L
L
D
S
F
R
Q
V
E
L
L
N
L
N
D
L
Q
I
E
E
I
D
T
Y
A
F
A
Y
A
H
T
I
Q
K
L
Y
M
G
F
N
A
-
I
R
Y
L
P
P
H
V
F
Q
N
V
P
L
L
T
V
L
V
L
E
R
N
D
L
S
S
L
P
R
G
I
F
H
N
T
P
K
L
T
T
L
S
M
S
N
N
N
L
--
E
R
I
E
D
D
T
F
Q
A
T
T
--------
S
L
Q
N
L
Q
L
-
S
S
N
R
L
T
H
V
D
L
S
L
I
P
S
------------------------
L
FHANVSYNLLS
T
L
A
I
P
I
A
V
E
E
L
D
A
S
H
N
S
I
N
V
V
R
G
P
VNVELTILKLQHNNLTDTA
W
---
L
L
N
Y
------------------------
P
G
L
V
E
V
D
L
S
Y
N
E
L
E
K
I
M
----
Y
H
--------
P
F
V
K
M
Q
R
L
E
R
L
Y
I
S
N
N
R
L
V
A
L
N
L
Y
-
G
Q
P
I
P
T
L
K
V
L
D
L
S
H
N
H
L
L
H
V
E
R
N
Q
-------
P
Q
F
D
R
L
E
N
L
Y
L
D
H
N
S
I
V
T
L
K
L
S
T
H
H
T
L
K
N
L
T
L
S
H
N
D
W
D
C
N
S
--
L
R
A
L
F
R
N
V
A
R
P
A
V
D
D
A
D
Q
H
C
K
I
D
Y
Q
L
E
H
G
L
C
C
K
E
S
D
K
P
Y
L
D
R
L
L
Q
Y
I
A
L
T
S
V
V
E
K
V
L
E
A
E
V
N
E
L
R
A
E
V
Q
Q
L
T
N
E
Q
I
Q
Q
E
Q
L
L
Q
G
L
H
A
E
-
I
D
T
N
L
R
R
Y
R
L
P
K
D
G
L
A
R
S
S
D
N
L
N
K
V
F
T
H
L
K
E
R
Q
A
F
K
L
R
E
T
Q
A
R
R
T
E
A
D
A
K
Q
K
E
T
E
D
L
E
Q
E
N
I
A
L
E
K
Q
L
D
N
K
R
A
K
Q
A
E
L
R
Q
E
T
S
L
K
R
Q
K
V
K
Q
L
E
A
K
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.34
31%
-113
- C1 -
4QXF
-
LGR4_HUMAN
A:
[8-253]
---------------------------------------------------------------------------------------------------------------
P
C
S
---
C
D
----
G
--
D
--
R
--
R
V
D
C
S
------
G
K
G
L
T
A
V
P
-
E
G
L
S
--
A
F
T
Q
A
L
D
I
S
M
N
N
I
T
Q
L
P
E
G
A
F
K
N
F
P
F
L
E
E
L
Q
L
A
G
N
D
L
S
F
I
H
P
K
A
L
S
G
L
K
E
L
K
V
L
T
L
Q
N
N
Q
-
L
K
T
V
P
S
E
A
I
R
G
L
S
A
L
Q
S
L
R
L
D
A
N
H
I
T
S
V
P
E
D
S
F
E
G
L
V
Q
L
R
H
L
W
L
D
D
N
S
L
--
T
E
V
P
V
H
P
L
S
N
L
P
--------
T
L
Q
A
L
T
L
-
A
L
N
K
I
S
S
I
P
D
F
A
F
T
N
------------------------
L
----------------
S
S
L
V
V
L
H
L
H
N
N
K
I
R
S
L
S
Q
H
-------------------
C
---
F
D
G
L
------------------------
D
N
L
E
T
L
D
L
N
Y
N
N
L
G
E
F
-----
P
Q
--------
A
I
K
A
L
P
S
L
K
E
L
A
L
D
T
N
Q
L
K
S
V
P
D
G
I
F
D
R
L
T
S
L
Q
K
I
W
L
H
T
N
P
W
D
C
S
C
P
R
I
D
------
Y
L
S
R
W
L
N
K
N
S
Q
K
E
Q
G
S
A
K
C
S
G
S
G
K
P
V
R
S
I
I
C
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
68.05
25%
-110
- C1 -
1XKU
3
PGS2_BOVIN
A:
[22-326]
--------------------------------------------------------------------------------------------------------------
G
P
V
C
PFR
C
Q
C
---
H
--
L
--
R
--
V
V
Q
C
S
------
D
L
G
L
E
K
V
P
-
K
D
L
P
--
P
D
T
A
L
L
D
L
Q
N
N
K
I
T
E
I
K
D
G
D
F
K
N
L
K
N
L
H
T
L
I
L
I
N
N
K
I
S
K
I
S
P
G
A
F
A
P
L
V
K
L
E
R
L
Y
L
S
K
N
Q
-
L
K
E
L
P
E
K
M
P
K
T
L
Q
E
L
R
---
V
H
E
N
E
I
T
K
V
R
K
S
V
F
N
G
L
N
Q
M
I
V
V
E
L
G
T
N
P
L
KS
S
G
I
E
N
G
A
F
Q
G
M
K
--------
K
L
S
Y
I
R
I
-
A
D
T
N
I
T
T
I
P
Q
G
L
P
-------------------------------------------
P
S
L
T
E
L
H
L
D
G
N
K
I
T
K
V
D
A
A
-------------------
S
---
L
K
G
L
------------------------
N
N
L
A
K
L
G
L
S
F
N
S
I
S
A
V
D
----
N
G
--------
S
L
A
N
T
P
H
L
R
E
L
H
L
N
N
N
K
L
V
K
V
P
G
G
-
L
A
D
H
K
Y
I
Q
V
V
Y
L
H
N
N
N
I
S
A
I
G
S
N
D
F
CPPGYN
T
K
K
A
S
Y
S
G
V
S
L
F
S
N
P
V
Q
Y
W
E
I
Q
P
S
T
F
R
C
V
Y
V
R
A
A
V
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
67.51
30%
-118
- C1 -
3KJ4
2
RTN4R_RAT
A:
[2-231]
---------------------------------------------------------------------------------------------------------------
P
G
A
---
C
V
C
Y
NE
P
--
K
--
V
--
T
T
S
C
P
------
Q
Q
G
L
Q
A
V
P
-
T
G
I
P
--
A
S
S
Q
R
I
F
L
H
G
N
R
I
S
Y
V
P
A
A
S
F
Q
S
C
R
N
L
T
I
L
W
L
H
S
N
A
L
A
G
I
D
A
A
A
F
T
G
L
T
L
L
E
Q
L
D
L
S
D
N
A
Q
L
R
V
V
D
P
T
T
F
R
G
L
G
H
L
H
T
L
H
L
D
R
C
G
L
Q
E
L
G
P
G
L
F
R
G
L
A
A
L
Q
Y
L
Y
L
Q
D
N
N
L
--
Q
A
L
P
---------------------------------
D
N
T
F
R
D
------------------------
L
----------------
G
N
L
T
H
L
F
L
H
G
N
R
I
P
S
V
P
E
H
-------------------
A
---
F
R
G
L
------------------------
H
S
L
D
R
L
L
L
H
Q
N
H
V
A
R
V
H
----
P
H
--------
A
F
R
D
L
G
R
L
M
T
L
Y
L
F
A
N
N
L
S
M
L
P
A
E
V
L
V
P
L
R
S
L
Q
Y
L
R
L
N
D
N
P
W
V
C
D
C
R
A
R
P
------
L
W
A
W
L
Q
K
F
R
G
S
S
S
E
V
P
C
N
L
P
Q
R
L
A
G
R
D
L
K
R
L
A
A
S
D
L
E
G
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.38
28%
-111
- C1 -
4R6F
-
?
A:
[19-330]
----------------------------------------------------------------------------------------------------
A
E
T
I
K
A
N
L
K
K
K
S
V
T
---
D
A
V
---
T
--
Q
--
N
--
E
L
N
S
I
D
Q
I
I
A
N
N
S
D
I
K
S
V
Q
-
G
-
I
Q
YL
P
N
V
R
Y
L
A
L
G
G
N
K
L
H
D
I
--
S
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
Q
L
E
T
L
P
Q
G
V
F
E
K
L
T
N
L
T
T
L
N
L
S
N
N
Q
-
L
T
S
L
P
Q
G
V
F
E
R
L
A
S
L
T
T
L
N
L
S
N
N
N
I
A
N
I
N
D
Q
M
L
E
G
L
T
N
L
T
T
L
N
L
S
H
N
N
L
--
A
R
L
W
K
H
A
N
P
G
G
P
IYFLKGLT
N
L
T
T
L
N
L
-
S
S
N
G
F
D
E
I
P
R
E
V
F
K
D
------------------------
L
----------------
T
S
L
T
T
L
N
L
S
N
N
N
I
A
N
I
N
D
Q
-------------------
M
---
L
E
G
L
------------------------
T
N
L
T
T
L
N
L
S
H
N
N
L
A
R
L
W
----
K
H
ANPGGPIY
F
L
K
G
L
T
N
L
T
T
L
N
L
S
S
N
G
F
D
E
I
P
R
E
V
F
K
D
L
T
S
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
------
E
R
L
T
N
L
K
T
L
N
L
S
N
N
Q
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
67.00
29%
-116
- C1 -
4U7L
4
LRIG1_HUMAN
A:
[174-398]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
Q
L
D
L
N
R
N
R
I
R
L
I
E
G
L
T
F
Q
G
L
N
S
L
E
V
L
K
L
Q
R
N
N
I
S
K
L
T
D
G
A
F
W
G
L
S
K
M
H
V
L
H
L
E
Y
N
S
-
L
V
E
V
N
S
G
S
L
Y
G
L
T
A
L
H
Q
L
H
L
S
N
N
S
I
A
R
I
H
R
K
G
W
S
F
C
Q
K
L
H
E
L
V
L
S
F
N
N
L
--
T
R
L
D
E
E
S
L
A
E
L
S
--------
S
L
S
V
L
R
L
-
S
H
N
S
I
S
H
I
A
E
G
A
F
K
G
------------------------
L
----------------
R
S
L
R
V
L
D
L
D
H
N
E
I
S
G
T
I
E
D
-------------------
T
SGA
F
S
G
L
------------------------
D
S
L
S
K
L
T
L
F
G
N
K
I
K
S
V
A
----
K
R
--------
A
F
S
G
L
E
G
L
E
H
L
N
L
G
G
N
A
I
R
S
V
Q
F
D
A
F
V
K
M
K
N
L
K
E
L
H
I
S
S
D
S
F
L
C
D
C
Q
L
K
W
------
L
P
P
W
L
I
G
R
M
L
Q
A
F
V
T
A
T
C
A
H
P
E
S
L
K
G
Q
S
I
F
S
V
P
P
E
S
F
V
C
D
D
--
F
L
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.76
32%
-115
- C1 -
4R6G
-
?
A:
[49-317]
-----------------------------------------------------------------------------------------------------------------------------------------------
N
S
D
I
K
S
V
Q
-
G
-
I
Q
YL
P
N
V
R
Y
L
A
L
G
G
N
K
L
H
D
I
--
S
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
Q
L
E
T
L
P
Q
G
V
F
E
K
L
T
N
L
T
T
L
N
L
S
N
N
Q
-
L
T
S
L
P
Q
G
V
F
E
R
L
A
S
L
T
T
L
N
L
S
N
N
N
L
A
N
L
N
D
R
V
F
E
G
L
T
N
L
T
T
L
N
L
S
N
N
N
L
--
A
R
L
W
K
H
A
N
P
G
G
P
IYFLKGLT
N
L
T
T
L
N
L
-
S
N
N
G
F
D
E
L
P
K
E
V
F
K
D
------------------------
L
----------------
T
S
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
-------------------
V
---
F
E
R
L
------------------------
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
----
Q
G
--------
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
S
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
K
G
V
L
------
E
R
L
T
N
L
K
T
L
N
L
S
N
N
Q
I
T
K
E
V
C
R
H
V
A
E
L
L
K
Q
A
A
S
L
H
E
L
H
L
S
N
--
N
N
I
G
E
E
G
A
A
E
L
V
E
A
L
L
H
P
G
S
T
L
E
T
L
D
L
S
N
C
N
L
T
K
E
A
C
R
E
I
A
R
A
L
K
Q
A
T
T
L
H
E
L
H
L
S
N
N
N
I
G
E
E
G
A
A
E
L
V
E
A
L
L
H
P
G
S
T
L
E
T
L
D
L
S
N
C
N
-
L
T
K
E
A
C
R
E
I
A
R
A
L
K
Q
A
T
S
L
H
E
L
H
L
S
N
N
N
I
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.14
31%
-114
- C1 -
2O6Q
-
?
A:
[24-237]
--------------------------------------------------------------------------------------------------------
E
A
L
C
K
K
D
G
G
V
---
C
S
C
---
N
NN
K
--
N
--
S
V
D
C
S
------
S
K
K
L
T
A
I
P
-
S
N
I
P
--
A
D
T
K
K
L
D
L
Q
S
N
K
L
S
S
L
P
S
K
A
F
H
R
L
T
K
L
R
L
L
Y
L
N
D
N
K
L
Q
T
L
P
A
G
I
F
K
E
L
K
N
L
E
T
L
W
V
T
D
N
K
-
L
Q
A
L
P
I
G
V
F
D
Q
L
V
N
L
A
E
L
R
L
D
R
N
Q
L
K
S
L
P
P
R
V
F
D
S
L
T
K
L
T
Y
L
S
L
G
Y
N
E
L
--
Q
S
L
P
K
G
V
F
D
K
L
T
--------
S
L
K
E
L
R
L
-
Y
N
N
Q
L
K
R
V
P
E
G
A
F
D
K
------------------------
L
----------------
T
E
L
K
T
L
K
L
D
N
N
Q
L
K
R
V
P
E
G
-------------------
A
---
F
D
S
L
------------------------
E
K
L
K
M
L
Q
L
Q
E
N
P
W
D
C
T
C
----
N
G
--------
I
I
Y
M
A
K
W
L
K
K
K
A
D
E
G
L
G
G
V
D
T
A
G
C
E
K
G
G
K
A
V
L
E
I
T
E
K
D
A
A
S
D
C
V
S
P
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.43
33%
-126
- C1 -
4R5D
3
?
A:
[50-267]
-----------------------------------------------------------------------------------------------------------------------------------------------
N
S
D
I
K
S
V
Q
-
G
-
I
Q
YL
P
N
V
R
Y
L
A
L
G
G
N
K
L
H
D
I
--
S
A
L
K
E
L
T
N
L
G
W
L
N
L
S
N
N
Q
L
E
T
L
P
Q
G
V
F
E
K
L
T
N
L
T
T
L
N
L
S
N
N
Q
-
L
T
S
L
P
Q
G
V
F
E
R
L
A
S
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
L
T
N
L
T
T
L
N
L
S
N
N
Q
L
--
T
S
L
P
Q
G
V
F
E
R
L
T
--------
N
L
T
T
L
N
L
-
S
N
N
Q
L
T
S
L
P
Q
G
V
F
E
R
------------------------
L
----------------
T
S
L
T
T
L
N
L
S
N
N
Q
L
T
S
L
P
D
G
-------------------
V
---
F
E
R
L
------------------------
T
N
L
K
T
L
N
L
S
N
N
Q
L
T
K
E
A
C
R
A
V
A
N
--------
A
L
K
Q
A
A
S
L
H
E
L
H
L
S
N
N
N
I
G
E
E
G
A
A
E
L
V
E
A
L
L
H
P
G
S
T
L
E
T
L
D
L
S
N
C
N
L
T
K
E
------
A
C
R
E
I
A
R
A
L
K
Q
A
T
T
L
H
E
L
H
L
S
N
N
N
I
G
E
E
G
A
A
E
L
V
E
A
L
L
H
P
G
--
S
T
L
E
T
L
D
L
S
N
C
N
L
T
K
E
A
C
R
E
I
A
R
A
L
K
Q
A
T
T
L
H
E
L
H
L
S
N
N
N
I
G
E
E
G
A
A
E
L
V
E
A
L
L
H
P
G
S
T
L
E
T
L
D
L
S
N
C
N
L
T
K
E
A
C
R
E
I
A
R
A
L
K
Q
A
T
S
L
-
H
E
L
H
L
S
N
N
N
I
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------