@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S1PR2_HUMAN: (2016-01-14 )
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
Atome Classification :
(20 SA)
.........10-----.........20...-.....30........40........50........60........70........80.....-.--..90........100......------.-110---......------...120.......130...-....140.----......150.......160.......-170--...-------.-.------.--..---------180---..-------.-..--------.------.--.---.190.....-..200.......210.......-220----.--------------------------------------------------------------------------------------------------------------------------------------------------------------.----------------------------------------------------------------------------------------------------------------------------------------------------------------...------------...230.......240.......250.......260..-.....270.......280.......290....---...300.......310.......320.......330.......340.......350.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
S
L
Y
S
E
YL
N
------
P
N
K
V
Q
E
H
Y
N
Y
T
K
E
T
-
L
E
T
Q
E
T
T
S
R
Q
V
A
S
A
F
I
V
I
L
C
C
A
I
V
V
E
N
L
L
V
L
I
AVARNS
K
F
H
S
A
M
Y
L
F
L
G
N
L
A
A
S
D
L
L
A
G
V
A
F
-
V
--
A
N
T
LLSG
S
V
T
L
R
L
T
P
V
Q
W
F
AR------E-G-----
S
A
F
I
T
L
------
S
A
S
V
F
S
L
L
A
I
A
I
E
R
H
V
A
I
A
-
K
V
K
L
YGSD----K
S
C
R
M
L
L
L
I
G
A
S
W
L
I
S
L
V
LGGLPIL
G
-
W
N
---
C
L
G
-------
H
-
L
------
E
--
A
C
---------
S
-----
T
V
-------
L
-
P
L
--------
Y
------
A
--
K
---
H
Y
V
L
C
V
V
T
I
-
F
S
I
I
L
L
A
I
V
A
L
Y
V
R
I
Y
C
V
V
RSS-HA-----D--------------------------------------------------------------------------------------------------------------------------------------------------------------M----------------------------------------------------------------------------------------------------------------------------------------------------------------AA
P
------------
Q
T
L
A
L
L
K
T
V
T
I
V
L
G
V
F
I
V
C
W
L
P
A
F
S
I
L
L
L
DYACPVHSC-
P
I
L
Y
K
A
H
Y
F
F
A
V
S
T
L
N
S
L
L
N
P
V
I
Y
TWRS
R
D
L
R
---
R
E
V
L
R
P
L
Q
CWRPGVGVQGRRRGGTPGH
H
L
LPLRSSS
S
L
E
RGMHMPTS
P
T
FLEGNTVV
28
HHSearch
88.32
49%
-155
- C3 -
3V2Y
2
ENLYS_BPT4
A:
[35-495]
-----
S
D
Y
V
N
------
Y
D
I
I
V
R
H
Y
N
Y
T
G
K
L
N
I
S
A
D
K
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
--
A
N
L
L
L
S
G
A
T
T
Y
K
L
T
P
A
Q
W
F
L
R
------
E
-
G
-----
S
M
F
V
A
L
------
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
-
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
-
W
N
---
C
I
S
-------
A
-
L
------
S
--
S
C
---------
S
-----
T
V
-------
L
-
P
L
--------
Y
------
H
K
H
Y
---
I
L
F
C
T
T
V
F
T
-
L
L
L
L
S
--
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
-
N
I
-----
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
S
------------
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
V
K
T
C
-
D
I
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
---
R
A
F
I
R
I
M
G
R
P
L
----------------------------------------------
39
HHSearch
72.48
28%
-157
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
--
P
W
V
V
Y
L
E
----
V
T
G
G
V
W
N
F
S
R
------
I
C
C
D
V
F
V
T
L
D
V
M
M
C
------
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
-
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
---
T
T
G
-------
D
-
P
------
T
--
V
C
---------
S
-----
I
S
-------
N
-
P
---------
D
------
F
--
V
---
I
Y
S
S
V
V
S
F
Y
-
L
P
F
G
V
--
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
-
R
R
-----
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYG
V
P
L
------------
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
-
H
-
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
---
K
A
F
L
K
I
L
S
C
------------------------------------------------
47
Fugue
72.17
19%
-117
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
VPFSNK
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
-
L
A
--
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
--
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
------
E
-
G
F
----
F
A
T
L
G
G
------
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
-
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
G
-------
M
-
Q
------
C
--
S
C
---------
G
I
DYYT
P
H
-------
E
-
E
T
--------
N
------
N
--
E
---
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
-----
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
--
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------
34
HHSearch
71.99
25%
-160
- C3 -
3EML
13
ENLYS_BPT4
A:
[20-472]
--------------------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
--
P
F
A
I
T
I
S
-
T
G
F
C
A
A
C
H
G
C
L
F
I
------
A
-
C
-----
F
V
L
V
L
T
------
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
-
I
P
L
R
Y
N
G
L
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
-------
Q
-
S
------
Q
--
G
C
---------
G
-----
E
G
QVACLFE
D
-
V
V
--------
P
M
N
Y
---
M
--
V
---
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
--
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-
L
N
-----
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
-
T
L
Q
------------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
---
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------
48
Fugue
69.93
20%
-108
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
VPFSNK
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
-
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
--
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
--
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
------
E
-
G
F
----
F
A
T
L
G
G
------
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
-
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
G
-------
M
-
Q
------
C
--
S
C
G
I
DYY----
T
-----
P
H
-------
E
-
E
T
--------
N
------
N
--
E
---
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
-
A
A
QQQES
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
--
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
-------
T
E
T
S
Q
V
A
P
A
----------------
31
HHSearch
69.78
24%
-158
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
---------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
--
P
F
G
A
A
H
I
-----
L
M
K
M
W
T
F
G
N
F
-----
W
-
C
E
F
W
T
S
I
D
V
L
C
V
------
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
-
S
P
F
K
Y
Q
S
L
L---
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
---
R
A
T
H
Q
-----
E
-
A
I
N
C
Y
A
E
E
--
T
C
---------
C
-----
D
F
-------
F
T
N
Q
--------
A
------
Y
--
A
---
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
--
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-
L
N
-----
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYK--
F
C
L
------------
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
---
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
---
I
A
F
Q
E
L
L
C
L
------------------------------------------------
35
HHSearch
67.31
23%
-160
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
----------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
--
P
M
N
I
L
Y
L
-----
L
M
S
K
W
S
L
G
R
------
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
------
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
-
Q
P
L
R
Y
L
K
Y
R---
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
-
V
I
P
I
L
G
-
W
N
---
H
--R------
R
-
E
------
D
--
K
C
---------
E
-----
T
D
-------
F
-
Y
D
--------
V
T
W
----
F
--
K
---
V
M
T
A
I
I
N
F
Y
-
L
P
T
L
L
--
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
-
C
N
-----
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL--
H
M
N
------------
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
---
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
---
K
T
F
K
R
I
L
H
I
------------------------------------------------
6
PsiBlast_PDB
66.90
28%
-159
- C3 -
3PWH
1
?
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
---------
A
C
------
H
-
G
-----
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
QP-----------------
G
C
GEGQVACLF
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
V
YF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
-
L
K
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
PLPGE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------------------
7
PsiBlast_PDB
66.83
28%
-163
- C3 -
3REY
1
AA2AR_HUMAN
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
---------
A
C
------
H
-
G
-----
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
QP-----------------
G
C
GEGQVACL
F
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
V
YF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
-
L
K
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
PLPGE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------------------
16
PsiBlast_PDB
66.81
27%
-164
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
----------
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
------
H
-
G
-----
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
QPKEGKA------------
G
C
GEGQVACLF
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
V
YF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-
L
K
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
-------------------------------------
10
PsiBlast_PDB
66.65
28%
-162
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
---------
A
C
------
H
-
G
-----
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
QP-----------------
G
C
GEGQVACL
F
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
V
YF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
-
L
K
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------------------
14
PsiBlast_PDB
66.03
27%
-161
- C3 -
2YDV
6
?
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
----------
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
------
H
-
G
-----
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
QPK
E
G
K
A
H
-
S
------
Q
--
G
C
GEGQVACLF
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
V
YF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-
L
K
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
S
T
L
Q
--------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
Q
-------------------------------
13
PsiBlast_PDB
65.90
27%
-160
- C3 -
2YDO
3
?
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
----------
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
------
H
-
G
-----
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
QPK
E
G
K
A
H
-
S
------
Q
--
G
C
GEGQVACLF
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
V
YF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-
L
K
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
-T
L
Q
---------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
--------------------------------
11
PsiBlast_PDB
65.86
27%
-164
- C3 -
3VG9
8
?
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
---------
A
C
------
H
-
G
-----
C
L
F
I
A
C
FV
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
Q--------
S
------
Q
--
G
C
GEGQV
A
C
L
F
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
VYF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-
L
K
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
PLPGERA
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------------------
9
PsiBlast_PDB
65.66
28%
-164
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
---------
A
C
------
H
-
G
-----
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
QP-----------------
G
C
GEGQVACL
F
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
V
YF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
-
L
K
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------------------
8
PsiBlast_PDB
65.59
28%
-160
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
---------
A
C
------
H
-
G
-----
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
QP-----------------
G
C
GEGQVACL
F
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
V
YF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
-
L
K
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
PLPG
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------------------------------------------
12
PsiBlast_PDB
65.42
27%
-162
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
---------
A
C
------
H
-
G
-----
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
Q--------
S
------
Q
--
G
C
GEGQ
V
A
C
L
F
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
V
YF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-
L
K
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Q
PLPGERA
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
------------------------------------------------
15
PsiBlast_PDB
65.39
27%
-166
- C3 -
4UG2
3
?
A:
[21-304]
------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
----------
L
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
------
H
-
G
-----
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
----
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
---
N
C
G
QPK
E
G
K
A
H
-
S
------
Q
--
G
C
GEGQVACLF
E
-----
D
V
-------
V
-
P
M
--------
N
------
Y
--
M
V
YF
N
F
F
A
C
V
L
-----
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A
R
S
T
L
Q
------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------------------
36
HHSearch
64.69
20%
-142
- C3 -
1U19
14
OPSD_BOVIN
A:
[35-326]
----------------------------------
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
--
T
T
T
L
Y
T
S
-----
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
-
F
-----
F
A
T
L
G
G
------
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
-
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
---
R
Y
I
-------
P
E
G
------
M
QC
S
C
---------
G
-----
I
D
-------
Y
-
Y
T
PHEETN
N
E
S
------
F
--
V
---
I
Y
M
F
V
V
H
F
I
-
I
P
L
I
V
--
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
-
A
A
-----
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QESA
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-
D
-
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------
33
HHSearch
63.57
19%
-135
* C3 *
2Z73
5
OPSD_TODPA
A:
[29-336]
----------------------------------
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
--
P
L
M
T
I
S
-----
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
-
F
-----
I
G
G
I
F
G
------
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
-
R
P
M
A
A
S
K
K
M
---
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
---
A
Y
T
L
E
G----
V
-
L
------
C
--
N
C
---------
S
-----
F
D
-------
Y
-
I
S
--------
R
D
S
T
T
R
S
N
--
I
---
L
C
M
F
I
L
G
F
F
-
G
P
I
L
I
--
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
-
E
K
-----
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
-----------------------------------------------------------------------------------------------------------------------------------------------
G
A
N
------------
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
-
W
-
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
---
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
----------------------