@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S1PR4_HUMAN: (2016-01-14 )
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.------.......70........80........90..-......-100....-.--..110.......120-......-..------130..--......140.......150....---...160.......170.......180-..--------.-----------..--.-----.190......-------.----..-----200--...-.-.-.-..210........---220...-.-.-----..230......-------------.------------------------------------------------------------------------------------------------------------------------------------------------------------240.---......250.......260.....-----..270.......280.......290-----........300-.......310.......320.......330.......340.......350.......360.......370.......380..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNATGTPVA
P
E
S
C
Q
Q
L
AAGGH
S
R
L
I
V
L
H
YNHSGRLAGRGGPEDGG
L
G
A
L
R
G
L
S
V
A
A
S
C
L
V
V
L
------
E
N
L
L
V
L
A
A
I
T
S
H
M
RSR
R
W
V
Y
Y
C
L
V
N
I
T
L
S
D
L
-
L
T
G
A
A
Y
-
L
A
N
V
L
L
S-G--A
R
T
F
R
L
A
P
A
Q
W
F
L
R--E
G
L
L
F
T
-
A
L
------
A
-
A
S
T
--
F
S
L
L
F
TA
G
E
R
F
A
T
M
V
R
P
V
A
ESGA---TK
T
S
R
V
Y
G
F
I
G
L
C
W
L
L
A
A
L
L
G
M
L
P
L
L-G
W
--------
N
-----------
C
L
--
C
-----
A
F
--
D
R
C
S
S
L
-------
L
----
P
L
-----
Y
S---K
R
Y
-
I
-
L
-
F
-
C
L
V
I
-
F
A
G
V
L
A
T
I
---
M
G
L
Y
G
A
-
I
-
F
-----
R
L
V
Q
ASGQKAP-------------R------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
A
R
---
R
K
A
R
R
L
L
K
T
V
L
M
I
L
L
A
F
L
V
C
W
G
P
L
-----
F
G
L
L
L
A
D
V
FGS
N
L
W
A
Q
E
Y
L
R
G
M
D
W
------
I
L
A
L
A
V
L
N
SA
V
-
N
P
I
I
Y
SFR
S
R
E
V
C
R
A
V
L
S
F
L
C
C
G
C
L
R
LGMRG
P
G
D
C
L
A
R
A
V
E
AHSGASTTDSSLRPRDSFRGSR
S
L
S
F
R
M
R
E
P
L
S
S
I
S
S
VRSI
37
HHSearch
93.35
39%
-158
- C5 -
3V2Y
2
ENLYS_BPT4
A:
[34-495]
---------------
V
S
D
Y
V
N
Y
D
I
I
V
R
H
Y
N
Y
T
G
K
L
N
I
S
A
-
D
K
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
------
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
-
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
-
G
--
A
T
T
Y
K
L
T
P
A
Q
W
F
L
R
--
E
G
S
M
F
V
-
A
L
------
S
-
A
S
V
--
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
-
G
W
--------
N
-----------
C
I
--
S
-----
A
L
--
S
S
C
S
T
V
-------
L
----
P
L
-----
Y
H
---
K
H
Y
-
I
-
L
-
F
-
C
T
T
V
-
F
T
L
L
L
L
S
I
---
V
I
L
Y
C
R
-
I
-
Y
-----
S
L
V
R
T
R
N
I
F
E
M
-------------
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
A
S
R
S
---
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
-----
F
I
L
L
L
L
D
V
G
C
K
V
K
-
T
C
D
I
L
F
R
A
E
Y
------
F
L
V
L
A
V
L
N
S
G
T
-
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
----------------------------------------------------------
46
HHSearch
75.66
22%
-153
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
------
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
-
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
-
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
--
V
T
L
D
V
M
-
M
C
------
T
-
A
S
I
--
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
F
--------
N
-----------
T
T
--
G
-----
D
P
--
T
V
C
S
I
S
-------
N
----
P
D
-----------
F
V
-
I
-
Y
-
S
-
S
V
V
S
-
F
Y
L
P
F
G
V
T
---
V
L
V
Y
A
R
-
I
-
Y
-----
V
V
L
K
Q
R
R
R
K
N
I
-------------
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDA
Y
G
V
P
---
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
-----
F
L
T
H
V
L
N
T
H
C
Q
T
C
--
H
V
S
P
E
L
Y
S
A
------
T
T
W
L
G
Y
V
N
S
A
L
-
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
------------------------------------------------------------
43
HHSearch
74.38
23%
-157
- C5 -
3EML
13
ENLYS_BPT4
A:
[21-472]
---------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
A
V
G
V
L
A
-
I
P
F
A
I
T
I
-
S
--
T
-
G
F
C
A
A
C
H
G
C
L
F
I
--
A
C
F
V
L
V
-
L
T
------
Q
-
S
S
I
--
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
--------
N
-----------
N
C
--
G
-----
Q
S
--
Q
G
C
G
E
G
QVACLFE
D
----
V
V
-----
P
M
---
N
Y
M
-
V
Y
F
-
N
-
F
F
A
C
-
V
L
V
P
L
L
L
M
---
L
G
V
Y
L
R
-
I
-
F
-----
L
A
A
R
R
Q
L
N
I
F
E
-------------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
-
R
S
T
L
---
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
-----
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
H
A
P
L
W
L
M
Y
L
------
A
I
V
L
S
H
T
N
S
V
V
-
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------------------
42
HHSearch
74.26
20%
-151
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-----------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
------
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
-
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
--
M
S
K
W
S
L
G
R
P
L
C
L
F
W
--
L
S
M
D
Y
V
-
A
S
------
T
-
A
S
I
--
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
--
W
--------
N
-----------
H
----R----
R
E
--
D
K
C
E
T
D
-------
F
----
Y
D
-----
V
----
T
W
F
-
K
-
V
M
T
-
A
I
I
N
-
F
Y
L
P
T
L
L
M
---
L
W
F
Y
A
K
-
I
-
Y
-----
K
A
V
R
Q
H
C
N
I
F
E
-------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
L
H
M
---
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
-----
F
I
F
F
M
V
I
A
F
C
K
N
C
---
C
N
E
H
L
H
M
F
------
T
I
W
L
G
Y
I
N
S
T
L
-
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------------------------------------------------------------
44
HHSearch
73.90
20%
-150
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
----------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
------
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
-
V
M
G
L
A
V
-
V
P
F
G
A
A
H
-
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
--
T
S
I
D
V
L
-
C
V
------
T
-
A
S
I
--
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
--------
Y
-----------
R
A
TH
Q
-----
E
A
--
I
N
C
Y
A
E
-------
E
TCCD
F
F
-----
T
N
---
Q
A
Y
-
A
-
I
-
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
---
V
F
V
Y
S
R
-
V
-
F
-----
Q
E
A
K
R
Q
L
N
I
F
E
-------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
K
F
C
---
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-----
F
I
V
N
I
V
H
V
I
Q
D
N
L
---
I
R
K
E
V
Y
I
L
------
L
N
W
I
G
Y
V
N
S
G
F
-
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------------------
58
Fugue
73.02
21%
-130
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
---------------
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
-
S
--
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
--
E
G
F
F
A
T
-
L
G
------
G
E
I
A
L
--
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
--------
S
R
Y
I
P
E
GMQ---
C
S
--
C
-----
G
I
--
D
Y
Y
T
P
H
-------
E
----
E
T
-----
N
N
---
E
S
F
-
V
-
I
-
Y
-
M
F
V
V
H
F
I
I
P
L
I
V
I
---
F
F
C
Y
G
Q
-
L
-
V
-----
F
T
V
K
E
A
A
A
S
A
T
-------------
T
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
---
K
E
V
T
R
M
V
---
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
------
F
F
A
K
T
S
A
V
--
Y
-
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
----------------
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------------------
39
HHSearch
71.46
19%
-146
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
------
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
-
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
--
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
--
L
A
L
D
Y
V
-
V
S
------
N
-
A
S
V
--
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
W
--------
Q
-----------
F
I
--
V
GVRTV
E
D
--
G
E
C
Y
I
Q
-------
F
----
F
S
-----
N
----
A
A
V
-
T
-
F
G
T
-
A
I
A
A
-
F
Y
L
P
V
I
I
M
---
T
V
L
Y
W
H
-
I
-
S
-----
R
A
S
K
S
R
I
N
I
F
E
-------------
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
P
P
P
---
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
-----
N
V
M
V
L
I
N
T
F
C
A
P
C
---
I
P
N
T
V
W
T
I
------
G
Y
W
L
C
Y
I
N
S
T
I
-
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------------------------------
19
PsiBlast_PDB
70.98
23%
-159
- C5 -
3PQR
9
OPSD_BOVIN
A:
[55-326]
---------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-
T
T
T
L
Y
T
S
-
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
---
E
G
F
-
F
A
-
T
L
------
G
-
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
PEGM
Q
-----------
C
S
--
C
-----
G
I
--
D
Y
Y
T
P
H
-------
E
----
E
T
-----
N
N
---
E
S
F
-
V
-
I
-
Y
-
M
F
V
V
H
F
I
I
P
L
I
V
I
---
F
F
C
Y
G
Q
L
V
-
F
-----
T
V
K
E
A
A
A
Q
Q
Q
E
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
---
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-
I
F
T
H
--------
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------
18
PsiBlast_PDB
70.44
23%
-159
- C5 -
3DQB
6
GNAT1_BOVIN (first)
A:
[55-326]
---------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-
T
T
T
L
Y
T
S
-
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
---
E
G
F
-
F
A
-
T
L
------
G
-
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
PEGM
Q
-----------
C
S
--
C
-----
G
I
--
D
Y
Y
T
P
H
-------
E
----
E
T
-----
N
N
---
E
S
F
-
V
-
I
-
Y
-
M
F
V
V
H
F
I
I
P
L
I
V
I
---
F
F
C
Y
G
Q
L
V
-
F
-----
T
V
K
E
A
A
A
Q
Q
Q
E
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
---
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-
I
F
T
H
--------
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------
20
PsiBlast_PDB
70.03
23%
-160
- C5 -
3PXO
5
OPSD_BOVIN
A:
[55-326]
---------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-
T
T
T
L
Y
T
S
-
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
---
E
G
F
-
F
A
-
T
L
------
G
-
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
PEGM
Q
-----------
C
S
--
C
-----
G
I
--
D
Y
Y
T
P
H
-------
E
----
E
T
-----
N
N
---
E
S
F
-
V
-
I
-
Y
-
M
F
V
V
H
F
I
I
P
L
I
V
I
---
F
F
C
Y
G
Q
L
V
-
F
-----
T
V
K
E
A
A
A
Q
Q
Q
E
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
---
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-
I
F
T
H
--------
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------
57
Fugue
69.90
20%
-110
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
-----
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
----
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
-
S
--
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
--
E
G
F
F
A
T
L
G
G
------
E
-
I
A
L
--
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
--------
S
R
Y
I
P
E
GMQ---
C
S
--
C
-----
G
I
--
D
Y
Y
T
P
H
-------
E
----
E
T
-----
N
N
---
E
S
F
-
V
-
I
-
Y
-
M
F
V
V
H
F
I
I
P
L
I
V
I
---
F
F
C
Y
G
Q
-
L
V
F
-----
T
V
K
E
A
A
A
Q
Q
Q
E
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
---
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
------
F
F
A
K
T
S
A
--
V
Y
-
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
------
K
N
P
L
G
----
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------------------
17
PsiBlast_PDB
67.16
23%
-136
- C5 -
1F88
7
OPSD_BOVIN
A:
[55-343]
---------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-
T
T
T
L
Y
T
S
-
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
---
E
G
F
-
F
A
-
T
L
------
G
-
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
GM
Q
-----------
C
S
--
C
-----
G
I
--
D
Y
Y
T
P
H
-------
E
----
E
T
-----
N
N
---
E
S
F
-
V
-
I
-
Y
-
M
F
V
V
H
F
I
I
P
L
I
V
I
---
F
F
C
Y
G
Q
L
V
-
F
-----
T
V
K
E
A
A
A
-----------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
---
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-
I
F
T
H
--------
Q
G
S
D
F
GPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
----------------
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------------------
15
PsiBlast_PDB
66.21
23%
-163
- C5 -
3CAP
5
OPSD_BOVIN
A:
[55-326]
---------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-
T
T
T
L
Y
T
S
-
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
---
E
G
F
-
F
A
-
T
L
------
G
-
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
PEGM
Q
-----------
C
S
--
C
-----
G
I
--
D
Y
Y
T
P
H
-------
E
----
E
T
-----
N
N
---
E
S
F
-
V
-
I
-
Y
-
M
F
V
V
H
F
I
I
P
L
I
V
I
---
F
F
C
Y
G
Q
L
V
-
F
-----
T
V
K
E
A
A
A
Q
Q
Q
E
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
---
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-
I
F
T
H
--------
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---------------------------------------------------------
16
PsiBlast_PDB
66.11
23%
-73
- C- -
3C9L
13
OPSD_BOVIN
A:
[55-332]
---------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
-
T
T
T
L
Y
T
S
-
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
---
E
G
F
-
F
A
-
T
L
------
G
-
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
GM
Q
-----------
C
S
--
C
-----
G
I
--
D
Y
Y
T
P
H
-------
E
----
E
T
-----
N
N
---
E
S
F
-
V
-
I
-
Y
-
M
F
V
V
H
F
I
I
P
L
I
V
I
---
F
F
C
Y
G
Q
L
V
-
F
-----
T
V
K
E
A
A
A
Q
Q
Q
E
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
---
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
-
I
F
T
H
--------
Q
G
S
D
F
GPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---
D
D
----------
E
-----------------------------------------
45
HHSearch
64.89
19%
-126
- C5 -
1U19
14
OPSD_BOVIN
A:
[40-327]
---------------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
-
G
G
------
E
-
I
A
L
--
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
--------
S
-----------
R
Y
--
I
P
----
E
G
MQ
C
S
C
G
I
D
-------
Y
----
Y
T
PHEET
N
N
---
E
S
F
-
V
-
I
-
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
---
F
F
C
Y
G
Q
-
L
-
V
-----
F
T
V
K
E
A
A
A
Q
Q
Q
-------------
E
S-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
---
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-----
A
G
V
A
F
Y
I
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
------
P
A
F
F
A
K
T
S
A
V
Y
-
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------------
11
PsiBlast_PDB
64.78
27%
-142
- C5 -
3REY
1
AA2AR_HUMAN
A:
[12-294]
---------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
-------------
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
-
A
C
F
V
L
V
L
A
Q
-
S
S
I
--
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
--------
N
NCGQPGCGEGQ
V
A
--
C
-----
L
F
--
E
---
D
V
-------
V
----
P
M
-----
N
Y
---
M
V
Y
-
F
-
N
-
F
------
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-------------
G
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
------
M
Y
L
------
A
I
V
L
A
H
T
N
S
V
V
-
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
------------------------------------------------------------
40
HHSearch
64.33
18%
-140
* C5 *
2Z73
5
OPSD_TODPA
A:
[32-335]
-------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
------
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
-
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
--
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
--
G
F
I
G
G
I
-
F
G
------
F
-
M
S
I
--
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
W
--------
G
-----------
A
Y
--
T
L
E
G--
V
L
--
C
N
C
S
F
D
-------
Y
----
I
S
-----
R
D
S
T
T
R
S
N
I
L
-
C
-
M
-
F
I
L
G
-
F
F
G
P
I
L
I
I
---
F
F
C
Y
F
N
-
I
-
V
-----
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
G
A
---
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
-----
A
V
V
A
L
L
A
Q
F
G
P
L
E
--
W
V
T
P
Y
A
A
Q
L
------
P
V
M
F
A
K
A
S
A
I
H
-
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
----------------------------------
2
PsiBlast_PDB
64.26
41%
-161
- C5 -
3V2Y
2
ENLYS_BPT4
A:
[34-248]
---------------
V
S
D
Y
V
N
Y
D
I
I
V
R
H
Y
N
Y
T
G
K
L
N
I
S
A
D
K
E
N
S
-
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
------
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
-
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
-
G
--
A
T
T
Y
K
L
T
P
A
Q
W
F
L
R
--
E
G
S
M
F
V
-
A
L
------
S
-
A
S
V
--
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
----------
N
N
F
-
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
-
G
W
--------
N
-----------
C
I
--
S
-----
A
L
--
S
S
C
S
T
V
-------
L
----
P
L
-----
Y
H
---
K
H
Y
-
I
-
L
-
F
-
C
T
T
V
-
F
T
L
L
L
L
S
I
---
V
I
L
Y
C
R
-
I
-
Y
-----
S
L
V
R
T
R
N
I
F
E
M
-------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
---
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-----
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
------
K
D
E
A
E
K
L
F
N
Q
D
-
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
14
PsiBlast_PDB
64.18
27%
-142
- C5 -
3UZC
1
AA2AR_HUMAN
A:
[12-294]
---------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
-------------
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
-
A
C
F
V
L
V
L
A
Q
-
S
S
I
--
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
--------
N
NCGQPGCGEGQ
V
A
--
C
-----
L
F
--
E
---
D
V
-------
V
----
P
M
-----
N
Y
---
M
V
Y
-
F
-
N
-
F
------
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-------------
G
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
------
M
Y
L
------
A
I
V
L
A
H
T
N
S
V
V
-
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
------------------------------------------------------------
12
PsiBlast_PDB
63.98
27%
-140
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[12-294]
---------------------------------------------------
V
E
L
A
I
A
V
L
A
I
L
------
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-
L
V
G
V
L
-------------
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
-
A
C
F
V
L
V
L
A
Q
-
S
S
I
--
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
--------
N
NCGQPGCGEGQ
V
A
--
C
-----
L
F
--
E
---
D
V
-------
V
----
P
M
-----
N
Y
---
M
V
Y
-
F
-
N
-
F
------
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-
I
-
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-------------
G
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
------
M
Y
L
------
A
I
V
L
A
H
T
N
S
V
V
-
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
------------------------------------------------------------