@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SCTR_HUMAN: (2016-01-14 )
MRPHLSPPLQQLLLPVLLACAAHSTGALPRLCDVLQVLWEEQDQCLQELSREQTGDLGTEQPVPGCEGMWDNISCWPSSVPGRMVEVECPRFLRMLTSRNGSLFRNCTQDGWSETFPRPNLACGVNVNDSSNEKRHSYLLKLKVMYTVGYSSSLVMLLVALGILCAFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDVTYCDAHRAGCKLVMVLFQYCIMANYSWLLVEGLYLHTLLAISFFSERKYLQGFVAFGWGSPAIFVALWAIARHFLEDVGCWDINANASIWWIIRGPVILSILINFILFINILRILMRKLRTQETRGNEVSHYKRLARSTLLLIPLFGIHYIVFAFSPEDAMEIQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWQQWHLREFPLHPVASFSNSTKASHLEQSQGTCRTSII
Atome Classification :
(20 SA)
---------.........10........20........30..-......40........50........60....----....70--.........80..---......90.......-.-----100.........110....-....120---..-.......---130.......140-..------.....150....----...160......---.170--------.........-180.........190...-....200.....---.--.210.......220.--......230.......240---.-......250---........260--.......270...----..-..280-..-------.....-.---.290-----.-.------.----.-----.--.----...300.......310.......320.....---------.---.330......-.340....---...350.......360-----------.-----.--------.-------..-----..370....-.-..380-.......390-----....----...400.......410.......420.......430.----......440--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MRPHLSP
P
L
Q
Q
L
L
L
P
V
L
L
A
C
AAHSTGA
L
P
R
L
C
D
-
V
L
Q
V
L
W
E
E
Q
D
Q
C
L
Q
E
L
S
R
EQTGDLGTEQPVPG----CEGMW---DNISCWPSSVPG
R
---
M
V
EVE
C
P
R
F
L
R
M
L
T
S-R-----N--
G
S
L
F
R
N
C
T
QD-GWSET-FPRPN-----
L
A
-
C
G
V
NVND---SSN
E
K
R
H
S
Y
L
L
K
L
-
K
V
------
M
Y
T
VGY
S
S
S
L
V
M
----
L
L
V
A
L
G
I
L
C
A
F
R
---
R
L
----------
H
C
T
R
N
Y
I
H
M
-
H
--
L
F
V
S
F
I
L
R
A
L
S
N
F
I
K
-
D
A
VLFSSDD
V
T
Y
---C--DAHRA
G
C
K
L
V
M
V
L
F
Q
--
Y
C
I
MAN
Y
S
W
L
L
V
E
G
L
Y
L
H
T
---
L
-
L
A
I
S
F
F
S
E
----
R
K
Y
L
Q
G
F
V
AFG--WG
S
P
A
I
F
V
A
L
W
A
I
----
A
R
-
H
F
L
---
E
D-------VGCWD-I---NA-------N-
A
------
S
----
I
-----
W
--
W
----
I
IR
G
P
V
I
L
S
I
L
I
N
F
I
L
F
I
N
I
L
R
I
L
M
R
K
LRTQ---------E---TRGN
E
V
S
H
Y
K
-
R
L
A
R
S
T
L
L
---
L
I
P
L
FG
I
H
Y
I
V
F
A
FSP-----------E-----D--------
A
-------
M
E
-----
I
Q
L
F
F
E
L
A
L
-
G
-
S
F
Q
G
L
-
V
V
A
V
L
Y
C
F
LN-----G
E
V
Q
----
L
E
V
Q
K
K
W
Q
Q
W
HLREFPLHPVASFSNST
K
A
S
H
L
E
QSQG----TCRTSII----
1
PsiBlast_PDB
87.14
48%
-164
- C4 -
4L6R
1
C562_ECOLX (first)
A:
[125-394]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
Q
V
------
M
Y
T
V
G
Y
S
L
S
L
G
A
----
L
L
L
A
L
A
I
L
G
G
L
S
---
K
L
----------
H
C
T
R
N
A
I
H
A
-
N
--
L
F
A
S
F
V
L
K
A
S
S
V
L
V
I
-
D
G
L
L
R
T
----------LS
D
G
A
V
A
G
C
R
V
A
A
V
F
M
Q
--
Y
G
I
V
A
N
Y
C
W
L
L
V
E
G
L
Y
L
H
N
---
L
-
L
G
L
A
T
L
P
E
----
R
S
F
F
S
L
Y
L
G
I
G
--
W
G
A
P
M
L
F
V
V
P
W
A
V
----
V
K
-
C
L
F
---
E
N
-------
V
Q
C
W
T
-
S
---
N
D
-------
N
-
M
------
G
----
F
-----
W
--
W
----
I
L
R
F
P
V
F
L
A
I
L
I
N
F
F
I
F
V
R
I
V
Q
L
L
V
A
K
L
R
A
R
---------
Q
---
M
H
H
T
D
---
Y
K
F
R
L
A
K
S
T
L
T
---
L
I
P
L
L
G
V
H
E
V
V
F
A
F
V
T
-----------
D
-----
E
--------
H
-------
A
Q
G
T
L
R
S
A
K
L
F
F
D
L
F
L
-
S
-
S
F
Q
G
L
-
L
V
A
V
L
Y
C
F
L
N
-----
K
E
V
Q
----
S
E
L
R
R
R
W
H
R
W
R
L
G
K
V
L
W
E
E
R
N
-------------------------------
21
PsiBlast_CBE
71.61
38%
-138
- C4 -
4K5Y
2
CRFR1_HUMAN
C:
[286-422]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
C
I
G
--
W
G
V
P
F
P
I
I
V
A
W
A
I
----
G
K
-
L
Y
Y
---
D
N
-------
E
K
C
W
A
-----
G
K
-------
R
-
P
------
G
----
V
-----
Y
TD
Y
----
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
A
S
---------
T
---
T
--
S
E
T
I
Q
A
R
-
K
A
V
K
A
T
L
V
---
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
P
G----------
E
-----
D
--------
E
-------
V
S
R
V
---
V
F
I
Y
F
N
A
F
L
-
E
-
S
F
Q
G
F
-
F
V
S
V
F
A
C
F
L
N
-----------------------------------------------------------------
51
Fugue
70.67
20%
-108
- C4 -
4K5Y
7
CRFR1_HUMAN (first)
A:
[13-423]
H
Y
H
V
A
A
I
I
N
Y
L
G
H
C
I
S
L
V
A
L
L
V
A
F
V
L
F
L
R
A
R
S
I
R
C
L
R
N
I
I
H
A
-
N
L
I
A
A
F
I
L
R
N
A
T
W
F
V
V
Q
L
T
M
S
P
E
V
H
Q
S
N
-
V
G
W
----
C
R
L
V
T
---
A
A
Y
N
Y
F
---
H
V
T
N
---
F
F
W
M
F
G
E
G
C
Y
L
H
T
A
I
-
V
-----
L
--
T
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
-
I
Y
K
D
T
EGYYT
I
G
-
I
G
H
L
L
T
K
---
S
P
S
L
S
V
A
K
S
E
L
D
K
-
A
I
GRNSNG
V
I
T
K
D
E
A
E
K
L
F
N
----
Q
D
V
D
A
A
V
R
G
I
L
R
---
N
A
----------
K
L
K
P
V
Y
D
S
L
D
A
--
V
R
R
S
A
L
I
N
M
V
F
Q
M
G
E
-
T
G
V
A
G
F
T
N
S
L
R
M
---
L
--
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
RW
Y
N
Q
T
P
N
R
A
K
R
V
I
A
T
F
R
T
G
T
---
W
---
D
A
Y
D
R
L
----
R
A
W
M
--
F
I
C
I
G
--
W
G
V
P
F
P
I
I
V
A
W
A
I
----
G
K
-
L
Y
Y
---
D
N
-------
E
K
C
W
A
G
K
---
R
P
-------
G
-
V
------
Y
----
T
-----
D
--
Y
----
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
A
S
---------
T
---
T
--
S
E
T
I
Q
A
R
-
K
A
V
K
A
T
L
V
---
L
L
P
L
L
G
I
T
Y
M
-
L
A
F
V
N
-----------
E
-----
V
--------
S
-------
R
V
-----
V
F
I
Y
F
N
A
F
L
-
E
-
S
F
Q
G
F
-
F
V
S
V
F
A
C
F
L
N
-----
S
-----------------------------------------------------------
56
Fugue
67.51
17%
-85
* C3 *
4RU0
4
?
A:
[30-444]
---------------
G
P
D
Q
Q
F
F
P
L
A
T
Y
R
V
G
A
Y
A
S
S
G
V
Q
V
W
A
G
M
I
---------
D
Y
L
N
Y
I
N
Q
V
E
G
G
I
N
G
V
K
L
V
W
Q
E
----
C
E
T
E
W
T
A
E
K
G
I
E
C
Y
E
R
F
K
N
G
L
DGA
P
V
A
V
Y
Q
P
N
--------------
G
--
A
P
A
A
Y
A
L
S
E
R
-
A
E
V
D
K
-
I
P
--
L
-----
I
T
-
L
G
Y
G
R
T
E
---
A
T
D
G
T
V
F
P
Y
--
N
F
-
P
V
M-----
L
T
F
Y
S
E
A
S
T
L
V
N
----
Y
I
A
Q
R
E
--
G
G
F
D
---
R
L
----------
K
G
K
K
I
A
T
L
Y
-
H
DS
A
Y
G
R
E
T
L
G
P
L
K
-
L
L
A
-
E
K
Y
G
F
E
N
I
Q
I
P
V
---
A
--
D
P
G
N
E
Q
----
S
A
Q
W
R
--
Q
I
R
Q
Q
N
P
D
W
V
F
L
R
T
W
G
V
S
T
---
P
-
V
A
V
K
T
A
A
R
-------------
F
G
--
F
P
V
D
H
I
I
G
D
I
W
A
S
----
S
S
-
E
D
V
---
L
P
-------
A
G
---------
A
-------
A
-
A
---------------------------
K
G
Y
L
A
L
T
P
Y
P
A
G
S
D
F
E
I
H
K
R
L
K
Q
Y
I
L
D
T
G
---------
K
---
S
D
L
K
D
L
K
N
F
G
-
S
V
Y
Y
N
S
G
L
---
V
N
A
A
V
A
V
E
A
I
R
T
A
Q
G
K
FGKRPLN
G
E
E
G
R
-----
W
--------
G
-------
L
E
-----
H
L
N
I
D
D
A
R
L
K
D
M
G
Y
L
G
L
M
Q
N
L
K
L
S
C
R
D
H
EGGG
A
A
R
V
Q
----
Q
W
D
G
A
N
W
T
L
I
S
E
W
I
A
A
D
R
A
L
L
R
P
L
I
D
E
K
A
A
A
F
A
K
E
K
R
LVPR
T
C
N
--------
54
Fugue
65.85
11%
-96
- C1 -
4JKV
10
C562_ECOLX (first)
A:
[2-470]
-----GTAD
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
-
A
A
L
D
A
Q
K
A
T
P
P
K
L
E
D
K
S
P
D
S
P
E
M
K
D
F
R
H
G
F
D
I
----
L
V
G
Q
I
---
D
D
A
L
K
L
A
N
E
G
K
V
K
---
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
-
Y
IQKYL
S
--
G
Q
C
E
V
P
L
V
R
T
-
D
N
P
K
S
-
W
Y
E
D
V
-----
E
G
-
C
G
I
Q
C
Q
N
PLF
T
E
A
E
H
Q
D
M
H
S
Y
I
A
-
A
F
------
G
A
V
T
G
L
C
T
L
F
T
L
----
A
T
F
V
A
D
W
R
N
S
N
R
YPA
V
I
----------
L
F
Y
V
N
A
C
F
F
-
V
--
G
S
I
G
W
L
A
Q
F
M
D
G
A
R
R
-
E
I
V
C
R
A
D
G
T
M
R
L
GEP
T
--
S
N
E
T
L
S
C
V
I
I
F
V
I
V
Y
--
Y
A
L
M
A
G
V
V
W
F
V
V
L
T
Y
A
W
H
T
---
S
F
K
A
L
G
T
T
Y
Q
----
P
G
K
T
S
Y
F
H
L
L
T
--
W
S
L
P
F
V
L
T
V
A
I
L
A
----
V
A
-
Q
V
D
---
G
D
SVSG
I
C
F
V
G
Y
K
N
-
Y
---
R
Y
-------
R
-
A
------
G
----
F
-----
V
-------
L
A
P
I
G
L
V
L
I
V
G
G
Y
F
L
I
R
G
V
M
T
L
F
S
I
K
S
N
H
P
G
---------
L
---
L
S
E
K
A
----
A
-
S
K
I
N
E
T
M
L
---
R
L
G
I
F
G
F
L
A
F
G
F
V
--------------
L
-----
I
--------
T
-------
F
S
-----
C
H
F
Y
D
F
F
N
Q
-
A
-
E
W
E
R
S
-
F
R
D
Y
V
L
C
Q
A
N
-----
C
E
I
K
N
R
P
S
L
L
V
E
K
I
N
L
F
A
M
F
G
T
G
I
A
M
S
T
W
V
W
T
K
A
T
L
L
I
W
R
R
T
W
C
----------------
58
Fugue
61.52
15%
-129
- C2 -
4DLQ
16
A:
[18-381]
---------------------------------------------------------------------
V
S
P
E
L
F
----
C
E
P
R
E
---
V
R
R
V
Q
W
P
A
T
Q
Q
G
M
---
L
V
E
R
P
C
P
------
K
G
-
T
-----
R
--
G
I
A
S
F
Q
C
L
P
A
-
L
G
L
W
N
-
P
R
G
P
D
-----
L
S
N
C
T
S
P
W
V
N
---
Q
V
A
Q
K
I
K
S
G
E
N
A
A
-
N
I
------
A
S
E
L
A
R
H
T
R
G
S
I
Y
A
G
D
V
S
S
S
V
K
L
M
E
Q
L
L
---
D
I
L
D
A
Q
L
Q
A
L
RN
K
M
H
K
R
E
R
T
C
-
K
--
D
Y
I
K
A
V
V
E
T
V
D
N
L
L
R
-
P
E
A
L
E
S
W
K
D
M
N
A
---
T
--
E
Q
V
H
T
A
T
M
L
L
D
V
L
E
E
--
G
A
F
L
L
A
D
N
V
R
E
P
A
R
F
L
A
A
K
QN
V
V
-
L
E
V
T
V
L
S
T
----
E
G
Q
V
Q
E
L
V
F
P
Q
--
E
Y
A
S
E
S
S
I
Q
L
S
A
N
----
T
I
-
K
Q
N
---
S
R
-------
N
G
-----------------------------------------------------
V
V
K
V
V
F
I
L
Y
N
N
L
G
L
F
L
S
T
E
N
A
T
V
---------
K
---
L
A
G
E
A
G
T
G
G
P
-
G
G
A
S
L
V
V
---------
N
S
Q
V
I
A
A
S
I
N
K
-----------
E
---------------------------------------
S
-
S
R
V
F
L
-
M
D
P
V
I
F
T
V
A
H
-----
L
E
A
K
----
N
H
F
N
A
N
C
S
F
W
N
Y
S
E
R
S
M
L
G
Y
W
S
-
T
Q
G
C
R
L
V
E
S
N
K
T
H
T
----
T
C
A
C
S
H
L
----
42
HHSearch
61.46
14%
-140
- C4 -
2KS9
1
NK1R_HUMAN
A:
[36-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
------
A
Y
T
V
I
V
V
T
S
V
V
G
----
N
V
V
V
M
W
I
I
L
A
H
K
---
R
M
----------
R
T
V
T
N
Y
F
L
V
-
N
--
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
-
N
F
T
Y
A
V
H
N
E
------
W
--
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
--
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
---
A
-
I
I
H
P
L
Q
P
R
LS--
A
T
A
T
K
V
V
I
C
V
I
--
W
V
L
A
L
L
L
A
F
P
Q
G
Y
----
Y
S
-
T
T
E
TMP
S
R
-------
V
V
C
M
I
-
E
WPE
H
P
-------
N
-
K
IY
E
K
--
V
----
Y
H
I
C
V
T
V
--
L
----
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
----
T
L
W
A
S
E
I
P
G
---------
D
SSD
R
Y
H
E
Q
V
S
A
K
R
-
K
V
V
K
M
M
I
V
---
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
-----------
L
-----
L
P
Y
I
N----
P
DLYLKKF
I
Q
-----
Q
V
Y
L
A
I
M
W
L
-
A
-
M
S
S
T
M
-
Y
N
P
I
I
Y
C
C
L
N
-----
D
R
F
R
----
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
----
V
S
R
L
E
T
T
----
33
HHSearch
58.16
8%
-144
- C4 -
2Z73
5
OPSD_TODPA
A:
[34-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
S
L
-
G
I
------
F
I
G
I
C
G
I
I
G
C
G
G
----
N
G
I
V
I
Y
L
F
T
K
T
K
---
S
L
----------
Q
T
P
A
N
M
F
I
I
-
N
--
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
---
K
---
W
--
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
--
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
---
V
-
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
--
W
L
W
S
V
L
W
A
I
G
P
I
F
----
G
W
G
A
Y
T
L
E
G
V
L
-------
C
N
C
S
F
-
D
---
Y
I
-------
S
-
R
D
S
T
T
R
S
N
I
L
C
M
F
-----
I
--
L
----
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
-
E
M
A
A
M
A
K
RLNAKE
L
R
---
K
A
Q
A
G
A
N
A
E
M
-
R
L
A
K
I
S
I
V
---
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
-----------
L
-----
L
A
Q
FGPLEW
V
-------
T
P
-----
Y
A
A
Q
L
P
V
M
F
-
A
-
K
A
S
A
I
-
H
N
P
M
I
Y
S
V
S
H
-----
P
K
F
R
----
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-----------------
38
HHSearch
57.59
13%
-128
- C4 -
1U19
14
OPSD_BOVIN
A:
[44-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
------
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
---
K
L
----------
R
T
P
L
N
Y
I
L
L
-
N
--
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
-
T
L
Y
T
S
L
H
G
Y
------
F
--
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
---
V
-
V
C
K
P
M
S
N
F
R
F
G
-
E
N
H
A
I
M
G
V
A
F
T
--
W
V
M
A
L
A
C
A
A
P
P
L
V
----
G
W
S
R
Y
I
P
--
E
G
MQ-----
C
S
C
G
I
-
D
---
Y
Y
TPHEETN
N
-
E
S
-----
F
----
V
-----
I
--
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
---------
Q
---
E
S
A
T
T
Q
K
A
E
K
-
E
V
T
R
M
V
I
I
---
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-----------
F
Y
I
F
T
H
Q
GS------
D
F------
G
P
-----
I
F
M
T
I
P
A
F
F
-
A
-
K
T
S
A
V
-
Y
N
P
V
I
Y
I
M
M
N
-----
K
Q
F
R
----
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------------
57
Fugue
55.55
19%
-96
- C3 -
4X90
12
PAG15_HUMAN
A:
[5-380]
---------------------
H
P
P
V
V
L
V
P
G
D
L
G
N
Q
L
E
A
K
L
D
K
-
P
T
V
V
H
Y
----
L
C
S
K
K
T
E
S
Y
F
T
I
W
L
N
L
E
L
L
L
P
-------------
V
I
I
D
C
W
I
D
N
I
-------------
R
L
V
Y
N
K
T
S
-
R
-----
A
--
T
Q
F
P
-----
D
-
G
V
D
V
R
-
V
P
G
F
G
-----
K
T
-
F
S
L
E
F
L
D
---
P
S
K
S
S
V
G
S
Y
F
H
T
M
V
E
S
------
L
V
G
W
G
Y
T
R
G
E
D
--------
V
R
G
A
P
Y
D
W
R
---
R
A
----------
P
N
E
N
------------
G
P
Y
F
L
A
L
R
E
M
I
E
-
E
M
Y
Q
L
Y
G
G
P
V
V
L
---
V
---
A
H
S
M
G
N
M
Y
T
L
Y
F
L
Q
--
R
-------------------------
Q
P
Q
A
W
K
----
D
K
Y
I
R
A
F
V
S
L
G
AP
W
G
G
V
A
K
T
L
R
V
L
A
S
GDNN
R
I
-
P
V
I
---
G
P
-------
L
K
I
R
E
-
Q
---
Q
R
-------
S
A
V
------
S
----
T
-----
S
--
W
----
L
L
P
Y
N
Y
T
W
S
P
E
K
V
F
V
Q
T
P
T
I
N
Y
T
L
R
D
Y
R
K
F
F
---------
Q
---
D
I
G
F
E
D
G
W
L
M
-
R
Q
D
T
E
G
L
V
EAT
M
P
P
G
V
Q
L
H
C
L
Y
G
T
G
V
P
----------------------------------
T
P
-----
D
S
F
Y
Y
E
------
S
F
P
D
R
-
D
P
K
I
C
F
G
D
G
D
-----
G
T
V
N
----
L
K
S
A
L
Q
C
Q
A
W
Q
S
R
Q
E
H
Q
V
L
L
Q
E
L
P
G
S
E
H
I
E
M
L
A
N
A
T
T
----
L
A
Y
L
K
R
V
L
LGP
49
Fugue
55.54
38%
-37
- C5 -
2JOD
-
PACR_HUMAN
A:
[17-122]
------------------------------------
M
G
S
M
A
H
-
S
D
G
I
F
K
K
E
Q
A
M
C
L
E
K
I
Q
R
A
N
E
L
M
-
G
F
N
D
S
S
P
G
----
C
P
G
M
W
---
D
N
I
T
C
W
K
P
A
H
V
G
E
---
M
V
L
V
S
C
P
E
L
F
R
I
F
N
P
-
D
-----
Q
DM
G
V
V
S
R
N
C
T
E
D
-
G
W
S
E
P
-
F
P
H
Y
F
-----
D
A
-
C
G
F
D
E
Y
E
---
S
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
54.89
38%
-36
- C5 -
2JOD
-
PACR_HUMAN
A:
[17-120]
--------------------------
M
G
S
M
A
H
S
D
G
-----------
I
F
K
K
E
Q
A
M
C
L
E
K
I
Q
R
A
N
E
-
L
M
G
F
N
D
S
S
P
G
----
C
P
G
M
W
---
D
N
I
T
C
W
K
P
A
H
V
G
E
---
M
V
L
V
S
C
P
E
L
F
R
I
F
N
P
-
D
-----
Q
DM
G
V
V
S
R
N
C
T
E
D
-
G
W
S
E
P
-
F
P
H
Y
F
-----
D
A
-
C
G
F
D
E
Y
E
---
S
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
54.22
38%
-141
- C4 -
4K5Y
7
CRFR1_HUMAN (first)
B:
[286-423]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
C
I
G
--
W
G
V
P
F
P
I
I
V
A
W
A
I
----
G
K
-
L
Y
Y
---
D
N
-------
E
K
C
W
A
-----
G
K
-------
R
-------------------
Y
TD
Y
----
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
A
S
---------
T
---
T
--
S
E
T
I
Q
A
R
-
K
A
V
K
A
T
L
V
---
L
L
P
L
L
G
I
T
Y
M
L
A
---------------------------------------------
V
F
I
Y
F
N
A
F
L
-
E
-
S
F
Q
G
F
-
F
V
S
V
F
A
C
F
L
N
-----
S
-----------------------------------------------------------
4
PsiBlast_PDB
53.98
42%
-34
- C5 -
3N94
1
MALE_ECOLI
A:
[376-466]
----------------------------------------------
I
F
K
K
E
Q
A
M
C
L
E
K
I
Q
R
A
N
E
L
-
M
G
F
N
D
S
S
P
G
----
C
P
G
M
W
---
D
N
I
T
C
W
K
P
A
H
V
G
E
---
M
V
L
V
S
C
P
E
L
F
R
I
F
N
P
-
D
-----
Q
DM
G
V
V
S
R
N
C
T
E
D
-
G
W
S
E
P
-
F
P
H
Y
F
-----
D
A
-
C
G
F
D
E
Y
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.31
43%
-20
- C5 -
2X57
-
VIPR2_HUMAN
A:
[33-110]
-------------------------------------------------
E
E
E
T
K
C
-
A
E
L
L
R
S
Q
T
------
E
K
H
K
A
----
C
S
G
V
W
---
D
N
I
T
C
W
R
P
A
N
V
G
E
---
T
V
T
V
P
C
P
K
V
F
S
N
F
Y
S
-
K
-----
A
--
G
N
I
S
K
N
C
T
S
D
-
G
W
S
E
T
-
F
P
D
F
V
-----
D
A
-
C
G
Y
S
D
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
51.37
35%
-21
- C5 -
3N94
1
MALE_ECOLI
A:
[373-468]
-------------------------------------------
E
F
A
I
F
K
K
E
Q
A
M
C
L
E
K
I
Q
R
A
N
E
-
L
M
G
F
N
D
S
S
P
G
----
C
P
G
M
W
---
D
N
I
T
C
W
K
P
A
H
V
G
E
---
M
V
L
V
S
C
P
E
L
F
R
I
F
N
P
-
D
QD---
M
--
G
V
V
S
R
N
C
T
E
D
-
G
-
W
S
E
P
F
P
H
-
Y
-----
F
D
-
A
C
G
F
D
E
Y
---
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
51.01
34%
-34
- C5 -
2XDG
2
GHRHR_HUMAN
A:
[2-86]
----------------------------------------------
M
L
R
E
D
E
S
A
C
L
Q
A
A
E
E
M
P
Q
T
T
L
G
-----------
C
P
A
T
W
---
D
G
L
L
C
W
P
T
A
G
S
G
E
---
W
V
T
L
P
C
P
D
F
F
S
H
F
S
S
-
E
-----
S
--
G
A
V
K
R
D
C
T
I
T
-
G
W
S
E
P
-
F
P
P
Y
P
-----
V
A
-
C
P
V
P
L
E
L
---
L
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
50.66
38%
-126
- C4 -
4K5Y
4
CRFR1_HUMAN (first)
A:
[286-423]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
C
I
G
--
W
G
V
P
F
P
I
I
V
A
W
A
I
----
G
K
-
L
Y
Y
---
D
N
-------
E
K
C
W
A
-----
G
K
-------
R
-
P
------
G
----
V
-----
Y
TD
Y
----
I
Y
Q
G
P
M
A
L
V
L
L
I
N
F
I
F
L
F
N
I
V
R
I
L
M
T
K
L
R
A
S
---------
T
---
T
--
S
E
T
I
Q
A
R
-
K
A
V
K
A
T
L
V
---
L
L
P
L
L
G
I
T
Y
M
L
A
F
V
N
---------------------------
E
-------
V
S
R
V
---
V
F
I
Y
F
N
A
F
L
-
E
-
S
F
Q
G
F
-
F
V
S
V
F
A
C
F
L
N
-----
S
-----------------------------------------------------------
8
PsiBlast_PDB
49.84
32%
-17
- C5 -
3C59
1
GLP1R_HUMAN
A:
[6-85]
------------------------------------
T
V
S
L
W
E
-
T
V
Q
K
W
R
E
Y
R
R
Q
C
Q
R
S
L
---------
T
E
D
P
P
P
A
TDLF
C
N
R
T
F
---
D
E
Y
A
C
W
P
D
G
E
P
G
S
---
F
V
N
V
S
C
P
W
Y
L
P
W
A
S
S
V
P
-----
Q
--
G
H
V
Y
R
F
C
T
A
E
-
G
L
W
L
Q
-
K
D
N
S
S
-----
L
P
-
W
R
D
L
S
E
C
---
E
E
S
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
49.46
34%
-21
- C5 -
2XDG
2
GHRHR_HUMAN
A:
[2-86]
----------------------------------------------
M
L
R
E
D
E
S
A
C
L
Q
A
A
E
E
-------
M
P
Q
T
T
L
G
----
C
P
A
T
W
---
D
G
L
L
C
W
P
T
A
G
S
G
E
---
W
V
T
L
P
C
P
D
F
F
S
H
F
S
S
-
E
-----
S
--
G
A
V
K
R
D
C
T
I
T
-
G
W
S
E
P
-
F
P
P
-
Y
-----
P
V
-
A
C
P
V
P
L
E
---
L
L
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------