@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SSR1_HUMAN: (2016-01-14 )
MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL
Atome Classification :
(20 SA)
.........10........20........30........40........50......----..60........70........80........90........100.......-110.-........-120.-.......130.......140.......150.......160......---.170.......180...-....190.......200-........210..---.....220-........230.......240....----...-250----------------------------------------..-----------------------------..--------------------------------..-----------------------------------------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------------------------------------------------------------------260....----...270.----......280.......290......------------.------300--------.------------....----...----.310--...--.....320...--....330--.......340.......350.......360.......370.......380........390-------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQG
S
----
A
I
L
I
S
F
I
Y
S
V
V
C
L
V
G
LCGN
S
M
V
I
Y
V
I
L
R
Y
AKMKTA
T
N
I
Y
I
L
N
L
A
I
A
D
E
L
L
M
L
-
S
--
V
-
P
F
L
V
T
S
T
L
-
L
R
-H-WP
F
G
A
L
L
C
R
L
V
L
S
V
D
A
V
N
M
F
T
S
I
Y
C
L
T
V
LSVD
R
Y
V
A
V
VHP
I
K
A
ARY---RR
P
T
V
A
K
V
V
N
L
G
V
W
V
L
S
-
L
L
V
I
L
P
I
V
V
FSRTAAN--SDG
T
V
A
C
NMLMPE---
P
A
Q
R
W
L
V
--
G
F
V
L
Y
T
F
L
M
G
F
L
L
P
V
G
A
I
C
L
C
Y
V
L
I
----
I
A
K
-
M
R
M
----------------------------------------
V
A
-----------------------------
L
K--------------------------------A
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
W
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
R
KRSE----R
K
I
T
L
M
V
----
M
M
V
V
M
V
F
V
I
C
W
M
P
F
Y
V
V
Q
L
V
N
V
F
AE------------Q------D----------D------------
A
T
V
S
----
Q
L
S
----
V
I
L
---
G
Y
A
--
N
SCA
N
P
I
L
Y
G
F
--LS
D
N
F
K
R
--
S
F
Q
R
I
L
C
L
S
W
M
D
NAAEE
P
V
D
Y
Y
A
T
A
L
K
SRAYSVEDFQPENLESGGVFRN-GTCTSRITTL--------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
95.18
44%
-161
- C5 -
4RWA
2
C562_ECOLX (first)
A:
[92-405]
-------------------------------
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
-
P
F
Q
S
A
K
Y
L
-
M
E
-
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
-
S
G
V
G
V
P
I
M
V
M
A
V
T
R
P
R
---
D
G
A
V
V
C
M
L
Q
F
P
S
---
P
S
W
Y
W
D
T
--
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
----
L
L
---------------------------------------------------------------------------------------------------------------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
R
S
L
----
R
R
I
T
R
M
V
----
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
------------
I
------
D
RR--------
D
------------
P
L
V
V
A
A
L
-
H
L
C
----
I
A
L
---
G
Y
A
--
N
S
S
L
N
P
V
L
Y
A
F
--
L
D
E
N
F
K
R
--
C
F
R
Q
L
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
94.51
44%
-160
- C5 -
4RWA
1
C562_ECOLX (first)
B:
[92-403]
-------------------------------
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
-
P
F
Q
S
A
K
Y
L
-
M
E
-
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
-
S
G
V
G
V
P
I
M
V
M
A
V
T
R
P
R
---
D
G
A
V
V
C
M
L
Q
F
P
S
---
P
S
W
Y
W
D
T
--
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
----
L
L
R
--------------------------------------------------------------------------------------------------------------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
R
S
L
----
R
R
I
T
R
M
V
----
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
------------
I
------
D
RR--------
D
------------
P
L
V
V
A
A
L
-
H
L
C
----
I
A
L
---
G
Y
A
--
N
S
S
L
N
P
V
L
Y
A
F
--
L
D
E
N
F
K
R
--
C
F
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.56
44%
-155
- C5 -
4RWD
6
C562_ECOLX (first)
B:
[92-405]
-------------------------------
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
G
A
R
S
A
S
SLAL
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
-
P
F
Q
S
A
K
Y
L
-
M
E
-
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
-
S
G
V
G
V
P
I
M
V
M
A
V
T
R
P
R
---
D
G
A
V
V
C
M
L
Q
F
P
S
---
P
S
W
Y
W
D
T
--
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
----
L
L
R
-
L
R
S
----------------------------------------
V
R
-----------------------------
L
L
--------------------------------
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
R
S
L
----
R
R
I
T
R
M
V
----
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
------------
I
------
D
RR--------
D
------------
P
L
V
V
AAL-
H
L
C
----
I
A
L
---
G
Y
A
--
N
S
S
L
N
P
V
L
Y
A
F
--
L
D
E
N
F
K
R
--
C
F
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
91.58
44%
-155
- C5 -
4RWD
7
C562_ECOLX (first)
A:
[92-405]
-------------------------------
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
-
P
F
Q
S
A
K
Y
L
-
M
E
-
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
-
S
G
V
G
V
P
I
M
V
M
A
V
T
R
P
R
---
D
G
A
V
V
C
M
L
Q
F
P
S
---
P
S
W
Y
W
D
T
--
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
----
L
L
R
-
L
R
S
----------------------------------------
V
R
-----------------------------
L
L
--------------------------------
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
R
S
L
----
R
R
I
T
R
M
V
----
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
------------
I
------
D
RR--------
D
------------
P
L
V
V
A
A
L
-
H
L
C
----
I
A
L
---
G
Y
A
--
N
S
S
L
N
P
V
L
Y
A
F
--
L
D
E
N
F
K
R
--
C
F
R
Q
L
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.79
43%
-157
- C5 -
5C1M
7
?
A:
[1-296]
-----------------------------------------
G
S
H
S
L
-
P
Q
T
G
S
P
S
M
V
T
----
A
I
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
-
P
F
Q
S
V
N
Y
L
-
M
G
-
T
-
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
-
S
A
I
G
L
P
-
V
M
F
M
A
T
T
K
Y
--
R
Q
G
S
I
D
C
T
L
T
F
S
H
---
P
T
W
Y
W
E
N
--
L
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
----
I
L
R
-
L
K
S
----------------------------------------
V
R
-----------------------------
M
L
--------------------------------
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
R
N
L
----
R
R
I
T
R
M
V
----
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
I
T
------------
I
------
P
----------
E
------------
T
T
F
Q
----
T
V
S
W
H
F
C
I
A
L
---
G
Y
T
--
N
S
C
L
N
P
V
L
Y
A
F
--
L
D
E
N
F
K
R
--
C
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
90.35
43%
-169
- C5 -
4EA3
3
C562_ECOLX (first)
B:
[123-407]
-------------------------------------------------------
G
L
----
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
-
T
--
L
-
P
F
Q
G
T
D
I
L
-
L
G
-
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
I
R
A
L
D
V
---
R
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
-
S
V
V
G
V
P
V
A
I
M
G
-
S
A
-------
E
I
E
C
L
V
E
I
P
T
---
P
Q
D
Y
W
G
P
--
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
----
I
R
R
-
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
N
L
----
R
R
I
T
R
L
V
----
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
------------
Q
------
P
----------
S
------------
S
E
T
A
V
A
I
L
R
F
C
----
T
A
L
---
G
Y
V
--
N
S
C
L
N
P
I
L
Y
A
F
--
L
D
E
N
F
K
A
--
C
F
R
K
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.99
46%
-161
- C5 -
4N6H
23
C562_ECOLX (first)
A:
[125-408]
-------------------------------------------------------------
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
-
P
F
Q
S
A
K
Y
L
-
M
E
-
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
-
S
G
V
G
V
P
I
M
V
M
A
V
T
R
P
R
---
D
G
A
V
V
C
M
L
Q
F
P
S
---
P
S
W
Y
W
D
T
--
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
----
L
L
R
-
L
R
S
----------------------------------------
V
R
-----------------------------
L
L
--------------------------------
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
R
S
L
----
R
R
I
T
R
M
V
----
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
------------
I
------
D
RR--------
D
------------
P
L
V
V
A
A
L
-
H
L
C
----
I
A
L
---
G
Y
A
--
N
S
S
L
N
P
V
L
Y
A
F
--
L
D
E
N
F
K
R
--
C
F
R
Q
L
C
R
K
P
C
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.50
43%
-168
- C5 -
4EA3
3
C562_ECOLX (first)
A:
[123-405]
-------------------------------------------------------
G
L
----
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
-
T
--
L
-
P
F
Q
G
T
D
I
L
-
L
G
-
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
-
S
V
V
G
V
P
V
A
I
M
G
-
S
A
Q
V
--
E
D
E
E
I
E
C
L
V
E
I
P
T
---
P
Q
D
Y
W
G
P
--
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
----
I
R
R
-
L
R
G
----------------------------------------
V
R
-----------------------------
L
L
--------------------------------
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
D
R
N
L
----
R
R
I
T
R
L
V
----
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
------------
Q
------
P
----------
S
------------
S
E
T
A
V
A
I
L
R
F
C
----
T
A
L
---
G
Y
V
--
N
S
C
L
N
P
I
L
Y
A
F
--
L
D
E
N
F
K
A
--
C
F
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
87.02
29%
-149
- C5 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-498]
----------------------------------------------
P
C
F
R
E
E
N
A
N
F
N
----
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
--
L
-
P
F
W
A
V
D
A
V
--
A
-
N
-
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
-
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
---
A
D
D
R
Y
I
C
D
R
F
Y
P
N
---
D
L
--
W
V
V
--
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
----
I
S
K
-
L
S
H
----------------------------------------
S
G
-----------------------------
S
N
--------------------------------
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY
G
S
K
G
H
Q
K
----
R
K
A
L
K
T
T
----
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
-
N
------
T
----------
V
------------
H
K
W
I
----
S
I
T
----
E
A
L
---
A
F
F
--
H
C
C
L
N
P
I
L
Y
A
F
--
L
G
A
K
F
K
T
--
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
86.53
28%
-162
- C5 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----------------
S
F
K
C
A
----------------------------
L
T
K
T
G
F
Q
----
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
--
L
-
P
A
L
I
F
Y
Y
F
-
N
K
-
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
K
K
N
A
I
C
I
S
V
L
-
V
W
L
I
V
-
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
--
K
N
K
T
I
T
C
Y
D
T
T
S
D
---
E
Y
L
R
S
Y
F
--
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
----
V
R
A
-
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCG
V
G
-----------------------------
K
D
--------------------------------
Q
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
E
E
P
L
R
----
R
K
S
I
Y
L
V
----
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
------------
L
------
D
----------
F
QTPAM
C
A
F
N
D
R
V
Y
A
T
Y
----
Q
V
T
----
R
G
L
---
A
S
L
--
N
S
C
V
N
P
I
L
Y
F
L
--
A
G
D
T
F
R
R
--
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
85.99
28%
-145
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
--
M
-
P
M
N
I
L
Y
L
L
-
M
S
-
K
-
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
-
F
L
W
V
I
P
I
L
G
W
N
H
-------
R
R
E
D
K
C
E
T
D
F
Y
D
---
V
-----
T
--
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
----
Y
K
A
-
V
R
Q
----------------------------------------
H
C
-----------------------------
N
I
--------------------------------
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
L
H
M
N
R
E
----
R
K
A
A
K
Q
L
----
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
------------
N
C-----
C
----------
N
------------
E
H
L
H
----
M
F
T
----
I
W
L
---
G
Y
I
--
N
S
T
L
N
P
L
I
Y
P
L
--
C
N
E
N
F
K
K
--
T
F
K
R
I
L
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
85.40
25%
-146
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
-------------------------------------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
--
M
-
N
L
Y
T
L
Y
T
V
-
I
G
-
Y
-
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
-
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
VR
T
V
E
D
G
E
C
Y
I
Q
F
F
S
---
N
-----
A
--
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
----
S
R
A
-
S
K
S
----------------------------------------
R
I
-----------------------------
N
I
--------------------------------
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
P
P
P
S
R
E
----
K
K
V
T
R
T
I
----
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
------------
P
C-----
I
----------
P
------------
N
T
V
W
----
T
I
G
----
Y
W
L
---
C
Y
I
--
N
S
T
I
N
P
A
C
Y
A
L
--
C
N
A
T
F
K
K
--
T
F
K
H
L
L
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
83.58
27%
-151
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
--
M
-
P
W
V
V
Y
L
E
V
T
G
G
-
V
-
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
-
F
A
V
S
C
P
L
L
F
G
F
N
T
T
-----
G
D
P
T
V
C
S
I
S
N
P
-------------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
----
Y
V
V
-
L
K
Q
----------------------------------------
R
R
-----------------------------
R
K
--------------------------------
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDA
Y
G
V
P
L
R
E
----
K
K
A
T
Q
M
V
----
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
------------
T
CH----
V
----------
S
------------
P
E
L
Y
----
S
A
T
----
T
W
L
---
G
Y
V
--
N
S
A
L
N
P
V
I
Y
T
T
--
F
N
I
E
F
R
K
--
A
F
L
K
I
L
S
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
83.23
26%
-142
* C5 *
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------------------------
D
E
V
W
----
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
--
V
-
P
F
G
A
A
H
I
L
-
M
K
-
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
-
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
--
H
Q
E
A
I
N
C
Y
A
E
E
T
C
---
C
D
F
F
T
N
Q
--
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
----
F
Q
E
-
A
K
R
----------------------------------------
Q
L
-----------------------------
N
I
--------------------------------
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
K
F
C
L
K
E
----
H
K
A
L
K
T
L
----
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
------------
N
L-----
I
----------
R
------------
K
E
V
Y
----
I
L
L
----
N
W
I
---
G
Y
V
--
N
S
G
F
N
P
L
I
Y
C
---
R
S
P
D
F
R
I
--
A
F
Q
E
L
L
C
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
82.17
25%
-163
- C5 -
4MBS
8
CCR5_HUMAN (first)
A:
[29-358]
------------------------------------------------------
Q
I
A
----
A
R
L
L
P
P
L
Y
S
L
V
F
I
F
G
F
V
G
N
M
L
V
I
L
I
L
I
N
Y
K
R
L
K
S
M
T
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
-
T
--
V
-
P
F
W
A
H
Y
A
A
-
A
Q
---
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
---
R
T
V
T
F
G
V
V
T
S
V
I
T
W
V
V
A
-
V
F
A
S
L
P
N
I
I
F
T
R
S
Q
K
E
--
G
L
H
Y
T
C
S
S
H
F
P
Y
S
---
Q
Y
Q
F
W
K
N
--
F
Q
T
L
K
I
V
I
L
G
L
V
L
P
L
L
V
M
V
I
C
Y
S
G
I
----
L
K
T
L
L
R
M
----------------------------------------
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKD
I
P
--------------------------------
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
W
VCPLCGVGKDQ
F
E
E
V
---------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
K
K
R
H
----
R
D
V
R
L
-
I
----
F
T
I
M
I
V
Y
F
L
F
W
A
P
Y
N
I
V
L
L
L
N
T
F
Q
E
FFGLNN
C
S
S
S
N
R
L
------
D
----------
Q
------------
A
M
------
Q
V
T
----
E
T
L
---
G
M
T
--
H
C
C
I
N
P
I
I
Y
A
F
--
V
G
E
E
F
R
N
--
Y
L
L
V
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
81.46
26%
-162
- C5 -
4XNV
15
P2RY1_HUMAN
A:
[56-382]
-------------------------------------------------------------------
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
--
L
-
P
A
L
I
F
Y
Y
F
-
N
K
T
D
-
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
-
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
--
K
N
K
T
I
T
C
Y
D
T
T
S
D
---
E
Y
L
R
S
Y
F
--
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
-
M
K
K
----------------------------------------
Y
T
-----------------------------
C
T
VCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCG
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
----
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
------------
L
------
D
FQTPAM
C
A
F
N
D
------------
R
V
Y
A
----
T
Y
Q
----
V
T
R
---
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
--
A
G
D
T
F
R
R
--
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
78.78
22%
-125
- C5 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-------------------
P
C
F
R
E
E
N
A
---------------------------
N
F
N
----
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
--
L
-
P
F
W
A
V
D
A
V
-
A
N
---
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
-
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
A
--
D
D
R
Y
I
C
D
R
F
Y
------
P
N
D
L
W
V
V
--
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
----
I
S
K
-
L
S
H
----------------------------------------
S
G
-----------------------------
S
N
--------------------------------
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
G
----
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
------------
A
IGRNTN
G
----------
V
------------
I
T
K
D
----
E
A
E
----
K
L
F
---
N
Q
D
--
V
D
A
A
V
R
G
I
L
R
N
AK
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
54
HHSearch
77.37
22%
-140
- C5 -
2Z73
5
OPSD_TODPA
A:
[27-335]
--------------------------------------------------
D
Q
V
P
D
A
V
----
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
-
V
N
G
F
-
P
L
M
T
I
S
C
F
-
L
K
-
K
-
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
-
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
--
E
G
V
L
C
N
C
S
F
D
Y
I
S
---
R
D
S
-
T
T
R
--
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
----
V
M
S
-
V
S
N
----------------------------------------
H
E
-----------------------------
K
E
--------------------------------
M
A
A
M
A
K
RLNAKE
L
R
K
----------------------------------------------------------------------------------------------------------------------------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
G
A
N
A
E
----
M
R
L
A
K
I
S
----
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
------------
L
EW----
V
----------
T
------------
P
Y
A
A
----
Q
L
P
----
V
M
F
---
A
K
A
--
S
A
I
H
N
P
M
I
Y
S
V
--
S
H
P
K
F
R
E
--
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
----------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
76.42
19%
-136
- C5 -
3EML
13
ENLYS_BPT4
A:
[20-472]
--------------------------------------------------------
G
----
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
--
I
-
P
F
A
I
T
I
S
---
T
-
G
-
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
-
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-----
S
Q
G
C
G
E
G
Q
V
A
CLF
E
D
V
V
P
M
N
--
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
----
F
L
A
-
A
R
R
----------------------------------------
Q
L
-----------------------------
N
I
--------------------------------
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
T
L
Q
K
E
----
V
H
A
A
K
S
L
----
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
------------
D
CSH---
A
----------
P
------------
L
W
L
M
----
Y
L
A
----
I
V
L
---
S
H
T
--
N
S
V
V
N
P
F
I
Y
A
Y
--
R
I
R
E
F
R
Q
--
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.03
29%
-154
- C5 -
4LDO
3
A:
[188-463]
-------------------------------------------------------------------
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-
A
--
V
V
P
F
G
A
A
H
I
L
-
T
K
-
T
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
--
Q
E
---
A
I
N
C
Y
A
E
E
---
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
----
F
Q
E
-
A
K
R
----------------------------------------
Q
L
-----------------------------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
L
K
E
H
K
----
A
L
K
T
L
G
I
----
I
M
--
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
--------------
Q
------
D
----------
N
------------
L
I
R
K
----
E
V
Y
----
I
L
L
N
W
I
G
Y
V
--
N
S
G
F
N
P
L
I
Y
C
---
R
S
P
D
F
R
I
--
A
F
Q
E
L
L
C
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------