@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SSR5_HUMAN: (2016-01-14 )
MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
Atome Classification :
(20 SA)
------.........10........20........30........40....--....50........60........70........80........90-.......--.100.-.-......110.......120.......130.......140.......150-.........160......-.170....-.-..--180-.------.---.--.----.....---190........200.......210.......220-........230....-------------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------..240........250.......260.......270.....-------..280.--------......290.......--300.......310.......320.......330.......340.......350.......360..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MEPLFPASTPSWNASSPGAASGGGDNR
T
L
VGPAPSAGA
R
A
V
L
V
P
V
--
L
Y
L
L
V
C
AAGLGG
N
T
L
V
I
Y
V
V
L
R
F
A
KMK
T
V
T
N
I
Y
I
L
N
L
A
V
A
D
V
L
Y
M
L-GL
P
F
LAT--QNA-A-S-FWP
F
G
P
V
L
C
R
L
V
M
T
LD
G
V
N
Q
F
T
S
V
F
C
L
T
V
M
S
V
D
R
Y
L
A
V
VHPLSSARW---RR
P
R
V
A
K
L
A
S
A
A
A
W
V
L
S
L
-
C
M
SL
P
L
L
V
-
F
-
A
D--V---Q------E---G--G----TCNAS---W-PEP
V
G
L
W
G
A
V
F
I
I
Y
T
A
V
L
G
F
F
A
P
L
L
V
I
C
L
C
Y
--
L
L
I
V
V
K
VRAAG
V
R
V
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
C
-----------------------------------------
V
R
R
-RSE
R
K
V
T
R
M
V
L
V
V
V
L
V
F
AGCWL
P
F
F
T
V
N
I
V
N
L
A
VALP-------QEPASA--------
G
L
Y
F
F
V
V
I
L
S
Y
A
N
SCA--
N
P
V
L
Y
G
F
L
S
D
N
F
R
Q
S
F
Q
K
V
L
C
LRKGSGAKDADATEP
R
P
D
R
I
R
Q
Q
QEATPP
A
H
R
A
A
ANGLMQTSKL
3
PsiBlast_PDB
85.00
40%
-147
- C3 -
4N6H
23
C562_ECOLX (first)
A:
[113-414]
---------------------
S
P
G
A
R
S
A
------------
S
S
L
A
L
A
I
A
I
T
A
--
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
--
K
Y
L
-
M
-
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
-
G
V
G
V
P
I
M
V
-
M
-
A
V
--
T
R
P
-
R
------
D
---
G
--
A
V---
V
C
M
L
Q
---
F
-
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
--
G
L
M
L
L
R
L
R
S
V
R
L
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------
K
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R------
R
D
P
L
V
V
--------
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
-
L
C
-
R
K
P
C
G
--------------------------------------
22
PsiBlast_CBE
84.15
40%
-145
- C3 -
4RWD
6
C562_ECOLX (first)
B:
[108-405]
-------------------------------
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
--
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
--
K
Y
L
-
M
-
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
-
G
V
G
V
P
I
M
V
-
M
-
A
V
--
T
RP-
R
------
D
---
G
--
A
V---
V
C
M
L
Q
---
F
-
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
--
G
L
M
L
L
R
L
R
S
V
R
L
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------
K
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R------
R
D
P
L
V
V
--------
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
-
L
---------------------------------------------
5
PsiBlast_PDB
84.13
40%
-146
- C3 -
4RWD
7
C562_ECOLX (first)
A:
[108-406]
-------------------------------
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
--
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
--
K
Y
L
-
M
-
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
-
G
V
G
V
P
I
M
V
-
M
-
A
V
--
T
R
P
-
R
------
D
---
G
--
A
V
---
V
C
M
L
Q
---
F
-
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
--
G
L
M
L
L
R
L
R
S
V
R
L
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------
K
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R------
R
D
P
L
V
V
--------
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
-
L
C
--------------------------------------------
4
PsiBlast_PDB
84.00
40%
-152
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[108-406]
-------------------------------
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
--
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
--
K
Y
L
-
M
-
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
-
G
V
G
V
P
I
M
V
-
M
-
A
V
--
T
R
P
-
R
------
D
---
G
--
A
V
---
V
C
M
L
Q
---
F
-
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
--
G
L
M
L
L
---------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------
K
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R------
R
D
P
L
V
V
--------
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
-
L
C
--------------------------------------------
23
PsiBlast_CBE
83.89
40%
-151
- C3 -
4RWA
1
C562_ECOLX (first)
B:
[108-403]
-------------------------------
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
A
I
T
A
--
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
A
--
K
Y
L
-
M
-
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
-
G
V
G
V
P
I
M
V
-
M
-
A
V
--
T
R
P
-
R
------
D
---
G
--
A
V
---
V
C
M
L
Q
---
F
-
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
--
G
L
M
L
L
R
--------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------
K
E
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R------
R
D
P
L
V
V
--------
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
------------------------------------------------
44
HHSearch
82.32
33%
-143
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------
Y
A
L
--
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
--
L
E
V
T
G
-
G
-
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
-
A
V
S
C
P
L
L
F
-
G
-
F
N
--
T
---
T
G-----
D
---
P
--
T
----
V
C
S
I
S
---
N
-
P
--------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
--
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDA
Y
-----------------------------------------
G
V
P
-
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
---------
H
V
S
P
--------
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
--
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------------------------------------
34
HHSearch
82.15
28%
-139
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
----------------------------------------------
V
G
M
G
I
--
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
--
H
I
L
-
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R-
A
---
T
H
Q
----
E
---
A
--
I
----
N
C
Y
A
E
---
E
-
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
--
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
-----------------------------------------
K
F
C
-
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
----------
N
L
I
R
K
--------
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
--
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------
21
PsiBlast_CBE
81.81
43%
-149
- C3 -
4EA3
3
OPRX_HUMAN
B:
[131-407]
-----------------------------------------------------
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
-
T
L
P
F
Q
G
T
--
D
I
L
-
L
-
G
-
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
I
R
A
L
D
V
---
R
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
-
V
V
G
V
P
V
A
I
-
M
-
G
S
--
A
--------------
E
--
I
----
E
C
L
V
E
---
I
-
P
T
P
Q
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
--
S
L
M
I
R
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
N
L
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
---
V
Q
V
F
V
L
A
Q
G
L
G
-------
V
Q
P
S
S
E
T
A
V
-----
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
--
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
K
F
----------------------------------------------
52
Fugue
81.45
29%
-153
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------
S
F
K
C
-----------------
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
--
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
L
P
A
L
I
F
--
Y
Y
F
-
N
K
T
-
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
-
A
I
S
-
P
I
L
F
-
Y
-
S
G
--
T
---
G
------
V
---
R
--
K
NKTI
T
C
Y
D
T
---
T
-
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
--
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
E
V
E
E
-
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
-------
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
--
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
--------------------------------------------------
1
PsiBlast_PDB
80.65
43%
-150
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[131-405]
-----------------------------------------------------
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
-
T
L
P
F
Q
G
T
--
D
I
L
-
L
-
G
-
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
-
V
V
G
V
P
V
A
I
-
M
-
G
S
--
A
---
Q
VED---
E
---
E
--
I
----
E
C
L
V
E
---
I
-
P
T
P
Q
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
--
S
L
M
I
R
R
L
R
G
V
R
L
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------
R
E
K
D
R
N
L
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
---
V
Q
V
F
V
L
A
Q
G
L
G
-------
V
Q
P
S
S
E
T
A
V
-----
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
--
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
------------------------------------------------
33
HHSearch
80.11
31%
-145
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-496]
-------------------------------------------
F
N
K
I
F
L
P
T
--
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
L
P
F
W
A
V
--
D
A
V
---
A
-
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
-
L
L
T
I
P
D
F
I
-
F
-
A
N
--
V
---
S
------
E
A
DD
R
--
Y
----
I
C
D
R
F
---
Y
-
P
N
D
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
--
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY
G
-----------------------------------------
S
K
G
-
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
--------
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
--
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
----------------------------------
2
PsiBlast_PDB
79.46
40%
-163
- C3 -
5C1M
7
?
A:
[17-296]
---------------------------------------------
A
I
T
I
M
A
--
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
L
P
F
Q
S
V
--
N
Y
L
-
M
-
G
-
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
-
A
I
G
L
P
V
M
F
-
M
-
A
T
--
T
K
Y
R
Q
------
G
---
S
--
I
----
D
C
T
L
T
---
F
-
S
H
P
T
W
Y
W
E
N
L
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
--
G
L
M
I
L
R
L
K
S
V
R
M
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------------------------------
K
E
K
D
R
N
L
R
R
I
T
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
I
T
I
P
-------
E
T
T
F
Q
T
--------
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
--
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
-------------------------------------------------
35
HHSearch
79.33
28%
-146
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[13-443]
--------------------------------------------------
V
--
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
--
Y
L
L
-
M
-
S
-
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
-
L
W
V
I
P
I
L
G
-
W
-
N
H
--------------RR-
E
--
D
----
K
C
E
T
D
---
F
-
Y
D
V
-----
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
--
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
-----------------------------------------
L
H
M
-
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
---------
C
-
C
N
E
--------
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
--
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------------------------------
51
Fugue
76.52
25%
-116
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
G
F
T
T
T
L
--
Y
T
S
-
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
A
P
P
L
V
G
W
-
S
R
--
Y
---
I
------
P
---
E
--
G
MQC-
S
C
G
I
D
---
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
--
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
--
A
G
V
A
F
Y
I
F
T
H
Q
-------
G
S
D
F
G
P
--------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
--
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
----------
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------
32
HHSearch
74.46
27%
-147
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------
V
F
I
V
L
--
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
--
Y
T
V
-
I
-
G
-
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
-
I
L
W
A
P
A
I
L
-
F
-
W
Q
--
F
---
I
V
GVRTV
E
---
D
--
G
----
E
C
Y
I
Q
---
F
-
F
S
-----
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
--
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
-----------------------------------------
P
P
P
-
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
----------
C
I
P
N
--------
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
--
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------------------------
49
Fugue
74.21
26%
-93
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
--------
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
--
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
--
T
S
L
-
H
-
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
A
P
P
L
V
-
G
-
W
S
R
Y
I
---
P
------
E
---
G
MQ
C
----
S
C
G
I
D
---
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------
T
T
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
--
A
G
V
A
F
Y
I
F
T
H
Q
-------
G
S
D
F
G
P
--------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
--
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
----
K
T
E
T
S
Q
V
A
P
A
--------------
17
PsiBlast_PDB
73.49
28%
-157
- C- -
3C9L
13
OPSD_BOVIN
A:
[38-332]
---------------------------------------------
S
M
L
A
A
Y
--
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
-
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
-
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
-
S
R
Y
-
I
---
P
------
E
---
G
--
M
----
Q
C
S
C
G
IDY
Y
-
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------
T
T
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
----
Y
I
F
T
-------
H
Q
G
S
D
F
--------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---
D
D
E
----------------------------------
19
PsiBlast_PDB
73.46
28%
-136
- C3 -
3DQB
6
GNAT1_BOVIN (first)
A:
[38-326]
---------------------------------------------
S
M
L
A
A
Y
--
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
-
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
-
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
-
S
R
Y
-
I
---
P
------
E
---
G
--
M
----
Q
C
S
C
G
IDY
Y
-
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------
T
T
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
----
Y
I
F
T
-------
H
Q
G
S
D
F
--------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------------------------
18
PsiBlast_PDB
73.22
28%
-123
- C3 -
1F88
7
OPSD_BOVIN
A:
[38-344]
---------------------------------------------
S
M
L
A
A
Y
--
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
-
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
-
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
-
S
R
Y
-
I
---
P
------
E
---
G
--
M
----
Q
C
S
C
G
I
DY
Y
-
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
----
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------
T
T
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
----
Y
I
F
T
-------
H
Q
G
S
D
F
--------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
VY
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
------
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
------------------
20
PsiBlast_PDB
72.97
28%
-142
- C3 -
3PQR
10
OPSD_BOVIN
A:
[38-326]
---------------------------------------------
S
M
L
A
A
Y
--
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
-
G
F
T
T
T
L
Y
T
S
L
-
H
-
G
-
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
-
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
-
S
R
Y
-
I
---
P
------
E
---
G
--
M
----
Q
C
S
C
G
IDY
Y
-
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------
T
T
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
----
Y
I
F
T
-------
H
Q
G
S
D
F
--------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------------------------