@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : T2R14_HUMAN: (2016-01-14 )
MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
Atome Classification :
(20 SA)
---------------.........10....-----------....20........30.......-.40........50.-.......60.-..-.-.-...70........-----------.80-........90........100.....---..110.......120.--......130.......140...--------------------------------...-.150-.......-.------------------------------------160---....------.-.-.--.---170--........180.......190.......200....-----...210.....-------.-----------------------------------------------------------------------------------------------------------------------------------------------------.-220....-----...-230--..----.......240...-----....250--....--------..---.-260...--.....270-.......280...------.--...290..-.....-300........310.....-------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------M
G
G
V
I
K
S
I
F
T
F
V
L
I
V
-----------
E
F
I
I
G
NL
G
N
S
F
I
A
L
V
N
C
I
D
W
VKG-RKI
S
S
V
D
R
I
L
T
A
L
A
-
I
S
R
I
S
L
V
W
L
I
-
F
G
-
S
-
W
-
C
V
S
V
-
F
F
P
A
L
F
A
T
-----------
E
K
M
-
F
R
M
L
T
N
I
W
T
V
I
N
H
F
S
V
W
L
A
TGL
G
T
F
Y
---
F
L
K
IANFSN
S
I
F
L
Y
L
K
--
W
R
V
K
K
V
V
L
V
L
L
L
V
T
S
V
F
L
F
L
N
I
--------------------------------
A
L
I
-
N
I
-
H
-
I
N
A
S
IN
G
-
Y
------------------------------------RR----NKTC------S-S-D--S---SN---
F
T
R
F
S
S
L
I
V
L
T
S
T
V
F
I
F
I
P
F
T
L
S
L
A
M
F
L
L
L
I
F
S
M
W
-----
K
H
R
K
KM
Q
H
T
V
K
-------I-----------------------------------------------------------------------------------------------------------------------------------------------------S-GDAS
T
K
A
-----HR
G
-
V
----
K
S
----
V
I
T
F
F
L
L
Y
A
I
F
S
L
-----
S
F
F
I
S
V
W
--
T
S
E
R
--------
L
E
---
E
-
N
L
-
I
I
L
--
S
Q
V
M
G
MAY-PSC
H
S
C
V
L
I
LGN
K
------
K
--
L
R
Q
A
S
L
S
V
-
L
L
W
L
R
-
Y
M
-FKDGEPSG
H
K
E
FRESS-------------------
7
HHSearch
84.17
12%
-110
- C1 -
1U19
14
OPSD_BOVIN
A:
[42-328]
----------------------
M
L
A
A
Y
M
F
L
-----------
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
----
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
G
G
-
F
T
-
T
-
T
-
L
Y
T
S
-
L
H
G
Y
F
V
F
G
-----------
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
---
Y
V
V
V
C
---
K
P
M
S
N
F
-
R
--
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
--------------------------------
A
P
P
-
L
V
-
G
-
W
S
R
--
Y
I
-
P
------------------------------------
E
G
----
M
Q
C
S
------
C
G
I
-
D
--
Y
YTP
H
E
ET-
N
N
E
S
F
--
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-----
E
A
A
A
Q
Q
Q
E
S
A
T
-------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
-----
T
R
M
V
I
----
I
M
----
V
I
A
F
L
I
C
W
L
P
Y
A
G
-----
V
A
F
Y
I
F
T
--
H
Q
G
S
--------
D
F
---
G
-
P
I
F
M
T
I
--
P
A
F
F
A
K
T
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
------
Q
--
F
R
N
C
M
V
T
T
-
L
C
C
G
K
-
N
P
-
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
-------------------
11
HHSearch
82.72
11%
-113
- C1 -
2KS9
1
NK1R_HUMAN
A:
[34-326]
----------------------
L
W
A
A
A
Y
T
V
-----------
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
----
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
-
F
A
E
A
S
M
A
A
F
N
-
T
V
-
V
-
N
-
F
T
Y
A
-
V
H
N
E
W
Y
Y
G
-----------
L
F
Y
-
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
---
Y
M
A
I
I
---
H
P
L
Q
P
R
L
---
S
--
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
--------------------------------
F
P
Q
-
G
Y
-
Y
-
S
T
T
E
--
T
-
M
------------------------------------
P
S
----
R
V
V
C
------
M
-
I
-
E
--
W
PE-
H
P
NKI
Y
E
K
V
Y
--
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
-----
A
S
E
I
P
G
D
S
S
D
R
-------
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
Q
V
S
A
-----
K
R
K
V
V
K
M
M
I
V
V
----
V
C
T
F
A
I
C
W
L
P
F
H
I
-----
F
F
L
L
P
Y
I
--
N
P
D
L
--------
Y
L
KKF
I
-
Q
Q
V
Y
L
A
--
I
M
W
L
A
M
S
S
-
T
M
Y
N
P
I
I
Y
C
C
L
N
D
------
R
--
F
R
L
G
F
K
H
A
-
F
R
C
C
P
-
F
I
-
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
-------------------
10
HHSearch
82.18
14%
-117
- C1 -
2Z73
5
OPSD_TODPA
A:
[33-337]
-------------------
V
Y
Y
S
L
G
I
F
I
G
I
-----------
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
----
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
-
F
S
D
F
T
F
S
L
V
N
G
F
P
-
L
-
M
-
T
I
S
C
-
F
L
K
K
W
I
F
G
-----------
F
A
A
-
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
---
Y
N
V
I
G
---
R
P
M
A
A
S
-
K
--
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
--------------------------------
I
G
P
-
I
F
-
G
-
W
G
A
--
Y
T
-
L
------------------------------------
E
G
----
V
L
C
N
------
C
S
F
-
D
--
Y
---
I
S
RD
S
T
T
R
S
N
--
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
-----
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
-
A
Q
A
G
A
N
A
-----
E
M
R
L
A
----
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
-----
V
A
L
L
A
Q
F
--
G
P
L
E
--------
W
V
---
T
-
P
Y
A
A
Q
L
--
P
V
M
F
A
K
A
S
-
A
I
H
N
P
M
I
Y
S
V
S
H
P
------
K
--
F
R
E
A
I
S
Q
T
-
F
P
W
V
L
-
T
C
-
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
-------------------
12
HHSearch
80.73
13%
-106
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[37-322]
------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
-----------
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
----
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
-
L
A
D
L
L
F
A
L
T
L
-
P
I
-
W
---
A
A
S
K
--
V
N
G
W
I
F
G
-----------
T
F
L
-
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
---
Y
L
A
I
V
---
H
A
T
R
T
L
-
T
---
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
--------------------------------
L
P
F
-
F
L
-
F
-
R
Q
A
Y
--
H
-
P
------------------------------------
N
N
----
S
S
P
V
------
C
-
Y
-
E
VL
G
---
N
D
TAK
W
R
M
V
L
--
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
-----
K
A
H
M
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
H
R
A
-----
M
R
V
I
F
----
A
V
----
V
L
I
F
L
L
C
W
L
P
Y
N
L
-----
V
L
L
A
D
T
L
--
M
R
T
Q
VIQE
S
C
E
R
R
N
---
N
I
G
R
A
L
D
A
--
T
E
I
L
G
F
L
H
-
S
C
L
N
P
I
I
Y
A
F
I
G
Q
------
N
--
F
R
H
G
F
L
K
I
-
L
A
M
H
G
---------------------------------------
4
HHSearch
76.47
17%
-123
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[48-243]
--------------------
K
I
F
L
P
T
I
Y
S
I
-----------
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
----
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
-
V
A
D
L
L
F
V
I
T
L
-
P
F
---
W
-
A
V
D
A
-
V
-
A
N
W
Y
F
G
-----------
N
F
L
-
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
---
Y
L
A
I
V
---
H
A
T
N
S
Q
-
R
--
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
--------------------------------
I
P
D
-
F
I
-
F
-
A
N
V
S
--
E
-
A
------------------------------------
D
D
----
R
Y
I
C
------
D
-
R
-
F
--
Y
---
P
N
D
L
-
W
V
V
V
F
--
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
-----
H
S
G
S
N
I
F
E
M
L
R
-------
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
D
-
E
G
L
R
L
K
I
-----
Y
K
D
-
T
----
E
G
----
Y
Y
T
I
G
I
G
H
L
L
T
K
S
-----
P
S
L
N
A
A
K
--
S
E
L
D
--------
K
A
---
I
-
G
R
-
N
T
N
--
G
V
I
T
K
D
E
A
-
E
K
L
F
N
Q
D
V
D
A
A
V
R
------
G
--
I
L
R
N
A
K
L
K
-
P
V
Y
D
S
-
L
D
-
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
-------------------
3
HHSearch
71.94
11%
-115
- C1 -
3EML
13
ENLYS_BPT4
A:
[22-472]
---------------------
S
V
Y
I
T
V
E
L
A
-----------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
----
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
-
A
-
I
T
I
S
---
T
G
F
C
A
A
-----------
C
H
G
-
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
---
Y
I
A
I
R
---
I
P
L
R
Y
N
-
G
--
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--------------------------------
L
T
P
-
M
L
-
G
-
W
N
N
C
G
Q
---------------------------------------------
S
Q
G
C
GEGQVA
C
-
L
F
E
--
D
---
V
V
---
P
M
N
Y
M
--
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-----
R
Q
L
N
I
F
E
M
L
R
I
-------
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
-
Y
R
S
T
L
Q
K
-----
E
V
H
A
A
----
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
-----
I
N
C
F
T
F
F
--
C
P
D
C
S-------
H
A
---
P
-
L
W
L
M
Y
L
--
A
I
V
L
S
H
T
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
------
E
--
F
R
Q
T
F
R
K
I
-
I
R
S
H
V
-
L
R
-
Q
----------------------------------
28
Fugue
70.07
10%
-115
- C2 -
3MX3
6
?
A:
[19-490]
KVT
S
S
L
L
A
T
G
L
L
L
D
I
T
S
S
S
A
S
K
S
F
I
Y
D
E
L
L
A
KQMAWGESME
D
Y
Q
Y
N
V
F
G
R
S
G
F
G
G
Y
T
T
L
I
N
A
Q
K
M
V
E
S
V
S
D
D
N
V
N
A
Y
D
G
-
L
A
H
F
I
K
A
Y
K
I
-
F
Y
M
S
M
E
M
G
D
L
P
-
Y
E
E
A
L
Q
G
E
L
GLVR
P
K
Y
N
T
Q
K
E
V
M
N
F
I
L
S
D
L
E
T
A
Y
E
L
F
S
T
A
K
D
F
D
G
D
P
I
L
GGS
I
S
K
W
K
K
A
T
T
A
F
Q
L
K
V
L
M
-
H
L
S
K
K
E
S
D
A
D
L
K
V
K
E
R
F
A
R
I
V
A
S
GSLMESNEDNL
Q
M
K
Y
AANTVYPFHNTNTKHA
G
Y
A
M
L
S
-
T
M
L
I
D
K
F
K
A
-
T
GDI
R
M
F
Y
Y
A
KPA
K
A
K
L
N
E
GVTADSWDA
Y
I
G
T
DPSLP
F
E
----
Q
I
E
K
------
A
-
Y
-
A
--
T
---
E
Q
---
Y
S
G
F
N
A
R
Y
T
D
Y
P
S
G
E
P
V
V
R
L
G
Y
A
E
Q
N
F
I
L
A
E
A
A
V
R
GWISG
D
A
S
A
Y
Y
K
K
A
I
R
-------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
F
I
A
S
N
T
-----
P
D
E
-
E
----
V
Y
----
H
H
G
H
P
I
T
E
E
A
I
A
A
-----
F
L
E
T
P
A
I
QL
S
G
E
K
--------
E
E
---
D
-
I
E
-
K
I
L
--
T
Q
R
Y
L
A
S
F
M
Q
H
P
Y
D
V
Y
Y
D
Y
R
R
T
GYP
V
L
P
I
--
N
P
A
T
N
R
N
T
M
N
D
R
L
P
M
R
W
M
Y
P
K
S
E
S
D
Y
N
L
E
H
Q
N
E
A
L
E
R
Q
FGGVDDVNKLMWILQ
25
Fugue
67.56
11%
-165
- C2 -
4CSO
-
?
A:
[1-216]
-------------AD
L
D
S
K
A
K
S
P
F
V
F
K
S
A
Y
-----------
Y
L
S
L
Y
T
----------------
K
-
R
R
A
R
N
L
R
Q
L
A
E
G
I
R
A
A
D
P
G
V
I
F
H
H
V
-
F
H
-
V
-
V
-
F
A
K
H
-
L
L
H
P
Y
Y
T
---------------------------
N
D
F
A
R
W
V
G
E
E
L
N
D
---------------------------
D
D
L
A
I
E
L
S
S
I
S
G
A
E
P
A
T
V
--------------------------------
E
D
V
-
R
R
-
E
-
L
L
A
V
L
E
P
-
R
------------------------------------
A
D
----
E
R
A
A
------
R
-
R
-
E
-------------------------
F
V
F
V
S
M
V
P
I
V
Y
E
V
G
L
K
A
E
T
L
A
-----
E
F
L
D
A
V
A
A
A
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
----
S
V
A
Y
H
F
V
T
A
R
V
L
Y
GNGRN
D
F
S
R
W
L
V
--
E
E
F
G
--------
L
T
---
S
-
A
A
-
D
A
L
--
S
R
I
D
P
L
I
Y
-
N
D
---------
E
R
------
Q
--
L
K
S
E
V
V
R
T
-
L
E
R
A
D
-
S
A
------------------------------------
5
HHSearch
63.28
11%
-122
- C1 -
2RH1
6
ADRB2_HUMAN (first)
A:
[42-239]
----------------------
G
M
G
I
V
M
S
L
-----------
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
----
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
-
C
A
D
L
V
M
G
L
A
V
-
V
P
-
F
-
G
-
A
A
H
I
-
L
M
K
M
W
T
F
G
-----------
N
F
W
-
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
---
Y
F
A
I
T
---
S
P
F
K
Y
Q
-
S
--
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
--------------------------------
F
L
P
-
I
Q
M
H
-
W
Y
R
A
T
H
Q
-
E
------------------------------------
A
I
N
C
Y
A
E
E
T
C
------
C
-
D
-
F
--
F
--------
T
N
Q
A
Y
--
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-----
R
Q
L
N
I
F
E
M
L
R
I
-------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
-
G
L
R
L
K
I
Y
-----
K
D
T
-
E
----
G
Y
----
Y
T
I
G
I
G
H
L
L
T
K
S
P
-----
S
L
N
A
A
K
S
--
E
L
D
K
--------
A
I
---
G
-
R
N
-
T
N
G
--
V
I
T
K
D
E
A
E
-
K
L
F
N
Q
D
V
D
A
A
V
R
G
------
I
--
L
R
N
A
K
L
K
P
-
V
Y
D
S
L
-
D
A
-
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
-------------------
29
Fugue
58.85
10%
-124
- C2 -
1A2Z
1
PCP_THELN
A:
[1-220]
--------------------------------------------------
M
K
K
V
L
I
T
G
F
E
P
F
G
G
-
D
S
K
N
P
T
E
Q
I
A
K
Y
F
D
-
R
K
Q
I
G
-------
N
-
A
-
M
-
V
Y
G
R
-
V
L
P
V
S
V
-------------
K
R
A
-
T
I
E
L
K
R
Y
L
E
E
I
K
------------------------------------------------
P
E
I
V
I
N
L
G
L
--------------------------------
A
P
T
-
Y
S
-
N
-
I
T
V
E
R
I
A
-
V
------------------------------------
N
I
----
I
D
A
R
------
I
-
P
-
D
--
N
---
D
G
---
Y
Q
P
I
D
E
K
I
E
E
D
A
P
L
A
Y
M
A
T
L
P
V
R
A
I
T
K
T
L
R
D
N
G
I
--------------
P
A
T
-------
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
-
Y
S
A
G
T
--------------------------
Y
L
C
N
Y
V
M
F
K
-----
T
L
H
F
S
K
I
--
E
G
Y
P
--------
L
K
---
A
-
G
F
-
I
H
V
--
P
Y
T
P
D
Q
V
V
-
N
K
F
F
L
L
G
K
N
T
P
S
M
------
C
--
L
E
A
E
I
K
A
I
-
E
L
A
V
K
-
V
S
-
L
D
Y
L
E
K
-
D
R
D
D
I
K
I
P
L
-------------------
13
HHSearch
58.19
12%
-124
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[63-252]
--------------------
I
K
L
T
S
V
V
F
I
L
-----------
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
----
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
-
L
S
D
L
L
A
G
V
A
Y
-
T
A
-
N
-
L
-
L
L
S
G
-
A
-
T
T
Y
K
L
T
-----------
P
A
Q
-
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
---
Y
I
T
M
L
---
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
--------------------------------
G
L
P
-
I
M
-
G
-
W
N
C
--
I
---------------------------------------
S
A
----
L
S
S
C
------
S
-
T
-
V
--
L
---
P
L
---
Y
H
K
H
Y
---
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
-----
T
R
N
I
F
E
M
L
R
I
D
-------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
-
L
R
L
K
I
Y
K
-----
D
T
E
-
G
----
Y
Y
----
T
I
G
I
G
H
L
L
T
K
S
P
S
-----
L
N
A
A
K
S
E
--
L
D
K
A
--------
I
G
---
R
-
N
T
-
N
G
V
--
I
T
K
D
E
A
E
K
-
L
F
N
Q
D
V
D
A
A
V
R
G
I
------
L
--
R
N
A
K
L
K
P
V
-
Y
D
S
L
D
-
A
V
-
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
-------------------
2
HHSearch
57.57
11%
-128
- C1 -
3RZE
2
ENLYS_BPT4 (first)
A:
[11-204]
-----------------------
L
V
V
V
L
S
T
-----------
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
----
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
-
V
A
D
L
I
V
G
A
V
V
-
M
P
-
M
-
N
-
I
L
Y
L
-
L
M
S
K
W
S
L
G
-----------
R
P
L
-
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
---
Y
R
S
V
Q
---
Q
P
L
R
Y
L
-
K
--
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
--------------------------------
I
P
I
-
L
G
-
W
-
N
H
--------------------------------------------
R
----
R
E
D
K
------
C
-
E
-
T
--
D
---
F
Y
---
D
V
T
W
F
--
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
-----
Q
H
C
N
I
F
E
M
L
R
I
-------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
-
G
L
R
L
K
I
Y
-----
K
D
T
-
E
----
G
Y
----
Y
T
I
G
I
G
H
L
L
T
K
S
P
-----
S
L
N
A
A
K
S
--
E
L
D
K
--------
A
I
---
G
-
R
N
-
T
N
G
--
V
I
T
K
D
E
A
E
-
K
L
F
N
Q
D
V
D
A
A
V
R
G
------
I
--
L
R
N
A
K
L
K
P
-
V
Y
D
S
L
-
D
A
-
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
-------------------
9
HHSearch
56.15
10%
-121
- C1 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-230]
-----------------------
Y
A
L
S
Y
C
A
-----------
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
----
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
-
V
A
D
L
L
V
A
T
L
V
-
M
P
-
W
-
V
-
V
Y
L
E
V
T
G
G
V
W
N
F
S
-----------
R
I
C
-
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
---
Y
T
A
V
V
---
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
--------------------------------
C
P
L
-
L
F
-
G
-
F
N
T
--
T
---------------------------------------
G
D
----
P
T
V
-------
C
-
S
-
I
--
S
---
N
------
P
D
F
--
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
-----
Q
R
R
R
K
N
I
F
E
M
L
-------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
E
G
L
R
L
K
-----
I
Y
K
-
D
----
T
E
----
G
Y
Y
T
I
G
I
G
H
L
L
T
K
-----
S
P
S
L
N
A
A
--
K
S
E
L
--------
D
K
---
A
-
I
G
-
R
N
T
--
N
G
V
I
T
K
D
E
-
A
E
K
L
F
N
Q
D
V
D
A
A
V
------
R
--
G
I
L
R
N
A
K
L
-
K
P
V
Y
D
-
S
L
-
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
-------------------
32
Fugue
54.82
18%
-102
- C2 -
2HJQ
-
YQBF_BACSU
A:
[1-111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
T
A
K
-------
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
-
K
G
K
T
Y
N
V
MG
I
T
F
R
A
G
-
V
----
S
Q
----
T
V
P
K
K
L
Y
E
Y
L
N
E
N
-----
P
Y
F
I
L
T
Q
--
E
L
N
N
--------
Q
K
---
D
-
D
P
-
I
N
Y
T
E
S
E
L
K
G
M
N
K
-
A
E
H
E
S
I
I
S
N
L
G
R
N
------
P
SD
F
K
N
A
D
E
R
I
-
A
Y
I
L
K
-
Q
I
-
D
N
K
G
E
L
E
H
H
H
H
H
H
----------------------
1
HHSearch
50.80
9%
-123
- C1 -
3UON
2
ACM2_HUMAN (first)
A:
[25-218]
----------------------
F
I
V
L
V
A
G
S
-----------
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
----
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
-
C
A
D
L
I
I
G
V
F
S
-
M
N
-
L
-
Y
-
T
L
Y
T
-
V
I
G
Y
W
P
L
G
-----------
P
V
V
-
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
---
Y
F
C
V
T
---
K
P
L
T
Y
P
-
V
--
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
--------------------------------
A
P
A
-
I
L
-
F
-
W
Q
F
I
V
G
V
R
T
------------------------------------
V
E
----
D
G
E
C
------
Y
-
I
-
Q
--
F
---
F
----
S
N
A
A
V
--
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
-----
S
R
I
N
I
F
E
M
L
R
I
-------
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
-
G
L
R
L
K
I
Y
-----
K
D
T
-
E
----
G
Y
----
Y
T
I
G
I
G
H
L
L
T
K
S
P
-----
S
L
N
A
A
K
S
--
E
L
D
K
--------
A
I
---
G
-
R
N
-
T
N
G
--
V
I
T
K
D
E
A
E
-
K
L
F
N
Q
D
V
D
A
A
V
R
G
------
I
--
L
R
N
A
K
L
K
P
-
V
Y
D
S
L
-
D
A
-
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
-------------------
19
HHSearch
37.48
8%
-43
- C1 -
1U19
8
OPSD_BOVIN
A:
[247-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
-----
E
K
E
V
T
----
R
M
----
V
I
I
M
V
I
A
F
L
I
C
W
L
-----
P
Y
A
G
V
A
F
--
Y
I
F
T
--------
H
Q
---
G
-
S
D
F
G
P
I
--
F
M
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
------
M
--
M
N
K
Q
F
R
N
C
-
M
V
T
T
L
-
C
C
-
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
-------------------
21
HHSearch
34.99
15%
-51
- C1 -
3PBL
1
DRD3_HUMAN (first)
A:
[407-472]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
F
I
V
C
W
L
P
F
F
L
-----
T
H
V
L
N
T
H
--
C
Q
T
C
--------
H
V
---
S
-
P
E
L
Y
S
A
--
T
T
W
L
G
Y
V
N
-
S
A
L
N
P
V
I
Y
T
T
F
N
I
------
E
--
F
R
K
A
F
L
K
I
-
L
S
C
-----------------------------------------
20
HHSearch
27.54
6%
-60
- C1 -
3VW7
5
A:
[395-455]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----
F
C
I
F
I
I
C
F
G
P
T
N
V
-----
L
L
I
A
H
Y
S
--
F
L
S
H
TSTT----
E
A
---
A
-
Y
F
A
Y
L
L
--
C
V
C
V
S
S
I
S
-
C
C
I
D
P
L
I
Y
Y
Y
A
S
S
------
E
--
C
----------------------------------------------------
30
Fugue
25.50
24%
82
* C2 *
2FQC
1
A:
[1-25]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
--------
P
R
---
I
-
C
N
-
L
A
C
--
R
A
G
I
G
H
K
Y
-
P
F
C
H
C
R
---------------------------------------------------------------------
18
HHSearch
24.47
10%
-69
- C1 -
2Z73
3
OPSD_TODPA
A:
[42-62]
-------------------------
G
I
C
G
I
-----------
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
-
N
M
F
I
I
N
L
A
F
S
D
F
T
F
-
S
L
V
N
G
F
P
L
M
T
-
I
S
-
C
-
F
-
L
K
K
W
-
I
F
G
F
A
A
C
K
-----------
V
Y
G
-
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
---
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
--
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
--------------------------------
Y
T
L
-
E
G
-
V
-
L
C
N
C
S
F
D
-
Y
------------------------------------
I
S
----
R
D
S
T
------
T
-
R
-
S
--
N
---
I
L
---
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
-----
A
K
R
L
N
A
K
E
L
R
K
-------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
A
G
A
N
A
E
M
-----
R
L
A
-
K
----
I
S
----
I
V
I
V
S
Q
F
L
L
S
W
S
P
-----
Y
A
V
V
A
L
L
--
A
Q
F
G
--------
P
L
---
E
-
W
V
-
T
P
Y
--
A
A
Q
L
P
V
M
F
-
A
K
A
S
A
I
H
N
P
M
I
Y
S
------
V
--
S
H
P
K
F
R
E
A
-
I
S
Q
T
F
-
P
W
-
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
-------------------