@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : T2R19_HUMAN: (2016-01-14 )
MMCFLLIISSILVVFAFVLGNVANGFIALVNVIDWVNTRKISSAEQILTALVVSRIGLLWVMLFLWYATVFNSALYGLEVRIVASNAWAVTNHFSMWLAASLSIFCLLKIANFSNLISLHLKKRIKSVVLVILLGPLVFLICNLAVITMDERVWTKEYEGNVTWKIKLRNAIHLSSLTVTTLANLIPFTLSLICFLLLICSLCKHLKKMRLHSKGSQDPSTKVHIKALQTVTSFLMLFAIYFLCIITSTWNLRTQQSKLVLLLCQTVAIMYPSFHSFILIMGSRKLKQTFLSVLWQMTR
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10-------........20........----------------------30..---------------......40..------------------......--50.....---------------------------..-----.60.-......---------.70....--.....80.....-...-.90....---------...----------------.100.......------------.110.....-..120.--.......-130....------...140--.-..-.--....-150..-....-..---160....-------.---------..---.--170-..---.-......180-------.........190....----------------...200.......210...-------.----------------------------------------------------------------------------------------------------------------------------------------------------.-....220.......230----.----......240.---....----..-----250---..----.---------..-..----------.260.......270....-----...280...--.-...290-----------.........---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
M
C
F
L
L
I
I
S
S
I
-------
L
V
V
F
A
F
V
L
G
N
VA
N
G
F
I
A
L
----------------------
V
N
V
I
---------------
D
W
V
NTRKI
S
S
------------------
A
E
Q
I
L
T
--
A
L
V
V
S
R
I
---------------------------
G
L
-----
L
W
V
M
-
L
F
L
W
Y
A
---------
T
V
-
F
N
S
A--LY
G
L
E
V
-
R
I
V
AS-N
A
W
-
A
V
T
N
H
F
S
---------
M
W
L
----------------
A
A
S
-
L
S
I
F
C
L
L
------------
K
IA
N
F
S
N
L
I
-
S
L
H
-
L
K
--
K
R
I
K
S
V
V
-
L
V
I
L
L
G
P
------
L
V
F
L
I
---
C
-
N
L
-
A
--
V
I
TM-D-ER
V
-
W
T
K
E-YE---G-
N
V
T
W
K
-------
I
---------
K
L---R--
N
---
A
I
---
H
-L
S
S
L
T
V
T
---------
T
L
A
N
L
I
P
F
T
L
S
L
I
C
F
L
----------------
L
L
I
C
S
L
C
K
H
L
K
K
M
R
--LHS-------K----------------------------------------------------------------------------------------------------------------------------------------------------G-SQDPST
K
V
H
I
K
A
L
Q
T
V
T
----
S
----
F
L
M
L
F
A
I
Y
F
L
---
C
I
IT----ST-----WN----LR----T---------QQ-
S
K
----------
L
V
L
L
L
C
Q
T
V
A
I
MYP
S
F
H
S
-----
F
I
L
I
MGS
R
K
--
L
-
K
Q
T
F
-------------
L
S
V
L
W
Q
MTR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
84.09
18%
-148
- C4 -
4RGP
6
?
A:
[2-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
T
E
Q
E
T
L
T
I
L
----------------------
L
D
V
Y
---------------
A
Y
Y
Q
A
Y
Q
I
V
K
------------------
A
S
Q
F
F
S
--
D
D
I
I
F
L
L
---------------------------
E
L
-----
L
K
E
R
-
R
E
L
N
V
D
---------
F
L
-
F
Q
N
Q
--
V
H
L
Q
E
L
-
E
L
T
Y
----------
H
I
S
---------
L
L
D
----------------
N
A
--------
Y
------------
E
E
E
L
L
A
N
Y
I
M
D
L
E
-
A
K
--
L
R
N
D
H
I
I
D
F
V
R
S
V
S
P
------
I
L
Y
R
L
---
L
M
R
L
M
Q
S
Q
V
A
D
I
-
N
-
D
Y
I
-
Y
D
A
K
-
N
D
---
Q
-
Y
D
T
W
K
-------
F
D
K
M
H
D
SAN
P
F
V
---
Q
--
N
---
F
V
A
K
G
R
-
D
S
K
I
T
S
R
---------
S
L
A
D
F
I
Q
L
T
D
L
P
Q
A
I
K
----------------
D
N
I
L
L
L
R
D
F
E
K
S
V
R
--
N
P
L
-------
A
----------------------------------------------------------------------------------------------------------------------------------------------------
H
-
L
I
K
P
F
D
E
E
E
L
H
R
T
T
G
F
S
----
S
----
Q
T
F
L
E
K
I
I
Q
L
---
A
V
F
S
----
G
-----------------------------------------------------
I
H
Y
D
N
-
D
K
-----
F
Y
F
D
K
V
N
E
L
--
I
-
K
R
I
Y
-------------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
72.19
16%
-133
* C4 *
3SPE
2
?
A:
[7-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
P
S
R
L
I
V
A
I
-------
E
I
V
E
D
E
I
P
L
T
K
V
D
G
L
K
A
R
----------------------
I
I
L
I
---------------
E
D
-
N
T
S
E
V
G
T
------------------
Q
R
V
L
P
G
--
T
L
V
S
D
K
D
---------------------------
G
S
-----
Q
S
L
V
-
Y
P
L
F
E
A
---------
P
V
S
F
F
G
K
--
L
G
D
S
N
G
M
R
V
W
S
T
-
T
T
-----------------------------------------------
A
------------
D
I
E
E
F
D
E
A
A
M
A
K
F
-
K
T
--
R
Q
F
R
I
Q
L
-
I
E
K
P
E
S
P
------
V
I
V
K
T
ADQ
Q
-
D
Y
-
L
--
N
I
T
F
-
D
-
K
G
V
-
Y
S
-
D
M
Y
N
---
A
-
D
L
Y
V
G
-------
D
---------
V
L
---
V
--
D
---
S
Y
---
S
-
D
D
G
V
V
S
G
---------
L
S
P
L
Y
S
P
F
S
Q
F
Y
V
------------------------
Y
H
E
N
I
D
L
V
R
Q
M
I
Y
D
-------
T
----------------------------------------------------------------------------------------------------------------------------------------------------
E
M
R
V
N
P
A
A
A
A
H
T
T
A
P
G
E
-----------------
I
D
F
L
---
T
F
L
A
----
V
D
-----
G
D
----
P
------------------------------------------
Y
Q
G
I
Q
V
-----
L
G
P
L
D
G
G
I
T
--
L
G
K
D
G
N
-------------
I
Y
A
S
G
G
T
D
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
70.44
15%
-122
- C6 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
V
V
I
I
-------
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
----------------------
V
I
L
Y
---------------
S
R
---
V
G
R
S
V
------------------
T
D
V
Y
L
L
--
N
L
A
L
A
D
L
---------------------------
L
F
-----
A
L
T
L
--
P
I
W
A
A
---------
S
K
-
V
N
G
W
--
I
F
G
T
F
L
-
C
K
V
V
S
-
L
L
K
-
E
V
N
F
Y
S
G
---------
I
L
L
----------------
L
A
C
-
I
S
V
D
R
Y
L
------------
A
I
V
---
H
A
T
-
R
T
L
--
T
---
Q
K
R
H
L
V
-
K
F
V
C
L
G
C
------
W
G
L
S
M
---
N
-
L
S
-
L
--
P
F
F
L
-
F
-
R
Q
A
-
Y
-
H
P
-
N
N
---
S
-
S
P
V
C
Y
-------
E
V--------
L
G
---
N
--
D
TAK
W
R
---
M
-
V
L
R
I
L
P
H
---------
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
----------------
F
T
L
R
T
L
F
K
A
H
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
----
F
L
L
C
W
L
P
Y
N
L
---
V
L
L
A
----
D
T
-----
L
M
----
R
T
----
Q
VIQE
S
C
E
R
R
N
N
-
I
G
----------
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
-----
I
I
Y
A
F
I
G
Q
N
--
F
-
R
H
G
F
-------------
L
K
I
L
A
M
H
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
67.85
11%
-122
- C6 -
2Z73
5
OPSD_TODPA
A:
[34-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
S
L
G
I
-------
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
----------------------
L
F
T
K
---------------
T
K
---
S
L
Q
T
P
------------------
A
N
M
F
I
I
--
N
L
A
F
S
D
F
---------------------------
T
F
-----
S
L
V
N
G
F
P
L
M
T
I
---------
S
C
-
F
L
K
K
W-
I
F
G
F
A
A
-
C
K
V
Y
G
-
F
I
G
-
G
I
F
G
F
M
S
---------
I
M
T
----------------
M
A
M
-
I
S
I
D
R
Y
N
------------
V
I
G
---
R
P
M
-
A
A
--
S
K
--
K
M
S
H
R
R
A
-
F
I
M
I
I
F
V
------
W
L
W
S
V
---
L
-
W
A
-
I
--
G
P
I
F
-
G
-
W
G
A
-
Y
-
T
L
-
E
G
---
V
-
L
C
N
C
S
-------
F
---------
D
Y
---
I
SR
D
S
--
T
T
---
R
-
S
N
I
L
C
M
F
---------
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
----------------
N
I
V
M
S
V
S
N
H
E
K
E
M
A
--
A
M
A
K
RLNAKE
L
----------------------------------------------------------------------------------------------------------------------------------------------------
R
-
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
----
V
----
I
V
S
Q
F
L
L
S
W
S
---
P
Y
A
V
----
V
A
-----
L
L
A
Q
FG
P
L
----
E
---------
W
V
-
T
P
----------
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
-----
M
I
Y
S
V
S
H
P
K
--
F
-
R
E
A
I
-------------
S
Q
T
F
P
W
V
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
67.64
20%
-163
- C5 -
4NM6
5
A:
[7-451]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SCRCE
G
P
F
Y
T
H
L
G
A
G
P
N
V
A
A
I
-------
R
E
I
M
E
E
R
F
G
Q
K
G
K
A
-
I
R
I
----------------------
E
R
V
I
Y
TG
K
E
G
K
S
SQGCPIA
K
W
V
V
R
R
--
S
S
------------------
S
E
E
K
L
L
--
C
L
V
R
E
R
A
---------------------------
G
H
TCEAA
V
I
V
I
-
L
I
L
V
W
E
---------
G
I
-
P
L
S
L
--
A
D
K
L
Y
S
-
E
L
T
E
T
L
R
K
Y
-
G
T
L
T
N
R
R
---------
C
A
L
NEERTCACQGLDPET
C
G
A
S
-
F
S
F
G
C
S
W
S
MYYNGCKFARS
K
I
P
R
K
F
K
L
L
-
G
D
D
-
P
K
--
E
E
E
K
L
E
S
-
H
L
Q
N
L
S
T
------
L
M
A
P
T
---
Y
-
K
K
-
L
--
A
P
D
A
-
Y
-
N
N
Q
-
I
E
Y
E
-
H
R
---
A
-
P
E
C
-
R
-------
L
---------
G
L
---
K
--
E
---
G
R
---
P
-
F
S
G
V
T
A
C
L
D
F
C
A
H
AHR
D
L
H
N
M
Q
N
G
S
-
T
L
V
C
T
L
T
R
EDNREF
G
G
K
P
ED
E
Q
L
H
V
L
P
L
Y
K
V
S
D
V
D
E
--
F
G
S
-------
V
----------------------------------------------------------------------------------------------------------------------------------------------------
E
-
A
Q
E
E
K
K
R
S
G
--
A
I
Q
V
L
S
----
S
----
F
R
R
K
V
R
M
L
A
E
---
P
V
K
T
----
G
S
-----
D
E
----
V
W
----
S
---------
D
--
S
E
----------
Q
S
F
L
D
P
D
I
G
G
V
A
V
A
P
T
H
G
-----
S
I
L
I
E
C
A
K
R
--
E
-
L
H
A
T
T
P
L
KNPNRNHPT
R
I
S
L
V
F
Y
Q
H
K
SMNEPKHG
L
A
L
W
E
A
K
M
A
E
K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
65.67
12%
-117
- C6 -
1U19
14
OPSD_BOVIN
A:
[42-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
A
A
-------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
----------------------
V
T
V
Q
---------------
H
K
---
K
L
R
T
P
------------------
L
N
Y
I
L
L
--
N
L
A
V
A
D
L
---------------------------
F
M
-----
V
F
G
G
-
F
T
T
T
L
Y
---------
T
S
-
L
H
G
Y
F-
V
F
G
P
T
G
-
C
N
L
E
G
-
F
F
A
-
T
L
G
G
E
I
A
---------
L
W
S
----------------
L
V
V
-
L
A
I
E
R
Y
V
------------
V
V
C
---
K
P
M
-
S
N
F
--
R
---
F
G
E
N
H
A
-
I
M
G
V
A
F
T
------
W
V
M
A
L
---
A
-
C
A
-
A
--
P
P
L
V
-
G
-
W
S
R
-
Y
-
I
P
-
E
G
---
M
-
Q
C
S
C
G
-------
I
---------
D
Y
YTP
H
--
E
ET-
N
N
---
E
-
S
F
V
I
Y
M
F
---------
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
----------------
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
--
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
----
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
---
V
A
F
Y
----
I
F
-----
T
H
----
Q
G
----
S
---------
D
F
-
G
P
----------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
-----
V
I
Y
I
M
M
N
K
Q
--
F
-
R
N
C
M
-------------
V
T
T
L
C
C
G
K
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
65.59
9%
-124
- C6 -
3V2Y
1
ENLYS_BPT4
A:
[63-495]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
T
S
V
-------
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
----------------------
T
I
W
K
---------------
T
K
---
K
F
H
R
P
------------------
M
Y
Y
F
I
G
--
N
L
A
L
S
D
L
---------------------------
L
A
-----
G
V
A
Y
-
T
A
N
L
L
L
---------
S
G
-
A
T
T
Y
--
K
L
T
P
A
Q
-
W
F
L
R
E
-
G
S
M
-
F
V
A
L
S
A
S
---------
V
F
S
----------------
L
L
A
-
I
A
I
E
R
Y
I
------------
T
M
L
---
K
-------------
N
N
F
R
L
-
F
L
L
I
S
A
C
------
W
V
I
S
L
---
I
-
L
G
-
G
--
L
P
I
M
-
G
-
W
N
C
-
I
--
S
------
A
-
L
S
S
C
S
-------
T
---------
V
L
---
P
--
L
---
Y
H
---
K
-
H
Y
I
L
-
F
C
---------
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
----------------
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
--
L
R
I
-------
D
EGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-
A
Y
A
S
R
S
S
E
N
V
A
L
L
K
T
V
I
----
I
----
V
L
S
V
F
I
A
C
W
A
---
P
L
F
I
----
L
L
-----
L
L
----
D
V
G
CK-
V
KT-------
C
D
-
I
L
----------
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
-----
I
I
Y
T
L
T
N
K
E
--
M
-
R
R
A
F
-------------
I
R
I
M
G
R
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
64.53
10%
-125
- C6 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
A
-------
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
----------------------
I
I
L
A
---------------
H
K
---
R
M
R
T
V
------------------
T
N
Y
F
L
V
--
N
L
A
F
A
E
A
---------------------------
S
M
-----
A
A
F
N
-
T
V
V
N
F
T
---------
Y
A
-
V
H
N
E
W-
Y
Y
G
L
F
Y
-
C
K
F
H
N
-
F
F
P
-
I
A
A
V
F
A
S
---------
I
Y
S
----------------
M
T
A
-
V
A
F
D
R
Y
M
------------
A
I
I
---
H
P
L
-
Q
P
R
-
L
-----
S
A
T
A
T
-
K
V
V
I
C
V
I
------
W
V
L
A
L
---
L
-
L
A
-
F
--
P
Q
G
Y
-
Y
-
S
T
T
-
E
--
T
-
M
P
---
S
-
R
V
V
C
M
-------
I
---------
E
W
PE-
H
--
P
NKI
Y
E
---
K
-
V
Y
H
I
C
V
T
---------
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
----------------
V
V
G
I
T
L
W
A
S
E
I
P
G
D
--
S
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
----
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
---
F
F
L
L
----
P
Y
-----
I
N
----
P
D
----
L
YLK------
K
F
-
I
Q
----------
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
-----
I
I
Y
C
C
L
N
D
R
--
F
-
R
L
G
F
-------------
K
H
A
F
R
C
C
P
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
60.94
16%
-133
- C6 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
F
L
P
T
-------
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
----------------------
V
M
G
Y
---------------
Q
K
---
K
L
R
S
M
------------------
T
D
K
Y
R
L
--
H
L
S
V
A
D
L
---------------------------
L
F
-----
V
I
T
--
L
P
F
W
A
V
---------
D
A
-
V
A
N
W
--
Y
F
G
N
F
L
-
C
K
A
V
H
-
V
I
Y
-
T
V
N
L
Y
S
S
---------
V
W
I
----------------
L
A
F
-
I
S
L
D
R
Y
L
------------
A
I
V
---
H
A
T
-
N
S
--
Q
R
--
P
R
K
L
L
A
E
-
K
V
V
Y
V
G
V
------
W
I
P
A
L
---
L
-
L
T
-
I
--
P
D
F
I
-
F
-
A
N
V
-
S
--
E
-
A
D
---
D
-
R
Y
I
C
D
-------
R
---------
F
Y
---
P
N
D
L
---
W
V
---
V
-
V
F
Q
F
Q
H
I
---------
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
----------------
I
I
I
S
K
L
S
H
S
G
S
N
I
F
--
E
M
L
-------
R
----------------------------------------------------------------------------------------------------------------------------------------------------
I
-
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
----
I
----
G
I
G
H
L
L
T
K
S
P
---
S
L
N
A
----
A
K
-----
S
E
----
L
D
----
K
---------
A
I
-
G
R
----------
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
-----
V
D
A
A
V
R
G
I
L
--
R
-
N
A
K
L
-------------
K
P
V
Y
D
S
L
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
57.07
8%
-153
- C5 -
1OCK
-
?
A:
[1-412]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
S
L
A
D
L
Q
R
R
I
E
T
GELS
P
N
A
A
I
A
Q
S
H
A
A
I
E
A
R
E
K
E
V
HAFVRHDKS
A
R
A
Q
ASGPLRG
I
A
V
G
I
K
---------------
D
I
I
D
T
A
N
M
P
T
EMGSEIYRGWQPRSDA
P
V
V
M
M
L
K
R
A
G
A
T
I
I
G
K
T
T
T
T
AFASRDPTATLNPHNTGHSPGGSS
S
G
-----
S
A
A
A
-
V
G
A
G
M
I
---------
P
L
-
A
L
G
T
--
Q
T
G
G
S
V
-
I
R
P
A
A
-
Y
C
G
-
T
A
A
I
K
P
S
FRMLPTVGV
K
C
Y
----------------
S
W
A
-
L
D
T
V
G
L
F
G
A----------
R
A
E
D
L
A
R
G
L
-
L
A
M
-
T
G
--
R
S
E
F
S
G
I
--
V
P
A
K
A
P
------
R
I
G
V
V
---
R
-
Q
E
-
F
--
A
G
A
V
-
E
-
P
A
A
-
E
Q
G
L
-
Q
A
---
A
-
I
K
A
A
E
R
A
G
A
S
--
V
---------
Q
A
---
I
--
D
---
L
P
---
E
-
A
V
H
E
A
W
R
---------
I
H
P
I
I
Q
D
F
E
A
H
R
A
L
A
W
----------------
E
F
S
E
H
H
D
E
I
A
P
M
L
R
--
A
S
L
-------
D
----------------------------------------------------------------------------------------------------------------------------------------------------
A
-
T
V
G
L
T
P
K
E
Y
D
E
A
R
R
I
G
R
----
R
----
G
R
R
E
L
G
E
V
F
E
GVD
V
L
L
T
----
Y
S
-----
A
P
----
G
T
----
A
---------
P
A
-
K
A
LASTGDPRYN
R
L
W
T
L
M
G
N
P
C
V
N
V
P
V
L
K
V
GG
L
P
I
G
V
Q
V
I
A
R
F
G
--
N
-
D
A
H
A
-------------
L
A
T
A
W
F
L
E
D
A
L
A
K-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
52.44
13%
-107
- C3 -
1HRU
1
TSAC_ECOLI
A:
[3-188]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
L
Q
R
D
A
------------------
I
A
A
A
I
D
--
V
L
N
E
E
R
-----------------------------------------
V
I
A
Y
P
---------
T
----
E
A
--
V
F
G
V
G
C
-
D
P
D
S
E
-
T
A
V
M
R
L
L
E
L
K
----------
Q
R
P
----------------
V
D
K
-
G
L
I
L
I
A
A
------------
N
Y
E
Q
L
K
P
Y
I
-
D
D
T
M
L
T
--
D
V
Q
R
E
T
I
-
F
S
R
W
P
G
P
------
V
T
F
V
F
---
P
-
A
----------
P
-
A
T
T
-
P
R
W
L
-
T
G
---
R
-
F
D
S
L
A
-------
V
---------
R
V
---
T
--
D
---
H
P
---
L
-
V
V
A
L
C
Q
A
---------
Y
G
K
P
L
V
S
T
S
A
N
L
----------------------------------------------
S
----------------------------------------------------------------------------------------------------------------------------------------------------
G
-
L
P
P
C
R
T
V
D
E
V
R
A
Q
F
G
A
A
----
F
----
P
-------------
V
V
P
----
G
E
-----
T
G
----
G
R
----
L
---------
N
P
-
S
E
----------
I
R
D
A
L
--
T
G
E
L
F
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
51.85
9%
-135
- C6 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-230]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
L
-------
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
----------------------
A
V
L
K
---------------
E
---
R
A
L
Q
T
T
------------------
T
N
Y
L
V
V
--
S
L
A
V
A
D
L
---------------------------
L
V
-----
A
T
L
V
-
M
P
W
V
V
Y
---------
L
E
-
V
T
G
G
VW
N
F
S
R
I
C
-
C
D
V
F
V
-
T
L
D
-
V
M
M
C
T
A
S
---------
I
W
N
----------------
L
C
A
-
I
S
I
D
R
Y
T
------------
A
V
V
---
M
P
V
-
H
Y
Q
-
H
G
T
G
Q
S
S
C
R
R
V
-
A
L
M
I
T
A
V
------
W
V
L
A
F
---
A
-
V
S
-
C
--
P
L
L
F
-
G
-
F
N
T
-
T
--
G
------
D
-
P
T
V
C
S
-------
I
---------
S
N
---------------
P
-
D
F
V
I
Y
S
S
---------
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
----------------
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
--
F
E
M
-------
L
----------------------------------------------------------------------------------------------------------------------------------------------------
R
-
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
----
T
----
I
G
I
G
H
L
L
T
K
S
---
P
S
L
N
----
A
A
-----
K
S
----
E
L
----
D
---------
K
A
-
I
G
----------
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
-----
D
V
D
A
A
V
R
G
I
--
L
-
R
N
A
K
-------------
L
K
P
V
Y
D
S
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
HHSearch
51.72
11%
-125
- C6 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-204]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
V
V
-------
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
----------------------
A
V
R
S
---------------
E
R
---
K
L
H
T
V
------------------
G
N
L
Y
I
V
--
S
L
S
V
A
D
L
---------------------------
I
V
-----
G
A
V
V
-
M
P
M
N
I
L
---------
Y
L
-
L
M
S
K
W-
S
L
G
R
P
L
-
C
L
F
W
L
-
S
M
D
-
Y
V
A
S
T
A
S
---------
I
F
S
----------------
V
F
I
-
L
C
I
D
R
Y
R
------------
S
V
Q
---
Q
P
L
-
R
Y
--
L
K
--
Y
R
T
K
T
R
A
-
S
A
T
I
L
G
A
------
W
F
L
S
F
---
L
-
W
V
-
I
--
P
I
L
G
-
W
-
N
H
--------
R
---
R
-
E
D
K
C
E
-------
T
---------
D
F
---
Y
--
D
----
V
---
T
-
W
F
K
V
M
T
A
---------
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
----------------
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
--
M
L
R
-------
I
----------------------------------------------------------------------------------------------------------------------------------------------------
D
-
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
----
G
----
I
G
H
L
L
T
K
S
P
S
---
L
N
A
A
----
K
S
-----
E
L
----
D
K
----
A
---------
I
G
-
R
N
----------
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
-----
D
A
A
V
R
G
I
L
R
--
N
-
A
K
L
K
-------------
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
50.42
14%
-141
- C1 -
4MT1
-
?
A:
[2-1040]
A
K
F
F
I
D
R
P
I
F
A
W
V
I
S
I
F
I
I
A
A
G
I
F
G
I
K
S
LPVSQYPSVA
A
P
T
I
T
L
H
A
I
Y
PGAS
A
Q
V
M
E
G
SV
L
S
V
I
E
R
N
MNGVEGLD
Y
M
S
T
S
A
D
SSG
S
G
S
V
S
L
T
F
T
PDTD
E
N
L
A
Q
V
E
V
Q
N
K
L
S
E
V
LSTLP
A
T
V
Q
Q
Y
G
V
T
V
S
KARSNFL
M
I
V
M
L
S
S
DVQS
T
E
E
M
N
D
Y
A
Q
R
N
V
VPELQRIEGVG
Q
V
R
L
FGAQRAM
R
I
W
V
D
P
K
K
L
Q
N
Y
NLS
F
A
D
V
G
S
A
L
S
A
Q
N
I
Q
I
S
A
G
S
I
GSLPAVRGQ
T
V
T
A
T
V
T
A
Q
GQLGT
A
E
E
F
G
N
VILRANTDG
S
N
I
Y
LKDVAK
V
G
L
G
M
EDYS
S
S
T
R
L
NG
V
N
T
T
G
M
A
V
M
L
S
NSGNA
M
A
T
A
K
A
V
K
E
R
L
A
V
L
E
K
Y
FPQG
M
S
W
K
T
PYDT
S
K
F
V
E
I
S
I
E
K
V
I
H
T
L
I
E
A
M
V
L
V
F
V
V
M
Y
L
F
L
QNIRYT
L
I
P
T
I
V
V
P
I
S
L
L
G
G
F
A
F
I
S
Y
M
G
M
S
I
N
V
L
T
M
F
A
M
-------
I
L
V
I
G
I
V
V
D
D
A
I
V
V
V
E
N
V
----------------------
E
R
I
M
---------------
A
G
E
G
L
P
P
K
E
A
------------------
T
K
K
A
M
G
--
Q
I
S
G
A
V
I
---------------------------
G
I
-----
T
A
V
L
-
I
S
V
F
V
P
LAMFSG
A
A
G
N
I
-
Y
K
Q
F
--
A
L
T
M
A
S
-
S
I
A
F
S
-
A
F
L
-
A
L
T
--
L
T
---------
P
A
L
----------------
C
A
T
G
F
F
G
W
F
N
K
------------
K
F
D
S
W
T
H
G
Y
-
E
G
R
-
V
A
--
K
V
L
R
K
T
F
-
R
M
M
V
V
Y
I
------
G
L
A
V
V
---
G
-
V
F
-
L
--
F
M
R
L
-
P
-
T
S
F
-
L
P
T
E
-
D
Q
---
G
-
F
V
M
V
S
-------
V
---------
Q
L
---
P
--
A
---
G
A
---
T
--
K
E
R
T
D
A
---------
T
L
A
Q
V
T
Q
L
A
K
S
I
P
E
I
E
----------------
N
I
I
T
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
F
S
F
S
G
S
G
---------
Q
----
N
----
M
A
M
G
F
A
I
F
-------------
K
D
-----
W
N
----
E
R
----
T
---------
A
S
G
S
D
----------
A
V
A
V
A
G
K
L
T
G
M
M
M
G
T
L
K
D
-----
G
F
G
I
A
V
V
P
P
PI
L
-
E
L
G
S
-------------
G
L
S
I
N
L
Q
D
R
NNTG
H
T
A
L
L
A
K
R
N
E
L
I
Q
K
M
R
A
SGLFDPST
V
R
A
G
G
L
E
D
S
P
Q
L
K
I
D
I
N
R
A
A
A
A
A
QGIS
F
A
D
I
R
T
A
L
A
S
A
LS
S
S
Y
V
S
D
F
P
N
QG
R
L
Q
R
V
M
V
Q
A
D
EDARMQPADILNLTVPNKSG
V
A
V
P
LSTI
A
T
V
S
W
E
N
G
T
E
Q
S
V
R
F
NG
Y
P
S
M
K
L
S
A
S
PATGVST
G
Q
A
M
E
A
V
Q
K
M
V
D
E
L
GGG
Y
S
F
E
W
G
G
Q
S
S
E
E
A
K
GGSQ
T
L
I
L
Y
G
L
A
V
A
A
V
F
L
V
L
A
A
L
Y
ESW
S
I
P
L
A
V
I
L
V
I
P
L
G
L
I
G
A
A
A
G
V
T
G
R
N
L
F
E
G
L
LGSVPSFAND
I
Y
F
Q
V
G
F
V
T
V
M
G
L
S
A
K
N
A
I
L
I
I
E
F
A
K
D
L
Q
A
Q
GKS
A
V
E
A
A
L
E
A
A
R
L
R
F
R
P
I
I
M
T
S
F
A
F
I
L
G
V
V
PLYIAAGAS
S
A
S
Q
R
A
I
G
T
T
V
F
W
G
M
L
V
G
T
L
L
S
V
F
L
V
P
L
F
Y
V
V
V
R
K
F
F
5
HHSearch
50.03
9%
-118
- C6 -
2RH1
6
ADRB2_HUMAN (first)
A:
[42-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
G
I
-------
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
----------------------
A
I
A
K
---------------
F
E
---
R
L
Q
T
V
------------------
T
N
Y
F
I
T
--
S
L
A
C
A
D
L
---------------------------
V
M
-----
G
L
A
V
-
V
P
F
G
A
A
---------
H
I
-
L
M
K
M
W-
T
F
G
N
F
W
-
C
E
F
W
T
-
S
I
D
-
V
L
C
V
T
A
S
---------
I
E
T
----------------
L
C
V
-
I
A
V
D
R
Y
F
------------
A
I
T
---
S
P
F
-
K
Y
--
Q
S
--
L
L
T
K
N
K
A
-
R
V
I
I
L
M
V
------
W
I
V
S
G
---
L
-
T
S
-
F
--
L
P
I
Q
M
H
W
Y
R
A
-
T
H
Q
E
-
A
I
N
C
Y
A
-
E
E
T
C
C
-------
D
---------
F
F
----------
T
N
---
Q
-
A
Y
A
I
A
S
S
---------
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
----------------
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
--
M
L
R
-------
I
----------------------------------------------------------------------------------------------------------------------------------------------------
D
-
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
----
G
----
I
G
H
L
L
T
K
S
P
S
---
L
N
A
A
----
K
S
-----
E
L
----
D
K
----
A
---------
I
G
-
R
N
----------
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
-----
D
A
A
V
R
G
I
L
R
--
N
-
A
K
L
K
-------------
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
49.71
10%
-114
- C6 -
3EML
8
ENLYS_BPT4
A:
[23-225]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
T
-------
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
----------------------
A
V
W
L
---------------
N
S
---
N
L
Q
N
V
------------------
T
N
Y
F
V
V
--
S
L
A
A
A
D
I
---------------------------
A
V
-----
G
V
L
A
-
I
P
F
A
I
T
---------
I
S
-
T
-
G
F
--
C
A
A
C
H
G
-
C
L
F
I
A
-
C
F
V
-
L
V
L
T
Q
S
S
---------
I
F
S
----------------
L
L
A
-
I
A
I
D
R
Y
I
------------
A
I
R
---
I
P
L
-
R
Y
--
N
G
--
L
V
T
G
T
R
A
-
K
G
I
I
A
I
C
------
W
V
L
S
F
---
A
-
I
G
-
L
--
T
P
M
L
-
G
-
W
N
N
-
C
G
Q
---------
S
Q
G
C
G
EGQVACL
F
---------
E
D
---
V
--
V
---
P
M
---
N
-
Y
M
V
Y
F
N
F
---------
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
----------------
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
--
M
L
R
-------
I
----------------------------------------------------------------------------------------------------------------------------------------------------
D
-
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
----
G
----
I
G
H
L
L
T
K
S
P
S
---
L
N
A
A
----
K
S
-----
E
L
----
D
K
----
A
---------
I
G
-
R
N
----------
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
-----
D
A
A
V
R
G
I
L
R
--
N
-
A
K
L
K
-------------
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
HHSearch
47.00
8%
-117
- C6 -
3UON
2
ACM2_HUMAN (first)
A:
[25-218]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
V
L
-------
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
----------------------
S
I
K
V
---------------
N
R
---
H
L
Q
T
V
------------------
N
N
Y
F
L
F
--
S
L
A
C
A
D
L
---------------------------
I
I
-----
G
V
F
S
-
M
N
L
Y
T
L
---------
Y
T
-
V
I
G
Y
W-
P
L
G
P
V
V
-
C
D
L
W
L
-
A
L
D
-
Y
V
V
S
N
A
S
---------
V
M
N
----------------
L
L
I
-
I
S
F
D
R
Y
F
------------
C
V
T
---
K
P
L
-
T
Y
--
P
V
--
K
R
T
T
K
M
A
-
G
M
M
I
A
A
A
------
W
V
L
S
F
---
I
-
L
W
-
A
--
P
A
I
L
-
F
-
W
Q
F
I
V
G
V
R
-
T
V
---
E
-
D
G
E
C
Y
-------
I
---------
Q
F
---
F
------
S
N
---
A
-
A
V
T
F
G
T
A
---------
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
----------------
H
I
S
R
A
S
K
S
R
I
N
I
F
E
--
M
L
R
-------
I
----------------------------------------------------------------------------------------------------------------------------------------------------
D
-
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
----
G
----
I
G
H
L
L
T
K
S
P
S
---
L
N
A
A
----
K
S
-----
E
L
----
D
K
----
A
---------
I
G
-
R
N
----------
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
-----
D
A
A
V
R
G
I
L
R
--
N
-
A
K
L
K
-------------
P
V
Y
D
S
L
D
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
43.04
19%
-100
- C6 -
3VW7
6
PAR1_HUMAN
A:
[380-455]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
R
S
K
K
S
R
A
L
F
L
S
A
----
A
----
V
F
C
I
F
I
I
C
F
G
---
P
T
N
V
L
L
I
A
H
Y
-----
S
F
----
L
S
HTST
T
---------
E
A
-
A
Y
----------
F
A
Y
L
L
C
V
C
V
S
S
I
S
C
C
I
D
P
-----
L
I
Y
Y
Y
A
S
S
E
--
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
38.07
12%
17
* C5 *
3OBH
3
?
A:
[7-72]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
--
F
E
I
E
E
H
L
-
L
T
L
S
E
N
E
KG
W
T
K
E
I
N
R
V
S
---
F
-
N
G
-
A
--
P
A
K
F
-
D
-
I
R
A
-
W
S
P
D
-
H
T
---
K
M
G
K
G
I
T
-------
L
---------
S
N
---
E
--
E
---
F
Q
---
T
M
V
D
A
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
35.68
10%
-52
- C6 -
3V2Y
1
A:
[415-495]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
A
L
L
K
T
V
I
I
V
L
S
----
V
----
F
I
A
C
W
A
P
L
F
I
---
L
L
L
L
----
D
V
G
CKVK
T
C
----
D
I
----
L
---------
F
R
-
A
E
----------
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
-----
L
T
N
K
E
M
R
R
A
--
F
-
I
R
I
M
-------------
G
R
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------