@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TA2R3_HUMAN: (2016-01-15 )
MMGLTEGVFLILSGTQFTLGILVNCFIELVNGSSWFKTKRMSLSDFIITTLALLRIILLCIILTDSFLIEFSPNTHDSGIIMQIIDVSWTFTNHLSIWLATCLGVLYCLKIASFSHPTFLWLKWRVSRVMVWMLLGALLLSCGSTASLINEFKLYSVFRGIEATRNVTEHFRKKRSEYYLIHVLGTLWYLPPLIVSLASYSLLIFSLGRHTRQMLQNGTSSRDPTTEAHKRAIRIILSFFFLFLLYFLAFLIASFGNFLPKTKMAKMIGEVMTMFYPAGHSFILILGNSKLKQTFVVMLRCESGHLKPGSKGPIFS
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.....----------------------------....10-........20........30....-------------....40.......--------------.50........60----..-.......70-........80-........90........100-.......--110-.-......120.---......130-........140......-.150.-......-.160.-----------------.-...----.-----.-170..-..-.---..----------..-180.......190.......200.......210------.........-----------------------------------------------------------------------------------------------------------------------------------------------------220----------------------------------------------------------------------------------------------------------------------------------------------------.---------------........230.......240...-----------....250........260---------.----.---.......270......--------.---280.......290...---....300.......310....------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMGLT----------------------------
E
G
V
F
L
I
-
L
SGT
Q
F
T
L
G
I
L
V
N
C
F
I
E
LVNGSS
W
-------------
F
K
T
KRM
S
L
S
D
F
I
I
--------------
T
T
L
A
L
L
R
I
I
L
L
C
-----
I
I
-LTD
S
F
L
I
E
F-SPNTHDS
G
I
I
-
M
Q
I
I
D
V
S
W
T
FT
N
H
L
S
I
W
L
A
T
C
-
L
G
V
L
Y
C
L
--
K
I
A-S-FSHP
T
F
L
W
L
K
---
W
R
V
S
R
V
M
V
--
W
M
L
L
G
A
L
L
L
SCG
S
T
A
S
L
-
I
N
E
-
F
-
K
L
Y
S
V
F
-
R
G
I
E
A
-----------------
T
-
R
N
V
----
T
-----
E
-
H
--
F
R
-
K
K-R---S
E
----------
Y
Y
-
L
I
H
V
L
G
T
L
WY
L
P
P
L
I
V
S
L
A
S
Y
S
L
L
I
F
S
L
G
R
H
--------
T
R
Q
M
L
QNGT-----------------------------------------------------------------------------------------------------------------------------------------------------S------------------------------------------------------------------------------------------------------------------------------------------------------S---------------RDP
T
T
E
A
H
K
R
A
I
R
I
I
L
S
F
F
F
L
F
L
L
-----------
Y
F
L
A
F
L
-
I
A
S
F
GNFLP-----------
K
----
T
---
K
M
A
K
M
I
G
E
V
M
T
M
F
YPA--------G---
H
S
F
I
L
I
LGNSK
L
K
Q
T
F
---
V
V
M
L
R
CESGHLKPGSKGPIFS------------------------------------------------------
41
Fugue
82.02
17%
-160
- C2 -
4XGC
-
?
D:
[5-457]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D
R
E
L
V
S
I
R
R
F
L
K
E
R
L
Q
RDYTTLRGY
A
K
E
R
S
N
V
R
L
L
L
Q
R
T
A
E
M
G
E
S
----------------------------
N
S
L
L
L
L
-
G
P
R
G
S
G
K
T
T
L
I
N
S
V
L
A
D
L
L
P
N
K
S
F
G
E
N
T
L
I
V
H
L
D
GNL
H
T
D
D
R
V
A
L
K
S
I
T
V
Q
M
QLENAADGKVFG
S
F
A
E
N
L
A
F
L
L
Q
C
L
KS
K
S
V
I
-
F
I
L
E
E
F
D
L
F
-
C
A
H
-
H
N
Q
T
L
L
-
Y
N
L
F
D
V
S
Q
S
A
Q
A
P
I
C
V
L
G
V
T
C
R
L
D
V
I
E
L
L
E
K
R
V
K
-
S
R
F
S
H
R
Q
V
F
L
F
P
----
S
L
R
R
F
E
D
--
Y
V
D
L
C
R
D
L
L
S
L
P
T
G
N
S
L
-
L
L
A
-
A
-
E
K
I
Y
N
L
-
Q
N
I
Q
S
GALYFSRNHFDPGE
Y
G
F
S
-
P
R
L
----
R
-----
D
-
A
--
W
N
-
K
Q
-
I
---
C
K
----------
V
L
A
T
Q
Q
A
R
S
T
L
Q
A
L
H
D
F
D
I
S
E
A
Y
L
K
N
F
L
F
R
L
V
A
H
LRPQSPHI
T
A
E
K
M
A
A
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---------------
F
E
G
D
D
K
I
E
L
L
C
G
L
S
V
L
E
L
C
L
I
I
A
I
K
H
H
S
Q
I
Y
DRDS
F
N
F
E
I
I
-
Y
A
R
F
S
K
F
A
K
-----------
V
S---
T
---
T
M
Q
A
V
E
R
S
I
V
L
K
A
F
E
H
--------
L
---
R
I
A
E
L
I
M
P
L
T
K
V
Q
K
E
F
E
M
H
K
L
A
L
T
Y
S
Q
I
H
H
C
M
Q
R
Y
Q
A
L
P
T
E
V
A
Q
W
A
QSS---------------------------------------------
30
HHSearch
81.16
14%
-128
* C2 *
1U19
14
OPSD_BOVIN
A:
[42-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
----------------
K
K
L
R
T
P
L
N
Y
I
L
--------------
L
N
L
A
V
A
D
L
F
M
V
F
-----
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-
L
A
I
E
R
Y
V
--
V
V
C
-
K
----
P
M
S
N
F
-
R
---
F
G
-
E
N
H
A
I
--
M
----
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
-
L
-
V
--
G
W
S
R
Y
I
P
E
G
-------------------
M
Q
C
----
S
-----
C
-
G
I
D
Y
Y
T
P
H
-
E
ET-
N
N
----------
E
S
-
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--------
A
A
Q
Q
Q
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
-----------
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q----------
G
SDF-
G
---
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
--------
Y
---
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
---
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
------------------------------------------------------
40
Fugue
80.85
14%
-108
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
G
T
E
G
PNFYVPFSNKTGVVRSPFEAPQYYLAE
P
W
Q
F
S
M
-
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
-------------
Q
H
K
K
L
R
T
P
L
N
Y
I
L
--------------
L
N
L
A
V
A
D
L
F
M
V
F
-----
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
-
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-
L
A
I
E
R
Y
V
--
V
V
C
K
P
-
M
S
N
F
R
F
G
E
N
H
---
A
I
M
G
V
A
F
T
--
W
V
M
A
L
A
C
A
A
------
P
P
-
L
V
G
-
W
-
S
R
Y
-
I
P
-
E
G
M
Q
C
-----------------
S
-
C
G
I
----
D
-----
Y
-
Y
--
T
P
-
H
E
-
E
TN-
N
E
----------
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
--------------
T
V
K
E
A
A
A
Q
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
E
---------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
-----------
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
-----------
Q
G---
S
---
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
--------
S
AV
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
---
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA--------------------------------------------
32
HHSearch
77.79
18%
-127
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------------------
K
Y
V
V
I
I
-
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
----------------
R
V
G
R
S
V
T
D
V
Y
L
--------------
L
N
L
A
L
A
D
L
L
F
A
L
-----
T
L
--
P
I
W
A
A
S
-
K
-
V
N
G
W
I
F
G
T
F
L
-
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
-
I
S
V
D
R
Y
L
--
A
I
V
-
H
----
A
T
R
T
L
-
T
---
Q
K
-
R
H
L
V
K
--
F
----
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
-
F
-
L
--
F
R
Q
A
Y
H
P
N
N
-----------------
S
-
S
P
V
----
C
-----
Y
-
E
--
V
L
-
G
N
-
D
TAK
W
R
----------
M
V
-
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
--------
H
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
-----------
C
W
L
P
Y
N
-
L
V
L
L
A
D
T
L
M
RTQVIQE
S
C
E
R
R
----
N
N
I
-
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
--------
L
---
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
---
L
K
I
L
A
M
H
G
-------------------------------------------------------------------
24
HHSearch
77.40
15%
-122
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[47-498]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------------------------
K
I
F
L
P
T
-
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
----------------
K
K
L
R
S
M
T
D
K
Y
R
--------------
L
H
L
S
V
A
D
L
L
F
V
I
-----
T
--
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
-
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
-
I
S
L
D
R
Y
L
--
A
I
V
-
H
----
A
T
N
S
Q
R
----
P
R
K
L
L
A
E
K
--
V
V
----
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
-
F
-
I
--
F
A
N
V
S
E
A
D
D
-------------------
R
Y
I
----
C
-----
D
-
R
F
-
Y
P
-
N
D
-
L
---
W
V
----------
V
V
-
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
--------
G
S
N
I
F
E
M
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
---------------
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
-----------
C
W
L
P
Y
Y
-
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
---
T
V
--
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
--------
L
---
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
---
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
------------------------------------------------------------
31
HHSearch
72.91
11%
-116
- C2 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
A
A
-
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
----------------
K
R
M
R
T
V
T
N
Y
F
L
--------------
V
N
L
A
F
A
E
A
S
M
A
A
-----
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
-
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
-
V
A
F
D
R
Y
M
--
A
I
I
-
H
----
P
L
Q
P
R
L
S
---
A
---
T
A
T
K
--
V
V
----
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
-
G
-
Y
--
Y
S
T
-
T
E
T
M
P
-----------------
S
-
R
V
V
----
C
-----
M
I
E
--
W
P
-
E
H
P
N
KI-
Y
E
----------
K
V
-
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
--------
E
I
P
G
D
S
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
-----------
C
W
L
P
F
H
-
I
F
F
L
L
P
Y
I
N
-----------
P
DLYL
K
KFI
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
--------
Y
---
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
---
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
------------------------------------------------------
46
Fugue
72.54
11%
-103
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
G
T
E
----------------------------
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
-------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
--------------
L
G
F
P
I
N
F
L
T
L
Y
V
-----
T
V
-
Q
H
K
K
L
R
T
P
L
-
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
-
F
G
P
T
G
C
N
--
L
E
G
-
F
-
F
A
T
L
G
G
E
I
A
L
---
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
-
A
I
M
-
G
-
V
A
F
T
W
V
-
M
A
L
A
C
-----------------
A
-
A
P
P
----
L
-----
V
-
G
--
W
S
-
R
Y
-
I
---
P
E
GMQC
S
C
G
I
DY
Y
T
-
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
--------
Q
L
V
F
T
V
K
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
-----------
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----------
G
----
S
---
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
--------
S
AVY
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
---
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A--------------------------------------------------
25
HHSearch
70.08
13%
-123
- C2 -
3EML
13
ENLYS_BPT4
A:
[22-472]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
I
T
-
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
----------------
S
N
L
Q
N
V
T
N
Y
F
V
--------------
V
S
L
A
A
A
D
I
A
V
G
V
-----
L
A
-
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
-
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-
I
A
I
D
R
Y
I
--
A
I
R
-
I
----
P
L
R
Y
N
G
L
----
V
T
G
T
R
A
K
--
G
I
----
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
-
Q
----------------------S
Q
G
C
----
G
EGQVA
C
-
L
--
F
E
-
D
V
-
V
---
P
M
----------
N
Y
-
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
--------
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
-----------
C
W
L
P
L
H
-
I
I
N
C
F
T
F
F
C
-----------
P
DCSH
A
P--
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
--------
V
---
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
---
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------------------------------------
21
HHSearch
68.13
12%
-130
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
V
L
-
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
----------------
R
H
L
Q
T
V
N
N
Y
F
L
--------------
F
S
L
A
C
A
D
L
I
I
G
V
-----
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
-
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
-
I
S
F
D
R
Y
F
--
C
V
T
-
K
----
P
L
T
Y
P
V
K
---
R
-
T
T
K
M
A
G
--
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
-
Q
----
F
I
V
-
G
V
R
T
V
-------------------
E
D
G
----
E
-----
C
-
Y
--
I
Q
-
F
--
F
---
S
N
----------
A
A
-
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
--------
I
N
I
F
E
M
L
R
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
---------------
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
-----------
T
W
A
P
Y
N
-
V
M
V
L
I
N
T
F
C
-----------
A
PCI-
P
---
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
--------
I
---
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
---
K
H
L
L
M
----------------------------------------------------------------------
49
Fugue
66.41
15%
-147
- C2 -
1EHK
6
COX1_THET8
A:
[14-562]
AYP
E
K
K
A
T
L
Y
F
L
V
L
G
F
L
A
L
I
V
G
S
L
F
G
P
F
Q
A
L
N
Y
G
NVDA
Y
P
L
L
K
R
L
L
PFVQS
Y
Y
Q
G
L
T
L
H
G
V
L
N
AI
V
F
T
Q
L
F
A
Q
A
I
M
V
Y
L
P
A
R
E
L
NMRPN
M
G
L
M
W
L
S
W
W
M
A
F
I
G
L
V
V
A
A
L
P
L
L
A
NEATVLYTFYPPLKGH
W
A
F
Y
L
G
A
S
V
F
V
L
S
T
W
V
S
I
Y
I
V
L
D
L
W
R
R
W
K
A
A
N
PGKVTP
L
V
T
Y
M
A
V
V
F
W
L
M
W
F
L
A
S
L
G
L
V
L
E
A
V
L
F
L
L
P
W
S
F
GLVEGVD
P
L
V
A
R
T
L
F
W
W
T
G
H
P
----------------------------
I
V
Y
F
W
L
-
L
P
A
Y
A
I
I
Y
T
I
L
P
K
Q
A
--------------------------
G
G
K
L
V
S
D
P
M
--------------
A
R
L
A
F
L
L
F
L
L
L
S
-----
T
P
-
V
--
G
F
H
H
Q
F
-
A
D
P
G
I
D
P
T
W
K
-
M
I
H
S
V
L
T
L
F
V
A
V
P
S
L
M
T
A
F
T
V
-
A
A
S
L
E
F
A
--
G
R
L
-
R
-
G
G
R
G
L
F
G
W
I
R
A
LP
W
D
N
P
A
F
V
A
--
P
V
L
G
L
L
G
F
I
P
G
G
A
G
G
I
V
-
N
A
S
-
F
-
T
L
D
Y
V
V
-
H
N
--------------------
T
-
A
W
V
----
P
-----
G
-
H
--
F
H
-
L
Q
-
V
---
A
S
----------
L
V
-
T
L
T
A
M
G
S
L
Y
W
L
L
P
N
L
T
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
I
S
D
A
Q
R
R
L
G
L
A
V
V
W
L
W
F
L
G
M
M
I
-----------
M
A
V
G
L
H
-
W
A
G
L
L
N
V
P
R
-----------
R
----
A
---
Y
I
A
Q
V
P
D
A
--
Y
P
H
A
A
V
--------
P
---
M
V
F
N
V
L
A
G
I
V
L
L
V
A
L
L
---
L
F
I
Y
G
L
F
S
V
L
L
S
R
L
A
E
A
P
L
P
F
A
E
V
I
S
G
PE
D
R
R
L
V
L
A
M
D
R
I
G
F
W
F
A
V
A
A
I
L
V
V
L
A
Y
G
P
T
L
V
Q
L
F
G
H
L
N
P
V
P
G
W
R
LW
33
HHSearch
65.34
12%
-111
- C2 -
2Z73
5
OPSD_TODPA
A:
[34-333]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
S
L
G
I
-
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
----------------
K
S
L
Q
T
P
A
N
M
F
I
--------------
I
N
L
A
F
S
D
F
T
F
S
L
-----
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
-
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-
I
S
I
D
R
Y
N
--
V
I
G
-
R
----
P
M
A
A
S
K
K
----
M
S
H
R
R
A
F
--
I
M
----
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
-
I
-
F
--
G
W
G
A
Y
T
L
E
G
-------------------
V
L
C
----
N
-----
C
-
S
F
D
Y
I
-
S
R
-
D
S
--
T
T
----------
R
S
-
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
--------
E
K
E
M
A
A
M
A
K
RLNAKE
L
----------------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------------
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
-----------
S
W
S
P
Y
A
-
V
V
A
L
L
A
Q
F
G
-----------
P
LEWV
T
---
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
--------
H
---
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
---
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
------------------------------------------------------
23
HHSearch
63.45
11%
-138
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[42-477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
G
I
-
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
----------------
E
R
L
Q
T
V
T
N
Y
F
I
--------------
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
-
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
-
I
A
V
D
R
Y
F
--
A
I
T
-
S
----
P
F
K
Y
Q
S
L
---
L
-
T
K
N
K
A
R
--
V
I
----
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-
I
-
Q
M
-
H
W
Y
R
A
T
H
Q
E
-----------------
A
-
I
N
C
Y
A
EE
T
-----
C
-
C
--
D
--
F
--
F
---
T
N
----------
Q
A
-
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
--------
L
N
I
F
E
M
L
R
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
---------------
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
-----------
C
W
L
P
F
F
-
I
V
N
I
V
H
V
I
Q
-----------
D
NLI-
R
---
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
--------
F
---
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
---
Q
E
L
L
C
L
---------------------------------------------------------------------
29
HHSearch
63.35
10%
-115
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[63-495]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
T
S
V
-
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
----------------
K
K
F
H
R
P
M
Y
Y
F
I
--------------
G
N
L
A
L
S
D
L
L
A
G
V
-----
A
Y
-
T
A
N
L
L
L
S
G
--
A
T
T
Y
K
L
T
P
A
Q
-
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
-
I
A
I
E
R
Y
I
--
T
M
L
-
K
----------------
N
N
F
R
L
F
--
L
----
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
-
I
-
M
--
G
W
--
N
C
I
S
--------------------
A
L
S
----
S
-----
C
-
S
--
T
V
-
L
P
-
L
---
Y
H
----------
K
H
-
Y
-
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
--------
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------
Y
A
S
R
S
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
-----------
C
W
A
P
L
F
-
I
L
L
L
L
D
V
G
C
-----------
K
VKT-
C
D
I
-
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
--------
T
---
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
---
I
R
I
M
G
R
P
L
-------------------------------------------------------------------
22
HHSearch
62.49
12%
-134
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
L
V
V
-
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
----------------
R
K
L
H
T
V
G
N
L
Y
I
--------------
V
S
L
S
V
A
D
L
I
V
G
A
-----
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
-
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
-
L
C
I
D
R
Y
R
--
S
V
Q
-
Q
----
P
L
R
Y
L
K
Y
---
R
-
T
K
T
R
A
S
--
A
T
----
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
-
L
G
W
N
-
H
---------------------------
R
R
E
----
D
-----
K
-
C
--
E
T
-
D
F
-
Y
---
D
V
----------
T
W
-
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
--------
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-----------------
T
P
-----------------------------------------------------------------------------------------------------------------------------------------------------
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
-----------
C
W
I
P
Y
F
-
I
F
F
M
V
I
A
F
C
-----------
K
NCC-
N
---
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
--------
L
---
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
---
K
R
I
L
H
I
---------------------------------------------------------------------
4
PsiBlast_PDB
59.97
23%
-91
- C- -
3C9M
1
OPSD_BOVIN
A:
[193-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
P
-
H
---
E
-
E
T
-
N
---
N
E
----------
S
F
-
V
I
Y
M
F
-
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--------
A
A
Q
Q
Q
E
S
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
-----------
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
------------------
T
---
H
Q
G
S
C
F
G
P
I
F
-
M
T
I
P
A
FFAKTSAV
Y
---
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
---
V
T
T
L
C
C
G
K
N
P
-----------------------------------------------------------------
27
HHSearch
58.07
10%
-123
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
L
-
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
----------------
R
A
L
Q
T
T
T
N
Y
L
V
--------------
V
S
L
A
V
A
D
L
L
V
A
T
-----
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
-
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
-
I
S
I
D
R
Y
T
--
A
V
V
-
M
----
P
V
H
Y
Q
H
G
T
G
-
Q
S
S
C
R
R
V
A
--
L
----
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
-
L
-
F
--
G
F
--
N
T
T
G
--------------------
D
P
T
----
V
-----
C
-
S
--
I
S
-
N
-------
P
-----------
D
-
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
--------
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
---------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW--------------------------------------------------------------------------------------------------------------------------------------
D
---------------
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
-----------
C
W
L
P
F
F
-
L
T
H
V
L
N
T
H
C
QTCH-------
V
----
S
---
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
--------
L
---
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
---
L
K
I
L
S
C
---------------------------------------------------------------------
1
PsiBlast_PDB
55.54
23%
-77
- C2 -
4A4M
5
OPSD_BOVIN
A:
[196-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
P
-
H
---
E
-
E
T
-
N
---
N
E
----------
S
F
-
V
I
Y
M
F
-
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--------
A
A
Q
Q
Q
E
S
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
Y
V
I
A
F
L
I
-----------
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
------------------
T
---
H
Q
G
S
C
F
G
P
I
F
-
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
---
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
---
V
T
T
L
C
C
G
K
N
------------------------------------------------------------------
5
PsiBlast_PDB
54.01
23%
-81
- C2 -
2X72
6
GNAT1_BOVIN (first)
A:
[196-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
P
-
H
---
E
-
E
T
-
N
---
N
E
----------
S
F
-
V
I
Y
M
F
-
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--------
A
A
Q
Q
Q
E
S
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
-----------
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
------------------
T
---
H
Q
G
S
C
F
G
P
I
F
-
M
T
I
P
A
F
F
A
K
T
SAV
Y
---
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
---
V
T
T
L
C
C
G
K
N
------------------------------------------------------------------
2
PsiBlast_PDB
53.89
23%
-77
- C2 -
4BEZ
2
OPSD_BOVIN
A:
[196-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
P
-
H
---
E
-
E
T
-
N
---
N
E
----------
S
F
-
V
I
Y
M
F
-
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--------
A
A
Q
Q
Q
E
S
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
-----------
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
------------------
T
---
H
Q
G
S
C
F
G
P
I
F
-
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
---
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
---
V
T
T
L
C
C
G
K
N
------------------------------------------------------------------
12
PsiBlast_PDB
53.11
23%
-120
- C2 -
3PXO
2
OPSD_BOVIN
A:
[193-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-----
P
-
H
---
E
-
E
T
-
N
---
N
E
----------
S
F
-
V
I
Y
M
F
-
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--------
A
A
Q
Q
Q
E
S
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
-----------
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
-----------
Q
----
G
---
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
--------
T
---
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
---
R
N
C
M
V
T
T
L
C
C
G
K
N
--------------------------------------------------------------