@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TAAR9_HUMAN: (2016-01-15 )
MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASLFHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEELVVALTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQAQSSSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD
Atome Classification :
(20 SA)
.........10........20........30........40.....------...50........60........70........80........90...-.....100.......110.......120.......130.......140.---......150.......160...----....170.....----..180.....---.---.190....--.--..--.200...-....210.......220.......230.....-----------------------------.---------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------240------------------------------------------------------------------.--------------------------------------------------------------------------.------------------.------------.----------------....-----------------.250-........260-----.......270.......280....--...290.......300.......310.......320.......330.......340......-------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVNNF
S
Q
A
E
A
V
E
L
C
Y
K
NV
N
E
S
C
IKTPYSP
G
P
R
S
I
L
Y
A
V
L
G
F
G
A
V
L
A
------
A
F
G
N
L
L
V
M
I
A
I
L
H
F
K
Q
LHT
P
T
N
F
L
I
A
S
L
A
C
A
D
F
L
V
G
V
T
VM
P
F
S
T
V
R
S
V
-
E
S
C
W
YFGD
S
Y
C
K
F
H
T
CFD
T
S
F
C
F
A
S
L
F
H
L
C
C
ISVD
R
Y
I
AVTDPLTYP
T
K
---
F
T
V
SV
S
G
I
C
I
V
L
S
W
F
F
S
V
T
Y
S
F
----
S
I
F
Y
TGAN
E
E
G
I
----
E
E
L
V
V
A
L
T
CV---G---GCQ-APLN--Q--
N
W
--
V
L
L
C
F
L
L
-
F
F
I
P
N
V
A
M
V
F
I
Y
S
K
I
F
L
VAK
H
Q
A
R
K
I
E
S
T
A
S
Q
-----------------------------
A
---------------------------------------------------------------------------------------------------------------Q-------------------------------------------------------------------------------------------------------------------------S--------------------------------------------------------------------S--------------------------------------------------------------------------
S
------------------
E
------------
S
----------------
Y
K
E
R
-----------------
V
A
K
--
R
E
R
K
A
A
K
T
L
G
I
-----
A
M
A
A
F
L
V
S
W
L
P
Y
L
V
D
A
V
I
D
A
Y
M
N
F--IT
P
P
Y
V
Y
E
I
L
V
W
C
V
Y
YNSAM
N
P
L
I
Y
A
F
F
Y
Q
W
F
G
K
A
I
K
L
IVS
G
K
V
L
RTDSSTTN
L
F
S
E
EVETD-------------------------------------------------------------------------------------------------------
73
HHSearch
90.55
32%
-141
- C6 -
2RH1
16
ADRB2_HUMAN (first)
A:
[42-477]
---------------------------------
G
M
G
I
V
M
S
L
I
V
L
A
I
------
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
----
L
P
I
Q
M
H
W
Y
R
A
T
H
----
Q
E
A
I
N
C
-
Y
A
E
---
E
---
T
C
C
D
F
F
T
N
--
Q
--
A
Y
A
-
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
-----------------------------
E
---------------------------------------------------------------------------------------------------------------
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T------------------------------------------------------------
P
--------------------------------------------------------------------------
N
------------------
R
A
K
R
V
I
T
T
F
R
TGT
W
----------------
D
A
Y
K
-----------------
F
C
L
--
K
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------------------------------------------------------------------------------------
74
HHSearch
86.31
28%
-140
- C6 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
------
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
----
P
A
I
L
F
-
W
Q
F
I
V
G
----
V
R
T
V
E
----
D
---
G
---
E
C
Y
-
I
Q
F
F
SN
A
--
A
V
T
-
F
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
-----------------------------
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
-------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
-----------------
Q
------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
P
-----------------
P
P
S
--
R
E
K
K
V
T
R
T
I
L
A
-----
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
--
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
----------------------------------------------------------------------------------------------------------------------------
75
HHSearch
85.54
29%
-149
- C6 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
----------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
------
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
----
P
I
L
G
--
W
N
H
--------------
R
R
E
---
D
---
K
C
E
-
T
D
F
Y
--
D
V
T
W
F
K
-
V
M
T
A
I
I
N
-
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
---------------------------------------------------------------------------------------------------------------
A
A
K
S
E
L
D
K
A
I
G---------------------------------------------------------------------------------------------------------------
R
--------------------------------------------------------------------
N
TNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
------
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
L
-----------------
H
M
N
--
R
E
R
K
A
A
K
Q
L
G
F
-----
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
--
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
---------------------------------------------------------------------------------------------------------------------------
78
HHSearch
83.17
28%
-138
- C6 -
3EML
13
ENLYS_BPT4
A:
[21-471]
-------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----
T
P
M
L
G
-
W
N
N
C
G
Q
---------
S
Q
G
C
G
---
E
GQV
A
C
L
-
F
E
D
V
VP
M
--
N
Y
M
V
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
-----------------------------
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
-------------------------------------------------------------------------------------------------------
T
--------------------------------------------------------------------
P
--------------------------------------------------------------------------
N
R
A
K
R
V
I
T
T
F
R
TGT-----
W
------------
D
----------------
A
Y
R
S
-----------------
T
L
Q
--
K
E
V
H
A
A
K
S
L
A
I
-----
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
CS
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------------------------------------------------------------------------------------------
79
HHSearch
82.83
30%
-146
- C6 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
------
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
----
P
L
L
F
-
G
F
N
T
T
G
D
---------
P
-------
T
---
V
C
S
-
I
S
N
P
--
D
--
F
V
--
I
Y
S
S
V
V
S
-
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
------------------
D
---------------------------------------------------------------------------------------------------------------
T
EG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN---------------------------------------------------------------------------------------
G
VIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
------------------------------------------------------------
N
------------------
Q
------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW
D
A
Y
G
-----------------
V
P
L
--
R
E
K
K
A
T
Q
M
V
A
I
-----
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C-
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
---------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.93
34%
-155
- C6 -
3SN6
1
R:
[182-475]
-------------------------------------
V
V
G
M
G
I
V
M
S
LIVLAI
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
LPIQ
M
H
W
Y
R
---
Q
E
A
I
NCYA
E
E
-----
T
C
---------
C
D
-
F
F
T
N
--
Q
--
A
Y
--
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
K
I
D
K
S
E
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CL
K
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
80.57
32%
-135
- C6 -
3ZPQ
13
ADRB1_MELGA
B:
[17-285]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------
S
--------------------------------------------------------------------------
K
------------------
R
------------
K
----------------
T
S
R
V
-----------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.43
32%
-145
- C6 -
2Y01
12
ADRB1_MELGA
A:
[17-285]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
D
P
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-----------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
80.26
32%
-147
- C6 -
2VT4
8
ADRB1_MELGA
D:
[17-283]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
QDP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.17
32%
-146
- C6 -
2Y02
13
ADRB1_MELGA
A:
[17-285]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-----------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.17
32%
-148
- C6 -
2Y00
13
ADRB1_MELGA
A:
[17-285]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-----------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.08
32%
-137
- C6 -
2YCX
3
ADRB1_MELGA
A:
[17-283]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
-----------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
---------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.05
32%
-144
- C6 -
3ZPQ
11
ADRB1_MELGA
A:
[17-285]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
-----------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------
92
Fugue
79.87
25%
-122
- C6 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
------
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
----
L
P
I
Q
M
H
W
Y
R
A
T
H
----
Q
E
A
I
N
C
Y
A
E
E
---
T
---
C
C
D
-
F
F
T
N
--
Q
--
A
Y
--
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
-----------------------------
E
---------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------
L
--------------------------------------------------------------------
R
--------------------------------------------------------------------------
L
------------------
K
------------
I
----------------
Y
K
D
T
EGYYTIGIGHLLTKSPS
L
N
A
--
A
K
S
E
L
D
K
A
I
G
R
NTNGV
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
--
A
K
L
K
P
V
Y
D
S
L
-----
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
28
PsiBlast_CBE
79.67
32%
-139
- C6 -
2Y01
12
ADRB1_MELGA
B:
[17-285]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------
S
--------------------------------------------------------------------------
K
------------------
R
------------
K
----------------
T
S
R
V
-----------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
79.65
32%
-137
- C6 -
2Y00
12
ADRB1_MELGA
B:
[17-285]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------
S
--------------------------------------------------------------------------
K
------------------
R
------------
K
----------------
T
S
R
V
-----------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
79.64
32%
-143
- C6 -
3ZPR
11
ADRB1_MELGA
A:
[17-285]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.46
32%
-144
- C6 -
2YCY
6
ADRB1_MELGA
A:
[17-283]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--
D
R
A
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
-----------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.44
32%
-147
- C6 -
2VT4
8
ADRB1_MELGA
A:
[17-283]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
79.43
32%
-139
- C6 -
2YCZ
2
ADRB1_MELGA
A:
[17-283]
-------------------------------------
L
M
A
L
V
V
L
L
I
------
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
---
P
I
M
M
H
W
W
R
D
E
D
P
----
Q
----
A
L
K
C
Y
Q
DP
G
---
C
C
D
-
F
V
T
N
--
R
--
A
Y
--
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
S
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
-----------------
M
L
M
--
R
E
H
K
A
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
--
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------