@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TRFR_HUMAN: (2016-01-15 )
MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
Atome Classification :
(20 SA)
.........10........20------------.........30........---40........50........60........70........80-......-..90........100.......110.......120.......130....---...140.......150.......-----160---.......-..170....-.....-------180.--......190...-------....-200.......210.......220-.......230----------..----------------------------.---.-------------------------.---.------------------------.--.--------240------------------.------------------------------------------------------------.----------------------------------------------------------------------.---------------------------------------------------.-------------------------------------------------.------------------...-----------------.------------250---------.-----------.--------------.......260.......270.......280.......290...-....--300.......---310.......320.......330.......340.......350.......360.......370.......380.......390......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEN
E
T
V
S
E
L
N
Q
TQLQP
R
A
V
V
-------------
A
L
E
Y
Q
V
V
T
I
L
L
V
L
I
I
C
G
L
G
---
I
V
G
N
I
M
V
V
L
V
V
M
R
TKHMRTPT
N
C
Y
L
V
S
L
A
V
A
D
L
M
V
L
V
AAGLP-N
I
T
D
S
I
-
Y
G
S
W
V
Y
G
Y
V
G
C
L
C
I
T
Y
L
Q
Y
LGINASS
C
S
I
T
A
F
T
I
E
R
Y
I
A
I
CHP
I
K
A
Q
F
L
---
C
T
F
SRA
K
K
I
I
I
F
V
W
A
F
T
S
L
Y
C
M
L
-----
W
-----
F
F
L
L
DLN-IST--YK
D
A
-
I
V
I
SC-------G
Y
K
I--SRNYYS
P
I
Y
L
M
D
-------
F
G
V
F
-
Y
V
V
P
M
I
L
A
T
V
L
Y
G
F
I
A
R
I
L
FLNP-IPSDPKENS-----------KT----------------------------W---K-------------------------N---D------------------------S--T--------H--------------------Q------------------------------------------------------------N----------------------------------------------------------------------T---------------------------------------------------
N
-------------------------------------------------
L
------------------
N
V
N-----------------T------------S-----------N-----------
R
--------------
C
F
N
S
T
V
S
S
R
K
Q
V
T
K
M
L
A
V
V
V
I
L
F
A
L
L
W
M
P
Y
R
T
L
V
V
V
N
S
F
LSS
P
-
F
QE
N
--
W
F
L
L
F
C
R
I
C
I
---
Y
L
NSA
I
N
P
V
I
Y
N
L
M
S
Q
K
F
R
A
A
F
R
K
L
CNCKQKPTEKPA
N
Y
S
V
A
L
N
Y
S
V
IKESDHFSTELD
D
I
T
V
TDTYLS
A
T
KVSFDDTCLASEVSFSQS
50
HHSearch
95.46
25%
-138
- C2 -
3EML
13
ENLYS_BPT4
A:
[22-472]
--------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
---
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
-
A
I
T
I
---
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
-----
P
-----
M
L
G
W
N
N
C
-
G
Q
---------
S
Q
G
C
GEGQVAC
L
F
E
D
--
V
V
P
-
M
N
Y
M
V
Y
F
N
-------
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
-
N
I
F
E
M
L
R
I
D
-----------
E
G
LR--------------------------
L
---
K
-------------------------
I
---
Y
K
D
TEGYYTIGIGHLL---------
T
--
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
----
Q
----------------------------------------------------------------------
Q
---------------------------------------------------
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
----------------------------------
N
------------------
Q
T
P
-----------------
N
R
A
K
R
V
I
T
T
F
R
TG
T
-----------
W
-----------
D
--------------
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
--
W
L
M
Y
L
A
I
V
L
S
---
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------------------------------------------
45
HHSearch
93.01
23%
-130
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
---------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
---
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
-
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
-----
A
-----
I
L
F
W
Q
F
I
-
V
G
V
---
R
T
V
-
E
D
G
E
C
-------
Y
I
Q
F
--
F
S
N
--
A
A
V
T
F
G
T
-------
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
-
N
I
F
E
M
L
R
I
D
EG---------
L
R
----------------------------
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLT----------
K
---
S
PS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
--
E
--------
A
--------------------
E
------------------------------------------------------------
K
----------------------------------------------------------------------
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
----------------------------------------------
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
-----------------
N
------------
R
-----------
A
K
R
V
I
T
T
F
R
TGT
W
--------------
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
--
I
P
N
--
T
V
W
T
I
G
Y
W
L
C
---
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------------------------------------------
46
HHSearch
89.85
21%
-142
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[12-443]
-----------------------------------------
V
V
V
L
S
T
I
C
L
V
T
---
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
-
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
-----
I
-----
L
G
W
N
H
-----------
R
-
R
E
D
K
C
-------
E
T
D
F
--
Y
D
V
T
--
W
F
K
V
M
T
-------
A
I
I
N
-
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
-
N
I
F
E
M
L
R
I
D
-----------
E
G
----------------------------
L
---
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
---
A
------------------------
A
--
K
S
E
L
D
K
A
I
-
G
RNTNGVIT
K
D
----------
E
------------------------------------------------------------
A
----------------------------------------------------------------------
E
---------------------------------------------------
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
-------------
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
------------
T
-----------
P
-----------
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
--
C
N
E
--
H
L
H
M
F
T
I
W
L
G
---
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------------------------------------------------
2
PsiBlast_PDB
89.41
26%
-154
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[108-406]
----------
Q
K
Y
L
G
A
R
S
A
S
-------------
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
---
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
--
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
---
G
V
-----
G
-----
V
P
I
M
V
M
A
-
V
T
R
--
P
R
D
G
-
A
V
V
-
C
-------
M
L
Q
------
F
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
----------
G
S
K
E
K
D
-----------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
-
R
R
D
P
--
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
---------------------------------------------------------------
1
PsiBlast_PDB
88.99
28%
-163
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[121-405]
---------------------------------
P
L
G
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
---
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
--
L
P
F
Q
G
T
D
I
L
-
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
-----
V
-----
A
I
M
G
S
A
Q
-
V
E
D
--
E
E
-----
I
E
C
-------
L
V
E
I
P
T
P
Q
D
Y
W
G
P
V
F
A
I
C
-------
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
R
G
V
R
-
L
L
S
G
S
R
E
K
D
-----------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------
L
---------------------------------------------------------------------------------------------------
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
Q
P
-
S
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
---
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
------------------------------------------------------------------
52
HHSearch
88.09
22%
-140
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
---
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
-
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
-----
L
-----
L
F
G
F
N
T
T
-
G
---------
D
P
T
V
C
-------
S
I
S
N
--
P
-----
D
F
V
I
Y
S
-------
S
V
V
S
-
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
-
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
T
----------------------------
E
---
G
-------------------------
Y
---
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
--
G
--------
R
NTNGVIT
K
D
E
----------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
----------------------------------------------------------------------
R
W
D
E
A
A
V
N
L
A
K
-----------------------------------------
S
R
W
Y
----------------------------------------------
N
------------------
Q
T
P
-----------------
N
R
A
K
R
V
I
T
T
F
R
T
-
G
-----------
T
-----------
W
--------------
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
-
H
V
S
P
--
E
L
Y
S
A
T
T
W
L
G
---
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------------------------------------------------------
3
PsiBlast_PDB
87.02
26%
-151
- C2 -
4RWD
7
C562_ECOLX (first)
A:
[108-406]
----------
Q
K
Y
L
G
A
R
S
A
S
-------------
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
---
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
--
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
---
G
V
-----
G
-----
V
P
I
M
V
M
A
-
V
T
R
--
P
R
D
G
-
A
V
V
-
C
-------
M
L
Q
------
F
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
-
L
L
S
G
S
K
E
K
D
-----------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
-
R
R
D
P
--
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
---------------------------------------------------------------
4
PsiBlast_PDB
86.80
26%
-152
- C2 -
4N6H
23
C562_ECOLX (first)
A:
[117-412]
----------------
R
S
A
S
-------------
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
---
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
--
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
---
G
V
-----
G
-----
V
P
I
M
V
M
A
-
V
T
R
--
P
R
D
G
-
A
V
V
-
C
-------
M
L
Q
------
F
P
S
P
S
W
Y
W
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
-
L
L
S
G
S
K
E
K
D
-----------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
-
R
R
D
P
--
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
---
R
K
P
C
G
-------------------------------------------------------
47
HHSearch
86.35
20%
-130
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[42-477]
---------------------------------------
G
M
G
I
V
M
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
-
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
-----
P
-----
I
Q
M
H
W
Y
R
-
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
-------
C
D
F
F
--
T
---
N
Q
A
Y
A
I
A
S
-------
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
-
N
I
F
E
M
L
R
I
D
-----------
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
---
A
-------------------------
K
S
E
L
D
K
A
----------------------
I
GR
N
--------
T
--------------------
N
GVIT
K
D
E
-----------------------------------------------------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
-----------------------------------------------
Y
-------------------------------------------------
N
------------------
Q
T
P
-----------------
N
------------
R
A
K
R
V
I
T
T
F
R
TG
T
-----------
W
--------------
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
--
I
R
K
--
E
V
Y
I
L
L
N
W
I
G
---
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------------------------------------
13
PsiBlast_PDB
86.09
25%
-151
- C2 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
-----
W
R
D
E
D
P
Q
A
L
K
C
--
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-------
F
Y
I
P
-
L
L
I
M
I
F
V
A
L
R
V
Y
--------------
R
E
A
K
E
Q
I
-----------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------
H
-----------
K
--------------
A
L
-----------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
-
L
V
P
D
--
W
L
F
V
A
F
N
W
L
G
---
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------
20
PsiBlast_PDB
85.69
26%
-155
- C2 -
4MQS
1
?
A:
[36-333]
------------------------------------
K
T
F
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
-
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
---
L
-----
W
APAIL
F
W
Q
F
I
V
G
-
V
R
T
--
V
E
D
G
----
E
C
-------
Y
I
Q
F
--
F
S
N
-
A
A
V
T
F
G
T
A
-------
I
A
A
F
-
Y
-
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
-
K
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
-
I
P
N
T
--
V
W
T
I
G
Y
W
L
C
----
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------------------------------------------
64
Fugue
84.52
22%
-127
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
RSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
-
L
G
---
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
-
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
-----
P
-----
L
V
G
W
S
R
Y
-
I
P
E
-----
G
-
M
Q
C
S
C
-------
G
I
------
D
Y
Y
T
P
H
E
--
E
-------
T
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
-----------
A
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-
D
F
G
P
--
I
F
M
T
I
P
A
F
F
A
---
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
------------------------------------------
T
E
T
S
Q
V
A
P
A
7
PsiBlast_PDB
84.07
25%
-153
- C2 -
2Y02
13
ADRB1_MELGA
A:
[9-300]
-----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
-----
W
R
D
E
D
P
Q
A
L
K
C
--
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-------
F
Y
I
P
-
L
L
I
M
I
F
V
A
L
R
V
Y
--------------
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------------------------------------------
R
-------------------------------------------------
V
------------------
M
L
M
-----------------
R
------------
E
-----------
H
-----------
K
--------------
A
L
-----------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
-
L
V
P
D
--
W
L
F
V
A
F
N
W
L
G
---
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------
12
PsiBlast_PDB
83.78
25%
-151
- C2 -
3ZPR
11
ADRB1_MELGA
A:
[9-299]
-----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
-----
W
R
D
E
D
P
Q
A
L
K
C
--
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-------
F
Y
I
P
-
L
L
I
M
I
F
V
A
L
R
V
Y
--------------
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
M
-----------------
R
------------
E
-----------
H
-----------
K
--------------
A
L
-----------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
-
L
V
P
D
--
W
L
F
V
A
F
N
W
L
G
---
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
---------------------------------------------------------------
5
PsiBlast_PDB
83.63
25%
-154
- C2 -
2Y00
13
ADRB1_MELGA
A:
[9-300]
-----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
-----
W
R
D
E
D
P
Q
A
L
K
C
--
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-------
F
Y
I
P
-
L
L
I
M
I
F
V
A
L
R
V
Y
--------------
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------------------------------------------
R
-------------------------------------------------
V
------------------
M
L
M
-----------------
R
------------
E
-----------
H
-----------
K
--------------
A
L
-----------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
-
L
V
P
D
--
W
L
F
V
A
F
N
W
L
G
---
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------
16
PsiBlast_PDB
83.27
25%
-143
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
-----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
-----
W
R
D
E
D
P
Q
A
L
K
C
--
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-------
F
Y
I
P
-
L
L
I
M
I
F
V
A
L
R
V
Y
--------------
R
E
A
K
E
Q
I
-----------
R
---------------------------------
K
-------------------------
I
---
D
------------------------
R
--
A
--------
S
--------------------
K
------------------------------------------------------------
R
----------------------------------------------------------------------
K
---------------------------------------------------
R
-------------------------------------------------
V
------------------
M
L
M
-----------------
R
------------
E
-----------
H
-----------
K
--------------
A
L
-----------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
-
L
V
P
D
--
W
L
F
V
A
F
N
W
L
G
---
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------------------------------------------------
18
PsiBlast_PDB
83.21
25%
-142
- C2 -
4BVN
11
ADRB1_MELGA
A:
[9-300]
-----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
-----
W
R
D
E
D
P
Q
A
L
K
C
--
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-------
F
Y
I
P
-
L
L
I
M
I
F
V
A
L
R
V
Y
--------------
R
E
A
K
E
Q
I
-----------
R
-------------------------------------------------------------------------------------------
K
--------
R
--------------------
K
------------------------------------------------------------
T
----------------------------------------------------------------------
S
---------------------------------------------------
R
-------------------------------------------------
V
------------------
M
L
M
-----------------
R
------------
E
-----------
H
-----------
K
--------------
A
L
-----------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
-
L
V
P
K
--
W
L
F
V
A
F
N
W
L
G
---
Y
A
N
S
A
M
N
P
I
I
L
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------
9
PsiBlast_PDB
83.19
25%
-154
- C2 -
2Y04
13
ADRB1_MELGA
A:
[9-300]
-----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
-----
W
R
D
E
D
P
Q
A
L
K
C
--
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-------
F
Y
I
P
-
L
L
I
M
I
F
V
A
L
R
V
Y
--------------
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------------------------------------------
R
-------------------------------------------------
V
------------------
M
L
M
-----------------
R
------------
E
-----------
H
-----------
K
--------------
A
L
-----------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
-
L
V
P
D
--
W
L
F
V
A
F
N
W
L
G
---
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------
11
PsiBlast_PDB
83.05
25%
-150
- C2 -
3ZPQ
11
ADRB1_MELGA
A:
[9-300]
-----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
-----
W
R
D
E
D
P
Q
A
L
K
C
--
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-------
F
Y
I
P
-
L
L
I
M
I
F
V
A
L
R
V
Y
--------------
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------------------------------------------
R
-------------------------------------------------
V
------------------
M
L
M
-----------------
R
------------
E
-----------
H
-----------
K
--------------
A
L
-----------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
-
L
V
P
D
--
W
L
F
V
A
F
N
W
L
G
---
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------
10
PsiBlast_PDB
83.04
25%
-151
- C2 -
4AMJ
12
ADRB1_MELGA
A:
[9-300]
-----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
-
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
-----
W
R
D
E
D
P
Q
A
L
K
C
--
Y
Q
D
P
---
G
C
C
-------
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-------
F
Y
I
P
-
L
L
I
M
I
F
V
A
L
R
V
Y
--------------
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------------------------------------------
R
-------------------------------------------------
V
------------------
M
L
M
-----------------
R
------------
E
-----------
H
-----------
K
--------------
A
L
-----------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
-
L
V
P
D
--
W
L
F
V
A
F
N
W
L
G
---
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------