@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TS1R2_HUMAN: (2016-01-15 )
MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQLLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60...-.-.-...70........80........90........100-----....-...110.......120.......130-..----.....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.........240.......250.......260..-.-..--..270.......280.......290....-.-..300...--....310.......320.....--.--.330.....-.-----------.340--...-------.....----.--350----..-------......----360------.-----.-----....-...370..-.....380...-----------.....390.......----400.-----.--.----...----.--410.-.....-------..-420--..-......-430-----.-------.--...-....440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGP
R
A
K
T
I
S
S
L
F
F
L
L
W
V
LAEPAENS
D
F
YL
P
G
D
Y
L
L
G
G
L
F
S
L
HANM
K
G
I
V
H
L
N
F
LQVPMCKE
Y
E
V
-
K
-
V
-
I
G
Y
N
L
M
Q
A
M
R
F
A
V
E
EINNDSSL
L
P
G
V
L
L
G
Y
E
I
V
D
V
C
-----
Y
ISN-NV
Q
P
V
L
Y
F
L
AHEDNLL
P
I
Q
E
D
Y
S
N
Y
I
-
S
R
----
V
V
A
V
IGPDNS
E
S
V
M
T
V
A
N
F
L
S
L
F
L
L
P
Q
I
T
Y
S
A
I
S
D
E
L
R
D
KVRFP
A
L
LRTTPSA
D
H
H
I
E
A
M
V
Q
L
M
L
HFRW
N
W
I
I
V
L
V
SSDTYGRD
N
G
Q
L
L
G
E
R
V
AR
R
--
D
I
C
I
A
F
Q
E
TLPTLQPNQNM
T
S
E
E
R
Q
R
L
V
T
I
V
D
K
L
-
Q
-QS--T
A
R
V
V
V
V
FSPD
L
T
L
Y
H
F
F
N
E
V
L
R
QNFT
G
A
-
V
-
W
I
ASESWA--
I
D
P
V
L
H
N
L
T
E
L
R
H
L
G
T
F
L
G
I
T
I
--Q--SVPIP
G
F
S
E
-
F
-----------
R
E
----WGP-------QAGPP----P--LS-----RT-------SQSYT
C
----
N
--------
Q
-----
E
-----
C
D
N
C
-
L
N
A
T
L
S
F
N
-
T
I
L
RLSG-
E
R
V
-----------
V
Y
S
V
Y
S
A
V
Y
A
V
A
H
A
L
----
H
S
L
L-----G--C----
D
K
S
----T--CT-K-RVV
Y
P
-------
W
Q
-
L
-
L
--
E
E
-
I
W
KV
N
F
-
T
-------
L
-------
L
--
D
H
Q
-
I
F
FDPQG
D
V
A
L
H
L
E
I
V
Q
W
Q
WDRSQ
N
P
F
Q
S
V
A
S
Y
Y
P
L
Q
R
Q
L
K
NIQD
I
S
W
H
TINNTI
P
M
S
M
C
S
K
R
C
QSGQKKKP
V
G
I
H
V
C
C
F
E
C
I
DCL
P
G
T
FLNHTEDEYECQACPNNEWSYQ
S
E
T
S
C
F
K
R
Q
L
V
F
L
E
WHEA
P
T
I
A
V
A
L
L
A
A
L
G
F
L
S
T
L
A
I
L
V
I
F
W
R
H
FQT
P
I
VRSAGG
P
M
C
F
L
M
L
T
L
L
L
V
A
Y
M
V
V
P
V
YVGP
P
K
V
S
T
C
L
C
R
Q
A
L
F
P
L
C
F
T
I
C
I
S
C
I
A
V
R
S
F
Q
I
V
C
A
F
K
M
A
S
RFP
R
A
Y
S
Y
W
V
R
YQGP
Y
V
S
M
A
F
I
T
V
L
K
M
V
I
V
V
I
G
M
L
ATGLSPTTRTDPDDP
K
I
T
I
V
SCNPNYR
N
S
L
L
FN
T
S
L
D
L
L
L
S
V
V
G
F
S
F
A
Y
MGKELPTNYNE
A
K
F
I
T
L
S
M
T
F
Y
FTSS
V
S
L
C
T
F
M
S
A
Y
S
G
V
L
V
T
I
V
D
L
L
V
T
V
L
N
L
L
A
I
S
L
GYFG
P
K
C
Y
M
I
L
F
YPERN
T
P
A
Y
F
N
S
M
I
QGYTMRRD
6
PsiBlast_PDB
86.79
27%
-110
- C2 -
2E4Z
1
GRM7_RAT
A:
[13-479]
----------------------------
I
E
G
D
V
T
L
G
G
L
F
P
V
H
A
K
G
P
S
G
V
P
C
G
D
I
K
----------
R
-
E
-
N
G
I
H
R
L
E
A
M
L
Y
A
L
D
Q
I
N
S
D
P
N
L
L
P
N
V
T
L
G
A
R
I
L
D
T
C
-------
S
R
-
D
T
Y
A
L
E
Q
S
L
T
F
V
Q
A
L
--
I
Q
K
------P
E
K
----
V
V
G
V
I
G
A
S
G
S
S
V
S
I
M
V
A
N
I
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
D
R
R
Y
D
F
F
S
R
V
V
P
P
D
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
S
Y
G
-
E
K
G
V
E
S
F
T
Q
I
S
K
E
A
G
G
L
C
I
A
Q
S
V
R
I
P
------
T
I
D
F
D
---
R
I
I
K
Q
L
--
L
-
D
-
T
P
--
N
S
R
A
V
V
I
F
A
N
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
D
Q
V
G
H
F
L
-
W
V
G
S
D
S
W
G
SK
I
N
P
-
L
H
Q
H
E
D
I
A
E
----
G
A
I
T
I
--
Q
P
K
R
A
T
V
E
G
F
D
A
-
Y
-----------
F
---------------------------
T
S
-----
R
T
-------
L
E
N
N
R
R
----
N
VW
F
A
E
Y
W
-
E
-----
E
-----
N
F
N
C
K------------
K
C
T
G
Q
E
R
I
GKDSN
Y
E
Q
E
G
K
V
Q
F
V
I
D
A
V
Y
A
M
A
H
A
L
----
H
H
M
--------------
N
K
D
----
L
--
C
---Y
R
G
V
C
P
EMEQAGG
K
K
-
L
-
L
--
K
Y
-
I
R
H
V
N
F
-
N
G
------
S
-------
A
--
G
T
P
-
V
M
F
N
K
N
G
D
A
P
G
R
Y
D
I
F
Q
Y
Q
T
T
N
T
T
N
P
G
Y
R
L
I
G
Q
W
T
D
E
L
Q
L
-
N
I
E
D
M
Q
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
85.24
27%
-96
- C2 -
2E4U
2
GRM3_RAT
A:
[7-543]
------------------------
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
--------
T
E
E
C
G
--
R
I
N
E
-
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
-----
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
-----------
I
P
-
L
L
----
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
--------
R
K
S
Y
D
S
V
I
R
E
L
-
L
Q
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
-
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
V
K
G
-
S
E
H
V
A
Y
G
A
I
T
L
E
L
--
A
--
S
H
P
V
R
Q
F
D
R
-
Y
-----------
F
Q
----
S
L
N
-------
P
Y
N
N
H
-------
R
N
PW
F
R
D
F
W
-------
E
Q
K
F
Q
C
----
S
--------
L
QQ---
V
-----
C
D
K
H
-
L
A
I
D
S
S
------
N
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
--
T
----
L
C
P
QTTK
L
--
C
D
A
M
-
K
I
L
D
G
-------
K
K
-
L
Y
K
--
E
Y
-
L
L
K
I
Q
F
-
T
APFNPNK
G
-------
A
--
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
--
L
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
---
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
82.64
26%
-105
- C2 -
3SM9
8
GRM3_HUMAN
A:
[6-475]
------------------------
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
---------
T
E
E
C
G
--
R
I
-
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
-----
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
---------------
L
L
----
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
S
I
A
T
A
E
K
V
G
R
--
I
--------
R
K
S
Y
D
S
V
I
R
E
L
-
L
Q
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
-
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
I
K
G
-
S
E
H
V
A
Y
G
A
I
T
L
E
L
--
A
--
S
Q
P
V
R
Q
F
D
R
-
Y
-----------
F
Q
----
S
L
N
-------
P
Y
N
N
H
RNPW
F
--
R
D
-----
F
W
-------
E
Q
K
F
Q
C
----
S
--------
L
QNHRR
V
-----
C
D
K
H
-
L
A
I
D
S
S
------
N
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
--
T
----
L
C
P
NTTK
L
--
C
D
A
M
-
K
I
L
D
G
-------
K
K
L
Y
-
K
--
D
Y
-
L
L
K
I
N
F
-
T
-------
A
-------
P
FN
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
--
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.19
25%
-89
- C2 -
2E4Y
2
GRM3_RAT
A:
[11-543]
----------------------------
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
SR
D
T
Y
A
L
E
Q
-
S
L
E
F
V
R
A
S
L
--------------------IPLL
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
-------
V
I
R
E
L
L
-
Q
-
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
-
A
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
-
I
T
L
E
L
--
A
--
S
H
P
V
R
Q
F
D
R
-
Y
-----------
F
Q
S
LNP
Y
N
N
-------
H
R
N
P
W
----
F
--
R
D
-----
F
W
-------
E
Q
K
F
Q
C
----
S
LQNKRNH
R
Q
-----
V
-----
C
D
K
H
-
L
A
I
D
S
S
------
N
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
T
L
C
----
P
Q
T
----
T
KL
C
D
-
A
-
M
K
I
L
D
-------
G
K
-
K
-
L
Y
K
E
Y
-
L
L
K
I
Q
F
-
T
-------
A
PFNPNKG
A
--
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
--
A
E
T
L
S
L
D
V
D
S
I
H
W
S
--
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
---
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
80.71
26%
-87
- C2 -
2E4U
2
GRM3_RAT
A:
[6-543]
-----------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
--------
T
E
E
C
G
R
I
N
E
-
D
-
R
--
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
-----
S
R
D
T
-
Y
A
L
E
Q
S
L
E
F
V
R
A
S
L
I
P
L
-----------
L
----
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
C
I
A
T
A
E
K
V
G
R
--------
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
-
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
-
I
T
L
E
L
--
A
--
S
H
P
V
R
Q
F
D
R
-
Y
-----------
F
Q
----
S
L
N
-------
P
Y
N
N
H
----
R
--
N
P
-----
W
F
-------
R
D
F
W
E
Q
----
K
--------
F
-----
Q
-----
C
S
L
Q
-
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
--
T
LCPQ
T
T
K
----
L
--
C
D
-
A
M
K
I
L
D
G
-------
K
K
-
L
-
Y
--
K
E
Y
L
L
K
I
Q
F
-
T
APFNPNK
G
-------
A
--
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
--
E
T
L
S
L
D
V
D
S
I
H
W
S
--
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
---
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
79.83
25%
-87
- C2 -
2E4X
2
GRM3_RAT
A:
[11-543]
----------------------------
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
SR
D
T
Y
A
L
E
Q
-
S
L
E
F
V
R
A
S
L
--------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
-------
V
I
R
E
L
L
-
Q
-
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
-
A
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
-
I
T
L
E
L
--
A
--
S
H
P
V
R
Q
F
D
R
-
Y
-----------
F
Q
S
LNP
Y
N
N
-------
H
R
N
P
W
----
F
--
R
D
-----
F
W
-------
E
Q
K
F
Q
C
----
S
LQNKRN
H
R
Q
-----
V
-----
C
D
K
H
-
L
A
I
D
S
S
------
N
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
T
L
C
----
P
Q
T
----
T
KL
C
D
-
A
-
M
K
I
L
D
-------
G
K
-
K
-
L
Y
K
E
Y
-
L
L
K
I
Q
F
-
T
-------
A
PFNPNKG
A
--
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
--
A
E
T
L
S
L
D
V
D
S
I
H
W
S
--
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
---
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.19
25%
-89
- C2 -
2E4U
2
GRM3_RAT
A:
[11-543]
----------------------------
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
SR
D
T
Y
A
L
E
Q
-
S
L
E
F
V
R
A
S
L
--------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
-------
V
I
R
E
L
L
-
Q
-
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
-
A
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
-
I
T
L
E
L
--
A
--
S
H
P
V
R
Q
F
D
R
-
Y
-----------
F
Q
S
LNP
Y
N
N
-------
H
R
N
P
W
----
F
--
R
D
-----
F
W
-------
E
Q
K
F
Q
C
----
S
LQ------
Q
-----
V
-----
C
D
K
H
-
L
A
I
D
S
S
------
N
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
T
L
C
----
P
Q
T
----
T
KL
C
D
-
A
-
M
K
I
L
D
-------
G
K
-
K
-
L
Y
K
E
Y
-
L
L
K
I
Q
F
-
T
-------
A
PFNPNKG
A
--
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
--
A
E
T
L
S
L
D
V
D
S
I
H
W
S
--
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
---
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.11
25%
-90
- C2 -
2E4W
2
GRM3_RAT
A:
[11-543]
----------------------------
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
SR
D
T
Y
A
L
E
Q
-
S
L
E
F
V
R
A
S
L
--------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
-------
V
I
R
E
L
L
-
Q
-
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
-
A
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
-
I
T
L
E
L
--
A
--
S
H
P
V
R
Q
F
D
R
-
Y
-----------
F
Q
S
LNP
Y
N
N
-------
H
R
N
P
W
----
F
--
R
D
-----
F
W
-------
E
Q
K
F
Q
C
----
S
LQNKRNH
R
Q
-----
V
-----
C
D
K
H
-
L
A
I
D
S
S
------
N
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
T
L
C
----
P
Q
T
----
T
KL
C
D
-
A
-
M
K
I
L
D
-------
G
K
-
K
-
L
Y
K
E
Y
-
L
L
K
I
Q
F
-
T
-------
A
PFNPNKG
A
--
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
--
A
E
T
L
S
L
D
V
D
S
I
H
W
S
--
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
---
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.96
25%
-112
- C2 -
3LMK
4
GRM5_HUMAN
A:
[17-459]
---------------------------
H
M
P
G
D
I
I
I
G
A
L
F
S
V
H
-
H
Q
P
T
V
D
K
V
H
E
R
K
C
G
A
V
R
E
Q
-------
Y
G
I
Q
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
P
T
L
L
P
N
I
T
L
G
C
E
I
R
D
S
C
-----
W
H
S
A
V
A
L
E
Q
S
I
E
F
I
--
R
D
----------------KP--
I
V
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
N
I
P
Q
I
A
Y
S
A
T
S
M
D
L
S
D
K
T
L
F
K
Y
F
M
R
V
V
P
S
D
A
Q
Q
A
R
A
M
V
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
E
A
F
K
D
M
S
A
K
E
--
G
I
S
I
A
H
S
Y
K
I
--------
Y
S
N
A
G
E
Q
S
F
D
K
L
L
K
K
L
-
T
-
S
H
LP
K
A
R
V
V
A
C
F
C
E
G
M
T
V
R
G
L
L
M
A
M
R
R
L
G
L
A
G
E
F
L
-
L
L
G
S
D
G
W
A
--
D
---
R
Y
D
V
T
D
G
Y
Q
R
E
A
V
G
G
I
T
I
--
K
---
L
Q
S
P
D
V
K
W
-
F
-----------
D
D
----
Y
Y
L
-------
K
L
R
P
E
----
T
--
N
H
-----
R
N
PW
F
Q
E
F
W
Q
H
R
F
Q
C
RLEG----------------------
N
K
T
-
C
N
S
S
L
T
L
K
-
T
-
H
H
V
Q
D
-
S
K
M
-----------
G
F
-
V
I
N
A
I
Y
S
M
A
Y
G
L
----
H
N
M
Q
M
S
L
C
P
G
--
Y
----
A
G
L
----
C
--
D
A
-
M
-
K
P
I
D
G
-------
R
K
-
L
-
L
--
E
S
-
L
M
K
T
N
F
-
T
-------
G
-------
V
--
S
G
D
T
I
L
F
D
E
N
G
D
S
P
G
R
Y
E
I
M
N
F
K
E
M
G
K
D
Y
F
D
Y
I
N
V
G
S
W
D
N
G
E
L
K
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.79
27%
-109
- C2 -
5CNM
5
?
A:
[37-474]
----------------------------
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
SR
D
T
Y
A
L
E
Q
-
S
L
E
F
V
R
A
S
L
--------------------IPLL
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
S
I
A
T
A
E
K
V
G
---
I
R
K
S
Y
D
S
-------
V
I
R
E
L
L
-
Q
-
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
-
A
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
-
I
T
L
E
L
--
A
--
S
Q
P
V
R
Q
F
D
R
Y
F
-----------
Q
S
----
L
N
P
Y------
N
N
H
R
N
----
P
--
W
F
-----
R
D
F
W
-----
E
Q
K
F
Q
C
----
S
--------
L
-----
Q
NH
R
R
V
C
D
K
H
-
L
-
A
I
D
S
S
N
-----
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
T
L
C
----
P
N
T
----
T
KL
C
D
-
A
-
M
K
I
L
D
-------
G
K
-
K
-
L
Y
K
D
Y
-
L
L
K
I
N
F
-
T
-------
A
PFNPNKD
A
--
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.64
25%
-109
- C2 -
3KS9
4
GRM1_HUMAN
A:
[14-459]
----------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
------
E
K
V
P
E
R
K
C
G
E
I
-
R
-
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
-----
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
--
R
D
S
L
--------------KP--
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
--
G
L
S
I
A
H
S
D
K
I
------
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
--
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
--
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
I
T
I
K
L
Q
--
S
P
E
V
R
S
F
D
D
-
Y
F
L
K
LRLDTNTR
N
P
----
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
----
G
----------
P
-------
N
F
K
R
I
C
----
T
--------
G
-----------------
N
E
S
L
E
E
N
-
Y
V
Q
-----
D
S
K
-----------
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
-----
P
--
G
----
H
V
G
----
L
--
C
D
-
A
M
K
P
I
D
G
-------
S
K
-
L
-
L
--
D
F
-
L
I
K
S
S
F
I
G
-------
V
-------
S
--
G
E
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.28
25%
-89
- C2 -
2E4V
2
GRM3_RAT
A:
[11-543]
----------------------------
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
SR
D
T
Y
A
L
E
Q
-
S
L
E
F
V
R
A
S
L
--------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
-------
V
I
R
E
L
L
-
Q
-
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
-
A
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
V
K
G
S
E
H
V
A
Y
G
A
-
I
T
L
E
L
--
A
--
S
H
P
V
R
Q
F
D
R
-
Y
-----------
F
Q
S
LNP
Y
N
N
-------
H
R
N
P
W
----
F
--
R
D
-----
F
W
-------
E
Q
K
F
Q
C
----
S
LQNKRNH
R
Q
-----
V
-----
C
D
K
H
-
L
A
I
D
S
S
------
N
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
T
L
C
----
P
Q
T
----
T
KL
C
D
-
A
-
M
K
I
L
D
-------
G
K
-
K
-
L
Y
K
E
Y
-
L
L
K
I
Q
F
-
T
-------
A
PFNPNKG
A
--
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
L
Q
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
--
A
E
T
L
S
L
D
V
D
S
I
H
W
S
--
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
---
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.77
27%
-99
- C2 -
4XAR
9
GRM3_HUMAN
A:
[37-474]
----------------------------
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
SR
D
T
Y
A
L
E
Q
-
S
L
E
F
V
R
A
S
L
--------------------LL--
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
-------
V
I
R
E
L
L
-
Q
-
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
-
A
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
-
I
T
L
E
L
--
A
--
S
Q
P
V
R
Q
F
D
R
Y
F
-----------
Q
S
----
L
N
P
Y------
N
N
H
R
N
----
P
--
W
F
-----
R
D
F
W
-----
E
Q
K
F
Q
C
----
S
--------
L
------RV---
C
D
K
H
-
L
-
A
I
D
S
S
N
-----
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
T
L
C
----
P
N
T
----
T
KL
C
D
-
A
-
M
K
I
L
D
-------
G
K
-
K
-
L
Y
K
D
Y
-
L
L
K
I
N
F
-
T
-------
A
PD-----
A
--
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
V
P
T
S
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.59
25%
-103
- C2 -
1EWT
2
GRM1_RAT
A:
[9-454]
----------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
------
E
K
V
P
E
R
K
C
G
E
I
-
R
-
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
-----
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
--
R
D
S
L
I
S
I
R
----------KP--
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
--
G
L
C
I
A
H
S
D
K
I
------
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
--
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
--
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
I
T
I
K
L
Q
--
S
P
E
V
R
S
F
D
D
-
Y
F
L
K
LRLDTNTR
N
P
----
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
----
G
HL
L
E
-----
N
P
-------
N
F
K
K
V
C
----
T
--------
G
-----------------
N
E
S
L
E
E
N
-
Y
V
Q
-----
D
S
K
-----------
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
-----
P
--
G
----
H
V
G
----
L
--
C
D
-
A
M
K
P
I
D
G
-------
R
K
-
L
-
L
--
D
F
-
L
I
K
S
S
F
-
V
G------
V
-------
S
--
G
E
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.15
27%
-99
- C2 -
5CNK
5
?
A:
[37-474]
----------------------------
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
N
E
D
R
------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
SR
D
T
Y
A
L
E
Q
-
S
L
E
F
V
R
A
S
L
--------------------I
P
L
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
-------
V
I
R
E
L
L
-
Q
-
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
-
A
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
-
I
T
L
E
L
--
A
--
S
Q
P
V
R
Q
F
D
R
Y
F
-----------
Q
S
----
L
N
P
Y------
N
N
H
R
N
----
P
--
W
F
-----
R
D
F
W
-----
E
Q
K
F
Q
C
----
S
--------
L
-----
Q
RV---
C
D
K
H
-
L
-
A
I
D
S
S
N
-----
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
T
L
C
----
P
N
T
----
T
KL
C
D
-
A
-
M
K
I
L
D
-------
G
K
-
K
-
L
Y
K
D
Y
-
L
L
K
I
N
F
-
T
-------
A
PFNP------
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.07
26%
-106
- C2 -
3SM9
8
GRM3_HUMAN
A:
[10-447]
----------------------------
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-
T
E
E
C
G
R
I
N
E
D
R
------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
SR
D
T
Y
A
L
E
Q
-
S
L
E
F
V
R
A
S
---------------------LL--
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
L
R
--
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
S
Y
D
S
-------
V
I
R
E
L
L
-
Q
-
K
P
--
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
-
A
S
F
-
T
-
W
V
A
S
D
G
W
G
--
A
Q
E
S
I
I
K
G
S
E
H
V
A
Y
G
A
-
I
T
L
E
L
--
A
--
S
Q
P
V
R
Q
F
D
R
-
Y
-----------
F
Q
S
LNP
Y
N
N
-------
H
R
N
P
W
----
F
--
R
D
-----
F
W
-------
E
Q
K
F
Q
C
----
S
--------
L
-----
Q
NHRRV
C
D
K
H
-
L
-
A
I
D
S
S
N
-----
Y
E
Q
-
E
S
K
-----------
I
M
F
V
V
N
A
V
Y
A
M
A
H
A
L
----
H
K
M
Q
-----
R
T
L
C
----
P
N
T
----
T
KL
C
D
-
A
-
M
K
I
L
D
-------
G
K
-
K
-
L
Y
K
D
Y
-
L
L
K
I
N
F
-
T
-------
A
PFN-------
D
S
I
-
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.84
25%
-100
- C2 -
1EWK
5
GRM1_RAT
A:
[9-454]
----------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
------
E
K
V
P
E
R
K
C
G
E
I
-
R
-
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
-----
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
--
R
-----------------KP--
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
--
G
L
C
I
A
H
S
D
K
I
------
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
--
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
--
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
I
T
I
K
L
Q
--
S
P
E
V
R
S
F
D
D
-
Y
F
L
K
LRLDTNTR
N
P
----
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
----
G
HL
L
E
-----
N
P
-------
N
F
K
K
V
C
----
T
--------
G
-----------------
N
E
S
L
E
E
N
-
Y
V
Q
-----
D
S
K
-----------
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
-----
P
--
G
----
H
V
G
----
L
--
C
D
-
A
M
K
P
I
D
G
-------
R
K
-
L
-
L
--
D
F
-
L
I
K
S
S
F
-
V
G
------
V
-------
S
--
G
E
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.41
25%
-102
- C2 -
1ISS
1
GRM1_RAT
A:
[9-454]
----------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
------
E
K
V
P
E
R
K
C
G
E
I
-
R
-
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
-----
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
--
R
D
S
L
I
-------------KP--
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
--
G
L
C
I
A
H
S
D
K
I
------
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
--
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
--
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
I
T
I
K
L
Q
--
S
P
E
V
R
S
F
D
D
-
Y
F
L
K
LRLDTNTR
N
P
----
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
----
G
HL
L
E
-----
N
P
-------
N
F
K
K
V
C
----
T
--------
G
-----------------
N
E
S
L
E
E
N
-
Y
V
Q
-----
D
S
K
-----------
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
-----
P
--
G
----
H
V
G
----
L
--
C
D
-
A
M
K
P
I
D
G
-------
R
K
-
L
-
L
--
D
F
-
L
I
K
S
S
F
-
V
G
------
V
-------
S
--
G
E
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
74.02
25%
-98
- C2 -
1ISR
2
GRM1_RAT
A:
[9-454]
----------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
------
E
K
V
P
E
R
K
C
G
E
I
-
R
-
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
-----
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
--
R
-----------------KP--
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
--
G
L
C
I
A
H
S
D
K
I
------
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
--
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
--
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
I
T
I
K
L
Q
--
S
P
E
V
R
S
F
D
D
-
Y
F
L
K
LRLDTNTR
N
P
----
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
----
G
HL
L
E
-----
N
P
-------
N
F
K
K
V
C
----
T
--------
G
-----------------
N
E
S
L
E
E
N
-
Y
V
Q
-----
D
S
K
-----------
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
-----
P
--
G
----
H
V
G
----
L
--
C
D
-
A
M
K
P
I
D
G
-------
R
K
-
L
-
L
--
D
F
-
L
I
K
S
S
F
-
V
G
------
V
-------
S
--
G
E
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.91
25%
-104
- C2 -
1EWV
-
GRM1_RAT
A:
[41-486]
----------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
------
E
K
V
P
E
R
K
C
G
E
I
-
R
-
E
Q
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
-----
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
--
R
-----------------KP--
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
Q
E
--
G
L
C
I
A
H
S
D
K
I
------
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
-
R
-
L
P
--
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
--
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
I
T
I
K
L
Q
--
S
P
E
V
R
S
F
D
D
-
Y
F
L
K
LRLDTNTR
N
P
----
W
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
----
G
HL
L
E
-----
N
P
-------
N
F
K
K
V
C
----
T
--------
G
-----------------
N
E
S
L
E
E
N
-
Y
V
Q
-----
D
S
K
-----------
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
A
L
C
-----
P
--
G
----
H
V
G
----
L
--
C
D
-
A
M
K
P
I
D
G
-------
R
K
-
L
-
L
--
D
F
-
L
I
K
S
S
F
-
V
G
------
V
-------
S
--
G
E
E
-
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------