@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TS1R3_HUMAN: (2016-01-15 )
MLGPAVLGLSLWALLHPGTGAPLCLSQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEAWLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYVKTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDCITLQNVSAGLNHHQTFSVYAAVYSVAQALHNTLQCNASGCPAQDPVKPWQLLENMYNLTFHVGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQDEWSPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPLACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFVESELPLSWADRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGCYNRARGLTFAMLAYFITWVSFVPLLANVQVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPEFFLGGGPGDAQGQNDGNTGNQGKHE
Atome Classification :
(20 SA)
.........10........20........30........40..----..----....50........60.....-..-.70........80........90........100.......110.......120.........130...-.--.----..140........150.......160.......170.......180.......190.......200.......210.......220.......230........240.......250.......260-.......270.......280......-.290---...-....300.-...--------.-..310........320..--------.....330......-.-.340.....-.--...---------350.......-----360.........370.......380.....-..390---.......400....---------...410--...----.----.....420...-.-...-430...-.--------.-.---.440-----........450....-...460........470.......480........490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ML
G
P
A
V
L
G
L
S
L
W
A
L
LHPGTGA
P
L
C
L
S
Q
Q
L
RMKG
D
Y
V
L
GGLFPL----GE----
A
E
E
AGLRSRTRPSS
P
V
C
T
RFS-SN-
G
L
L
W
A
L
A
M
K
M
A
V
E
E
IN
N
K
S
DLL
P
G
L
R
L
G
Y
D
L
F
D
TCSE
P
V
V
AMKP
S
L
M
F
L
AKA--GSR
D
I
A
A
YCNYTQYQ-
P
--
R
----
V
L
A
-
V
IGPHSS
E
L
A
M
V
T
G
K
F
F
S
F
F
LMPQVSYGA
S
M
E
L
L
S
A
R
E
T
F
P
S
F
F
R
TVPSD
R
V
Q
L
T
A
A
A
E
L
L
Q
E
FG
W
N
W
V
A
ALGSD
D
E
Y
G
R
Q
G
L
S
I
F
S
A
L
A
A
-AR
G
I
C
I
AHEGLVPLPRADDSR
L
G
K
V
Q
D
V
L
H
Q
-VNQSS
V
Q
V
V
L
L
F
A
S
V
H
A
A
H
A
L
F
NYSI-SSRL---SP
K
-
V
W
V
A
S
E
A
W
-
L
T
S
--------
D
-
L
V
MG-LP
G
M
A
Q
M
G
T
V
L
G
F
--------
L
Q
RGA
Q
-
L
H
E
F
P
Q
Y
-
V
-
K
T
--
H
L
ALA-T--
D
P
A
---------
F
C
S
A
L
G
E
R
EQ-----G--LE
E
D
V
V
GQRCPQC
D
C
I
T
L
Q
N
V
S
AGLNH-H
Q
T
F
S
---
V
Y
A
A
V
Y
S
V
A
Q
A
L
H
N
---------
T
LQC----NAS----G----CPAQDPV
K
P
W
Q
-
L
-
L
E
N
-
M
YN
L
T
F
-
H
--------V-G---
G
L
P
------
L
R
FDSSGN
V
D
M
E
Y
D
L
-
K
L
W
V
-WQGSVPR
L
H
D
V
GRFNGS
L
R
T
-
E
R
L
K
I
R
W
HTSDNQ
K
P
V
S
R
C
S
R
Q
C
QEG
Q
V
R
R
V
K
G
F
H
S
C
C
Y
D
C
VDCEAGSYRQNPD
D
I
A
C
T
FCGQDEWSP
E
R
S
T
R
C
F
R
R
R
S
RFLAWG
E
P
A
V
L
L
L
L
L
L
L
S
L
A
L
G
L
V
L
A
A
L
G
L
F
V
HHRDS
P
L
V
QASGG
P
L
A
C
F
G
L
V
C
L
G
L
V
C
L
S
V
L
LFPGQP
S
P
A
R
C
L
A
QQPLSHL
P
L
T
G
C
L
S
T
L
F
L
Q
A
A
E
I
F
V
ESELP
L
S
W
A
D
R
L
S
G
C
LRG
P
W
A
W
L
V
V
L
L
A
M
L
V
E
V
A
L
C
T
W
Y
L
V
AF
P
P
E
V
VTDWHML
P
T
E
A
L
V
H
CRT
R
S
W
V
S
F
G
L
A
HAT
N
A
T
L
A
F
L
C
F
L
G
T
F
L
VRSQPGCYNRAR
G
L
T
F
A
M
L
A
Y
F
I
T
W
V
S
F
V
P
L
L
A
N
V
Q
V
V
L
R
P
A
V
Q
M
G
A
L
L
L
C
V
L
G
I
L
A
A
F
H
L
P
R
C
Y
L
L
M
RQPGLNTP
E
F
F
LGGGPGDAQGQNDGNTGNQGKHE
52
Fugue
87.35
25%
-87
- C2 -
2E4U
2
GRM3_RAT
A:
[6-543]
-------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
-----------------
N
E
K
G
T
G
T
E
E
C
G
R
I
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
--------------
A
S
L
I
P
-
L
--
L
----
I
A
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
----
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
-
R
V
N
A
----
S
F
-
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
-
S
I
V
K
-
G
S
E
H
V
A
Y
G
A
-
I
T
L
--------
E
L
A
S
H
P
-
V
R
Q
F
D
R
Y
-
F
Q
S
L
--
N
P
Y
N
N
-
H
--
R
N
P
---------
W
F
R
D
F
W
E
Q
K
F
-----
Q
--
C
S
L
Q
---
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
---
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
---------
M
Q
R
T
LCPQ
T
T
K
----
L
----
C
D
A
M
K
I
L
D
G
K
K
-
L
-
Y
K
E
-
Y
L
L
K
I
Q
-
F
T
APFNPNK
G
-
A
---
D
S
I
------
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
-
F
N
L
Q
-
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
-
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
D
E
F
--
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.33
26%
-76
- C2 -
2E4Y
2
GRM3_RAT
A:
[6-543]
-------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
----
N
E
KGTG
T
E
E
C
G
R
I
N
E
D
R
--------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
--
L
-------------------IPLL
I
A
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
---
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
--
A
A
-
A
N
R
V
---
N
A
S
F
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
S
I
V
K
G
-
S
E
H
V
A
Y
G
A
I
T
L
E
L
--------
A
S
H
--
P
-
V
R
Q
F
D
R
Y
-
F
-
Q
S
--
L
N
P
Y
N
-
N
HR
N
P
W
---------
F
R
D
F
W
E
Q
K
F
Q
-----
C
--
S
L
Q
N
K
R
N
H
R
-
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
PQT
T
K
L
C
----
D
A
M
----
K
----
I
L
D
G
K
K
L
Y
K
E
Y
-
L
-
L
K
I
-
Q
F
T
A
P
F
-
N
--------
P
-
N
KGA
D
S
I
------
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
-
F
N
L
Q
-
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
-
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.35
26%
-79
- C2 -
2E4U
2
GRM3_RAT
A:
[6-543]
-------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
----
N
E
KGTG
T
E
E
C
G
R
I
N
E
D
R
--------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
--
L
-------------------I
P
L
L
I
A
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
---
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
--
A
A
-
A
N
R
V
---
N
A
S
F
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
S
I
V
K
G
-
S
E
H
V
A
Y
G
A
I
T
L
E
L
--------
A
S
H
--
P
-
V
R
Q
F
D
R
Y
-
F
-
Q
S
--
L
N
P
Y
N
-
N
HR
N
P
W
---------
F
R
D
F
W
E
Q
K
F
Q
-----
C
--
S
L
Q
-------
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
LCPQT
T
K
L
C
----
D
A
M
----
K
----
I
L
D
G
K
K
L
Y
K
E
Y
-
L
-
L
K
I
-
Q
F
T
A
P
F
-
N
--------
P
-
N
KGA
D
S
I
------
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
-
F
N
L
Q
-
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
-
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
85.29
26%
-85
- C2 -
2E4U
2
GRM3_RAT
A:
[8-543]
---------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
----
N
E
----
K
G
T
---------
G
T
E
E
C
G
R
I
N
E
D
R
-
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
--
L
------------
I
P
-
L
--
L
----
I
A
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
-
R
K
S
Y
D
S
V
I
R
E
L
L
---
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
-
R
V
N
A
----
S
F
-
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
-
S
I
V
K
-
G
-
S
E
H
V
A
Y
G
A
I
T
L
--------
E
L
A
S
H
P
-
V
R
Q
F
D
R
Y
-
F
-
Q
S
--
L
N
P
Y
N
N
H
R-
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
--------------------
Q
V
C
D
K
H
L
A
I
D
S
S
N
---
Y
E
Q
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
---------
M
Q
R
T
----
L
C
P
QTTK
L
----
C
D
A
M
K
I
L
D
G
K
K
-
L
Y
K
E
Y
-
L
L
K
I
Q
F
-
T
APFNPNK-
G
-
A
---
D
S
I
------
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
-
F
N
L
Q
-
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
-
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
--
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.26
26%
-80
- C2 -
2E4W
2
GRM3_RAT
A:
[6-543]
-------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
----
N
E
KGTG
T
E
E
C
G
R
I
N
E
D
R
--------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
--
L
-------------------I
P
L
L
I
A
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
---
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
--
A
A
-
A
N
R
V
---
N
A
S
F
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
S
I
V
K
G
-
S
E
H
V
A
Y
G
A
I
T
L
E
L
--------
A
S
H
--
P
-
V
R
Q
F
D
R
Y
-
F
-
Q
S
--
L
N
P
Y
N
-
N
HR
N
P
W
---------
F
R
D
F
W
E
Q
K
F
Q
-----
C
--
S
L
Q
N
K
R
N
H
R
-
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
PQT
T
K
L
C
----
D
A
M
----
K
----
I
L
D
G
K
K
L
Y
K
E
Y
-
L
-
L
K
I
-
Q
F
T
A
P
F
-
N
--------
P
-
N
KGA
D
S
I
------
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
-
F
N
L
Q
-
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
-
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.08
26%
-78
- C2 -
2E4V
2
GRM3_RAT
A:
[6-543]
-------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
----
N
E
KGTG
T
E
E
C
G
R
I
N
E
D
R
--------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
--
L
-------------------I
P
L
L
I
A
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
---
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
--
A
A
-
A
N
R
V
---
N
A
S
F
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
S
I
V
K
G
-
S
E
H
V
A
Y
G
A
I
T
L
E
L
--------
A
S
H
--
P
-
V
R
Q
F
D
R
Y
-
F
-
Q
S
--
L
N
P
Y
N
-
N
HR
N
P
W
---------
F
R
D
F
W
E
Q
K
F
Q
-----
C
--
S
L
Q
N
K
R
N
H
R
-
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
PQT
T
K
L
C
----
D
A
M
----
K
----
I
L
D
G
K
K
L
Y
K
E
Y
-
L
-
L
K
I
-
Q
F
T
A
P
F
-
N
--------
P
-
N
KGA
D
S
I
------
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
-
F
N
L
Q
-
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
-
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.07
26%
-78
- C2 -
2E4X
2
GRM3_RAT
A:
[6-543]
-------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
----
N
E
KGTG
T
E
E
C
G
R
I
N
E
D
R
--------------
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
--
L
-------------------I
P
L
L
I
A
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
C
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
---
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
--
A
A
-
A
N
R
V
---
N
A
S
F
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
S
I
V
K
G
-
S
E
H
V
A
Y
G
A
I
T
L
E
L
--------
A
S
H
--
P
-
V
R
Q
F
D
R
Y
-
F
-
Q
S
--
L
N
P
Y
N
-
N
HR
N
P
W
---------
F
R
D
F
W
E
Q
K
F
Q
-----
C
--
S
L
Q
N
K
R
N
H
R
-
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
M
Q
R
T
L
C
PQT
T
K
L
C
----
D
A
M
----
K
----
I
L
D
G
K
K
L
Y
K
E
Y
-
L
-
L
K
I
-
Q
F
T
A
P
F
-
N
--------
P
-
N
KGA
D
S
I
------
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
-
F
N
L
Q
-
Q
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
-
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
79.92
25%
-95
* C2 *
3SM9
8
GRM3_HUMAN
A:
[7-475]
---------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
----
N
E
----
K
G
T
----------
T
E
E
C
G
R
I
N
E
D
R
-
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
------------------
L
--
L
----
I
A
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
-
R
K
S
Y
D
S
V
I
R
E
L
L
---
Q
K
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
-
R
A
N
A
----
S
F
-
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
-
S
I
I
K
-
G
-
S
E
H
V
A
Y
G
A
I
T
L
--------
E
L
A
S
Q
P
-
V
R
Q
F
D
R
Y
-
F
-
Q
S
--
L
N
P
Y
N
N
H
R-
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
N
-----------------
H
R
R
V
C
D
K
H
L
A
I
D
S
S
---
N
Y
E
Q
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
---------
M
Q
R
T
----
L
C
P
NTTK
L
----
C
D
A
M
K
I
L
D
G
K
K
L
Y
-
K
D
Y
-
L
L
K
I
N
F
-
T
--------
A
-
P
FN-
D
S
I
------
V
K
F
D
T
F
G
D
G
M
G
R
Y
N
V
-
F
N
F
Q
-
N
V
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
L
-
D
V
N
S
I
H
W
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.84
28%
-91
- C2 -
5CNJ
2
?
A:
[28-465]
----------------------------
L
T
L
E
G
D
L
V
L
G
G
L
F
P
V
HQKG
G
P
----
A
E
D
C
G
P
V
N
E
H
R
--------------
G
I
Q
R
L
E
A
M
L
F
A
L
D
R
I
N
R
D
P
H
L
L
P
G
V
R
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Q
A
L
D
F
V
R
A
S
L---------------
P
-
T
--
A
----
I
T
G
-
V
I
G
G
S
Y
S
D
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
L
E
A
R
-
A
R
N
I
S
V
A
T
S
E
K
V
G
R
A
M
S
R
A
A
F
E
G
V
V
R
A
L
L
Q
----
K
P
S
A
R
V
A
V
L
F
T
R
S
E
D
A
R
E
L
L
--
A
A
-
S
Q
R
L
---
N
A
S
F
T
W
V
A
S
D
G
W
G
A
L
E
--------
S
-
V
V
A
G
-
S
E
G
A
A
E
G
A
I
T
I
E
L
--------
A
S
--
Y
P
-
I
S
D
F
A
S
Y
-
F
-
Q
S
LD
P
W
N
N
S
-
R
--
N
P
W
---------
F
------
R
E
F
-----
W
--
E
Q
R
F
R
C
S
F
R
Q
R
D
C
A
A
H
S
L
R
A
V
P
F
E
Q
E
S
-
K
I
M
F
----
V
V
N
A
V
Y
A
M
A
H
A
L
H
N
---------
M
H
R
A
LCPN
T
T
R
----
L
----
C
D
A
M
R
P
V
N
G
R
R
-
L
-
Y
K
D
F
V
L
N
V
K
F
-
D
--------
A
-
P
---
F
R
P
ADTH
N
E
V
R
F
D
R
F
G
D
G
I
G
R
Y
N
I
-
F
T
Y
L
-
R
A
G
S
G
R
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
-
L
D
T
S
L
I
P
W
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.55
23%
-91
- C2 -
2E4Z
1
GRM7_RAT
A:
[8-479]
-------------------------
P
H
S
I
R
I
E
G
D
V
T
L
G
G
L
F
P
V
----
H
A
----
K
G
P
S
G
V
--------
P
C
G
D
I
K
R
-
E
N
-
G
I
H
R
L
E
A
M
L
Y
A
L
D
Q
I
N
S
D
P
N
L
L
P
N
V
T
L
G
A
R
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
T
F
V
Q
A
L
--
I
Q
K
--------------PE
K
----
V
V
G
-
V
I
G
A
S
G
S
S
V
S
I
M
V
A
N
I
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
D
R
R
Y
D
F
F
S
R
V
V
P
P
D
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
S
Y
G
E
K
G
V
E
S
F
T
Q
I
S
K
E
A
G
G
L
C
I
A
Q
S
V
R
I
P
--------
T
I
D
F
D
R
I
I
K
Q
L
L
D
T
P
N
S
R
A
V
V
I
F
A
N
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
D
Q
V
---
G
H
F
-
L
W
V
G
S
D
S
W
-
G
S
K
INPLHQHE
D
-
I
A
E
G
A
I
T
I
Q
P
K
R
A
T
V
E
G
F
D
A
Y
F
T
S
RT
L
E
N
N
R
R
-
N
V
W
F
A
E
Y
-
W
-
E
E
--
N
F
N
C
K
-------------------------------------
K
C
T
G
Q
----------
E
R
I
G
K
D
S
N
Y
-
E
Q
E
G
K
V
Q
F
V
I
D
A
V
Y
A
M
A
H
A
L
H
H
M
N
K
------
D
L
C
------
Y
R
----
G
V---
C
P
E
M
E
Q
A
G
G
K
K
-
L
-
L
K
Y
-
I
R
H
V
N
F
-
N
G
-------
S
-
A
---
G
T
P
------
V
M
F
N
K
N
G
D
A
P
G
R
Y
D
I
F
Q
Y
Q
T
-
T
N
T
T
N
P
G
Y
R
L
I
G
Q
W
T
D
E
L
Q
L
-
N
I
E
D
M
Q
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
74.74
23%
-83
- C2 -
1EWK
5
GRM1_RAT
A:
[4-480]
-------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
------------
H
H
Q
P
P
A
E
K
V
P
E
R
K
C
G
E
I
R
E
-
Q
Y
-
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
K
----------------------
P
----
I
A
G
-
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
L
R
K
L
R
E
---
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
-
R
L
G
V
---
V
G
E
F
S
L
I
G
S
D
G
W
-
A
D
R
--------
D
-
E
V
I
E
-
G
Y
E
V
E
A
N
G
G
-
I
T
I
--------
K
L
Q
S
P
E
-
V
R
S
F
D
D
Y
-
F
-
L
K
L-
R
L
D
T
N
-
T
--
R
N
P
---------
W
F
P
E
F
W
Q
H
R
F
-----
Q
C
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
N
Y
V
Q
D
S
K
M
G
F
---
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
---------
M
H
H
A
----
L
C
P
----
G
HVGL
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
-
V
--------
G
V
S
---
G
E
E
------
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
-
M
N
L
Q
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.48
25%
-83
- C2 -
1ISS
1
GRM1_RAT
A:
[8-449]
-----------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
----
H
H
----
Q
P
P
A
----
E
K
V
P
E
R
K
C
G
E
I
R
E
-
Q
Y
-
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I----------------
K
--
P
----
I
A
G
-
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
--
D
R
L
L
R
K
L
R
-
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
--
S
A
-
M
R
R
L
GVV
G
E
F
-
S
L
I
G
S
D
G
W
-
A
D
R
--------
D
-
E
V
I
E
-
G
Y
E
V
E
A
N
G
G
I
T
I
K
--------
L
Q
-
S
P
E
-
V
R
S
F
D
D
Y
F
L
-
K
L
--
R
L
D
T
N
-
T
R-
N
P
W
---------
F
P
E
F
W
Q
H
R
F
Q
C
R
L
PG
H
--
L
L
E
N
------
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
N
Y
-
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
---------
M
H
H
A
----
L
C
P
----
G
HVGL
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
G
--------
V
-
S
---
G
E
E
------
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
-
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
-
N
I
D
D
Y
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.05
25%
-81
- C2 -
1EWK
5
GRM1_RAT
A:
[8-449]
-----------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
----
H
H
----
Q
P
P
A
----
E
K
V
P
E
R
K
C
G
E
I
R
E
-
Q
Y
-
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
--------------------
K
--
P
----
I
A
G
-
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
--
D
R
L
L
R
K
L
R
-
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
--
S
A
-
M
R
R
L
GVV
G
E
F
-
S
L
I
G
S
D
G
W
-
A
D
R
--------
D
-
E
V
I
E
-
G
Y
E
V
E
A
N
G
G
I
T
I
K
--------
L
Q
-
S
P
E
-
V
R
S
F
D
D
Y
F
L
-
K
L
--
R
L
D
T
N
-
T
R-
N
P
W
---------
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
--
L
L
E
N
------
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
N
Y
-
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
---------
M
H
H
A
----
L
C
P
----
G
HVGL
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
G
--------
V
-
S
---
G
E
E
------
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
-
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
-
N
I
D
D
Y
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.70
25%
-82
- C2 -
1EWT
2
GRM1_RAT
A:
[8-449]
-----------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
----
H
H
----
Q
P
P
A
----
E
K
V
P
E
R
K
C
G
E
I
R
E
-
Q
Y
-
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L
I
S
I
R
-------------
K
--
P
----
I
A
G
-
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
--
D
R
L
L
R
K
L
R
-
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
--
S
A
-
M
R
R
L
GVV
G
E
F
-
S
L
I
G
S
D
G
W
-
A
D
R
--------
D
-
E
V
I
E
-
G
Y
E
V
E
A
N
G
G
I
T
I
K
--------
L
Q
-
S
P
E
-
V
R
S
F
D
D
Y
F
L
-
K
L
--
R
L
D
T
N
-
T
R-
N
P
W
---------
F
P
E
F
W
Q
H
R
F
Q
C
R
L
PG
H
--
L
L
E
N
------
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
N
Y
-
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
---------
M
H
H
A
----
L
C
P
----
G
HVGL
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
G
--------
V
-
S
---
G
E
E
------
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
-
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
-
N
I
D
D
Y
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
72.60
25%
-82
- C2 -
1ISR
2
GRM1_RAT
A:
[8-449]
-----------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
----
H
H
----
Q
P
P
A
----
E
K
V
P
E
R
K
C
G
E
I
R
E
-
Q
Y
-
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
--------------------
K
--
P
----
I
A
G
-
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
--
D
R
L
L
R
K
L
R
-
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
--
S
A
-
M
R
R
L
GVV
G
E
F
-
S
L
I
G
S
D
G
W
-
A
D
R
--------
D
-
E
V
I
E
-
G
Y
E
V
E
A
N
G
G
I
T
I
K
--------
L
Q
-
S
P
E
-
V
R
S
F
D
D
Y
F
L
-
K
L
--
R
L
D
T
N
-
T
R-
N
P
W
---------
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G
H
--
L
L
E
N
------
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
N
Y
-
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
---------
M
H
H
A
----
L
C
P
----
G
HVGL
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
G
--------
V
-
S
---
G
E
E
------
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
-
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
-
N
I
D
D
Y
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.27
25%
-88
- C2 -
3KS9
4
GRM1_HUMAN
A:
[13-454]
-----------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
----
H
H
----
Q
P
P
A
----
E
K
V
P
E
R
K
C
G
E
I
R
E
-
Q
Y
-
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
D
S
L-----------------
K
--
P
----
I
A
G
-
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
S
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
--
D
R
L
L
R
K
L
R
-
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
--
S
A
-
M
R
R
L
GVV
G
E
F
-
S
L
I
G
S
D
G
W
-
A
D
R
--------
D
-
E
V
I
E
-
G
Y
E
V
E
A
N
G
G
I
T
I
K
--------
L
Q
-
S
P
E
-
V
R
S
F
D
D
Y
F
L
-
K
L
--
R
L
D
T
N
-
T
R-
N
P
W
---------
F
P
E
F
W
Q
H
R
F
Q
C
R
L
P
G-------------
P
N
F
K
R
I
C
T
G
N
E
S
L
E
E
N
Y
-
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
---------
M
H
H
A
----
L
C
P
----
G
HVGL
C
D
A
M
K
P
I
D
G
S
K
-
L
-
L
D
F
-
L
I
K
S
S
F
I
G
--------
V
-
S
---
G
E
E
------
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
-
M
N
L
Q
-
Y
T
E
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
-
D
D
Y
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
70.79
25%
-84
- C2 -
1EWV
-
GRM1_RAT
A:
[40-481]
-----------------------------
R
M
D
G
D
V
I
I
G
A
L
F
S
V
----
H
H
----
Q
P
P
A
----
E
K
V
P
E
R
K
C
G
E
I
R
E
-
Q
Y
-
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
V
A
L
E
Q
S
I
E
F
I
R
--------------------
K
--
P
----
I
A
G
-
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
L
A
A
-
Q
E
G
L
C
I
A
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
--
D
R
L
L
R
K
L
R
-
E
R
L
P
K
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
--
S
A
-
M
R
R
L
GVV
G
E
F
-
S
L
I
G
S
D
G
W
-
A
D
R
--------
D
-
E
V
I
E
-
G
Y
E
V
E
A
N
G
G
I
T
I
K
--------
L
Q
-
S
P
E
-
V
R
S
F
D
D
Y
F
L
-
K
L
--
R
L
D
T
N
-
T
R-
N
P
W
---------
F
P
E
F
W
Q
H
R
F
Q
CRLPG
H
--
L
L
E
N
------
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
N
Y
-
V
Q
D
S
K
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
---------
M
H
H
A
----
L
C
P
----
G
HVGL
C
D
A
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
G
--------
V
-
S
---
G
E
E
------
V
W
F
D
E
K
G
D
A
P
G
R
Y
D
I
-
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
-
N
I
D
D
Y
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
69.83
28%
-98
- C2 -
3SM9
7
GRM3_HUMAN
A:
[5-380]
-------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
----
N
E
----
K
G
---------
T
-
T
E
E
C
G
R
I
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
----------------------LL--
I
A
G
-
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
--
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
---
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
--
A
A
-
A
S
R
A
---
N
A
S
F
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
-
S
I
I
K
-
G
S
E
H
V
A
Y
G
A
I
T
----------
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
-
F
-
Q
S
--
L
N
P
Y
N
-
N
HR
N
P
W
---------
F
R
D
F
W
E
Q
K
F
Q
C----
S
--
L
Q
N
---
H
R
R
V
--
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
---------
M
Q
R
T
----
L
C
P
----
N
----
T
T
K
L
C
D
A
M
K
I
L
-
D
-
G
K
K
-
L
Y
K
D
Y
L
-
L
--------
K
-
I
---
N
F
T
------
A
P
F
N
D
S
I
V
K
F
D
T
F
G
D
-
G
M
G
R
-
Y
N
V
F
N
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
H
-
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.16
28%
-96
- C2 -
5CNM
5
?
A:
[32-407]
-------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
----
N
E
----
K
G
---------
T
G
T
E
E
C
G
R
I
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
--
L
--------------I
P
--
L
----
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
---
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
---
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
--
A
A
-
A
S
R
A
---
N
A
S
F
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
-
S
I
I
K
-
G
S
E
H
V
A
Y
G
A
I
T
----------
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
-
F
-
Q
S
--
L
N
P
Y
N
-
N
HR
N
P
W
---------
F
R
D
F
W
E
Q
K
F
Q
C----
S
--
L
Q
N
---
H
R
R
V
--
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
---------
M
Q
R
T
----
L
C
P
----
N
----
T
T
K
L
C
D
A
M
K
I
L
-
D
-
G
K
K
-
L
Y
K
D
Y
L
-
L
--------
K
-
I
---
N
F
T
------
A
P
F
N
P
N
K
D
A
D
S
I
V
K
F
-
D
T
F
G
-
D
G
M
G
R
Y
N
V
F
N
F
Q
S
Y
L
K
V
G
H
W
-
A
E
T
L
S
L
D
V
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.70
28%
-90
- C2 -
4XAR
8
GRM3_HUMAN
A:
[32-407]
-------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
----
N
E
----
K
G
---------
T
G
T
E
E
C
G
R
I
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
--
L
------------------
L
----
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
E
A
R
-
L
R
N
I
S
I
A
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
K
-
P
N
---
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
--
A
A
-
A
S
R
A
---
N
A
S
F
T
W
V
A
S
D
G
W
-
G
A
Q
--------
E
-
S
I
I
K
-
G
S
E
H
V
A
Y
G
A
I
T
----------
L
E
L
A
S
Q
P
V
R
Q
F
D
R
Y
-
F
-
Q
S
--
L
N
P
Y
N
-
N
HR
N
P
W
---------
F
R
D
F
W
E
Q
K
F
Q
C----
S
--
L
-------
R
V
--
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
-
S
K
I
M
F
---
V
V
N
A
V
Y
A
M
A
H
A
L
H
K
---------
M
Q
R
T
----
L
C
P
----
N
----
T
T
K
L
C
D
A
M
K
I
L
-
D
-
G
K
K
-
L
Y
K
D
Y
L
-
L
--------
K
-
I
---
N
F
T
------
A
P
D
A
D
S
I
V
K
F
D
T
F
G
D
-
G
M
G
R
-
Y
N
V
F
N
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
H
-
W
A
E
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
V
P
T
S
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------