@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : V1BR_HUMAN: (2016-01-15 )
MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
Atome Classification :
(20 SA)
---..---.......10........20........30........40........50........60........70........80----........90.....-...--100.----......110.......120.......130.......140-...----.....150.....-...160.......170..--......180.......190---.---...---.....-200---.....----..210.......220.......230.......240----..---------------------.--------------------.--------------------------------.------------.------------------------------------------------------.---------------------------------------------------------------------.-----------------.--------------250-----------------------------------------..-------------------------------------------------.-----------------------.------------------------------------------------------------.--------------------------------------------------.---------------..--------------------.--260-------------.---------..-----------.....--------------.270.......280.......290-.......300......-----.310-----.........320....-...330.......----340.......350.....-..360.......370.......380.......390.......400.......410.......420..----------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MD---SGPLWDANPTPRGTLSAPNATTPWLGRD
E
E
L
A
K
V
E
I
G
V
L
A
T
V
L
V
L
ATGG
N
L
A
V
L
L
T
L
G
Q
LGRKRS
R
M
H
L
F
V
L
H
L
A
L
T
D
L
----
A
V
A
L
F
Q
V
L
P
Q
L
L
W
D
I
-
T
YR--FQ
G
P
----
D
L
L
C
R
A
V
K
Y
L
Q
V
L
S
M
F
A
S
T
Y
M
L
L
A
M
T
L
D
R
Y
L
A
V
C
H
P
L
R
--
S
L
Q----QPGQ
S
T
-
Y
L
L
I
A
A
-
P
W
L
L
A
A
I
F
S
L
P
Q
V
F
I
-
F
S
--
L
R
E
V
IQGSG
V
L
D
C
W
A
DF-----G---FPW---GP
R
A
Y
-
L
T
W
---
T
T
L
A
I
----
F
V
L
P
V
T
M
L
T
A
C
Y
S
L
I
C
H
E
I
C
KNL
K
V
K
T
Q
A
W
R
VG------GG---------------------G--------------------W--------------------------------R------------T------------------------------------------------------W---------------------------------------------------------------------D-----------------R--------------P-------------------------------------------SP-------------------------------------------------
S
-----------------------
T
------------------------------------------------------------
L
--------------------------------------------------
A
---------------
A
T
--------------------T--R---------------G---------L
P
-----------
S
R
V
S
S
--------------INTIS
R
A
K
I
R
T
V
K
M
T
F
V
I
V
L
A
Y
I
A
-
C
W
A
P
F
F
S
V
Q
M
W
SVWDK-----NA-------PDEDST
N
V
A
F
T
I
S
M
L
L
-
G
N
L
N
S
C
CN
P
W
I
Y
M----GFNSHLL
P
R
P
L
R
H
L
ACCG-GP
Q
P
R
M
R
R
RLSDGSLSS
R
H
T
T
L
L
TRSSC
P
A
T
L
S
L
S
L
S
L
T
LSGRPRPEESPRDLELADGEGTA
E
T
IIF----------------------------------------
26
HHSearch
90.31
21%
-116
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
----------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
----
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
--
W
S
L
G
----
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
--
Y
L
K
Y---
R
T
K
T
R
A
-
S
A
T
I
L
G
-
A
W
F
L
S
F
L
W
V
I
P
I
L
-
G
-
W
N
--
H
------
R
R
E
D
K
C
E
T
D
F
-----
Y
---
D
V
------
T
W
F
-
K
V
M
---
T
A
I
I
N
----
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
------
G
L
---------------------
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLT
K
--------------------------------
S
PS
L
---------
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT-----------------------------------
K
---------------------------------------------------------------------
D
-----------------
E
--------------
A
-------------------------------------------
E
K
L
F
-----------------------------------------------
N
-----------------------
Q
------------------------------------------------------------
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
---------------
Q
Q
--------------------
K
--
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
---------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
--------------
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
-
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
-----
N
C
-------
C
----
N
E
H
L
H
M
F
T
I
W
L
-
G
Y
I
N
S
T
L
N
P
L
I
Y
P
----
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------------------------------------------------------------------------
44
Fugue
88.30
17%
-101
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
----
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
--
F
V
F
G
----
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--
N
F
R
----
F
G
E
N
H
A
-
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
---
R
Y
I
P
E
G
M
Q
C
-
S
C
G
I
D
Y
YTP--
H
---
E
E
T
---
N
N
E
S
F
-
V
I
Y
---
M
F
V
V
H
----
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
A
A
A
--------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----
G
S
-------
D
---
F
G
P
I
F
M
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-
N
P
S
T
----------------------------------
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------------------------------------
21
HHSearch
88.23
20%
-114
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
----
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
--
W
P
L
G
----
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
--
Y
P
V
K---
R
T
T
K
M
A
-
G
M
M
I
A
A
-
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
--
F
I
V
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
-----
F
---
S
N
------
A
A
V
-
T
F
G
---
T
A
I
A
A
----
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
E
------
G
L
---------------------
R
--------------------
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTK------------
S
------------
P
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT--------------------------------
K
---------------------------------------------------------------------
D
-----------------
E
--------------
A
-------------------------------------------
E
K
L
F
-----------------------------------------------
N
-----------------------
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
---------------
T
--------------------------------------------------
N
---------------
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
---------------
P
N
R
A
K
R
V
I
T
T
F
R
-----------
T
G
T
W
D
--------------
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
-
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
-----
P
C
-------
I
----
P
N
T
V
W
T
I
G
Y
W
L
-
C
Y
I
N
S
T
I
N
P
A
C
Y
A
----
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------------------------------------------------------------
43
Fugue
87.24
17%
-99
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
---
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
----
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
--
F
V
F
G
----
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--
N
F
R
----
F
G
E
N
H
A
-
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
------
H
---
E
E
T
---
N
N
E
S
F
-
V
I
Y
---
M
F
V
V
H
----
F
I
I
P
L
I
V
I
F
F
C
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------------------------------------------------------------
L
--------------------------------------------------
V
---------------
F
T
--------------------
V
--
K
---------------
E
---------
A
A
-----------
A
Q
Q
Q
E
--------------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----
G
S
-------
D
---
F
G
P
I
F
M
T
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
Y
I
----
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-
N
P
-------
L
G
D
D
E
------------------------
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------------------------------
22
HHSearch
85.97
17%
-118
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[41-498]
--------------------------------
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
----
L
F
V
-
I
T
L
P
F
W
A
V
D
A
V
--
A
N
--
W
Y
F
G
----
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
--
S
Q
R
P
---
R
K
L
L
A
E
-
K
V
V
Y
V
G
-
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
N
--
V
S
E
A
---
D
D
R
Y
I
C
D
R
F
Y
-----
P
---
N
D
L
---
W
V
V
V
F
-
Q
F
Q
---
H
I
M
V
G
----
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
------
E
G
---------------------
L
--------------------
R
--------------------------------
L
------------
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
---------------------------------------------------------------------
D
-----------------
A
--------------
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
-------------------------------------------------
M
-----------------------
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
-----------------------------------
K
--------------------------------------------------
R
---------------
V
I
--------------------
T
--
T
---------------
F
---------
R
T
-----------
G
T
W
D
A
--------------
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
-
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
-----
L
E
I
I
K
Q
G
C
-
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
-
A
F
F
H
C
C
L
N
P
I
L
Y
A
----
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
-
P
L
E
V
L
F
Q
----------------------------------------------------------------------------------------------------
32
HHSearch
84.98
20%
-128
* C2 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
----
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
--
W
N
F
S
----
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
--
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
-
A
L
M
I
T
A
-
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
--
T
T
G
-----
D
P
T
V
C
S
I
S
N
-----
P
------------
D
F
-
V
I
Y
---
S
S
V
V
S
----
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
------
D
E
---------------------
G
--------------------
L
RL
K
I
Y
K
--------------------------
D
TEG
Y
Y
T
I
G
IGHL
L
------------------------------------------------------
T
KS-------------------------------------------------------------------
P
-----------------
S
--------------
L
N
A
A
K
S
E
L
D
K
A
I
GR------------------------------
N
T
-------------------------------------------------
N
-----------------------
G
VIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
--------------------------------------------------
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
---------------
Q
--
T
P
N
R
A
K
R
V
I
T
------
T
---------
F
R
-----------
T
G
T
W
D
--------------
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
-
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
-----
T
C
-------
H
---
V
S
P
E
L
Y
S
A
T
T
W
L
-
G
Y
V
N
S
A
L
N
P
V
I
Y
T
----
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------------------------------------------------------------------------------
48
Fugue
84.45
15%
-93
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
----------------
P
C
F
R
E
E
------------
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
----
L
F
V
I
--
T
L
P
F
W
A
V
D
A
-
V
A
N
--
W
Y
F
G
----
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
--
S
Q
R
----
P
R
K
L
L
A
E
K
V
V
Y
V
G
-
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
N
--
V
S
E
---
A
D
D
R
Y
I
C
D
R
F
Y
-----
P
---
N
D
L
---
W
V
V
V
F
-
Q
F
Q
---
H
I
M
V
G
----
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
------
E
G
---------------------
L
--------------------
R
--------------------------------
L
------------
K
------------------------------------------------------
I
---------------------------------------------------------------------
Y
-----------------
K
D
TEG
Y
Y
T
I
GIGHLL
T
-------------------------------------------
K
S
-------------------------------------------------
P
-----------------------
S
------------------------------------------------------------
L
--------------------------------------------------
N
---------------
A
A
--------------------
K
--
S
---------------
E
---------
L
D
-----------
K
A
I
G
R
NTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
-
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
-----
G
---------
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
----
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
30
HHSearch
83.30
18%
-120
- C2 -
3EML
13
ENLYS_BPT4
A:
[21-472]
---------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
----
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
---
G
--
F
C
A
A
----
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
--
Y
N
G
L
---
V
T
G
T
R
A
-
K
G
I
I
A
I
-
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
--
N
C
G
Q
-----
S
Q
G
C
G
E
G
Q
VACLF
E
---
D
V
V
---
P
M
N
Y
M
-
V
Y
F
---
N
F
F
A
C
----
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
------
G
L
RL
K
I
Y
K
D
TEGYYTIGIGHLLT
K
S-------------------
P
S
L
N
A
A
K
--------------------------
S
------------
E
------------------------------------------------------
L
D
K
A
I
GRNTNGVIT
K
-------------------------------------------------------
D
E
A
E
--------------
K
--------------
L
F
N
Q
D
V
--------------------------------------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-----------------------
K
------------------------------------------------------------
R
W
D
E
A
A
V
N
L
------------------------------------------
A
K
S
R
W
Y
N
Q
--------
T
P
--------------------
N
--
R
A
K
R
V
I
T
T
--------
F
---------
R
T
-----------
G
T
W
D
A
--------------
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
-
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-----
D
C
-------
S
H
--
A
P
L
W
L
M
Y
L
A
I
V
L
-
S
H
T
N
S
V
V
N
P
F
I
Y
A
----
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
-
L
R
Q
--------------------------------------------------------------------------------------------------------
27
HHSearch
83.25
19%
-104
- C2 -
2KS9
1
NK1R_HUMAN
A:
[2-326]
----
D
---
N
V
L
P
V
D
S
D
L
S
P
N
I
S
T
N
T
S
E
--
P
N
Q
F
V
Q
P
A
W
Q
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
----
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
--
W
Y
Y
G
----
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
--
P
R
L
-----
S
A
T
A
T
-
K
V
V
I
C
V
-
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
--
T
E
T
M
---
P
S
R
V
V
C
M
I
E
W
-----
P
---
E
H
P
NKI
Y
E
K
V
Y
-
H
I
C
---
V
T
V
L
I
----
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
--------------
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
-
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
-----
D
L
-------
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
-
A
M
S
S
T
M
Y
N
P
I
I
Y
C
----
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
-
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-------------------------------------------------------------------
24
HHSearch
82.02
18%
-126
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[37-477]
------------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
----
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
--
W
T
F
G
----
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
--
Y
Q
S
L---
L
T
K
N
K
A
-
R
V
I
I
L
M
-
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
--
R
A
T
H
Q
---
E
A
I
N
C
Y
A
E
E
-----
T
CC-
D
F
F
---
T
N
Q
A
Y
-
A
I
A
---
S
S
I
V
S
----
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
------
G
L
---------------------
R
--------------------
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
------------
A
------------------------------------------------------
I
GR-------------------------------------------------------------------
N
-----------------
T
--------------
N
GVIT
K
D
E
A
E
K
L
F
N
Q
D
V
---------------------------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
------------------
Q
MG
E
T
G
V
A
G
F
T
N
S
L
----------
R
M
L
----------------------------------------------------------
Q
Q
KR
W
D
E
A
-------------------------------------------
A
V
N
L
------------
A
K
S
R
W
Y
N
---------------
Q
--
T
---------------
P
N
R
A
K
R
V
I
T
T
F
R
-----------
T
G
T
W
D
--------------
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
-
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
-----
N
L
-----------
I
R
K
E
V
Y
I
L
L
N
W
I
-
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-----
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.92
23%
-135
- C2 -
4MBS
8
CCR5_HUMAN (first)
A:
[42-366]
-------------------------------------------------
V
F
I
F
G
F
V
G
N
M
L
V
I
L
I
L
I
N
Y
K
R
L
K
S
M
T
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
T
V
P
F
W
A
H
Y
A
A
A
Q
W
D
F
-
G
------------
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
--
A
L
K
----
A
R
T
V
T
F
-
G
V
V
T
S
V
I
T
W
V
V
A
V
F
A
S
L
P
N
I
-
I
-
F
T
---
R
S
Q
K
E
G
---
L
H
Y
T
C
S
S
-----
H
---
F
P
Y
---
S
Q
Y
Q
F
W
K
N
F
---
Q
T
L
K
I
V
I
L
G
L
V
L
P
L
L
V
M
V
I
C
Y
S
G
I
L
K
T
L
---
L
R
M
K
K
Y
T
C
T
V
C
------
G
Y
---------------------
I
--------------------
Y
--------------------------------
N
------------
P
------------------------------------------------------
E
---------------------------------------------------------------------
D
GDPDNGVNPGTDF----
K
--------------
D
-------------------------------------------
I
P
-------------------------------------------------
D
-----------------------
D
------------------------------------------------------------
W
--------------------------------------------------
V
---------------
C
P
--------------------
L
--
C
---------------
G
---------
V
G
-----------
K
D
Q
F
E
--------------
E
V
E
E
E
K
K
R
H
R
D
V
R
L
I
F
T
I
M
I
V
Y
F
L
-
F
W
A
P
Y
N
I
V
L
L
L
N
T
F
Q
E
FFGLN
N
C
-------
S
S
S
N
R
L
D
Q
A
M
Q
V
T
E
T
L
-
G
M
T
H
C
C
I
N
P
I
I
Y
A
F
VG
E
E
F
R
N
Y
L
L
V
F
F
Q
-------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
80.63
26%
-137
- C2 -
3ZPQ
11
ADRB1_MELGA
A:
[17-285]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
----
V
V
G
L
L
-
V
V
P
---
F
G
A
-
T
L
V
--
V
R
G
T
WLWG
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
----
T
R
A
R
A
K
--
V
I
I
C
T
-
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
--
W
R
D
--
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
CCD
F
V
----
T
N
R
A
Y
-
A
I
A
---
S
S
I
I
S
----
F
Y
I
P
L
L
I
M
--------------
I
F
V
A
L
R
V
Y
R
E
A
------
K
E
---------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
R
---------------
V
---------
M
L
-----------
M
R
------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
-
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
-------
V
-
P
D
W
L
F
V
A
F
N
---
W
L
-
G
Y
A
N
S
A
M
N
P
I
I
Y
C
----
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.61
26%
-140
- C2 -
2Y00
13
ADRB1_MELGA
A:
[17-285]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
----
V
V
G
L
L
-
V
V
P
---
F
G
A
-
T
L
V
--
V
R
G
T
WLWG
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
----
T
R
A
R
A
K
--
V
I
I
C
T
-
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
--
W
R
D
--
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
CCD
F
V
----
T
N
R
A
Y
-
A
I
A
---
S
S
I
I
S
----
F
Y
I
P
L
L
I
M
--------------
I
F
V
A
L
R
V
Y
R
E
A
------
K
E
---------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
R
---------------
V
---------
M
L
-----------
M
R
------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
-
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
-------
V
-
P
D
W
L
F
V
A
F
N
---
W
L
-
G
Y
A
N
S
A
M
N
P
I
I
Y
C
----
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.25
25%
-130
- C2 -
2YCW
7
ADRB1_MELGA
A:
[17-283]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
----
V
V
G
L
L
-
V
V
P
---
F
G
A
-
T
L
V
--
V
R
G
T
WLWG
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
YQ
S
L
M
----
T
R
A
R
A
K
--
V
I
I
C
T
-
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
--
W
R
D
--
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
CCD
F
V
----
T
N
R
A
Y
-
A
I
A
---
S
S
I
I
S
----
F
Y
I
P
L
L
I
M
--------------
I
F
V
A
L
R
V
Y
R
E
A
------
K
E
---------------------
Q
--------------------
I
--------------------------------
R
------------
K
------------------------------------------------------
I
---------------------------------------------------------------------
D
-----------------
R
--------------
A
-------------------------------------------
S
K
-------------------------------------------------
R
-----------------------
K
------------------------------------------------------------
R
--------------------------------------------------
V
---------------
M
L
--------------------
M
--
R
----------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
-
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
-------
V
-
P
D
W
L
F
V
A
F
N
---
W
L
-
G
Y
A
N
S
A
M
N
P
I
I
Y
C
----
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
79.93
26%
-137
- C2 -
3ZPR
11
ADRB1_MELGA
A:
[17-285]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
----
V
V
G
L
L
-
V
V
P
---
F
G
A
-
T
L
V
--
V
R
G
T
WLWG
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
----
T
R
A
R
A
K
--
V
I
I
C
T
-
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
--
W
R
D
--
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
CCD
F
V
----
T
N
R
A
Y
-
A
I
A
---
S
S
I
I
S
----
F
Y
I
P
L
L
I
M
--------------
I
F
V
A
L
R
V
Y
R
E
A
------
K
E
---------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
-----------
M
R
------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
-
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
-------
V
-
P
D
W
L
F
V
A
F
N
---
W
L
-
G
Y
A
N
S
A
M
N
P
I
I
Y
C
----
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------------------------------------------------------------------------------------------------------------
29
HHSearch
79.83
19%
-122
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[58-495]
----------------------------------
D
K
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
----
L
A
G
V
A
Y
T
A
N
L
L
L
S
G
A
--
T
T
--
Y
K
L
T
----
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-------------
N
N
F
R
L
-
F
L
L
I
S
A
-
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
-
W
N
--
C
I
S
-----
A
L
S
S
C
S
T
V
L
-----
P
---
L
Y
H
-----
K
H
Y
--
I
L
---
F
C
T
T
V
----
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
D
E
G
------
L
R
---------------------
L
--------------------
K
--------------------------------
I
------------
Y
------------------------------------------------------
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
--------------
E
-------------------------------------------
T
G
-------------------------------------------------
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
------------------------------------------------------------
S
R
W
Y
N
Q
T
P
N
R
A
K
---------------------------------------
R
---------------
V
I
--------------------
T
--
T
---------------
F
---------
R
T
-----------
G
T
W
D
A
--------------
Y
A
S
R
S
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
-
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
-----
V
K
-------
T
C
--
D
I
L
F
R
A
E
Y
F
L
V
L
-
A
V
L
N
S
G
T
N
P
I
I
Y
T
----
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
------------------------------------------------------------------------------------------------------------
45
Fugue
79.72
19%
-124
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----------
S
F
K
C
A
L
T
K
T
G
F
----------------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
----
L
Y
V
L
--
T
L
P
A
L
I
F
Y
Y
-
F
N
K
TD
W
I
F
G
----
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
--
S
L
G
----
R
L
K
K
K
N
-
A
I
C
I
S
V
-
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
-
Y
S
---
G
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
-----
S
---
D
E
Y
----
L
R
S
Y
-
F
I
Y
S
M
C
T
T
V
A
M
----
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
-
K
Y
T
C
T
V
C
G
Y
I
Y
N
PE
D
G
---------------------
D
--------------------
P
--------------------------------
D
------------
N
------------------------------------------------------
G
---------------------------------------------------------------------
V
-----------------
N
--------------
P
-------------------------------------------
G
T
-------------------------------------------------
D
-----------------------
F
------------------------------------------------------------
K
--------------------------------------------------
D
---------------
I
V
--------------------
C
--
P
---------------
L
---------
C
G
-----------
V
G
K
D
Q
--------------
F
E
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
-----
L
D
FQTPAM
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
-
A
S
L
N
S
C
V
N
P
I
L
Y
F
----
L
----------------
A
-
G
D
T
F
R
R
R
----------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
79.50
26%
-136
- C2 -
2Y02
13
ADRB1_MELGA
A:
[17-285]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
----
V
V
G
L
L
-
V
V
P
---
F
G
A
-
T
L
V
--
V
R
G
T
WLWG
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
----
T
R
A
R
A
K
--
V
I
I
C
T
-
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
--
W
R
D
--
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
CCD
F
V
----
T
N
R
A
Y
-
A
I
A
---
S
S
I
I
S
----
F
Y
I
P
L
L
I
M
--------------
I
F
V
A
L
R
V
Y
R
E
A
------
K
E
---------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
R
---------------
V
---------
M
L
-----------
M
R
------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
-
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
-------
V
-
P
D
W
L
F
V
A
F
N
---
W
L
-
G
Y
A
N
S
A
M
N
P
I
I
Y
C
----
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.30
26%
-138
- C2 -
2Y01
12
ADRB1_MELGA
A:
[17-285]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
----
V
V
G
L
L
-
V
V
P
---
F
G
A
-
T
L
V
--
V
R
G
T
WLWG
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
----
T
R
A
R
A
K
--
V
I
I
C
T
-
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
--
W
R
D
--
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
CCD
F
V
----
T
N
R
A
Y
-
A
I
A
---
S
S
I
I
S
----
F
Y
I
P
L
L
I
M
--------------
I
F
V
A
L
R
V
Y
R
E
A
------
K
E
---------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
R
---------------
V
---------
M
L
-----------
M
R
------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
-
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
-------
V
-
P
D
W
L
F
V
A
F
N
---
W
L
-
G
Y
A
N
S
A
M
N
P
I
I
Y
C
----
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.27
26%
-136
- C2 -
2Y04
13
ADRB1_MELGA
A:
[17-285]
---------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
----
V
V
G
L
L
-
V
V
P
---
F
G
A
-
T
L
V
--
V
R
G
T
WLWG
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
----
T
R
A
R
A
K
--
V
I
I
C
T
-
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
--
W
R
D
--
E
D
P
Q
A
L
K
C
Y
Q
D
P
-----
G
CCD
F
V
----
T
N
R
A
Y
-
A
I
A
---
S
S
I
I
S
----
F
Y
I
P
L
L
I
M
--------------
I
F
V
A
L
R
V
Y
R
E
A
------
K
E
---------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
R
---------------
V
---------
M
L
-----------
M
R
------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
-
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-----
D
L
-------
V
-
P
D
W
L
F
V
A
F
N
---
W
L
-
G
Y
A
N
S
A
M
N
P
I
I
Y
C
----
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------