@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : V2R_HUMAN: (2016-01-15 )
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
Atome Classification :
(20 SA)
.........10...-.....20........30-.-----.......40........50........60........70........80....-..-..90.-.......100......----.----.110.......120.......130.......140.......150-.........160.......170....-...180...--..---..190.....----..---200-..--...-....210.......220...-....230-------..-...----------..240...----.-------.---------------------------.----------------------------.-------------------------------------------------------------------------------------------------------------250---------------------------------------------------------------------------.----------------------------------------------------------------------.----------------------------------------------.-------------------------------.----.--------------..--------------..260----........270.......280....---.--..---290....--...---------300-...-------......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLMASTTSAVPGHP-SLPSLPSNSSQERPLDT-R-----D
P
L
L
A
R
A
E
L
A
L
L
S
I
V
F
V
A
V
A
LSN
G
L
V
L
A
A
L
A
RRGRRGHW
A
P
I
H
V
F
I
G
H
L
C
L
A
D
-
L
A
-
V
A
L
F
Q
-
V
L
P
Q
L
A
W
K
A
-TDRFR
G
----
P
----
D
A
L
C
R
A
V
K
Y
L
Q
M
V
G
M
Y
AS
S
Y
M
I
L
A
M
T
L
D
R
H
R
A
I
C
R
P
M
L
A
YRH---GSGAHWNRP
V
L
V
A
W
A
F
S
L
L
L
S
L
P
Q
L
F
-
I
F
A
QRNVEG--GS---
G
V
T
D
C
W
A
C
F
A----EP---W---GR--
R
T
Y
-
V
T
W
I
A
L
M
V
F
VAP
T
L
G
I
A
A
C
Q
-
V
L
I
F
R
E
I
-------
H
A
-
S
LV----------PGPSERPG----G-------R---------------------------R----------------------------R-------------------------------------------------------------------------------------------------------------G-----------------------------------------------------------------------------R----------------------------------------------------------------------R----------------------------------------------T-------------------------------G----S--------------PG--------------EG
A
H
-----
V
S
A
A
V
A
K
T
V
R
M
T
L
V
I
V
V
V
Y
V
L
C
W
A
P
---
F
--
F
L
---
V
Q
L
W
A
AW--DPE---------A---PLE-------G
A
P
F
V
L
L
M
L
L
A
S
L
NSCTN
P
W
I
Y
A
SF
S
S
S
V
S
S
E
L
R
S
L
L
C
C
ARGRTPPSLGPQDESCTTA
S
S
SLAKDTSS
22
HHSearch
78.03
20%
-134
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
--------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
--
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
-
L
V
-
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
----
G
----
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
--
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
--------------
N
--
Q
A
Y
-
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
-------
K
R
-
Q
L
N
----------
I
F
E
M
L
R
I
D
----
E
-------
G
---------------------------
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
-------------------------------------------------------------------------------------------------------------
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
----------------------------------------------------------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
------------------------------------------
Y
N
------------------------------
Q
----
T
P
N
R
A
K
R
V
I
T
T
F
R
TG
T
W
--------------
D
A
Y
K
-----
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
---
F
--
F
I
---
V
N
I
V
H
V
I
--
Q
D
N
---------
L
---
I
-
R
-------
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------
45
Fugue
76.52
22%
-145
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------
S
F
K
C
A
L
-
T
-
K
-----
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
--
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
-
F
L
Y
V
L
T
L
P
-
A
L
I
F
Y
Y
F
N
K
-
T
D
W
I
F
G
---------
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
---
I
-
L
F
Y
S
G
T
G
V
R
--
K
N
---
K
T
I
T
C
Y
D
T
T
S
----
D
E
---
Y
---
L
R
S
Y
F
I
Y
-
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
-
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
-
T
V
C
G
Y
I
Y
N
PEDGD
P
D
N
G
V
N
P
G
----
T
-------
D
---------------------------
F
----------------------------
K
-------------------------------------------------------------------------------------------------------------
D
-----------------------------------------------------------------------------
I
----------------------------------------------------------------------
V
----------------------------------------------
C
-------------------------------
P
----
L
--------------
C
G
--------------
V
G
K
D
Q
F
E
E
V
E
E
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
---
F
--
H
V
M
K
T
M
N
L
R
A
R
L
--
D
F
Q
---------
T
---
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------------------------
6
PsiBlast_PDB
74.22
27%
-125
- C3 -
4RWD
7
C562_ECOLX (first)
A:
[121-405]
------------------------------------------
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
--
N
L
A
L
A
D
--
A
-
L
A
T
S
T
-
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
----
G
----
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
-
M
A
V
T
R
P
R
D
G
--
A
------
V
V
C
M
L
Q
F
P
----
S
P
S
W
Y
W
---
D
T
--
V
T
K
-
I
C
-
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
-------
S
V
-
R
L
L
----------
S
G
S
K
E
K
D
R
----
S
-------
L
---------------------------
R
----------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
--
V
I
---
V
W
T
L
V
D
I
--
D
R
R
---------
D
---
P
L
V
-------
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------
5
PsiBlast_PDB
73.55
27%
-135
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[121-405]
------------------------------------------
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
--
N
L
A
L
A
D
--
A
-
L
A
T
S
T
-
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
----
G
----
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
-
M
A
V
T
R
P
R
D
G
--
A
------
V
V
C
M
L
Q
F
P
----
S
P
S
W
Y
W
---
D
T
--
V
T
K
-
I
C
-
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
---------------------------
G
S
K
E
K
D
R
----
S
-------
L
---------------------------
R
----------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
--
V
I
---
V
W
T
L
V
D
I
--
D
R
R
---------
D
---
P
L
V
-------
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------
26
HHSearch
72.97
19%
-142
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
--
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
-
L
L
-
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
----
S
----
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
F
N
T
T
G
----------
D
P
T
V
C
S
I
S
N
------------------
P
D
F
-
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
-
A
R
I
Y
V
V
L
-------
K
Q
-
R
R
R
----------
K
N
I
F
E
M
L
R
I
D
E
G
L
RL
K
I
Y
K
D
T
---------------------------
E
----------------------------
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
---------
K
-----------------------------------------------------------------------------
R
W
D
E
A
A
V
N
L
--------------------------------------------------------------
A
----------------------------------------------
K
S
R
W
Y
N
--------------------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G----
T
W
--------------
D
A
Y
G
-----
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
---
F
--
F
L
---
T
H
V
L
N
T
H
--
C
Q
T
---------
C
---
H
V
S
-------
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-----------------------------
4
PsiBlast_PDB
72.03
27%
-129
- C3 -
4N6H
23
C562_ECOLX (first)
A:
[124-408]
------------------------------------------
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
--
N
L
A
L
A
D
--
A
-
L
A
T
S
T
-
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
----
G
----
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
-
M
A
V
T
R
P
R
D
G
--
A
------
V
V
C
M
L
Q
F
P
----
S
P
S
W
Y
W
---
D
T
--
V
T
K
-
I
C
-
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
-------
S
V
-
R
L
L
----------
S
G
S
K
E
K
D
R
----
S
-------
L
---------------------------
R
----------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
--
V
I
---
V
W
T
L
V
D
I
--
D
R
R
---------
D
---
P
L
V
-------
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
--------------------------
24
HHSearch
71.79
17%
-122
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[48-497]
-------------------------------------------
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
--
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
-
L
L
-
F
V
I
-
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
----
G
----
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
-
F
A
N
V
S
E
A
-----
D
---
D
R
Y
I
C
D
R
F
Y
P
----
N
D
---
L
---
W
V
--
V
V
F
-
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
-
C
I
I
I
S
K
L
-------
S
H
-
S
G
S
----------
N
I
F
E
M
L
R
I
----
D
-------
E
---------------------------
G
----------------------------
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
--------------------------------------------------------------------
L
A
K
S
R
------------------------------------------------------------------
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------------------------
T
-------------------------------
G
----
T
--------------
W
D
--------------
A
Y
G
S
-----
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
---
Y
--
Y
I
---
G
I
S
I
D
S
F
--
I
L
L
EI
I
K
Q
G
C
E
F
E
---
N
T
V
-------
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
--------------------
28
HHSearch
71.30
20%
-135
* C3 *
2KS9
1
NK1R_HUMAN
A:
[35-329]
----------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
--
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
-
A
S
-
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
----
G
----
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
S
-----
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-
Y
S
T
T
E
T
M
-
P
-------
S
R
V
V
C
M
I
E
W
P
----
E
H
---
P
NKI
Y
E
--
K
V
Y
-
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
-
T
V
V
G
I
T
L
-------
W
A
-
S
E
I
----------
P
G
D
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------
R
Y
H
E
-----
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
---
F
--
H
I
---
F
F
L
L
P
Y
I
--
N
P
D
---------
L
YLK
K
F
I
-------
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
23
HHSearch
70.83
19%
-131
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
----------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
--
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
-
L
I
-
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
----
G
----
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
--
G
W
N
H
--------
R
---
R
E
D
K
C
E
T
D
F
Y
----
D
V
-----------
T
W
F
-
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
-
A
K
I
Y
K
A
V
-------
R
Q
-
H
C
N
----------
I
F
E
M
L
R
I
D
----
E
-------
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
----------------------------
A
A
K
S
E
L
D
K
A
I
G---------------------------------------------------------------------------------------------------
R
NTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
--------
Q
----------------------------------------------------------------------
Q
----------------------------------------------
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
---------------
Q
----
T
--------------
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
L
-----
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
---
Y
--
F
I
---
F
F
M
V
I
A
F
--
C
K
N
---------
C
---
C
N
--------
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-----------------------------
43
Fugue
70.72
18%
-98
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
-----
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
--
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
-
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
----
G
----
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
MQ
C
S
---
C
G
I
D
Y
Y
T
-
P
H
----
E
E
---
T
---
N
N
--
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
F
T
V
-------
K
E
-
A
A
A
----------
S
A
T
T
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
---
Y
--
A
G
---
V
A
F
Y
I
F
T
--
H
Q
G
---------
S
---
D
F
G
-------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
--
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------
42
Fugue
70.60
17%
-93
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----
M
N
G
T
E
G
P
N
F
-
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
-
P
QYYLA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
--
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
-
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
----
G
----
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
MQ
C
S
---
C
G
I
D
-
Y
Y
T
P
H
----
E
E
---
T
---
N
N
--
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
F
T
V
-------
K
E
-
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------
A
----
Q
--------------
Q
Q
--------------
E
S
A
T
-----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
---
Y
--
A
G
---
V
A
F
Y
I
F
T
--
H
Q
G
---------
S
---
D
F
G
-------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
1
PsiBlast_PDB
70.01
26%
-134
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[141-405]
-----------------------------------------------------------
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
--
N
L
A
L
A
D
-
T
L
-
V
L
L
------
T
L
P
F
Q
G
-
T
D
I
L
L
G
FWPF
G
----
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
-
V
A
-
I
M
G
S
A
Q
V
E
D
--
E
E
-----
I
E
C
L
V
E
I
P
----
T
P
QDY
W
---
G
P
---
V
F
-
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
-
S
L
M
I
R
R
L
-------
R
G
V
R
L
L
----------
S
G
S
R
E
K
D
R
----
N
-------
L
---------------------------
R
----------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
---
V
Q
V
F
V
---
L
A
Q
G
L
G
V
--
Q
P
S
---------
S
---
E
T
A
-------
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
----------------------------------
2
PsiBlast_PDB
68.74
24%
-148
- C3 -
5C1M
7
?
A:
[21-286]
-----------------------------------------------
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
--
N
L
A
L
A
D
A
L
A
-
T
S
-------
T
L
P
F
Q
S
-
V
N
Y
L
M
G
----
T
WPFG
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
-
M
A
T
T
K
Y
R
Q
G
--
S
------
I
D
C
T
L
T
F
S
----
H
P
T
W
Y
W
---
E
N
--
L
L
K
-
I
C
-
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
K
-------
S
V
-
R
M
L
----------
S
G
S
K
E
K
D
R
----
N
-------
L
---------------------------
R
----------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
---
I
--
H
I
---
Y
V
I
I
K
A
L
I
T
I
P
E
---------
T
---
T
F
Q
-------
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
-----------------------------------
31
HHSearch
68.31
17%
-120
- C3 -
2Z73
5
OPSD_TODPA
A:
[34-333]
-------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
--
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
-
F
T
-
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
----
G
----
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
W
G
A
Y
T
L
E
----
G
---
V
L
C
N
C
S
F
D
Y
I
----
S
R
D--
S
---
T
T
--
R
S
N
-
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
-
F
N
I
V
M
S
V
-------
S
N
-
H
E
K
----------
E
M
A
A
M
A
K
R
----
L
-------
N
---------------------------
A
----------------------------
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------
L
R
--------------
K
A
Q
A
-----
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
---
Y
--
A
V
---
V
A
L
L
A
Q
F
--
G
P
L
---------
E
---
W
V
T
-------
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
---
3
PsiBlast_PDB
68.24
89%
53
- C3 -
2JX4
-
V2R_RAT
A:
[226-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
F
R
E
I
-------
H
A
-
S
L
V
----------
P
G
P
S
E
R
A
G
----
R
-------
R
---------------------------
R
----------------------------
R
-------------------------------------------------------------------------------------------------------------
G
-----------------------------------------------------------------------------
R
----------------------------------------------------------------------
R
----------------------------------------------
T
-------------------------------
G
----
S
--------------
P
S
--------------
E
G
A
H
-----
V
S
A
A
-
A
K
T
V
R
-
T
-------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
67.99
18%
-129
- C3 -
3EML
13
ENLYS_BPT4
A:
[22-472]
--------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
--
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-
I
A
-
V
G
V
L
A
-
I
P
F
A
I
T
I
S
---
T
G
F
C
A
----
A
----
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
Q
----------
S
Q
G
C
G
E
G
Q
V
ACLF
E
D
---
V
---
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
-
L
R
I
F
L
A
A
-------
R
R
-
Q
L
N
----------
I
F
E
M
L
R
I
D
----
E
-------
G
---------------------------
L
RL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
------------------------------------------------------------------------------------------------------------
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
----------------------------------------------------------------------
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
----------------------------
T
-------------------------------
P
----
N
R
A
K
R
V
I
T
T
F
R
TGT-
W
D
--------------
A
Y
R
S
-----
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
---
L
--
H
I
---
I
N
C
F
T
F
F
--
C
P
D
---------
C
S--
H
A
P
-------
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
------------------------
13
PsiBlast_PDB
67.26
20%
-126
- C3 -
3DQB
6
GNAT1_BOVIN (first)
A:
[71-326]
-------------------------------------------------------------------------------
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
-
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
----
G
----
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
--
M
Q
-----
C
S
C
G
I
D
Y
Y
----
T
P
---
H
EET
N
N
--
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
----------------
Y
G
-
Q
L
V
----------
F
T
V
K
E
A
A
A
----
Q
-------
Q
---------------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
-----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
---
Y
--
A
G
---
V
A
F
Y
I
F
T
--
H
Q
G
---------
S
---
D
F
G
-------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
--
G
K
N
------------------------
21
HHSearch
66.90
17%
-127
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
---------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
--
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
-
L
I
-
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
----
G
----
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
W
Q
F
I
V
G
V
R
--
T
V
---
E
D
G
E
C
Y
I
Q
F
F
----
S
---------
N
--
A
A
V
-
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
-
W
H
I
S
R
A
S
-------
K
S
-
R
I
N
----------
I
F
E
M
L
R
I
D
----
E
-------
G
LRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKS---
P
----------------------------
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNTN--------------------------------------------------------------------------------------------
G
VIT
K
-------------------------------------------------------------------------
D
----------------------------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
----
T
P
N
R
A
K
R
V
I
T
T
F
R
TG
T
W
--------------
D
A
Y
P
-----
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
---
Y
--
N
V
---
M
V
L
I
N
T
F
--
C
A
P
---------
C
---
I
-
P
-------
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
------------------------------
14
PsiBlast_PDB
66.82
20%
-128
- C3 -
3PQR
9
OPSD_BOVIN
A:
[71-326]
-------------------------------------------------------------------------------
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
-
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
----
G
----
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
--
M
Q
-----
C
S
C
G
I
D
Y
Y
----
T
P
---
H
EET
N
N
--
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
----------------
Y
G
-
Q
L
V
----------
F
T
V
K
E
A
A
A
----
Q
-------
Q
---------------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
-----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
---
Y
--
A
G
---
V
A
F
Y
I
F
T
--
H
Q
G
---------
S
---
D
F
G
-------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
--
G
K
N
------------------------
15
PsiBlast_PDB
66.68
20%
-123
- C3 -
3PXO
5
OPSD_BOVIN
A:
[71-326]
-------------------------------------------------------------------------------
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
-
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
----
G
----
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
--
M
Q
-----
C
S
C
G
I
D
Y
Y
----
T
P
---
H
EET
N
N
--
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
----------------
Y
G
-
Q
L
V
----------
F
T
V
K
E
A
A
A
----
Q
-------
Q
---------------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
-----
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
---
Y
--
A
G
---
V
A
F
Y
I
F
T
--
H
Q
G
---------
S
---
D
F
G
-------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
--
G
K
N
------------------------