@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAPK1_HUMAN: (2013-07-18 )
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
Atome Classification :
(81 SA)
.........10........20........30........40......---..50........----60........70-........80...-......90........100.......110.......120.......130.......140-.......150.....---.-----.160--..---.---.--....170.-..-.....180.......190.......200-----.--......210.......220.......230-...-..--..240.--.-...----..---..250-...--.....260..-...-----.-----.-----270.......280--------------.......290.......--300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHE---LTGHKVAVKILN----RQKIRSLDVVGK-IRREIQNLK-LFR-HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH-RHMVVHRDLKPENVL---L-----DAH---MN---A---K--IADFGL-S-NM-MSDGEFLRTSCGSPNYAAPEVISGRLYA-----G--PEVDIWSSGVILYALLCGTLPFDDDHVPT-LFK-KI--CDG--I--F-YTP----QY---LNPS--VIS--LLKHMLQVDP-MKR-----A-----T-----IKDIREHEWFKQD--------------LPKYLFPEDPSYSSTMI--DDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
119
HHSearch
90.48
100%
-112
- C4 -
2Y94
2
AAPK1_RAT
A:
[9-471]
-----------------
H
D
G
R
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
---
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
R
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
-
S
-
N
M
-
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
-
L
F
K
-
K
I
--
C
D
G
--
I
--
F
-
Y
T
P
----
Q
Y
---
L
N
P
S
--
V
I
S
--
L
L
K
H
M
L
Q
V
D
P
-
M
K
R
-----
A
-----
T
-----
I
K
D
I
R
E
H
E
W
F
K
Q
D
--------------
L
P
K
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
--
D
D
E
A
L
K
E
V
C
E
K
-------------------------------
R
R
I
M
N
E
A
K
D
F
Y
L
A
T
S
P
P
D
S
F
L
D
D
H
H
L
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
A
R
H
T
L
D
E
L
N
P
Q
K
S
K
H
Q
G
V
R
K
A
K
W
H
L
G
I
R
S
Q
S
R
P
N
D
I
M
A
E
V
C
R
A
I
K
Q
L
D
Y
E
W
K
V
V
N
P
Y
Y
L
R
V
R
R
K
N
P
V
T
S
T
F
S
K
M
S
L
Q
L
Y
Q
V
D
S
R
T
Y
L
L
D
F
R
S
I
D
D
E
-------------------------------------------------------------------------------
4
PsiBlast_PDB
75.21
90%
-115
- C4 -
3AQV
1
AAPK2_HUMAN
A:
[4-276]
-----------------
H
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
---
L
T
G
H
K
V
A
V
K
I
L
N
----
R
Q
K
I
R
S
L
D
V
V
G
K
-
I
K
R
E
I
Q
N
L
K
-
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
-----
D
A
H
---
M
N
---
A
---
K
--
I
A
D
F
G
L
-
S
-
N
M
-
M
S
D
G
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
--
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
-
L
F
K
-
K
I
--
R
G
G
--
V
--
F
-
Y
I
P
----
E
Y
---
L
N
R
S
--
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
-
L
K
R
-----
A
-----
T
-----
I
K
D
I
R
E
H
E
W
F
K
Q
D
--------------
L
P
S
Y
L
F
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
58.00
37%
-100
- C4 -
3BHH
1
KCC2B_HUMAN
A:
[6-266]
--------------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
S
K
---
C
K
---
G
A
A
V
K
--
L
A
D
F
G
L
-
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
--
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
K
-
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
----
E
W
DT-
V
T
P
E
--
A
K
N
--
L
I
N
Q
M
L
T
I
N
P
-
A
K
R
-----
I
-----
T
-----
A
H
E
A
L
K
H
P
W
V
C
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
57.95
38%
-106
- C4 -
4GV1
5
AKT1_HUMAN
A:
[4-270]
--------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
----
K
E
V
I
V
A
K
D
E
V
A
H
-
T
L
T
E
N
R
V
L
Q
-
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
-----
D
K
D
---
G
H
---
I
---
K
--
I
T
D
F
G
L
-
C
-
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
------
G
--
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
-
L
F
E
-
L
I
--
L
M
E
--
E
--
I
-
R
F
P
----
R
T
---
L
G
P
E
--
A
K
S
--
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-----
L
-----
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
57.23
37%
-96
- C4 -
3IGO
8
?
A:
[30-282]
--------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
-
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
S
K
EKD
C
D
---
I
---
K
--
I
I
D
F
G
L
-
S
-
T
C
-
F
Q
Q
N
T
-------
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
-
I
L
K
-
R
V
--
E
T
G
KY
A
--
F
-
D
L
P
----
Q
W
R
T
-
I
S
D
D
--
A
K
D
--
L
I
R
K
M
L
T
F
H
P
-
S
L
R
-----
I
-----
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
56.95
37%
-93
- C4 -
3MWU
1
?
A:
[30-282]
--------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
S
K
EKD
C
D
---
I
---
K
--
I
I
D
F
G
L
-
S
-
T
C
-
F
Q
Q
N
----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
-
I
L
K
-
R
V
--
E
T
G
KY
A
--
F
-
D
L
P
----
Q
W
R
T
-
I
S
D
D
--
A
K
D
--
L
I
R
K
M
L
T
F
H
P
-
S
L
R
-----
I
-----
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
56.74
37%
-99
- C4 -
3NCG
1
?
A:
[30-282]
--------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
S
K
EKD
C
D
---
I
---
K
--
I
I
D
F
G
L
-
S
-
T
C
-
F
Q
Q
N
T
-----
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
-
I
L
K
-
R
V
--
E
T
G
KY
A
--
F
-
D
L
P
----
Q
W
R
T
-
I
S
D
D
--
A
K
D
--
L
I
R
K
M
L
T
F
H
P
-
S
L
R
-----
I
-----
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
56.09
35%
-100
- C4 -
3HX4
3
?
A:
[57-330]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
-------
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
KK-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
55.97
37%
-110
- C4 -
4FG8
1
KCC1A_HUMAN
A:
[20-279]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
E
-------------
N
E
I
A
V
L
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
E
D
---
S
K
---
I
---
M
--
I
S
D
F
--------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
--------
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
----
Y
W
DD-
I
S
D
S
--
A
K
D
--
F
I
R
H
L
M
E
K
D
P
-
E
K
R
-----
F
-----
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
55.38
37%
-106
- C4 -
2CN8
1
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
---
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
55.37
37%
-109
- C4 -
4BDB
10
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
---------
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
55.27
37%
-112
- C4 -
4BDJ
1
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
55.17
37%
-108
- C4 -
4FG9
1
KCC1A_HUMAN
A:
[20-279]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
E
------------
E
N
E
I
A
V
L
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
E
D
---
S
K
---
I
---
M
--
I
S
D
F
---------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
--------
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
----
Y
W
DD-
I
S
D
S
--
A
K
D
--
F
I
R
H
L
M
E
K
D
P
-
E
K
R
-----
F
-----
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
55.12
37%
-96
- C4 -
3MA6
1
?
A:
[39-292]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
-
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
K
K
-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
55.03
33%
-84
- C4 -
2UZT
1
KAPCA_BOVIN
A:
[34-332]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
-
A
-
K
R
-
V
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
----
S
H
---
F
S
S
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
-
T
K
R
-----
F
GNLKD
G
-----
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
RKVEAPF
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
54.99
35%
-90
- C4 -
3SX9
1
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
K
K
-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
-----
D
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
54.97
36%
-103
- C4 -
3HZT
9
?
A:
[12-262]
--------------------------------
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
---
L
T
G
A
E
R
A
I
K
I
I
K
----
K
S
S
V
T
T
T
S
N
S
G
A
-
L
L
D
E
V
A
V
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
---
S
R
D
A
L
I
---
K
--
I
V
D
F
G
L
-
S
-
A
H
-
F
E
V
G
--------
T
A
Y
Y
I
A
P
E
V
L
--
R
K
K
Y
-----
D
--
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
D
Q
E
-
I
L
K
-
R
V
--
E
K
G
--
K
--
F
S
F
D
P
PDW-
T
Q
---
V
S
D
E
--
A
K
Q
--
L
V
K
L
M
L
T
Y
E
P
-
S
K
R
-----
I
-----
S
-----
A
E
E
A
L
N
H
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
54.94
35%
-84
- C4 -
3T3V
2
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
K
K
-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
-----
D
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
54.84
35%
-86
- C4 -
3UPX
1
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
KK-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
------
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
54.59
37%
-104
- C4 -
2YCS
1
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
54.58
37%
-103
- C4 -
2XM9
1
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
54.44
37%
-92
- C4 -
3MA6
1
?
B:
[39-292]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
-
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
KK-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
54.43
36%
-97
- C4 -
2WEL
7
KCC2D_HUMAN
A:
[6-266]
--------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
S
K
---
S
K
---
G
A
A
V
K
--
L
A
D
F
G
L
-
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
--
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
Q
-
Q
I
--
K
A
G
--
A
YD
F
-
P
S
P
----
E
W
DT-
V
T
P
E
--
A
K
D
--
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
-----
T
-----
A
S
E
A
L
K
H
P
W
I
C
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
54.43
33%
-80
- C4 -
2UZW
1
KAPCA_BOVIN
E:
[34-332]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
-
A
-
K
R
-
V
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
----
S
H
---
F
S
S
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
-
T
K
R
-----
F
GNLKD
G
-----
V
N
D
I
K
N
H
K
W
F
A
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
54.42
37%
-104
- C4 -
2WTJ
5
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
54.38
35%
-90
- C4 -
2VN9
2
KCC2D_HUMAN
A:
[4-268]
------------------------
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
N
----
T
K
K
L
S
A
R
D
H
-
Q
K
-
L
E
R
E
A
R
I
C
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
A
S
K
---
S
K
G
A
A
V
---
K
--
L
A
D
F
G
L
-
A
I
E
V
-
Q
G
D
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
------
G
--
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
Q
-
Q
I
--
K
A
G
--
A
--
Y
-
D
F
P
SPEW
D
T
---
V
T
P
E
--
A
K
D
--
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
-----
T
-----
A
S
E
A
L
K
H
P
W
I
C
Q
R
--------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
54.38
37%
-106
- C4 -
4BDF
3
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
HHSearch
54.32
37%
-99
- C4 -
1O6L
1
AKT2_HUMAN
A:
[2-266]
---------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
R
----
K
E
V
I
I
A
K
D
E
V
A
H
-
T
V
T
E
S
R
V
L
Q
-
N
T
R
-
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
-----
D
K
D
---
G
H
---
I
---
K
--
I
T
D
F
G
L
-
C
-
K
E
G
I
S
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
------
G
--
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
R
-
L
F
E
-
L
I
--
L
M
E
--
E
--
I
-
R
F
P
----
R
T
---
L
S
P
E
--
A
K
S
--
L
L
A
G
L
L
K
K
D
P
-
K
Q
R
-----
L
GGGPS
D
-----
A
K
E
V
M
E
H
R
F
F
L
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
54.27
46%
-93
- C4 -
4BL1
1
MELK_HUMAN
A:
[9-291]
-----------------------
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
---
L
T
G
E
M
V
A
I
K
I
M
D
----
K
N
T
L
-----
L
P
R
-
I
K
T
E
I
E
A
L
K
-
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
-
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
-----
D
E
Y
---
H
K
---
L
---
K
--
L
I
D
F
G
L
-
C
-
A
K
-------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
--
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
-
L
Y
K
-
K
I
--
M
R
G
--
K
--
Y
-
D
V
P
----
K
W
---
L
S
P
S
--
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
-
K
K
R
-----
I
-----
S
-----
M
K
N
L
L
N
H
P
W
I
M
Q
D
-----------------
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
HL
D
D
D
C
V
T
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
54.24
35%
-89
- C4 -
3UPZ
1
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
K
K
-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
------
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
54.22
37%
-103
- C4 -
2WTI
3
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
54.11
33%
-78
- C4 -
2UZV
1
KAPCA_BOVIN
A:
[34-332]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
-
A
-
K
R
-
V
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
----
S
H
---
F
S
S
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
-
T
K
R
-----
F
GNLKD
G
-----
V
N
D
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
RKVEAP
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
54.10
37%
-103
- C4 -
2YCQ
1
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
54.08
37%
-106
- C4 -
4A9S
1
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
53.86
37%
-106
- C4 -
2YCR
1
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
53.85
35%
-87
- C4 -
3KU2
1
?
A:
[56-329]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
K
K
-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
53.75
37%
-104
- C4 -
4BDG
2
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
53.59
37%
-110
- C4 -
4BDD
3
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
53.57
33%
-84
- C4 -
2F7Z
1
KAPCA_BOVIN
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
-
A
-
K
R
-
V
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
----
S
H
---
F
S
S
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
-
T
K
R
FGNLK
N
-----
G
-----
V
N
D
I
K
N
H
K
W
F
A
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
53.55
37%
-102
- C4 -
4FG8
1
KCC1A_HUMAN
B:
[20-279]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
--------------
N
E
I
A
V
L
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
E
D
---
S
K
---
I
---
M
--
I
S
D
F
G
----------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
--------
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
----
Y
W
DD-
I
S
D
S
--
A
K
D
--
F
I
R
H
L
M
E
K
D
P
-
E
K
R
-----
F
-----
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
53.54
37%
-105
- C4 -
2WTC
1
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
W
A
E
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
53.49
33%
-78
- C4 -
2F7X
1
KAPCA_BOVIN
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
-
A
-
K
R
-
V
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
----
S
H
---
F
S
S
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
-
T
K
R
FGNLK
N
-----
G
-----
V
N
D
I
K
N
H
K
W
F
A
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
53.47
33%
-81
- C4 -
2OJF
1
KAPCA_BOVIN
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
-
A
-
K
R
-
V
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
----
S
H
---
F
S
S
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
-
T
K
R
FGNLK
N
-----
G
-----
V
N
D
I
K
N
H
K
W
F
A
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
53.46
37%
-105
- C4 -
2W0J
1
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
53.40
37%
-97
- C4 -
4A9T
4
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
W
A
E
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
53.36
37%
-102
- C4 -
2YIT
1
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
---------
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
53.30
37%
-109
- C4 -
4BDE
5
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
53.28
33%
-82
- C4 -
2UZU
1
KAPCA_BOVIN
E:
[34-332]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
-
A
-
K
R
-
V
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
----
S
H
---
F
S
S
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
-
T
K
R
-----
F
GNLKD
G
-----
V
N
D
I
K
N
H
K
W
F
A
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
53.26
37%
-101
- C4 -
4A9U
10
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
------
D
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
53.26
37%
-112
- C4 -
4BDH
4
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
53.23
37%
-105
- C4 -
2WTD
4
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
53.23
35%
-86
- C4 -
3V5P
1
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
K
K
-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
------
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
53.22
37%
-103
- C4 -
4BDK
4
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
53.19
37%
-104
- C4 -
4BDI
6
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
--------
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
53.16
37%
-91
- C4 -
2WEI
1
?
A:
[30-282]
--------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
----
K
A
S
A
K
N
K
D
T
-
S
T
-
I
L
R
E
V
E
L
L
K
-
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
E
S
K
EKD
C
D
---
I
---
K
--
I
I
D
F
G
L
-
S
-
T
C
-
F
Q
Q
N
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
-------
D
--
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
-
I
L
K
-
R
V
--
E
T
G
KY
A
--
F
-
D
L
P
----
Q
W
RT-
I
S
D
D
--
A
K
D
--
L
I
R
K
M
L
T
F
H
P
-
S
L
R
-----
I
-----
T
-----
A
T
Q
C
L
E
H
P
W
I
Q
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
53.02
35%
-85
- C4 -
3V5T
1
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
K
K
-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
-----
D
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
52.97
37%
-99
- C4 -
2YCF
1
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
52.97
33%
-81
- C4 -
2F7E
1
KAPCA_BOVIN
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
-
A
-
K
R
-
V
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
----
S
H
---
F
S
S
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
-
T
K
R
FGNLK
N
-----
G
-----
V
N
D
I
K
N
H
K
W
F
A
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
52.86
37%
-102
- C4 -
2CN5
1
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
R
---------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
52.85
37%
-105
- C4 -
4FG7
1
KCC1A_HUMAN
A:
[20-277]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
---------------
S
-
M
E
N
E
I
A
V
L
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
E
D
---
S
K
---
I
---
M
--
I
S
D
F
G
L
-
S
-
K
M
-
E
D
P
G
--------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
S
--------
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
----
Y
W
DD-
I
S
D
S
--
A
K
D
--
F
I
R
H
L
M
E
K
D
P
-
E
K
R
-----
F
-----
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
52.69
37%
-99
- C4 -
2Y7J
1
PHKG2_HUMAN
D:
[100-365]
------------------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
M
E
V---
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
D
N
---
M
Q
---
I
---
R
--
L
S
D
F
G
F
-
S
-
C
H
-
L
E
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
-
M
L
R
-
M
I
--
M
E
G
QY
Q
--
F
-
S
S
P
----
E
W
---
D
D
R
S
ST
V
K
D
--
L
I
S
R
L
L
Q
V
D
P
-
E
A
R
-----
L
-----
T
-----
A
E
Q
A
L
Q
H
P
F
F
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
52.48
37%
-105
- C4 -
2YIR
1
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
---------
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
52.45
37%
-101
- C4 -
2Y7J
1
PHKG2_HUMAN
C:
[100-365]
------------------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
M
E
VTAE
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
D
N
---
M
Q
---
I
---
R
--
L
S
D
F
G
F
-
S
-
C
H
-
L
E
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
-
M
L
R
-
M
I
--
M
E
G
QY
Q
--
F
-
S
S
P
----
E
W
---
D
D
R
S
ST
V
K
D
--
L
I
S
R
L
L
Q
V
D
P
-
E
A
R
-----
L
-----
T
-----
A
E
Q
A
L
Q
H
P
F
F
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
52.42
37%
-110
- C4 -
4BDC
2
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
52.28
33%
-80
- C4 -
2OH0
1
KAPCA_BOVIN
E:
[49-347]
-------------------------------
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
---
E
T
G
N
H
Y
A
M
K
I
L
D
----
K
Q
K
V
V
K
L
K
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
-
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
-----
D
Q
Q
---
G
Y
---
I
---
Q
--
V
T
D
F
G
F
-
A
-
K
R
-
V
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
------
N
--
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
-
I
Y
E
-
K
I
--
V
S
G
--
K
--
V
-
R
F
P
----
S
H
---
F
S
S
D
--
L
K
D
--
L
L
R
N
L
L
Q
V
D
L
-
T
K
R
FGNLK
N
-----
G
-----
V
N
D
I
K
N
H
K
W
F
A
T
T
DWIAIYQRKVEAPF
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
--
E
E
E
I
R
V
S
I
N
E
K
--
C
G
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
52.22
37%
-106
- C4 -
4A9R
2
CHK2_HUMAN
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
-------
P
A
L
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
51.90
36%
-94
- C4 -
2JC6
1
KCC1D_HUMAN
C:
[12-283]
-----
S
W
K
K
Q
A
E
D
I
K
K
I
F
E
F
K
---------
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
---
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
--------
S
-
I
E
N
E
I
A
V
L
R
-
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
-
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ--
D
E
E
---
S
K
---
I
---
M
--
I
S
-----------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
-
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
----
Y
W
DD-
I
S
D
S
--
A
K
D
--
F
I
R
N
L
M
E
K
D
P
-
N
K
R
-----
Y
-----
T
-----
C
E
Q
A
A
R
H
P
W
I
A
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
51.89
37%
-105
- C4 -
2YIQ
1
CHK2_HUMAN
A:
[11-281]
-------------------------
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
------------
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
51.75
37%
-104
- C4 -
4FG9
1
KCC1A_HUMAN
B:
[20-279]
--------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
----
K
---------------
E
I
A
V
L
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
-----
D
E
D
---
S
K
---
I
---
M
--
I
S
D
F
-------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
--------
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
-
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
----
Y
W
DD-
I
S
D
S
--
A
K
D
--
F
I
R
H
L
M
E
K
D
P
-
E
K
R
-----
F
-----
T
-----
C
E
Q
A
L
Q
H
P
W
I
A
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
51.33
37%
-102
- C4 -
2Y7J
1
PHKG2_HUMAN
A:
[100-365]
------------------------------
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
M
E
VTA
E
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
-
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
-----
D
D
N
---
M
Q
---
I
---
R
--
L
S
D
F
G
F
-
S
-
C
H
-
L
E
P
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
--
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
-
M
L
R
-
M
I
--
M
E
G
QY
Q
--
F
-
S
S
P
----
E
W
---
D
D
R
S
S
T
V
K
D
--
L
I
S
R
L
L
Q
V
D
P
-
E
A
R
-----
L
-----
T
-----
A
E
Q
A
L
Q
H
P
F
F
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
51.21
35%
-81
- C4 -
3SXF
3
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
K
K
-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
51.16
36%
-93
- C4 -
2JC6
1
KCC1D_HUMAN
A:
[12-283]
-----
S
W
K
K
Q
A
E
D
I
K
K
I
F
E
F
K
---------
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
---
A
T
G
K
L
F
A
V
K
C
I
P
----
K
K
A
-------
S
S
-
I
E
N
E
I
A
V
L
R
-
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
-
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ--
D
E
E
---
S
K
---
I
---
M
--
I
S
-----------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
S
K
-
L
F
E
-
Q
I
--
L
K
A
EY
E
--
F
-
D
S
P
----
Y
W
DD-
I
S
D
S
--
A
K
D
--
F
I
R
N
L
M
E
K
D
P
-
N
K
R
-----
Y
-----
T
-----
C
E
Q
A
A
R
H
P
W
I
A
G
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
51.00
35%
-85
- C4 -
3I7B
4
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
K
K
-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
50.84
39%
-100
- C4 -
2JAM
3
KCC1G_HUMAN
A:
[11-264]
--------------------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
I
K
----
K
S
---------
S
-
L
E
N
E
I
A
V
L
K
-
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y--
L
-----
T
P
E
---
E
N
---
S
---
K
I
M
I
T
D
F
G
L
-
S
-
K
M
-
E
Q
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
-
L
F
E
-
K
I
--
K
E
G
--
Y
YE
F
-
E
S
P
----
F
W
DD-
I
S
E
S
--
A
K
D
--
F
I
C
H
L
L
E
K
D
P
-
N
E
R
-----
Y
-----
T
-----
C
E
K
A
L
S
H
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
50.80
39%
-100
- C4 -
2JAM
3
KCC1G_HUMAN
B:
[11-264]
--------------------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
I
K
----
K
S
---------
S
-
L
E
N
E
I
A
V
L
K
-
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y--
L
-----
T
P
E
---
E
N
---
S
---
K
I
M
I
T
D
F
G
L
-
S
-
K
M
-
E
Q
N
G
-
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
S
-----
K
--
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
-
L
F
E
-
K
I
--
K
E
G
--
Y
YE
F
-
E
S
P
----
F
W
DD-
I
S
E
S
--
A
K
D
--
F
I
C
H
L
L
E
K
D
P
-
N
E
R
-----
Y
-----
T
-----
C
E
K
A
L
S
H
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
50.78
37%
-105
- C4 -
4BDA
8
?
A:
[17-287]
-------------------------
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
---
K
T
C
K
K
V
A
I
K
I
I
S
----
K
----------
N
-
V
E
T
E
I
E
I
L
K
-
K
L
N
-
H
P
C
I
I
K
I
K
N
F
F
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
-----
S
S
Q
---
E
E
D
C
L
I
---
K
--
I
T
D
F
G
H
-
S
-
K
I
-
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
-----
G
YN
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
-
S
L
K
D
Q
I
--
T
S
G
--
K
--
Y
N
F
I
P
----
E
V
WAE
V
S
E
K
--
A
L
D
--
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
-----
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
50.69
35%
-85
- C4 -
3N51
3
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
KK-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
50.54
35%
-86
- C4 -
3T3U
5
?
A:
[33-306]
-------------------------------
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
----
K
R
Q
V
K
Q
K
T
D
K
E
S
-
L
L
R
E
V
Q
L
L
K
-
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
-----
E
S
K
SKD
A
N
---
I
---
R
--
I
I
D
F
G
L
-
S
-
T
H
-
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
-------
D
--
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
-
I
L
K
-
K
V
--
E
K
G
KY
T
--
F
-
E
L
P
----
Q
W
K
K
-
V
S
E
S
--
A
K
D
--
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
-----
S
-----
A
R
D
A
L
D
H
E
W
I
Q
T
Y
--------------
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
--
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
50.14
39%
-103
- C4 -
2W4O
1
KCC4_HUMAN
A:
[61-308]
--------------------------------
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
---
G
T
Q
K
P
Y
A
L
K
V
L
K
----
K
----------------
I
G
V
L
L
-
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
ATPAP
D
A
P
---
L
--------
K
--
I
A
D
F
-------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
Y
------
G
--
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
-
R
I
L
N
C
E
Y
--
Y
--
F
-
I
S
P
----
W
W
---
D
E
V
S
--
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
-
K
K
R
-----
L
-----
T
-----
T
F
Q
A
L
Q
H
P
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
47.94
31%
-91
- C4 -
3UBD
1
KS6A3_MOUSE
A:
[20-287]
--------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
----
K
A
T
L
K
V
R
D
R
V
--------
D
I
L
V
-
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
-----
D
E
E
---
G
H
---
I
---
K
--
L
T
D
F
G
L
-
S
-
K
E
-----
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
G
H
------
T
--
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
R
K
E
-
T
M
T
-
M
I
--
L
K
A
--
K
--
L
-
G
M
P
----
Q
F
---
L
S
P
E
--
A
Q
S
--
L
L
R
M
L
F
K
R
N
P
-
A
N
R
-----
L
-----
G
AGPD
G
V
E
E
I
K
R
H
S
F
F
S
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
44.65
36%
-91
- C4 -
3TXO
1
A:
[23-276]
------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
K
---
E
T
G
D
L
Y
A
V
K
V
L
K
----
K
D
V
I
L
Q
D
D
D
V
E
C
-
T
M
T
E
K
R
I
L
S
-
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
---
L
-----
D
H
E
---
G
H
---
C
---
K
--
L
A
D
F
G
M
C
K
-
E
G
-
I
C
---------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
Y
------
G
--
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
D
D
-
L
F
E
-
A
I
--
L
N
D
--
E
--
V
-
V
Y
P
----
T
W
---
L
H
E
D
--
A
T
G
--
I
L
K
S
F
M
T
K
N
P
T
M
R
L
-----
G
-----
S
-----
L
T
Q
G
G
E
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------