@TOME V2.3
(Nov 2016)

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3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
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Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : AAPK1_HUMAN: (2013-07-18 )
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ

Atome Classification :

(81 SA) .........10........20........30........40......---..50........----60........70-........80...-......90........100.......110.......120.......130.......140-.......150.....---.-----.160--..---.---.--....170.-..-.....180.......190.......200-----.--......210.......220.......230-...-..--..240.--.-...----..---..250-...--.....260..-...-----.-----.-----270.......280--------------.......290.......--300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHE---LTGHKVAVKILN----RQKIRSLDVVGK-IRREIQNLK-LFR-HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH-RHMVVHRDLKPENVL---L-----DAH---MN---A---K--IADFGL-S-NM-MSDGEFLRTSCGSPNYAAPEVISGRLYA-----G--PEVDIWSSGVILYALLCGTLPFDDDHVPT-LFK-KI--CDG--I--F-YTP----QY---LNPS--VIS--LLKHMLQVDP-MKR-----A-----T-----IKDIREHEWFKQD--------------LPKYLFPEDPSYSSTMI--DDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
119 HHSearch 90.48100%-112 - C4 -2Y94 AAPK1_RAT A:[9-471] -----------------HDGRVKIGHYILGDTLGVGTFGKVKVGKHE---LTGHKVAVKILN----RQKIRSLDVVGK-IRREIQNLK-LFR-HPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCH-RHMVVHRDLKPENVL---L-----DAH---MN---A---K--IADFGL-S-NM-MSDGEFLRTSCGSPNYAAPEVISGRLYA-----G--PEVDIWSSGVILYALLCGTLPFDDDHVPT-LFK-KI--CDG--I--F-YTP----QY---LNPS--VIS--LLKHMLQVDP-MKR-----A-----T-----IKDIREHEWFKQD--------------LPKYLFPEDPSYSSTMI--DDEALKEVCEK-------------------------------RRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDE-------------------------------------------------------------------------------
4 PsiBlast_PDB 75.2190%-115 - C4 -3AQV AAPK2_HUMAN A:[4-276] -----------------HDGRVKIGHYVLGDTLGVGTFGKVKIGEHQ---LTGHKVAVKILN----RQKIRSLDVVGK-IKREIQNLK-LFR-HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCH-RHMVVHRDLKPENVL---L-----DAH---MN---A---K--IADFGL-S-NM-MSDGEFL------PNYAAPEVISGRLYA-----G--PEVDIWSCGVILYALLCGTLPFDDEHVPT-LFK-KI--RGG--V--F-YIP----EY---LNRS--VAT--LLMHMLQVDP-LKR-----A-----T-----IKDIREHEWFKQD--------------LPSYLFPE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105 PsiBlast_CBE 58.0037%-100 - C4 -3BHH KCC2B_HUMAN A:[6-266] --------------------------YQLYEDIG----SVVRRCVKL---CTGHEYAAKIIN----TKKLSARDH-QK-LEREARICR-LLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH-QMGVVHRDLKPENLL---L-----ASK---CK---GAAVK--LADFGL-AIEV-QGDQQAWFGFAGTPGYLSPEVLRKEAYG-----K--P-VDIWACGVILYILLVGYPPFWDEDQHK-LYQ-QI--KAG--AYDF-PSP----EWDT-VTPE--AKN--LINQMLTINP-AKR-----I-----T-----AHEALKHPWVCQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124 HHSearch 57.9538%-106 - C4 -4GV1 AKT1_HUMAN A:[4-270] --------------------RVTMNEFEYLKLLGKGTFGKVILVKEK---ATGRYYAMKILK----KEVIVAKDEVAH-TLTENRVLQ-NSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLM---L-----DKD---GH---I---K--ITDFGL-C-KEGIKDGATMKTFCGTPEYLAPEVLEDNDY------G--RAVDWWGLGVVMYEMMCGRLPFYNQDHEK-LFE-LI--LME--E--I-RFP----RT---LGPE--AKS--LLSGLLKKDP-KQR-----L-----GGGSEDAKEIMQHRFFAG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52 PsiBlast_CBE 57.2337% -96 - C4 -3IGO ? A:[30-282] --------------------------------LGKGSFGEVLKCKDR---ITQQEYAVKVIN----KASAKNK-T-ST-ILREVELLK-KLD-HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH-KHNIVHRDLKPENIL---L-----ESKEKDCD---I---K--IIDFGL-S-TC-FQQNT-------TAYYIAPEVLRGTY-------D--EKCDVWSAGVILYILLSGTPPFYGKNEYD-ILK-RV--ETGKYA--F-DLP----QWRT-ISDD--AKD--LIRKMLTFHP-SLR-----I-----T-----ATQCLEHPWIQK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51 PsiBlast_CBE 56.9537% -93 - C4 -3MWU ? A:[30-282] --------------------------------LGKGSFGEVLKCKDR---ITQQEYAVKVIN----KASAKNKDT-ST-ILREVELLK-KLD-HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH-KHNIVHRDLKPENIL---L-----ESKEKDCD---I---K--IIDFGL-S-TC-FQQN----DRIGTAYYIAPEVLRGTY-------D--EKCDVWSAGVILYILLSGTPPFYGKNEYD-ILK-RV--ETGKYA--F-DLP----QWRT-ISDD--AKD--LIRKMLTFHP-SLR-----I-----T-----ATQCLEHPWIQK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50 PsiBlast_CBE 56.7437% -99 - C4 -3NCG ? A:[30-282] --------------------------------LGKGSFGEVLKCKDR---ITQQEYAVKVIN----KASAKNKDT-ST-ILREVELLK-KLD-HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMH-KHNIVHRDLKPENIL---L-----ESKEKDCD---I---K--IIDFGL-S-TC-FQQNT-----IGTAYYIAPEVLRGTY-------D--EKCDVWSAGVILYILLSGTPPFYGKNEYD-ILK-RV--ETGKYA--F-DLP----QWRT-ISDD--AKD--LIRKMLTFHP-SLR-----I-----T-----ATQCLEHPWIQK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30 PsiBlast_CBE 56.0935%-100 - C4 -3HX4 ? A:[57-330] -------------------------------VLGKGSFGEVILCKDK---ITGQECAVKVIS----K-------DKES-LLREVQLLK-QLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---L-----ESKSKDAN---I---R--IIDFGL-S-TH-FEASKKMKDKIGTAYYIAPEVLHGTY-------D--EKCDVWSTGVILYILLSGCPPFNGANEYD-ILK-KV--EKGKYT--F-ELP----QWKK-VSES--AKD--LIRKMLTYVP-SMR-----I-----S-----ARDALDHEWIQTY--------------TKEQISVDVPSLDNAIL--N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46 PsiBlast_CBE 55.9737%-110 - C4 -4FG8 KCC1A_HUMAN A:[20-279] --------------------------YDFRDVLGTGAFSEVILAEDK---RTQKLVAIKCIA----KE-------------NEIAVLH-KIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH-DLGIVHRDLKPENLLYYSL-----DED---SK---I---M--ISDF--------------------TPGYVAPEVLAQKPYS--------KAVDCWSIGVIAYILLCGYPPFYDENDAK-LFE-QI--LKAEYE--F-DSP----YWDD-ISDS--AKD--FIRHLMEKDP-EKR-----F-----T-----CEQALQHPWIAGD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99 PsiBlast_CBE 55.3837%-106 - C4 -2CN8 CHK2_HUMAN A:[17-287] -------------------------EYIMSKTLGS----EVKLAFER---KTCKKVAIKIIS----K----------N-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-L--TSLMRTLC--PTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEH---V-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88 PsiBlast_CBE 55.3737%-109 - C4 -4BDB ? A:[17-287] -------------------------EYIMSKTL------EVKLAFER---KTCKKVAIKIIS----K---------LN-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-L-ETSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80 PsiBlast_CBE 55.2737%-112 - C4 -4BDJ ? A:[17-287] -------------------------EYIMSKTLG-----EVKLAFER---KTCKKVAIKIIS----K----------N-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-L-ETSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44 PsiBlast_CBE 55.1737%-108 - C4 -4FG9 KCC1A_HUMAN A:[20-279] --------------------------YDFRDVLGTGAFSEVILAEDK---RTQKLVAIKCIA----KE------------ENEIAVLH-KIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLH-DLGIVHRDLKPENLLYYSL-----DED---SK---I---M--ISDF---------------------PGYVAPEVLAQKPYS--------KAVDCWSIGVIAYILLCGYPPFYDENDAK-LFE-QI--LKAEYE--F-DSP----YWDD-ISDS--AKD--FIRHLMEKDP-EKR-----F-----T-----CEQALQHPWIAGD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49 PsiBlast_CBE 55.1237% -96 - C4 -3MA6 ? A:[39-292] -------------------------------VLGKGSFGEVILCKDK---ITGQECAVKVIS----KRQVKQKTDKES-LLREVQLLK-QLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---L-----ESKSKDAN---I---R--IIDFGL-S-TH-FE-SKKMKDKIGTAYYIAPEVLHGTY-------D--EKCDVWSTGVILYILLSGCPPFNGANEYD-ILK-KV--EKGKYT--F-ELP----QWKK-VSES--AKD--LIRKMLTYVP-SMR-----I-----S-----ARDALDHEWIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78 PsiBlast_CBE 55.0333% -84 - C4 -2UZT KAPCA_BOVIN A:[34-332] -------------------------------TLGTGSFGRVMLVKHM---ETGNHYAMKILD----KQKVVKLKQIEH-TLNEKRILQ-AVN-FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH-SLDLIYRDLKPENLL---I-----DQQ---GY---I---Q--VTDFGF-A-KR-VKGRTW--TLCGTPEYLAPEIILSKGY------N--KAVDWWALGVLIYEMAAGYPPFFADQPIQ-IYE-KI--VSG--K--V-RFP----SH---FSSD--LKD--LLRNLLQVDL-TKR-----FGNLKDG-----VNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE--EEEIRVSINEK--CGKE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39 PsiBlast_CBE 54.9935% -90 - C4 -3SX9 ? A:[33-306] -------------------------------VLGKGSFGEVILCKDK---ITGQECAVKVIS----KRQVKQKTDKES-LLREVQLLK-QLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---L-----ESKSKDAN---I---R--IIDFGL-S-TH-FEASKKMKDKIGTAYYIAPEVLHGTY-------D--EKCDVWSTGVILYILLSGCPPFNGANEYD-ILK-KV--EKGKYT--F-ELP----QWKK-VSES--AKD--LIRKMLTYVP-SMR-----I-----S-----ARDALDHEWIQTY--------------TK-----DVPSLDNAIL--N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103 PsiBlast_CBE 54.9736%-103 - C4 -3HZT ? A:[12-262] --------------------------------LGSGAYGEVLLCKDK---LTGAERAIKIIK----KSSVTTTSNSGA-LLDEVAVLK-QLD-HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH-KHNIVHRDLKPENLL---L-----ESK---SRDALI---K--IVDFGL-S-AH-FEVG--------TAYYIAPEVL--RKKY-----D--EKCDVWSCGVILYILLCGYPPFGGQTDQE-ILK-RV--EKG--K--FSFDPPDW-TQ---VSDE--AKQ--LVKLMLTYEP-SKR-----I-----S-----AEEALNHPW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36 PsiBlast_CBE 54.9435% -84 - C4 -3T3V ? A:[33-306] -------------------------------VLGKGSFGEVILCKDK---ITGQECAVKVIS----KRQVKQKTDKES-LLREVQLLK-QLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---L-----ESKSKDAN---I---R--IIDFGL-S-TH-FEASKKMKDKIGTAYYIAPEVLHGTY-------D--EKCDVWSTGVILYILLSGCPPFNGANEYD-ILK-KV--EKGKYT--F-ELP----QWKK-VSES--AKD--LIRKMLTYVP-SMR-----I-----S-----ARDALDHEWIQTY--------------TK-----DVPSLDNAIL--N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35 PsiBlast_CBE 54.8435% -86 - C4 -3UPX ? A:[33-306] -------------------------------VLGKGSFGEVILCKDK---ITGQECAVKVIS----KRQVKQKTDKES-LLREVQLLK-QLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---L-----ESKSKDAN---I---R--IIDFGL-S-TH-FEASKKMKDKIGTAYYIAPEVLHGTY-------D--EKCDVWSTGVILYILLSGCPPFNGANEYD-ILK-KV--EKGKYT--F-ELP----QWKK-VSES--AKD--LIRKMLTYVP-SMR-----I-----S-----ARDALDHEWIQTY--------------TK------VPSLDNAIL--N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70 PsiBlast_CBE 54.5937%-104 - C4 -2YCS CHK2_HUMAN A:[11-281] -------------------------EYIMSKTLGS---GEVKLAFER---KTCKKVAIKIIS----K----------N-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-L--TSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94 PsiBlast_CBE 54.5837%-103 - C4 -2XM9 CHK2_HUMAN A:[17-287] -------------------------EYIMSKTLGS---GEVKLAFER---KTCKKVAIKIIS----K-------PALN-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-LGETSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48 PsiBlast_CBE 54.4437% -92 - C4 -3MA6 ? B:[39-292] -------------------------------VLGKGSFGEVILCKDK---ITGQECAVKVIS----KRQVKQ-TDKES-LLREVQLLK-QLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---L-----ESKSKDAN---I---R--IIDFGL-S-TH-FEASKKMKDKIGTAYYIAPEVLHGTY-------D--EKCDVWSTGVILYILLSGCPPFNGANEYD-ILK-KV--EKGKYT--F-ELP----QWKK-VSES--AKD--LIRKMLTYVP-SMR-----I-----S-----ARDALDHEWIQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107 PsiBlast_CBE 54.4336% -97 - C4 -2WEL KCC2D_HUMAN A:[6-266] --------------------------YQLFEELGKGAFSVVRRCMKI---PTGQEYAAKIIN----TKKLSARDH-QK-LEREARICR-LLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH-LNGIVHRDLKPENLL---L-----ASK---SK---GAAVK--LADFGL-AIEV-QGDQQAWFGFAGTPGYLSPEVLRKDPYG-----K--P-VDMWACGVILYILLVGYPPFWDEDQHR-LYQ-QI--KAG--AYDF-PSP----EWDT-VTPE--AKD--LINKMLTINP-AKR-----I-----T-----ASEALKHPWICQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75 PsiBlast_CBE 54.4333% -80 - C4 -2UZW KAPCA_BOVIN E:[34-332] -------------------------------TLGTGSFGRVMLVKHM---ETGNHYAMKILD----KQKVVKLKQIEH-TLNEKRILQ-AVN-FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH-SLDLIYRDLKPENLL---I-----DQQ---GY---I---Q--VTDFGF-A-KR-VKGRTW--TLCGTPEYLAPEIILSKGY------N--KAVDWWALGVLIYEMAAGYPPFFADQPIQ-IYE-KI--VSG--K--V-RFP----SH---FSSD--LKD--LLRNLLQVDL-TKR-----FGNLKDG-----VNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE--EEEIRVSINEK--CGKE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95 PsiBlast_CBE 54.4237%-104 - C4 -2WTJ CHK2_HUMAN A:[17-287] -------------------------EYIMSKTLGS----EVKLAFER---KTCKKVAIKIIS----K-------PALN-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-L-ETSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109 PsiBlast_CBE 54.3835% -90 - C4 -2VN9 KCC2D_HUMAN A:[4-268] ------------------------DEYQLFEELGKGAFSVVRRCMKI---PTGQEYAAKIIN----TKKLSARDH-QK-LEREARICR-LLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCH-LNGIVHRDLKPENLL---L-----ASK---SKGAAV---K--LADFGL-AIEV-QGDQQAWFGFAGTPGYLSPEVLRKDPY------G--KPVDMWACGVILYILLVGYPPFWDEDQHR-LYQ-QI--KAG--A--Y-DFPSPEWDT---VTPE--AKD--LINKMLTINP-AKR-----I-----T-----ASEALKHPWICQR--------------S--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84 PsiBlast_CBE 54.3837%-106 - C4 -4BDF ? A:[17-287] -------------------------EYIMSKTLG----GEVKLAFER---KTCKKVAIKIIS----K----------N-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-LGETSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142 HHSearch 54.3237% -99 - C4 -1O6L AKT2_HUMAN A:[2-266] ---------------------VTMNDFDYLKLLGKGTFGKVILVREK---ATGRYYAMKILR----KEVIIAKDEVAH-TVTESRVLQ-NTR-HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLH-SRDVVYRDIKLENLM---L-----DKD---GH---I---K--ITDFGL-C-KEGISDGATMKTFCGTPEYLAPEVLEDNDY------G--RAVDWWGLGVVMYEMMCGRLPFYNQDHER-LFE-LI--LME--E--I-RFP----RT---LSPE--AKS--LLAGLLKKDP-KQR-----LGGGPSD-----AKEVMEHRFFLS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16 PsiBlast_PDB 54.2746% -93 - C4 -4BL1 MELK_HUMAN A:[9-291] -----------------------LKYYELHETIGTGGFAKVKLACHI---LTGEMVAIKIMD----KNTL-----LPR-IKTEIEALK-NLR-HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVH-SQGYAHRDLKPENLL---F-----DEY---HK---L---K--LIDFGL-C-AK-------------SLAYAAPELIQGK--------G--SEADVWSMGILLYVLMCGFLPFDDDNVMA-LYK-KI--MRG--K--Y-DVP----KW---LSPS--SIL--LLQQMLQVDP-KKR-----I-----S-----MKNLLNHPWIMQD-----------------YNYPVEWQSKNPFIHLDDDCVTEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34 PsiBlast_CBE 54.2435% -89 - C4 -3UPZ ? A:[33-306] -------------------------------VLGKGSFGEVILCKDK---ITGQECAVKVIS----KRQVKQKTDKES-LLREVQLLK-QLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---L-----ESKSKDAN---I---R--IIDFGL-S-TH-FEASKKMKDKIGTAYYIAPEVLHGTY-------D--EKCDVWSTGVILYILLSGCPPFNGANEYD-ILK-KV--EKGKYT--F-ELP----QWKK-VSES--AKD--LIRKMLTYVP-SMR-----I-----S-----ARDALDHEWIQTY--------------TK------VPSLDNAIL--N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96 PsiBlast_CBE 54.2237%-103 - C4 -2WTI CHK2_HUMAN A:[17-287] -------------------------EYIMSKTLGS----EVKLAFER---KTCKKVAIKIIS----K-------PALN-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-L-ETSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76 PsiBlast_CBE 54.1133% -78 - C4 -2UZV KAPCA_BOVIN A:[34-332] -------------------------------TLGTGSFGRVMLVKHM---ETGNHYAMKILD----KQKVVKLKQIEH-TLNEKRILQ-AVN-FPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH-SLDLIYRDLKPENLL---I-----DQQ---GY---I---Q--VTDFGF-A-KR-VKGRTW--TLCGTPEYLAPEIILSKGY------N--KAVDWWALGVLIYEMAAGYPPFFADQPIQ-IYE-KI--VSG--K--V-RFP----SH---FSSD--LKD--LLRNLLQVDL-TKR-----FGNLKDG-----VNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYE--EEEIRVSINEK--CGKE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71 PsiBlast_CBE 54.1037%-103 - C4 -2YCQ CHK2_HUMAN A:[11-281] -------------------------EYIMSKTLGSGACGEVKLAFER---KTCKKVAIKIIS----K----------N-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-LGETSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92 PsiBlast_CBE 54.0837%-106 - C4 -4A9S CHK2_HUMAN A:[17-287] -------------------------EYIMSKTL------EVKLAFER---KTCKKVAIKIIS----K-------PALN-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-L--TSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73 PsiBlast_CBE 53.8637%-106 - C4 -2YCR CHK2_HUMAN A:[11-281] -------------------------EYIMSKTLGS---GEVKLAFER---KTCKKVAIKIIS----K----------N-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-LGETSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29 PsiBlast_CBE 53.8535% -87 - C4 -3KU2 ? A:[56-329] -------------------------------VLGKGSFGEVILCKDK---ITGQECAVKVIS----KRQVKQKTDKES-LLREVQLLK-QLD-HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMH-KNKIVHRDLKPENLL---L-----ESKSKDAN---I---R--IIDFGL-S-TH-FEASKKMKDKIGTAYYIAPEVLHGTY-------D--EKCDVWSTGVILYILLSGCPPFNGANEYD-ILK-KV--EKGKYT--F-ELP----QWKK-VSES--AKD--LIRKMLTYVP-SMR-----I-----S-----ARDALDHEWIQTY--------------TKEQISVDVPSLDNAIL--N-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83 PsiBlast_CBE 53.7537%-104 - C4 -4BDG ? A:[17-287] -------------------------EYIMSKTLGS---GEVKLAFER---KTCKKVAIKIIS----K----------N-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-LGETSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86 PsiBlast_CBE 53.5937%-110 - C4 -4BDD ? A:[17-287] -------------------------EYIMSKTL------EVKLAFER---KTCKKVAIKIIS----K----------N-VETEIEILK-KLN-HPCIIKIKNFFDA-EDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVL---L-----SSQ---EEDCLI---K--ITDFGH-S-KI-L--TSLMRTLCGTPTYLAPEVLVSVGTA-----GYNRAVDCWSLGVILFICLSGYPPFSEHRTQV-SLKDQI--TSG--K--YNFIP----EVWAEVSEK--ALD--LVKKLLVVDP-KAR-----F-----T-----TEEALRHPWLQDE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------