@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AURKB_HUMAN: (2013-07-19 )
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Atome Classification :
(91 SA)
.........10........20........30........40........50........60........70........80........90......---..100.......110.......120......-.130-.......140.......150.......160.......170.......180.......190..-.....200.....---..210.......220..--.--....230.......240.......250.......260.......270.......280.......290..----.....300.......310....-----.-----.------.-320.......330.......340..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREK---KSHFIVALKVLFKSQIEKEGVEHQLRREIEI-QAHL-HHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGK-KVIHRDIKPENLL---LGLKGELKIADFGWSVH--A--PSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPA----SVPMGAQDLISKLLRHNPSERL-----P-----L------A-QVSAHPWVRANSRRVLPPSALQSVA
1
PsiBlast_PDB
87.90
99%
-123
- C1 -
4AF3
1
AURKB_HUMAN
A:
[18-286]
---------------------------------------------------------------------
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H
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------
5
PsiBlast_PDB
86.80
80%
-117
- C1 -
2VGO
1
AUKBA_XENLA
A:
[10-276]
----------------------------------------------------------------------
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-
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V
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A
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R
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-------
2
PsiBlast_PDB
84.85
77%
-119
- C1 -
4B8M
1
?
A:
[11-277]
----------------------------------------------------------------------
K
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---
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-----
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------
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-
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E
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A
N
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R
R
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L
P
P
-------
6
PsiBlast_PDB
84.77
80%
-117
- C1 -
3ZTX
1
AUKBA_XENLA
A:
[10-276]
----------------------------------------------------------------------
K
F
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A
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R
V
L
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-------
4
PsiBlast_PDB
84.58
80%
-118
- C1 -
2VGP
1
AUKBA_XENLA
A:
[11-276]
-----------------------------------------------------------------------
F
T
I
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R
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L
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7
PsiBlast_PDB
84.17
77%
-116
- C1 -
2VRX
1
AUKBA_XENLA
A:
[11-277]
----------------------------------------------------------------------
K
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28
PsiBlast_CBE
84.13
71%
-132
- C1 -
3EFW
1
AURKA_HUMAN
A:
[126-388]
---------------------------------------------------------------------
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Q
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------
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-
E
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E
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W
I
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A
N
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S
------------
89
PsiBlast_CBE
83.62
72%
-126
- C1 -
3H0Y
1
AURKA_HUMAN
A:
[3-265]
---------------------------------------------------------------------
R
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------
R
-
E
V
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E
H
P
W
I
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A
N
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S
------------
88
PsiBlast_CBE
83.62
72%
-123
- C1 -
3H0Z
1
AURKA_HUMAN
A:
[5-265]
-----------------------------------------------------------------------
W
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F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
-----------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------
9
PsiBlast_PDB
83.58
79%
-113
- C1 -
2BFY
1
AUKBA_XENLA
A:
[9-276]
---------------------------------------------------------------------
R
K
F
T
I
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
K
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
L
R
R
R
T
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
-----
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
P
P
-------
60
PsiBlast_CBE
83.36
72%
-133
- C1 -
2X81
1
AURKA_HUMAN
A:
[8-269]
----------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
---
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
---------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------
76
PsiBlast_CBE
83.23
71%
-125
- C1 -
4JBQ
1
?
A:
[4-269]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
-------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
------
53
PsiBlast_CBE
82.35
72%
-123
- C1 -
2W1E
1
AURKA_HUMAN
A:
[7-269]
----------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
---------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
12
PsiBlast_PDB
82.09
73%
-129
- C1 -
3DJ5
1
AURKA_MOUSE
A:
[9-269]
-----------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
N
G
E
L
K
I
A
D
F
G
W
-------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
-----
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
------------
46
PsiBlast_CBE
82.02
71%
-114
- C1 -
3UOD
3
AURKA_HUMAN
A:
[4-267]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
79
PsiBlast_CBE
81.90
71%
-121
- C1 -
3FDN
1
AURKA_HUMAN
A:
[4-272]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
N
C
Q
---
27
PsiBlast_CBE
81.63
71%
-125
- C1 -
3EFW
1
AURKA_HUMAN
B:
[126-389]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
---------------------
L
D
Y
L
P
P
E
M
I
E
-----
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
14
PsiBlast_PDB
81.53
73%
-120
- C1 -
3DJ7
1
AURKA_MOUSE
A:
[7-269]
---------------------------------------------------------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
N
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
-----
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
------------
82
PsiBlast_CBE
81.40
72%
-127
- C1 -
3P9J
1
AURKA_HUMAN
A:
[3-265]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
---------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
---
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------
94
PsiBlast_CBE
81.33
72%
-119
- C1 -
4DHF
1
AURKA_HUMAN
A:
[8-269]
-----------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
8
PsiBlast_PDB
81.26
77%
-120
- C1 -
4B8L
1
?
A:
[11-275]
----------------------------------------------------------------------
K
F
T
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
E
K
E
G
V
E
H
Q
L
R
R
E
I
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
-
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
G
Y
K
G
E
L
K
I
A
D
F
--------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
V
D
L
K
F
P
P
----
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
-----
L
------
K
-
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
---------
54
PsiBlast_CBE
81.04
72%
-123
- C1 -
2W1D
1
AURKA_HUMAN
A:
[7-269]
----------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
---------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
74
PsiBlast_CBE
80.91
70%
-125
- C1 -
3LAU
1
AURKA_HUMAN
A:
[1-268]
-------------------------------------------------------------------
M
K
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
---------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
------
11
PsiBlast_PDB
80.77
73%
-119
- C1 -
3D14
1
AURKA_MOUSE
A:
[7-269]
---------------------------------------------------------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
N
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
-----
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
------------
78
PsiBlast_CBE
80.73
71%
-122
- C1 -
3K5U
1
AURKA_HUMAN
A:
[4-272]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
-------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
S
N
C
Q
---
66
PsiBlast_CBE
80.43
72%
-123
- C1 -
3O50
1
AURKA_HUMAN
A:
[2-264]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------
65
PsiBlast_CBE
80.42
72%
-121
- C1 -
3O50
1
AURKA_HUMAN
B:
[2-265]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
---------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
10
PsiBlast_PDB
80.38
71%
-121
- C1 -
2WTW
1
AURKA_HUMAN
A:
[10-271]
-----------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
51
PsiBlast_CBE
80.31
71%
-114
- C1 -
3UNZ
3
AURKA_HUMAN
B:
[5-267]
----------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
62
PsiBlast_CBE
80.28
72%
-118
- C1 -
1MQ4
1
AURKA_HUMAN
A:
[7-269]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
--
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------
13
PsiBlast_PDB
80.20
73%
-124
- C1 -
3DJ6
1
AURKA_MOUSE
A:
[9-269]
-----------------------------------------------------------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
N
G
E
L
K
I
A
D
F
G
W
-------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
-----
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
------------
44
PsiBlast_CBE
80.11
71%
-116
- C1 -
3UOH
3
AURKA_HUMAN
B:
[4-267]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
93
PsiBlast_CBE
80.07
72%
-122
- C1 -
4DHF
1
AURKA_HUMAN
B:
[8-269]
-----------------------------------------------------------------------
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
16
PsiBlast_PDB
79.89
73%
-125
- C1 -
3D2I
1
AURKA_MOUSE
A:
[8-269]
----------------------------------------------------------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
N
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
-----
L
------
A
-
E
V
L
E
H
P
W
I
K
A
N
S
S
------------
83
PsiBlast_CBE
79.86
72%
-116
- C1 -
3H10
1
AURKA_HUMAN
D:
[3-265]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
--------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------
64
PsiBlast_CBE
79.77
72%
-130
- C1 -
3O51
1
AURKA_HUMAN
A:
[2-264]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
---------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------
86
PsiBlast_CBE
79.75
72%
-124
- C1 -
3H0Z
1
AURKA_HUMAN
C:
[3-265]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
---------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------
45
PsiBlast_CBE
79.68
71%
-115
- C1 -
3UOH
4
AURKA_HUMAN
A:
[4-267]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
75
PsiBlast_CBE
79.52
72%
-124
- C1 -
2XNE
1
AURKA_HUMAN
A:
[7-268]
----------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
-------
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
N
F
G
W
S
V
H
--
A
--
P
---------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------
38
PsiBlast_CBE
79.51
71%
-114
- C1 -
3UOL
8
AURKA_HUMAN
B:
[5-267]
----------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
85
PsiBlast_CBE
79.50
72%
-110
- C1 -
3H10
1
AURKA_HUMAN
A:
[3-266]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
A
A
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
49
PsiBlast_CBE
79.47
71%
-113
- C1 -
3UO5
1
AURKA_HUMAN
A:
[4-268]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
---
P
-------
55
PsiBlast_CBE
79.45
71%
-114
- C1 -
4JAJ
1
?
A:
[14-277]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
80
PsiBlast_CBE
79.43
71%
-119
- C1 -
2C6E
1
AURKA_HUMAN
B:
[9-270]
----------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
--------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------
39
PsiBlast_CBE
79.40
71%
-114
- C1 -
3UOL
6
AURKA_HUMAN
A:
[5-267]
----------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
95
PsiBlast_CBE
79.39
72%
-119
- C1 -
3R22
1
AURKA_HUMAN
A:
[6-269]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
-----------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
37
PsiBlast_CBE
79.38
71%
-116
- C1 -
3UP2
3
AURKA_HUMAN
A:
[4-267]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
48
PsiBlast_CBE
79.18
71%
-112
- C1 -
3UO6
3
AURKA_HUMAN
A:
[4-267]
---------------------------------------------------------------------
R
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
--
A
--
P
S
S
R
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
81
PsiBlast_CBE
79.17
71%
-121
- C1 -
2C6E
1
AURKA_HUMAN
A:
[9-271]
----------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------
96
PsiBlast_CBE
79.06
72%
-126
- C1 -
3R21
1
AURKA_HUMAN
A:
[7-269]
----------------------------------------------------------------------
Q
W
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
-
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
-------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
------
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------