@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CHK2_HUMAN: (2013-07-19 )
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
Atome Classification :
(74 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220..-.....230.......240.......250--........260.......270------.---.......280-..--......290-..-.-------.-.-.-.300.......310..--....----.320.......330.......-340.......350.......360-.......370-..-.-..-----..380-.......390....---...400.......410.......420.......--430----.........440.......450-------------------------..----------------------.......460.......470....-----...480......--------.490.......500.......510.......520.......530.......540.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSK-TLGSGACGEVKLAFERKTCKKVAIKII---SKRKFAIGSAREADPALNVE-------T---EIEILKKL-N-HP--CIIKIKNFF-DA-E-------D-Y-Y-IVLELMEGGELFDKVV--GNKR----LKEATCKLYFYQMLLAVQYLH-ENGIIHRDLKPENVLLSSQEEDC-LIKITDFGHS-KI-L-GE-----TSLMR-TLCGTPTYLAPEVL---VSVGTAGYNRAVDCWSLGVILFICLSGYPPFSE--H------RTQVSLKDQITSGKYNFIPE---------------------------VW----------------------AEVSEKALDLVKKLLVVDPKARFT-----TEEALRHPWLQD--------EDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
25
PsiBlast_CBE
75.97
100%
-133
- C1 -
4BDG
2
?
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
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I
T
D
F
G
H
S
-
K
I
-
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-
G
E
-----
T
S
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M
R
-
T
L
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P
T
Y
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A
P
E
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---
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A
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--
H
------
R
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V
S
L
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D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
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A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
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T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
23
PsiBlast_CBE
75.95
100%
-129
- C1 -
4BDI
7
?
A:
[8-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
-------------
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
-
G
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
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L
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G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
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A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Q
P
----------------------------
7
PsiBlast_PDB
75.24
100%
-132
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
-
G
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
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G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
6
PsiBlast_PDB
74.78
100%
-133
- C1 -
2YIT
1
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
--------------
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
-
G
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
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G
Y
P
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F
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--
H
------
R
T
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V
S
L
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D
Q
I
T
S
G
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Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
13
PsiBlast_PDB
74.63
100%
-129
- C1 -
2WTI
3
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
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E
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V
L
L
S
S
Q
E
E
D
C
-
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H
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-
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I
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--
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-----
T
S
L
M
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-
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G
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P
T
Y
L
A
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E
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---
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V
G
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A
G
Y
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A
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--
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Q
I
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G
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Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
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A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
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H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
31
PsiBlast_CBE
74.21
100%
-130
- C1 -
2YCF
1
CHK2_HUMAN
A:
[2-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
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I
I
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E
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V
L
L
S
S
Q
E
E
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C
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F
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H
S
-
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E
-----
T
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G
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T
Y
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A
P
E
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---
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V
G
T
A
G
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A
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Q
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Y
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F
I
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---------------------------
V
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----------------------
A
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A
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-----
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A
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L
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E
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A
L
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Q
---------------------------------
26
PsiBlast_CBE
74.16
100%
-133
- C1 -
4BDF
3
?
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
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D
L
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P
E
N
V
L
L
S
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Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
-
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E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
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I
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--
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R
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S
L
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D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
21
PsiBlast_CBE
74.06
100%
-130
- C1 -
4BDK
4
?
A:
[9-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
-------------
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
-
G
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------
22
PsiBlast_CBE
73.98
100%
-132
- C1 -
4BDJ
1
?
A:
[9-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------
29
PsiBlast_CBE
73.94
100%
-133
- C1 -
4BDC
2
?
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
4
PsiBlast_PDB
73.91
100%
-132
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
----------------
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
-
G
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
5
PsiBlast_PDB
73.76
100%
-132
- C1 -
2YIR
1
CHK2_HUMAN
A:
[2-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
--------------
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
-
G
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
----------------------------------
12
PsiBlast_PDB
73.68
100%
-132
- C1 -
2WTD
4
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--------
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
14
PsiBlast_PDB
73.47
100%
-132
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
20
PsiBlast_PDB
73.08
100%
-135
- C1 -
4BDA
8
?
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
9
PsiBlast_PDB
73.08
100%
-131
- C1 -
2CN5
1
CHK2_HUMAN
A:
[8-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
R
--------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
-
G
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
---------------------------------------
32
PsiBlast_CBE
72.63
99%
-132
- C1 -
2YCR
1
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
-
G
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
---------------------------------
28
PsiBlast_CBE
72.46
100%
-140
- C1 -
4BDD
4
?
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--------
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
15
PsiBlast_PDB
72.33
100%
-130
- C1 -
2XM9
1
CHK2_HUMAN
A:
[9-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
-
G
E
-----
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
3
PsiBlast_PDB
72.11
100%
-133
- C1 -
2W0J
1
CHK2_HUMAN
A:
[2-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--------
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
-
T
A
L
P
Q
---------------------------------
11
PsiBlast_PDB
71.96
100%
-129
- C1 -
2WTC
1
CHK2_HUMAN
A:
[9-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
------------
P
A
L
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--------
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
8
PsiBlast_PDB
70.59
100%
-130
- C1 -
2YCS
1
CHK2_HUMAN
A:
[2-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--------
T
S
L
M
R
-
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
------
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
10
PsiBlast_PDB
68.75
100%
-135
- C1 -
2CN8
1
CHK2_HUMAN
A:
[10-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
K
A
L
R
D
E
Y
I
M
S
K
-
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
---
S
K
---------------
N
V
E
-------
T
---
E
I
E
I
L
K
K
L
-
N
-
H
P
--
C
I
I
K
I
K
N
F
F
-
D
A
-
E
-------
D
-
Y
-
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
--
G
N
K
R
----
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
-
L
I
K
I
T
D
F
G
H
S
-
K
I
-
L
--------
T
S
L
M
R
-
T
L
C
--
P
T
Y
L
A
P
E
V
L
---
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
--
H
---------
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
---------------------------
V
W
----------------------
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
-----
T
E
E
A
L
R
H
P
W
L
Q
D
--------
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
----------------------------------------
41
PsiBlast_CBE
55.29
42%
-126
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[16-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
----------------
S
M
E
-------
N
---
E
I
A
V
L
H
K
I
-
K
-
H
P
--
N
I
V
A
L
D
D
I
Y
-
E
S
-
G
-------
G
-
H
L
Y
-
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
-
K
I
M
I
S
D
F
G
L
S
-
K
M
-
E
-
D
P
-----
G
---------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---------
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
---------------------------
Y
W
----------------------
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
-----------------------------------------------------------------
46
PsiBlast_CBE
54.27
42%
-126
- C1 -
3LIJ
1
?
A:
[35-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
E
M
Y
Q
R
V
K
-
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
-----
R
K
-----
S
S
N
S
----
K
L
L
-------
E
---
E
V
A
V
L
K
L
L
-
D
-
H
P
--
N
I
M
K
L
Y
D
F
F
E
D
K
-
R
-------
N
-
Y
-
Y
-
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
--
H
R
M
K
----
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
K
D
A
-
L
I
K
I
V
D
F
G
L
S
-
A
V
-
F
-
E
N
-----
Q
K
K
M
K
-
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-------
R
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
--
Q
------
T
D
Q
E
I
L
R
-
K
V
E
K
G
K
Y
T
F
D
S
P
---------------------------
E
W
----------------------
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
Q
Q
A
L
E
H
P
W
I
K
E
---------------------------------------------------------------
74
PsiBlast_CBE
53.07
38%
-121
- C1 -
3MFS
1
CSKP_HUMAN
A:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
-
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
---
D
V
A
K
F
T
------
S
S
P
G
L
S
T
E
-------
D
L
K
R
E
A
S
I
C
H
M
L
-
K
-
H
P
--
H
I
V
E
L
L
E
T
Y
-
S
S
-
D
-------
G
-
M
L
Y
-
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
--
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
N
S
A
-
P
V
K
L
G
D
F
G
V
A
-
I
Q
-
L
-
G
E
-----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
------
V
K
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
----
Y
------
G
T
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
---------------------------
Q
W
----------------------
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
--------
R
D
-----------------------------------------------------
73
PsiBlast_CBE
52.69
38%
-120
- C1 -
3MFU
1
CSKP_HUMAN
A:
[22-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
-
V
I
G
K
G
A
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
---
D
V
A
K
F
T
------
S
S
P
G
L
S
T
E
-------
D
L
K
R
E
A
S
I
C
H
M
L
-
K
-
H
P
--
H
I
V
E
L
L
E
T
Y
-
S
S
-
D
-------
G
-
M
L
Y
-
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
--
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
-
D
N
N
I
I
H
R
D
V
K
P
E
N
V
L
L
A
S
K
E
N
S
A
-
P
V
K
L
G
D
F
G
V
A
-
I
Q
-
L
-
G
E
-----
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
------
V
K
R
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
----
Y
------
G
T
K
E
R
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
---------------------------
Q
W
----------------------
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
-----
V
Y
E
A
L
N
H
P
W
L
K
E
--------
R
D
-----------------------------------------------------
70
PsiBlast_CBE
51.88
38%
-116
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[1-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
T
D
E
Y
Q
L
F
E
-
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
---
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
H
D
S
I
-
S
E
-
E
-------
G
-
F
H
Y
-
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
E
Y
----
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
-
G
D
-----
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
---------
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
---------------------------
E
W
----------------------
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
I
-----------------------------------------------------------------
39
PsiBlast_CBE
51.73
42%
-131
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[16-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
K
-------------------------
N
---
E
I
A
V
L
H
K
I
-
K
-
H
P
--
N
I
V
A
L
D
D
I
Y
-
E
S
-
G
-------
G
-
H
L
Y
-
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
-
K
I
M
I
S
D
F
G
---------------
G
S
V
L
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---------
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
---------------------------
Y
W
----------------------
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
-----------------------------------------------------------------
53
PsiBlast_CBE
51.35
41%
-126
- C1 -
3HX4
3
?
A:
[50-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Y
K
G
Q
R
-
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
---
S
K
-------
D
K
E
S
-----
L
L
-------
R
---
E
V
Q
L
L
K
Q
L
-
D
-
H
P
--
N
I
M
K
L
Y
E
F
F
-
E
D
-
K
-------
G
-
Y
F
Y
-
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
--
S
R
K
R
----
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
K
D
A
-
N
I
R
I
I
D
F
G
L
S
-
T
H
-
F
-
E
A
-----
S
K
K
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
-----
H
G
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
--
A
------
N
E
Y
D
I
L
K
-
K
V
E
K
G
K
Y
T
F
E
L
P
---------------------------
Q
W
----------------------
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
Q
----------------------------------------------------------------
45
PsiBlast_CBE
51.30
42%
-130
- C1 -
2JC6
1
KCC1D_HUMAN
A:
[28-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
---
P
K
K
A
--------
S
----
S
I
E
-------
N
---
E
I
A
V
L
R
K
I
-
K
-
H
E
--
N
I
V
A
L
E
D
I
Y
-
E
S
-
P
-------
N
-
H
L
Y
-
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
G
F
----
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
-
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
Q
D
E
E
S
-
K
I
M
I
S
-----------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
--
E
------
N
D
S
-
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
---------------------------
Y
W
----------------------
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
-----
C
E
Q
A
A
R
H
P
W
I
-----------------------------------------------------------------
83
PsiBlast_CBE
51.28
36%
-114
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[31-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
Y
Q
L
F
E
-
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
---
N
T
K
K
L
---
S
A
R
D
H
Q
---
K
L
E
-------
R
---
E
A
R
I
C
R
L
L
-
K
-
H
P
--
N
I
V
R
L
H
D
S
I
-
S
E
-
E
-------
G
-
F
H
Y
-
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
E
Y
----
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
-
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
I
E
V
-
Q
-
G
E
-----
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
---
R
K
---
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
---------
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
---------------------------
E
W
----------------------
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
D
Q
A
L
K
H
P
W
V
-----------------------------------------------------------------
69
PsiBlast_CBE
50.79
39%
-123
- C1 -
3Q5I
1
?
A:
[38-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
K
V
R
-
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
---
K
K
------------------KF
H
E
E
I
Y
N
---
E
I
S
L
L
K
S
L
-
D
-
H
P
--
N
I
I
K
L
F
D
V
F
E
D
K
-
K
-------
Y
-
F
-
Y
-
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
--
N
R
H
K
----
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
-
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
N
S
L
L
-
N
I
K
I
V
D
F
G
L
S
-
S
F
-
F
-
S
K
-----
D
Y
K
L
R
-
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
-------
K
K
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
--
Q
------
N
D
Q
D
I
I
K
-
K
V
E
K
G
K
Y
Y
F
D
F
N
---------------------------
D
W
----------------------
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
E
E
A
L
N
S
R
W
I
K
----------------------------------------------------------------
40
PsiBlast_CBE
50.26
42%
-133
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[16-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
-
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---
A
K
E
------------------------
N
---
E
I
A
V
L
H
K
I
-
K
-
H
P
--
N
I
V
A
L
D
D
I
Y
-
E
S
-
G
-------
G
-
H
L
Y
-
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
G
F
----
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
-
K
I
M
I
S
D
F
--------------------------
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
---------
E
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
---------------------------
Y
W
----------------------
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
-----------------------------------------------------------------
42
PsiBlast_CBE
50.14
44%
-118
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[7-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
K
T
F
I
F
M
E
-
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
---
K
K
-----------
S
---
S
L
E
-------
N
---
E
I
A
V
L
K
K
I
-
K
-
H
E
--
N
I
V
T
L
E
D
I
Y
-
E
S
-
T
T------
H
-
Y
-
Y
-
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
--
E
R
G
V
----
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
-
K
I
M
I
T
D
F
G
L
S
-
K
--
M
-
E
Q
-----
N
G
I
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
---------
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
---------------------------
F
W
----------------------
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
-----------------------------------------------------------------
43
PsiBlast_CBE
50.12
44%
-120
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[7-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
K
T
F
I
F
M
E
-
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
---
K
K
-----------
S
---
S
L
E
-------
N
---
E
I
A
V
L
K
K
I
-
K
-
H
E
--
N
I
V
T
L
E
D
I
Y
-
E
S
-
T
T------
H
-
Y
-
Y
-
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
--
E
R
G
V
----
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
-
K
I
M
I
T
D
F
G
L
S
-
K
--
M
-
E
Q
-----
N
G
I
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
---------
E
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
---------------------------
F
W
----------------------
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
-----------------------------------------------------------------