@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CLK2_HUMAN: (2013-07-19 )
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
Atome Classification :
(12 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220-...--.....230.....----..240.......250.......260.......270.......280..-.....290......-.300...------...------.310.......320------------------.......330.......340.......350.......360.......370.......380...------...------.390.......400.......410-.....--..--..420.......430.........440.....-----...450.......460.......470.......480.......490.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPD--NKN--LCVQMFDWFDYHG----HMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDN-KLTHTDLKPENILF-VNSDYEL------TYN------LEKKRDERSVKSTA------------------VRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHD------NRE------HLAMMERILGPIPSRMIRKTRK---QKYFY--RG--RLDWDENTSAGRY--VRENCKPLRRY-LTSEA-----EEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
22
PsiBlast_CBE
92.94
99%
-119
- C1 -
3NR9
1
CLK2_HUMAN
B:
[8-354]
---------------------------------------------------------------------------------------------------------------------------------------
S
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
--
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
------
T
Y
N
------
L
E
K
K
R
D
E
R
S
V
K
S
T
A
------------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
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I
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Y
R
A
P
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E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
------
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
---
Q
K
Y
F
Y
--
R
G
--
R
L
D
W
D
E
N
T
S
A
G
R
Y
--
V
R
E
N
C
K
P
L
R
R
Y
-
L
T
S
E
A
-----
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
-----------------
1
PsiBlast_PDB
92.65
99%
-123
- C1 -
3NR9
1
CLK2_HUMAN
A:
[9-356]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
--
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
------
T
-------------
D
E
R
S
V
K
S
T
A
------------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
------
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
---
Q
K
Y
F
Y
--
R
G
--
R
L
D
W
D
E
N
T
S
A
G
R
Y
--
V
R
E
N
C
K
P
L
R
R
Y
-
L
T
S
E
A
-----
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
A
---------------
21
PsiBlast_CBE
92.44
99%
-119
- C1 -
3NR9
1
CLK2_HUMAN
C:
[9-355]
----------------------------------------------------------------------------------------------------------------------------------------
S
R
R
A
K
S
V
E
D
D
A
E
G
H
L
I
Y
H
V
G
D
W
L
Q
E
R
Y
E
I
V
S
T
L
G
E
G
T
F
G
R
V
V
Q
C
V
D
H
R
R
G
G
A
R
V
A
L
K
I
I
K
N
V
E
K
Y
K
E
A
A
R
L
E
I
N
V
L
E
K
I
N
E
K
D
P
D
--
N
K
N
--
L
C
V
Q
M
F
D
W
F
D
Y
H
G
----
H
M
C
I
S
F
E
L
L
G
L
S
T
F
D
F
L
K
D
N
N
Y
L
P
Y
P
I
H
Q
V
R
H
M
A
F
Q
L
C
Q
A
V
K
F
L
H
D
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
D
Y
E
L
------
T
Y
N
------
L
E
K
K
R
D
E
R
S
V
K
S
T
A
------------------
V
R
V
V
D
F
G
S
A
T
F
D
H
E
H
H
S
T
I
V
S
T
R
H
Y
R
A
P
E
V
I
L
E
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
I
F
E
Y
Y
V
G
F
T
L
F
Q
T
H
D
------
N
R
E
------
H
L
A
M
M
E
R
I
L
G
P
I
P
S
R
M
I
R
K
T
R
K
---
Q
K
Y
F
Y
--
R
G
--
R
L
D
W
D
E
N
T
S
A
G
R
Y
--
V
R
E
N
C
K
P
L
R
R
Y
-
L
T
S
E
A
-----
E
E
H
H
Q
L
F
D
L
I
E
S
M
L
E
Y
E
P
A
K
R
L
T
L
G
E
A
L
Q
H
P
F
F
A
R
L
R
----------------
2
PsiBlast_PDB
86.33
71%
-118
- C1 -
2WU6
7
CLK3_HUMAN
A:
[31-375]
--------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
--
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
------
L
Y
N
------
E
H
K
S
C
E
E
K
S
V
K
N
T
S
------------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
---
Q
K
Y
F
Y
--
K
G
--
G
L
V
W
D
E
N
S
S
D
G
R
Y
--
V
K
E
N
C
K
P
L
K
S
Y
-
M
L
Q
D
S
-----
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
3
PsiBlast_PDB
84.41
71%
-117
- C1 -
2WU7
1
CLK3_HUMAN
A:
[32-375]
---------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
--
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
------
L
Y
N
------
E
H
K
S
C
E
E
K
S
V
K
N
T
S
------------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
---
Q
K
Y
F
Y
--
K
G
--
G
L
V
W
D
E
N
S
S
D
G
R
Y
--
V
K
E
N
C
K
P
L
K
S
Y
-
M
L
Q
D
S
-----
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
4
PsiBlast_PDB
84.10
71%
-118
- C1 -
3RAW
1
CLK3_HUMAN
A:
[31-375]
--------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
--
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
------
L
Y
N
------
E
H
K
S
C
E
E
K
S
V
K
N
T
S
------------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
---
Q
K
Y
F
Y
--
K
G
--
G
L
V
W
D
E
N
S
S
D
G
R
Y
--
V
K
E
N
C
K
P
L
K
S
Y
-
M
L
Q
D
S
-----
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
23
PsiBlast_CBE
83.14
71%
-114
- C1 -
3RAW
1
CLK3_HUMAN
B:
[33-375]
----------------------------------------------------------------------------------------------------------------------------------------------
V
E
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
K
E
K
D
K
E
--
N
K
F
--
L
C
V
L
M
S
D
W
F
N
F
H
G
----
H
M
C
I
A
F
E
L
L
G
K
N
T
F
E
F
L
K
E
N
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
H
E
N
-
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
-
V
N
S
E
F
E
T
------
L
Y
N
------
E
H
K
S
C
E
E
K
S
V
K
N
T
S
------------------
I
R
V
A
D
F
G
S
A
T
F
D
H
E
H
H
T
T
I
V
A
T
R
H
Y
R
P
P
E
V
I
L
E
L
G
W
A
Q
P
C
D
V
W
S
I
G
C
I
L
F
E
Y
Y
R
G
F
T
L
F
Q
T
H
E
------
N
R
E
------
H
L
V
M
M
E
K
I
L
G
P
I
P
S
H
M
I
H
R
T
R
K
---
Q
K
Y
F
Y
--
K
G
--
G
L
V
W
D
E
N
S
S
D
G
R
Y
--
V
K
E
N
C
K
P
L
K
S
Y
-
M
L
Q
D
S
-----
L
E
H
V
Q
L
F
D
L
M
R
R
M
L
E
F
D
P
A
Q
R
I
T
L
A
E
A
L
L
H
P
F
F
A
G
L
T
P
E
--------------
35
HHSearch
82.10
66%
-118
- C1 -
1Z57
1
CLK1_HUMAN
A:
[1-337]
---------------------------------------------------------------------------------------------------------------------------------------------------
S
M
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
--
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
------
A
Y
N
----------
R
D
E
R
T
L
I
N
P
D
------------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
---
R
K
Y
F
H
--
H
D
--
R
L
D
W
D
E
H
S
S
A
G
R
Y
--
V
S
R
A
C
K
P
L
K
E
F
-
M
L
S
Q
D
-----
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
K
---------------
8
PsiBlast_PDB
82.05
65%
-122
- C1 -
2VAG
1
CLK1_HUMAN
A:
[3-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
--
S
T
F
--
R
C
V
Q
M
L
E
W
F
E
H
H
G
----
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
H
S
N
-
K
L
T
H
T
D
L
K
P
E
N
I
L
F
-
V
Q
S
D
Y
T
E
------
A
Y
N
---------
K
R
D
E
R
T
L
I
N
P
D
------------------
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
------
S
K
E
------
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
---
R
K
Y
F
H
--
H
D
--
R
L
D
W
D
E
H
S
S
A
G
R
Y
--
V
S
R
A
C
K
P
L
K
E
F
-
M
L
S
Q
D
-----
V
E
H
E
R
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
K
----------------
41
HHSearch
69.69
38%
-113
- C1 -
3LLT
1
?
A:
[20-360]
-------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
L
V
I
R
K
M
G
D
G
T
F
G
R
V
L
L
C
Q
H
I
D
N
-
K
K
Y
Y
A
V
K
V
V
R
N
I
K
K
Y
T
R
S
A
K
I
E
A
D
I
L
K
K
I
Q
N
D
D
I
N
--
N
N
---
N
I
V
K
Y
H
G
K
F
M
Y
Y
D
----
H
M
C
L
I
F
E
P
L
G
P
S
L
Y
E
I
I
T
R
N
N
Y
N
G
F
H
I
E
D
I
K
L
Y
C
I
E
I
L
K
A
L
N
Y
L
R
K
M
-
S
L
T
H
T
D
L
K
P
E
N
I
L
L
-
D
D
P
Y
F
E
K
------
S
L
I
T
V
R
R
VT
D
G
K
K
I
Q
I
Y
R
T
K
S
T
G
------------------
I
K
L
I
D
F
G
C
A
T
F
K
S
D
Y
H
G
S
I
I
N
T
R
Q
Y
R
A
P
E
V
I
L
N
L
G
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
G
S
L
L
F
R
T
H
E
------
H
M
E
------
H
L
A
M
M
E
S
I
I
Q
P
I
P
K
N
M
L
Y
E
A
T
K
T
NG
S
K
Y
V
N
--
K
D
EL
K
L
A
W
P
E
N
A
S
S
I
N
S
I
K
H
V
K
K
C
L
P
L
Y
K
I
-
I
----------
K
H
E
L
F
C
D
F
L
Y
S
I
L
Q
I
D
P
T
L
R
P
S
P
A
E
L
L
K
H
K
F
L
E
-------------------
11
PsiBlast_PDB
62.35
30%
-113
- C1 -
3BEG
2
SRPK1_HUMAN
A:
[12-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
K
I
G
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
S
W
D
-
I
Q
G
K
K
F
V
A
M
K
V
V
K
S
A
E
H
Y
T
E
T
A
L
D
E
I
R
L
L
K
S
V
R
N
S
D
P
N
--
D
P
N
RE
M
V
V
Q
L
L
D
D
F
K
I
S
G
VNGT
H
I
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
Q
G
L
P
L
P
C
V
K
K
I
I
Q
Q
V
L
Q
G
L
D
Y
L
H
T
K
C
R
I
I
H
T
D
I
K
P
E
N
I
L
L
S
V
N
E
Q
Y
I
R
------
R
L
A
------
A
E
A
-----------AGNFLVNPLEPKNAEK
L
K
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
L
E
V
L
I
G
S
G
Y
N
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
------
G
E
E
YT
R
D
E
D
H
I
A
L
I
I
E
L
L
G
K
V
P
R
K
L
I
V
A
G
K
Y
---
S
K
E
F
F
--
T
K
--
K
G
D
L
K
H
I
T
K
L
K
P
W
--
G
L
F
E
V
L
-
V
E
K
Y
-
E
W
S
Q
------
E
E
A
A
G
F
T
D
F
L
L
P
M
L
E
L
I
P
E
K
R
A
T
A
A
E
C
L
R
H
P
W
L
--------------------
10
PsiBlast_PDB
61.23
30%
-106
- C1 -
2X7G
7
SRPK2_HUMAN
A:
[25-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
D
L
F
N
G
R
Y
H
V
I
R
K
L
G
W
G
H
F
S
T
V
W
L
C
W
D
-
M
Q
G
K
R
F
V
A
M
K
V
V
K
S
A
Q
H
Y
T
E
T
A
L
D
E
I
K
L
L
K
C
V
R
E
S
D
P
S
DP
N
K
D
--
M
V
V
Q
L
I
D
D
F
K
I
S
G
MN
G
I
H
V
C
M
V
F
E
V
L
G
H
H
L
L
K
W
I
I
K
S
N
Y
Q
G
L
P
V
R
C
V
K
S
I
I
R
Q
V
L
Q
G
L
D
Y
L
H
S
K
C
K
I
I
H
T
D
I
K
P
E
N
I
L
M
-
C
V
D
D
A
Y
V
R
R
M
A
A
E--
L
------
L
V
N
P
L
D
P
R
N
A
D
K
I
R
------------------
V
K
I
A
D
L
G
N
A
C
W
V
H
K
H
F
T
E
D
I
Q
T
R
Q
Y
R
S
I
E
V
L
I
G
A
G
Y
S
T
P
A
D
I
W
S
T
A
C
M
A
F
E
L
A
T
G
D
Y
L
F
E
P
H
S
G
EDYS
R
D
E
D
------
H
I
A
H
I
I
E
L
L
G
S
I
P
R
H
F
A
L
S
G
K
Y
---
S
R
E
F
F
NR
R
G
--
E
L
---------
R
H
--
I
T
K
-
L
K
P
W
S
L
F
D
V
L
V
E
K
YGWP
H
E
D
A
A
Q
F
T
D
F
L
I
P
M
L
E
M
V
P
E
K
R
A
S
A
G
E
C
L
R
H
P
W
L
--------------------