@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DAPK3_HUMAN: (2013-07-19 )
MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTTRLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIYEEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRYEALAKQVASEMRFVQDLVRALEQEKLQGVECGLR
Atome Classification :
(61 SA)
.........10.....--...20........30..---......40........50........60........70..-......80........90........100.-.....--.110.......120.......130.-......140.......150.......160.......-170-.-.....---.180.......--190.........200.......210.......220........230.......240.......250.......260...-----....270...------.--------.-------..280--.......290.----......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSTFRQEDVEDHYEMG--EELGSGQFAIVRKCRQK---GTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRH-PNIITLHDIFENKTDVVLILELVSGGELFD-FLAEK--ESLTEDEATQFLKQILDGVHYLHSK-RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIE-AGN-E-FKNIF---GTPEFVAPEIV--N--YEPLGLEADMWSIGVITYILLSGASPFLGE-TKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI------K--------A-------IRRRN--VRGEDSGRKPE----RRRLKTTRLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIYEEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRYEALAKQVASEMRFVQDLVRALEQEKLQGVECGLR
5
PsiBlast_PDB
87.55
82%
-102
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
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K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
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I
T
Y
I
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-
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Q
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K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.91
82%
-98
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
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K
R
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R
R
G
V
S
R
E
D
I
E
R
E
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S
I
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I
Q
H
-
P
N
V
I
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L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
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A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
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Q
I
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N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
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E
N
I
M
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L
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V
P
K
P
R
I
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I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
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A
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P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
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L
V
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D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
86.73
82%
-102
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[3-276]
--
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
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K
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S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
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I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
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N
V
P
K
P
R
I
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I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.03
82%
-103
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[4-276]
---
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
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D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.07
82%
-96
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[1-275]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
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E
N
I
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L
D
R
N
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P
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P
R
I
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I
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D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
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G
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E
A
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M
W
S
I
G
V
I
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Y
I
L
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A
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P
F
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D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
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R
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D
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R
M
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-----
I
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D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
84.90
82%
-99
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[1-275]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
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G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
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K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.83
81%
-96
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
A
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
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K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
84.47
82%
-100
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[1-275]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
-
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
84.44
74%
-90
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[4-302]
--
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
TPVD
T
Q
Q
--------
A
-------
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
84.26
74%
-89
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[3-302]
-
E
T
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
TPVD
T
Q
Q
--------
A
-------
M
V
R
R
E
SV
V
N
L
E
N
F
K
K
Q
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
84.16
81%
-98
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
84.16
81%
-99
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
84.04
81%
-100
- C1 -
3GUB
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
83.96
82%
-98
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[1-275]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.88
82%
-97
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.64
82%
-94
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
83.54
81%
-98
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
83.38
81%
-96
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
83.37
81%
-100
- C1 -
3GU8
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
83.36
82%
-97
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[1-275]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
83.06
81%
-97
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[2-276]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
82.02
73%
-90
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[3-302]
-
E
P
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
------
T
--------
P
VD
N
Q
Q
A
M
V
R
R
E
S
--
V
V
N
L
E
N
F
R
K
Q
Y
----
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
81.75
82%
-97
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[1-275]
-
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
---------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
--
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-
F
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
80.75
73%
-87
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[3-302]
-
E
P
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
------
T
--------
P
VDNQQAM
V
R
R
E
S
--
V
V
N
L
E
N
F
R
K
Q
Y
----
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
80.59
73%
-88
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[2-302]
M
E
P
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
------
T
--------
P
VD
N
Q
Q
A
M
V
R
R
E
S
--
V
V
N
L
E
N
F
R
K
Q
Y
----
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
80.54
73%
-88
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[3-302]
-
E
P
F
K
Q
Q
K
V
E
D
F
Y
D
I
G
--
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
S
R
R
G
V
S
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
-
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
--
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
-
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
Q
E
A
L
R
H
P
W
I
------
T
--------
P
VDNQQAM
V
R
R
E
S
--
V
V
N
L
E
N
F
R
K
Q
Y
----
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
78.93
82%
-116
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
------
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
-----------
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
----------------
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
78.36
82%
-102
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[7-276]
------
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
-
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
----
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
----------------
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.10
82%
-108
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
------
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
--------
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
------------------
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
77.06
82%
-107
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[5-276]
----
R
Q
E
N
V
D
D
Y
Y
D
T
G
--
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
R
R
G
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
--
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
-
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-----------------
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
-
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
Q
D
S
L
Q
H
P
W
I
------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
68.59
36%
-104
* C1 *
3Q5I
1
?
A:
[30-309]
----
K
E
G
K
I
G
E
S
Y
F
K
V
--
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
---
N
G
H
S
E
K
A
I
K
V
I
K
K
---------
K
F
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
D
H
-
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
-
Q
I
I
N
R
--
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
-
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
K
-
N
S
L
L
N
I
K
I
V
D
F
G
L
S
S
F
F
S
-
K
D
Y
-
K
-
L
R
D
R
L
---
G
T
A
Y
Y
I
A
P
E
V
L
--
K
---
K
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
-
N
D
Q
D
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
E
E
A
L
N
S
R
W
I
------
K
--------
K
-------
Y
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
68.08
41%
-108
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[12-276]
----
Q
A
E
D
I
R
D
I
Y
D
F
R
--
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
---------------
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
-----------------------
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
67.95
41%
-108
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-276]
------
E
D
I
R
D
I
Y
D
F
R
--
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----------------
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
------------
V
-
L
S
T
A
C
---
G
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
67.61
41%
-106
- C1 -
2X4F
3
MYLK4_HUMAN
B:
[79-355]
--
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
KT
E
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
---
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
K
D
------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
--
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
-
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
A
K
--
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
-
P
R
E
-
K
-
L
K
V
N
F
---
G
T
P
E
F
L
A
P
E
V
V
--
N
--
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
-
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
-----
A
S
E
A
L
K
H
P
W
L
------
S
D
H
K
L
H
S
R
L-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
66.86
36%
-103
- C1 -
3HX4
3
?
A:
[50-317]
----------
D
R
Y
K
G
Q
--
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
----------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
--
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
A
S
K
-
K
-
M
K
D
K
I
---
G
T
A
Y
Y
I
A
P
E
V
L
--
H
GT
Y
D
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
------
Q
--------
T
-------
Y
T
K
E
Q
--
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
66.59
41%
-105
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-276]
------
E
D
I
R
D
I
Y
D
F
R
--
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
----------------
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
--------
G
S
-
V
-
L
S
T
A
C
---
G
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
66.51
41%
-100
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[79-358]
--
T
A
K
Q
G
A
V
N
S
F
Y
T
V
S
KT
E
I
L
G
-----
Q
V
H
K
C
E
E
T
---
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
K
D
------
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
D
H
-
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
--
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
-
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
A
K
--
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
-
P
R
E
-
K
-
L
K
V
N
F
---
G
T
P
E
F
L
A
P
E
V
V
--
N
--
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
-
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
-----
A
S
E
A
L
K
H
P
W
L
------
S
D
H
K
L
H
S
R
L
S
-------
A
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
66.37
35%
-100
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[2-264]
--------
M
T
D
E
Y
Q
L
Y
--
E
D
I
G
----
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
-
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
H
E
A
L
K
H
P
W
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
65.87
38%
-94
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[2-264]
--------
M
T
D
E
Y
Q
L
F
--
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
65.83
38%
-94
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[2-264]
--------
M
T
D
E
Y
Q
L
F
--
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
65.80
38%
-97
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[31-291]
----------
D
D
Y
Q
L
F
--
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
---
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
-
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
A
A
V
K
L
A
D
F
G
L
A
--
I
E
-
V
Q
G
-
E
-
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
D
Q
A
L
K
H
P
W
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
65.42
41%
-108
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[12-276]
----
Q
A
E
D
I
R
D
I
Y
D
F
R
--
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
--------------
E
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
------------------------
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
65.40
35%
-101
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[2-264]
--------
M
T
D
E
Y
Q
L
Y
--
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
-
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
-
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
E
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
H
E
A
L
K
H
P
W
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
65.31
48%
-98
- C1 -
3LM5
1
ST17B_HUMAN
A:
[34-292]
---------------
S
--
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
---
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
----
R
G
Q
D
C
R
A
E
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
-
L
C
L
P
E
L-
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
-
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
R
K
I
------------
M
---
G
T
P
E
Y
L
A
P
E
I
L
--
N
--
Y
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
-
D
N
Q
E
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
-----
A
E
I
C
L
S
H
S
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
65.02
48%
-97
- C1 -
3LM0
2
ST17B_HUMAN
A:
[34-292]
---------------
S
--
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
---
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
----
R
G
Q
D
C
R
A
E
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
-
L
C
L
P
E
LA
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
-
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
R
K
I
------------
M
---
G
T
P
E
Y
L
A
P
E
I
L
--
N
--
Y
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
-
D
N
Q
E
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
-----
A
E
I
C
L
S
H
S
W
L
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
64.52
42%
-104
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[12-277]
----
Q
A
E
D
I
R
D
I
Y
D
F
R
--
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
--------------
S
M
E
N
E
I
A
V
L
H
K
I
K
H
-
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
--
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
L
S
K
M
E
D
-
P
G
-------------
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
E
Q
A
L
Q
H
P
W
I
------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
64.19
38%
-96
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[2-264]
--------
M
T
D
E
Y
Q
L
F
--
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
-
G
D
Q
-
Q
A
W
F
G
F
A
---
G
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
S
E
A
L
K
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
61.84
36%
-91
- C1 -
3I7B
4
?
A:
[26-293]
----------
D
R
Y
K
G
Q
--
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
---
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
--
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
A
S
K
-
K
-
M
K
D
K
I
---
G
T
A
Y
Y
I
A
P
E
V
L
--
H
GT
Y
D
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
------
Q
--------
T
-------
Y
T
K
E
Q
--
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
61.49
36%
-92
- C1 -
3N51
3
?
A:
[26-293]
----------
D
R
Y
K
G
Q
--
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
---
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
--
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
-
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
A
S
K
-
K
-
M
K
D
K
I
---
G
T
A
Y
Y
I
A
P
E
V
L
--
H
GT
Y
D
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
-
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
R
D
A
L
D
H
E
W
I
------
Q
--------
T
-------
Y
T
K
E
Q
--
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
60.72
36%
-98
- C1 -
3HZT
9
?
A:
[3-263]
---------
S
D
R
Y
Q
R
V
--
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
---
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
T
T
T
S
N
S
G
A
---
L
L
D
E
V
A
V
L
K
Q
L
D
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
-
E
I
I
L
R
--
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
R
D
A
L
I
K
I
V
D
F
G
L
S
A
H
F
E
-
V
G
-------------
T
A
Y
Y
I
A
P
E
V
L
R
K
K
--
Y
D
E
---
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
-
T
D
Q
E
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
E
E
A
L
N
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
60.46
38%
-89
- C1 -
3MWU
1
?
A:
[24-281]
------------
Y
N
I
V
--
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
----
A
S
A
K
N
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
-
Q
N
------
D
R
I
---
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
--
Y
D
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
-
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
60.27
36%
-72
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-301]
------
T
R
F
T
E
E
Y
Q
L
F
--
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
---
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
L
S
A
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
-
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
-
L
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
-
G
E
Q
Q
A
-
W
F
G
F
A
---
G
T
P
G
Y
L
S
P
E
V
L
--
R
--
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
-
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
-----
A
A
E
A
L
K
H
P
W
I
------
S
--------
H
-------
R
S
T
V
A
--
S
C
M
---
H
---------
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
---------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
59.98
44%
-100
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[15-265]
------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
I
K
K
---
S
------
S
---
L
E
N
E
I
A
V
L
K
K
I
K
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
L
E
R
--
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
E
-
Q
N
G
-
I
-
M
S
T
A
C
---
G
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
-
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
59.95
37%
-82
- C1 -
2WEI
1
?
A:
[15-281]
---
Y
F
Q
G
T
F
A
E
R
Y
N
I
V
--
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
----
A
S
A
K
N
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
-
Q
N
T
-
K
-
M
K
D
R
I
---
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
--
Y
D
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
-
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
59.81
44%
-100
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[15-265]
------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
I
K
K
---
S
------
S
---
L
E
N
E
I
A
V
L
K
K
I
K
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
L
E
R
--
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
-
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
E
-
Q
N
G
-
I
-
M
S
T
A
C
---
G
T
P
G
Y
V
A
P
E
V
L
--
A
--
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
-
T
E
S
K
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
E
K
A
L
S
H
P
W
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
59.60
38%
-90
- C1 -
3NCG
1
?
A:
[24-281]
------------
Y
N
I
V
--
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
----
A
S
A
K
N
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
-
Q
N
T
-------
I
---
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
--
Y
D
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
-
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
58.77
38%
-91
- C1 -
3IGO
8
?
A:
[24-281]
------------
Y
N
I
V
--
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
----
A
S
A
K
N
K
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
D
H
-
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
--
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
-
Q
N
T
------------
T
A
Y
Y
I
A
P
E
V
L
R
G
T
--
Y
D
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
-
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
T
Q
C
L
E
H
P
W
I
------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
58.64
31%
-101
- C1 -
4GV1
5
AKT1_HUMAN
A:
[8-276]
----------
N
E
F
E
Y
L
--
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
---
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
-
H
L
S
R
E
--
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
----
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
-
T
-
M
K
T
F
C
---
G
T
P
E
Y
L
A
P
E
V
L
--
E
--
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
-
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
K
E
I
M
Q
H
R
F
F
------
A
--------
G
-------
I
V
W
Q
H
--
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
58.27
40%
-82
- C1 -
2W4O
1
KCC4_HUMAN
A:
[48-336]
-----
R
D
A
L
S
D
F
F
E
V
E
--
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
---
G
T
Q
K
P
Y
A
L
K
V
L
K
K
------------------
I
G
V
L
L
R
L
S
H
-
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
-
R
I
V
E
K
--
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
-
G
I
V
H
R
D
L
K
P
E
N
-
L
L
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
----------------------
G
T
P
G
Y
C
A
P
E
I
L
--
R
--
G
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
F
Q
A
L
Q
H
P
W
V
------
T
--------
G
-------
K
A
A
N
F
--
V
H
M
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
49.03
32%
-85
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-292]
----------
S
Q
F
E
L
L
--
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
----
R
V
------
D
I
L
V
E
V
N
H
-
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
-
R
L
S
K
E
--
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
----
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------
K
K
A
Y
S
F
C
---
G
T
V
E
Y
M
A
P
E
V
V
--
N
--
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
-
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
----
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
AGPD
G
V
E
E
I
K
R
H
S
F
F
------
S
--------
T
-------
I
D
W
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
47.37
97%
-34
- C1 -
2J90
3
DAPK3_HUMAN
B:
[27-295]
-----------
H
Y
E
M
G
--
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
-------
E
Y
A
A
K
F
I
K
K
R
R
L
S
S
-
R
R
G
V
S
R
E
E
I
E
R
E
V
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
---
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
-
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
V
P
N
P
R
I
K
L
I
D
F
G
I
A
H
K
I
E
-
A
G
N
-
E
-
F
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
--
N
--
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
E
-
T
K
Q
E
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
------
I
A
Q
S
L
E
H
S
W
I
------
K
--------
A
-------
I
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------