@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DCLK1_HUMAN: (2013-07-19 )
MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
Atome Classification :
(69 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380...---....390.......400.......410-.........420-------.......-.--430---.--.-----...-------....440..-.....450......------.460.......470.......480.......490.......500..-.....510.......520.......530.....-..--540.-------.---.---..-....550.......------560----.-.-.......570.......580.......590.......600.......610--------------------------.---------------------------..----------------------.....620.......630.....-----.-----.640.....----..650.......660.......670.......680.......690..---.....700.......710.......720.......730.......740
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQIPAT---ITERYKVGRTIGDGNFAVVKECVER---STAREYALKII--------KKSKCRG-K--E-----H--M-----IQN-------EVSILRRVK-HPNIVLLIEEMDVP------TELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHS-LNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLA-TI--V--D-------G---P---LY-TVCGTPTYVAPEII------A------E-T-GYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSP---------------------------Y---------------------------WD----------------------NVSDSAKELITMMLLVDVDQRFS-----A-----VQVLEHPWV----NDDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGVSVIATTALDKER---QVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF
3
PsiBlast_PDB
81.96
46%
-106
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[16-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
--------
A
K
E
------------------------
E
N
-------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
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F
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T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
-----------------------------------
P
G
Y
V
A
P
E
V
L
------
A
------
Q
-
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
---------------------------
Y
---------------------------
W
D
----------------------
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
A---
G
D
T
A
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
--------------------------------------------------------------------------
6
PsiBlast_PDB
81.88
46%
-107
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[16-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
--------
A
K
E
-------------------------
N
-------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
----------------------------------
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
-
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
---------------------------
Y
---------------------------
W
D
----------------------
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
A---
G
D
T
A
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
--------------------------------------------------------------------------
22
PsiBlast_CBE
80.85
46%
-110
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[16-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
--------
A
K
----------------------------------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
-----------------------
V
---
L
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
-
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
---------------------------
Y
---------------------------
W
D
----------------------
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
A---
G
D
T
A
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
--------------------------------------------------------------------------
10
PsiBlast_PDB
80.49
43%
-118
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[20-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
A
T
CTR
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
---
T
P
T
Q
E
Y
A
A
K
I
I
--------
N
T
K
K
L
S
A
-
R
--
D
-----
H
--
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
-
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
--
V
--
Q
-------
G
EQQ
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
-
D
-
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
---------------------------
E
---------------------------
W
D
----------------------
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
D
Q
A
L
K
H
P
W
V
----------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.46
43%
-128
- C1 -
3BHH
1
KCC2B_HUMAN
B:
[2-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
I
--------
N
T
K
K
L
S
A
-
R
--
D
-----
H
--
Q
K
----
L
E
R
-------
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
--
V
--
Q
-------
G
DQQ
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
-
E
-
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
---------------------------
E
---------------------------
W
D
----------------------
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
H
E
A
L
K
H
P
W
V
----------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
80.28
46%
-108
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[16-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
--------
A
K
--------------------------
N
-------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
G
-----------G------
S
---
V
---
L
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
-
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
---------------------------
Y
---------------------------
W
D
----------------------
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
A---
G
D
T
A
L
D
K
N
I
H
Q
-
S
V
S
E
Q
I
K
K
N
F
--------------------------------------------------------------------------
11
PsiBlast_PDB
80.04
43%
-125
- C1 -
3BHH
1
KCC2B_HUMAN
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
D
E
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
---
C
T
G
H
E
Y
A
A
K
I
I
--------
N
T
K
K
L
S
A
-
R
--
D
-----
H
--
Q
K
----
L
E
R
-------
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
S
E
E
------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
--
V
--
Q
-------
G
DQQ
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
-
E
-
A
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
---------------------------
E
---------------------------
W
D
----------------------
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
H
E
A
L
K
H
P
W
V
----------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.34
46%
-122
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[16-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
--------
A
-------------------
S
-----
M
E
N
-------
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
E
D
S
K
-
I
M
I
S
D
F
G
L
S
-
K
M
--
E
--
D
PG--------------------
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
-
K
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
--
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
---------------------------
Y
---------------------------
W
D
----------------------
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
-----
C
-----
E
Q
A
L
Q
H
P
W
I
A---------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.35
42%
-121
- C1 -
2WEL
7
KCC2D_HUMAN
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
K
L
S
A
-
R
--
D
-----
H
--
Q
K
----
L
E
R
-------
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
--
V
--
Q
-------
G
DQQ
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
-
D
-
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
---------------------------
E
---------------------------
W
D
----------------------
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
----------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.83
42%
-120
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
K
L
S
A
-
R
--
D
-----
H
--
Q
K----
L
E
R
-------
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
--
V
--
Q
-------
G
DQQ
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
-
D
-
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
---------------------------
E
---------------------------
W
D
----------------------
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
----------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.32
42%
-121
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
M
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
---
P
T
G
Q
E
Y
A
A
K
I
I
--------
N
T
K
K
L
S
A
-
R
--
D
-----
H
--
Q
K
----
L
E
R
-------
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
------
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
K
G
A
-
A
V
K
L
A
D
F
G
L
A
-
I
E
--
V
--
Q
-------
G
DQQ
A
---
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
-
D
-
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
---------------------------
E
---------------------------
W
D
----------------------
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
-----
A
-----
S
E
A
L
K
H
P
W
I
----------------------------------------------------------------------------------------------------
136
HHSearch
76.98
39%
-99
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
---
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
---
L
A
G
Q
E
Y
A
A
M
I
I
--------
N
T
K
K
L
S
A
-
R
--
D
H
----
Q
--
K
-----
L
E
R
-------
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
------
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
K
-
G
A
A
V
K
L
A
D
F
G
L
A
-
I
E
--
V
--
E
-------
G
---
E
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
-
D
-
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
--
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
---------------------------
E
---------------------------
W
D
----------------------
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
-----
A
-----
A
E
A
L
K
H
P
W
I
----
S
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
---------------------------------------------------------------------
91
PsiBlast_CBE
75.40
38%
-115
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
Q
S
R
A
-
S
--
R
R
G
V
S
R
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
------
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
--
E
--
D
-------
G
---
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
---------------------------
F
---------------------------
F
S
----------------------
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
75.36
40%
-120
- C1 -
3LIJ
1
?
A:
[35-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
---
V
T
H
V
E
R
A
I
K
I
I
--------
R
K
------
S
--
S
-----
N
S
-
K
-----
L
L
E
-------
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
------
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
E
K
D
A
L
I
K
I
V
D
F
G
L
S
-
A
V
--
F
--
E
-------
N
Q
K
-
K
---
M
K
-
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
------
R
------
K
-
K
--
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
-
G
G
Q
T
D
Q
E
I
L
-
R
K
V
E
K
G
K
Y
T
F
D
S
P
---------------------------
E
---------------------------
W
K
----------------------
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
-----
A
-----
Q
Q
A
L
E
H
P
W
I
----
K
E
----------------------------------------------------------------------------------------------
90
PsiBlast_CBE
75.23
38%
-112
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
Q
S
R
A
-
S
--
R
RGVSR
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
------
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
--
E
--
D
-------
G
---
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
---------------------------
F
---------------------------
F
S
----------------------
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
75.04
35%
-112
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[82-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
--
W
A
A
A
K
E
---
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
M
--------
E
V
---
R
L
-
S
--
P
-----
E
--
Q
-----
L
E
E
VREATRR
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
--
L
--
E
PG-----
E
---
K
---
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
------
H
-
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
---------------------------
E
---------------------------
W
D
----------------------
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
-----------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
74.87
35%
-112
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[82-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
--
W
A
A
A
K
E
---
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
M
--------
E
V
T
A
E
R
L
-
S
--
P
-----
E
--
Q
-----
L
E
E
VREATRR
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
--
L
--
E
PG-----
E
---
K
---
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
------
H
-
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
---------------------------
E
---------------------------
W
D
----------------------
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
-----------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
74.85
37%
-113
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[8-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
74.85
37%
-88
- C1 -
3HZT
9
?
A:
[3-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
---
L
T
G
A
E
R
A
I
K
I
I
--------
K
K
S
S
V
T
T
-
T
--
S
-----
N
S
G
A
-----
L
L
D
-------
E
V
A
V
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
------
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
R
D
A
L
I
K
I
V
D
F
G
L
S
-
A
H
FE
V
--
G
----------------------
T
A
Y
Y
I
A
P
E
V
L
------
R
------
K
-
K
--
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
-
G
G
Q
T
D
Q
E
I
L
-
K
R
V
E
K
G
K
F
S
F
D
P
P
---------------------------
D
---------------------------
W
T
----------------------
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
-----
A
-----
E
E
A
L
N
H
P
W
I
V
K
F
C
S
Q
----
V
G
K
H
A
L
T
G
A
L
G
N
M
K
K
F
Q
S
S
Q
K
L
A
Q
A
A
M
L
F
M
G
S
K
L
T
T
L
E
E
T
K
E
L
T
Q
I
F
R
Q
L
D
N
--------------------------------------
24
PsiBlast_CBE
74.73
42%
-101
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[7-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
I
--------
K
K
S
-----------------
S
-----
L
E
N
-------
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
------
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
-
I
M
I
T
D
F
G
L
S
-
K
M
E-
Q
--
N
-------
G
---
I
---
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
-
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
--
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
---------------------------
F
---------------------------
W
D
----------------------
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
-----
E
K
A
L
S
H
P
W
I
----
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
--------------------------------------------------------------------------
99
PsiBlast_CBE
74.72
38%
-116
- C1 -
3HX4
3
?
A:
[46-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
---
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
-------D-
K
-----
E
--
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
------
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
--
F
--
E
-------
A
S
K
-
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
---------------------------
Q
---------------------------
W
K
----------------------
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
-----------------------------------------------------------------------------------------------
88
PsiBlast_CBE
74.71
35%
-113
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[82-362]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
D
--
W
A
A
A
K
E
---
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
---
A
T
G
H
E
F
A
V
K
I
M
--------
E
V
T
A
E
R
L
-
S
--
P
-----
E
--
Q
-----
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
------
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
--
L
--
E
P
G-----
E
---
K
---
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
T
------
H
-
P
-
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
--
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
---------------------------
E
---------------------------
W
D
----------------------
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-----
A
-----
E
Q
A
L
Q
H
P
F
-----------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
74.64
37%
-108
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
F
G
-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
74.58
38%
-114
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
Q
S
R
A
-
S
--
R
R
G
V
S
R
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
------
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
--
E
--
D
-------
G
---
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
---------------------------
F
---------------------------
F
S
----------------------
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
74.28
37%
-110
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
74.24
38%
-112
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
Q
S
R
A
-
S
--
R
RGVSR
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
L
-
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
------
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
--
E
--
D
-------
G
---
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
Q
E
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
---------------------------
F
---------------------------
F
S
----------------------
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
74.02
42%
-99
- C1 -
2JAM
3
KCC1G_HUMAN
A:
[7-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
---
L
T
G
K
L
F
A
L
K
C
I
--------
K
K
S
-----------------
S
-----
L
E
N
-------
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
------
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
E
N
S
K
-
I
M
I
T
D
F
G
L
S
-
K
M
E
-
Q
--
N
-------
G
---
I
---
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
-
K
-
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
--
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
---------------------------
F
---------------------------
W
D
----------------------
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
-----
C
-----
E
K
A
L
S
H
P
W
I
----
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
--------------------------------------------------------------------------
65
PsiBlast_CBE
74.00
38%
-114
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
Q
S
R
A
-
S
--
R
RGVC
R
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
------
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
--
E
--
D
-------
G
---
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
---------------------------
F
---------------------------
F
S
----------------------
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
73.90
37%
-110
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
73.64
37%
-110
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
73.52
37%
-112
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
73.50
37%
-111
- C1 -
3GU8
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
73.47
37%
-110
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
73.42
37%
-111
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
--------
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
73.41
37%
-111
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
K
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VSRED
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
73.38
37%
-108
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
73.16
37%
-110
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
72.84
38%
-113
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[14-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
---
S
T
G
L
E
Y
A
A
K
F
I
--------
K
K
R
Q
S
R
A
-
S
--
R
RGVC
R
E
--
E
-----
I
E
R
-------
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
------
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
-
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
--
E
--
D
-------
G
---
V
---
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
---------------------------
F
---------------------------
F
S
----------------------
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
-----
I
-----
Q
E
A
L
R
H
P
W
I
----------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
72.73
37%
-111
- C1 -
3GUB
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
72.62
37%
-110
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
72.57
37%
-107
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
V
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
72.55
37%
-111
- C1 -
1QL6
1
PHKG1_RABIT
A:
[17-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
---
P
T
C
K
E
Y
A
V
K
I
I
DVTGGGSF
S
A
E
E
V
Q
E
-
L
--
R
-----
E
--
A
-----
T
L
K
-------
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
------
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
-
C
Q
--
L
--
D
PG-----
E
---
K
---
L
R
-
S
V
C
G
T
P
S
Y
L
A
P
E
I
I
------
E
C
S
M
N
D
N
H
-
P
-
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
--
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
---------------------------
E
---------------------------
W
D
----------------------
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
-----
E
E
A
L
A
H
P
F
F
----
Q
Q
Y
V
--------------------------------------------------------------------------------------------
57
PsiBlast_CBE
72.46
37%
-110
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
72.44
37%
-114
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
-------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
--
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
72.30
37%
-107
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
72.22
37%
-109
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
72.16
38%
-108
- C1 -
3V5P
1
?
A:
[22-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
---
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
Q
V
K
Q
-
K
TD
K
-----
E
--
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
------
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
--
F
--
E
-------
A
SK-
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
---------------------------
Q
---------------------------
W
K
----------------------
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
-----------------------------------------------------------------------------------------------
107
PsiBlast_CBE
72.11
38%
-107
- C1 -
3UPX
1
?
A:
[22-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
---
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
Q
V
K
Q
-
K
TD
K
-----
E
--
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
------
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
--
F
--
E
-------
A
SK-
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
---------------------------
Q
---------------------------
W
K
----------------------
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
-----------------------------------------------------------------------------------------------
56
PsiBlast_CBE
71.92
38%
-112
- C1 -
3Q5I
1
?
A:
[31-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
K
---
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
---
N
G
H
S
E
K
A
I
K
V
I
--------
K
K
-------KF
H
-----
E
--
E
-----
I
Y
N
-------
E
I
S
L
L
K
S
L
D
-
H
P
N
I
I
K
L
F
D
V
F
E
D
K
------
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
K
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
-
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
-
E
N
K
N
S
L
L
N
I
K
I
V
D
F
G
L
S
-
S
F
--
F
S
K
D
-------
Y
---
K
---
L
R
-
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
------
K
------
K
-
K
--
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
-
G
G
Q
N
D
Q
D
I
I
-
K
K
V
E
K
G
K
Y
Y
F
D
F
N
---------------------------
D
---------------------------
W
K
----------------------
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
-----
A
-----
E
E
A
L
N
S
R
W
I
----------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
71.78
37%
-110
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
FG-----
N
---
E
---
F
K
-
N
I
F
G
T
P
A
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
71.54
37%
-115
- C1 -
1PHK
1
PHKG1_RABIT
A:
[17-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
---
P
T
C
K
E
Y
A
V
K
I
I
DVTGGGSF
S
A
E
E
V
Q
E
-
L
--
R
-----
E
--
A
-----
T
L
K
-------
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
------
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----
D
D
D
M
N
I
K
L
T
D
F
G
F
S
-
C
Q
--
L
--
D
PG-----
E
---
K
---
L
R
-
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
------
E
C
S
M
N
DN
H
-
P
-
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
--
K
Q
M
L
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
---------------------------
E
---------------------------
W
D
----------------------
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
-----
A
-----
E
E
A
L
A
H
P
F
F
----
Q
Q
Y
V
--------------------------------------------------------------------------------------------
109
PsiBlast_CBE
71.25
38%
-105
- C1 -
3T3U
5
?
A:
[22-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
---
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
Q
V
K
Q
-
K
TD
K
-----
E
--
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
------
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
--
F
--
E
-------
A
SK-
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
---------------------------
Q
---------------------------
W
K
----------------------
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
-----------------------------------------------------------------------------------------------
103
PsiBlast_CBE
71.11
38%
-105
- C1 -
3V5T
1
?
A:
[22-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
---
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
Q
V
K
Q
-
K
TD
K
-----
E
--
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
------
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
--
F
--
E
-------
A
SK-
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
---------------------------
Q
---------------------------
W
K
----------------------
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
-----------------------------------------------------------------------------------------------
108
PsiBlast_CBE
70.80
38%
-106
- C1 -
3T3V
2
?
A:
[22-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
---
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
Q
V
K
Q
-
K
TD
K
-----
E
--
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
------
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
--
F
--
E
-------
A
SK-
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
--
N
E
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
---------------------------
Q
---------------------------
W
K
----------------------
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
-----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.39
41%
-93
- C1 -
2W4O
1
KCC4_HUMAN
A:
[50-346]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
---
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
---
G
T
Q
K
P
Y
A
L
K
V
L
--------
K
K
-----------------------------------
I
G
V
L
L
R
L
S
-
H
P
N
I
I
K
L
K
E
I
F
E
T
P
------
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
-
Y
A
T
P
A
P
D
A
P
L
K
I
A
D
F
---------------------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
------
G
-
C
-
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
D
E
R
G
D
Q
-
F
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
---------------------------
W
---------------------------
W
D
----------------------
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
-----
T
-----
F
Q
A
L
Q
H
P
W
V
----
T
--
G
K
A
A
N
F
V
H
M
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
--
A
A
V
K
A
V
V
A
S
S
-------------------------------------------------------
35
PsiBlast_CBE
70.23
39%
-105
- C1 -
3IGO
8
?
A:
[17-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
---
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
--------
N
K
A
S
A
K
N
-
K
---T----
S
--
T
-----
I
L
R
-------
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
------
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
--
F
Q
Q
N
-------
T
--------------
T
A
Y
Y
I
A
P
E
V
L
------
R
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
--
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
---------------------------
Q
---------------------------
W
R
----------------------
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
69.99
37%
-110
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
----------------R
E
D
--
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
------------------------
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
128
HHSearch
69.78
37%
-114
- C1 -
4GV1
5
AKT1_HUMAN
A:
[8-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
---
A
T
G
R
Y
Y
A
M
K
I
L
--------
K
K
E
V
I
V
A
-
K
--
D
E
V
---
A
--
H
-----
T
L
T
-------
E
N
R
V
L
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
------
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
--
K
D
G
--
H
I
K
I
T
D
F
G
L
C
-
K
E
--
G
--
I
KDG----
A
---
T
---
M
K
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
-
N
-
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
--
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
P
----------------------------------------------------------
R
----------------------
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
GGS
E
D
A
-----
K
E
I
M
Q
H
R
F
F
----
A
G
----------------------------------------------------------------------------------------------
59
PsiBlast_CBE
69.60
37%
-116
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
-----------------------------VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
----
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
----------------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
69.08
37%
-107
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
----
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
----------------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
-------------------------
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
133
HHSearch
69.00
30%
-105
- C1 -
4IC7
1
MK07_HUMAN
A:
[52-352]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
---
L
T
G
Q
Q
V
A
I
K
K
I
--------
P
N
A
F
D
V
V
-
T
N
-
A
-----
K
--
R
-----
T
L
R
-------
E
L
K
I
L
K
H
F
K
-
H
D
N
I
I
A
I
K
D
I
L
R
P
T
VPYGEF
K
S
V
Y
V
V
L
D
L
M
-
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
-
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
--
N
--
C
E
L
K
I
G
D
F
G
M
A
-
R
G
--
L
--
C
TSPAEHQ
Y
---
F
---
M
T
-
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
------
L
------
S
-
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
--
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
---------------------------
V
I
Q
A
VGAERVRAYIQSLPP
R
Q
P
V
P
W
E
T
V
Y
P
----------------------
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
-----
A
-----
A
A
A
L
R
H
P
F
L
----
A
K
Y
---------------------------------------------------------------------------------------------
60
PsiBlast_CBE
68.80
37%
-110
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[9-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
--------
K
K
R
R
T
K
S
-
S
--
R
-----
R
--
G
VS
R
E
D
I
E
R
-------
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
------
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
--
I
--
D
-----------------------
P
E
F
V
A
P
E
I
V
------
N
------
Y
-
E
-
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
--
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
---------------------------
Y
---------------------------
F
S
----------------------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
-----
I
-----
Q
D
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
68.60
37%
-105
- C1 -
3MA6
1
?
B:
[29-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
---
I
T
G
Q
E
C
A
V
K
V
I
--------
S
K
R
Q
V
K
Q
--TD
K
-----
E
--
S
-----
L
L
R
-------
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
------
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
-
E
S
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
--
F
--
E
-------
A
S
K
-
K
---
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
--
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
---------------------------
Q
---------------------------
W
K
----------------------
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
-----
A
-----
R
D
A
L
D
H
E
W
I
----
Q
-----------------------------------------------------------------------------------------------
33
PsiBlast_CBE
67.87
39%
-106
- C1 -
3NCG
1
?
A:
[14-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
G
T
---
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
--------
N
K
A
S
A
K
N
-
K
--
D
T
----
S
--
T
-----
I
L
R
-------
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
------
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
--
F
Q
Q
N
-------
T
------------
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
--
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
---------------------------
Q
---------------------------
W
R
----------------------
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
67.28
39%
-104
- C1 -
3MWU
1
?
A:
[14-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
G
T
---
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
--------
N
K
A
S
A
K
N
-
K
--
D
T
----
S
--
T
-----
I
L
R
-------
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
------
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
--
F
QQ
N
------------------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
--
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
---------------------------
Q
---------------------------
W
R
----------------------
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
66.56
39%
-100
- C1 -
2WEI
1
?
A:
[12-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
Y
F
Q
G
T
---
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
---
I
T
Q
Q
E
Y
A
V
K
V
I
--------
N
K
A
S
A
K
N
-
K
--
D
T
----
S
--
T
-----
I
L
R
-------
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
E
D
S
------
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
-
E
S
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
--
F
QQ
N
-------
T
---
K
---
M
K
-
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
------
G
-
T
--
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
--
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
---------------------------
Q
---------------------------
W
R
----------------------
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
-----
A
-----
T
Q
C
L
E
H
P
W
I
----
Q
-----------------------------------------------------------------------------------------------
129
HHSearch
65.39
30%
-103
- C1 -
4B99
1
MK07_HUMAN
A:
[51-352]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
---
L
T
G
Q
Q
V
A
I
K
K
I
--------
P
N
A
F
D
V
V
T
N
--
A
-----
K
--
R
-----
T
L
R
-------
E
L
K
I
L
K
H
F
K
-
H
D
N
I
I
A
I
K
D
I
L
R
P
T
VPYGEF
K
S
V
Y
V
V
L
D
L
M
-
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
-
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
--
N
--
C
E
L
K
I
G
D
F
G
M
A
-
R
G
--
L
--
Q
-------
Y
---
F
---
M
T
-
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
------
L
------
S
-
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
--
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
---------------------------
V
---------------------------
I
Q
R
V
R
A
Y
I
QSLPP
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
-----
A
-----
A
A
A
L
R
H
P
F
L
----
A
K
Y
H
--------------------------------------------------------------------------------------------
134
HHSearch
60.45
31%
-85
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[3-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
---
N
T
G
Q
I
V
A
I
K
I
F
--------
Y
----------
N
-----
K
--
I
-----
A
M
R
-------
E
I
K
F
L
K
Q
F
H
-
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
------
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
H
Y
C
H
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
-
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
--
S
--
G
I
T
K
L
C
D
F
G
F
A
-
R
T
-------------
D
---
I
---
Y
D
-
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
------
L
------
K
D
T
-
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
P
Y
L
P
S
S
--
S
D
L
D
L
L
H
K
I
V
L
K
V
G
N
L
S
P
H
L
Q
N
I
F
S
K
SPIFAGVV
L
P
Q
V
Q
H
P
KN
A
R
K
K
---------------------------
Y
P
----------------------
K
L
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
-----
S
-----
S
D
L
L
H
H
E
Y
F
----
T
R
D
G
F
I
E
K
----------------------------------------------------------------------------------------
130
HHSearch
59.52
33%
-88
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[24-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
SGS
D
A
R
Q
L
Y
A
M
K
V
L
--------
K
K
A
T
L
K
V
-
R
--
D
R
----
V
--------------------
D
I
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
------
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
--
E
G
--
H
I
K
L
T
D
F
G
L
S
-
K
------
E
-------
K
---
K
---
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
------
N
------
R
-
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
--
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
----------------------------------------------------------
Q
----------------------
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-----
A
GPD
G
V
E
E
I
K
R
H
S
F
F
----
S
T
I
---------------------------------------------------------------------------------------------