@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : EPHA2_HUMAN: (2013-07-20 )
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI
Atome Classification :
(88 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570......-.580.......590.......600.......610....-.-..620.......630.......640.......650..-.....660.......670.......680.......690.......700.......-710..-.....720.......730.......740.......750.......760....---...770..-...--..780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSK-SEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQ-K-VIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTE-KQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDG-EFSVL-QLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLED---DPEATYTT-SGG--KIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI
22
PsiBlast_CBE
74.89
100%
-115
- C2 -
1MQB
1
B:
[35-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
-
K
-
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
----
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
-
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
---------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.89
100%
-115
- C2 -
1MQB
1
EPHA2_HUMAN
A:
[38-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
-
K
-
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
---
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
-
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
-
E
F
S
V
L
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
-----------------------------------------------------------------------------------------
30
PsiBlast_CBE
71.95
74%
-118
- C2 -
2XYU
7
A:
[1-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
A
S
C
I
K
I
E
-
K
-
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
P
-
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
-
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
G
-
R
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.84
65%
-109
- C2 -
3FXX
1
A:
[30-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
-
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
---
D
----------
G
--
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
--
A
A
R
P
S
N
L
L
L
D
-------------------------------------------------------------------------------
41
PsiBlast_CBE
71.40
67%
-107
- C2 -
2VWZ
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
-
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
---------
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
42
PsiBlast_CBE
71.13
67%
-108
- C2 -
2VWY
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
-
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
---------
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.09
64%
-110
- C2 -
2QOC
2
A:
[10-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
-
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-----------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
A
A
A
R
P
S
N
L
L
L
D
Q
S
-----------------------------------------------------------------------------
27
PsiBlast_CBE
71.05
70%
-108
- C2 -
1JPA
1
EPHB2_MOUSE
A:
[8-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
I
D
P
F
T
F
E
D
P
N
E
A
V
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
----
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
-
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
---------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
---------------------------------------------------------------------------------------------
40
PsiBlast_CBE
70.97
67%
-110
- C2 -
2VX0
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
-
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
----------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
38
PsiBlast_CBE
70.90
67%
-110
- C2 -
2X9F
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
-
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
---------------
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
39
PsiBlast_CBE
70.63
67%
-111
- C2 -
2VX1
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
-
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
---------
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
36
PsiBlast_CBE
70.53
67%
-112
- C2 -
4BB4
1
A:
[9-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
-
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
-----------------
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.51
65%
-110
- C2 -
2QO9
1
A:
[34-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
-
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-------------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-------
N
L
L
L
D
-------------------------------------------------------------------------------
24
PsiBlast_CBE
70.46
69%
-106
- C2 -
3DKO
1
A:
[19-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
I
D
P
E
T
Y
E
D
P
N
R
A
V
H
Q
F
A
K
E
L
D
A
S
C
I
K
I
E
-
R
-
V
I
G
A
-
E
F
G
E
V
C
S
G
R
L
K
L
P
-
G
K
R
D
V
A
V
A
I
K
T
L
K
V
G
Y
T
E
-
K
Q
R
R
D
F
L
C
E
A
S
I
M
G
Q
F
D
H
P
N
V
V
H
L
E
G
V
V
T
R
G
K
P
V
M
I
V
I
E
F
M
E
N
G
A
L
D
A
F
L
R
K
H
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
A
P
M
D
C
P
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
V
G
I
L
D
K
M
I
R
N
P
N
S
------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
70.41
74%
-115
- C2 -
2Y6M
3
A:
[4-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
E
I
D
A
S
C
I
K
I
E
-
K
-
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
P
-
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
-
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
G
-
R
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
---------------------------
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
----------------------------------------------------------------------------------------------
28
PsiBlast_CBE
70.40
74%
-117
- C2 -
2Y6O
1
A:
[4-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
E
I
D
A
S
C
I
K
I
E
-
K
-
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
K
V
P
-
G
K
R
E
I
C
V
A
I
K
T
L
K
A
G
Y
T
D
-
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
G
-
R
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
P
N
S
L
K
----------------------------------------------------------------------------------------------
43
PsiBlast_CBE
70.35
67%
-109
- C2 -
2VWX
1
A:
[11-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
-
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
E
NSS
D
---------
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
26
PsiBlast_CBE
70.32
70%
-110
- C2 -
1JPA
1
B:
[8-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
F
I
D
P
F
T
F
E
D
P
N
E
A
V
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
-----
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
-
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
-
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
---------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
-
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
----------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.26
64%
-111
- C2 -
4G2F
1
A:
[23-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
-
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
-----
P
S
N
L
L
L
--------------------------------------------------------------------------------
34
PsiBlast_CBE
69.74
71%
-110
- C2 -
2HEN
1
EPHB2_MOUSE
B:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
-
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
-
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.39
64%
-115
- C2 -
3DZQ
1
A:
[23-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
E
F
A
K
E
L
D
A
T
N
I
S
I
D
-
K
-
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
S
-
K
K
E
I
S
V
A
I
K
T
L
K
V
G
Y
T
E
-
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
--
L
K
I
I
T
-------
N
L
L
L
D
-------------------------------------------------------------------------------
33
PsiBlast_CBE
69.24
71%
-108
- C2 -
2HEN
1
EPHB2_MOUSE
C:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
-
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
-
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------
37
PsiBlast_CBE
69.01
67%
-105
- C2 -
2XVD
1
A:
[10-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
---
Y
T
E
-
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
----------
S
S
-
L
G
G
--
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
35
PsiBlast_CBE
68.99
71%
-110
- C2 -
2HEN
1
EPHB2_MOUSE
A:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
-
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
-
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------
32
PsiBlast_CBE
68.94
71%
-109
- C2 -
2HEN
1
D:
[1-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
I
D
I
S
C
V
K
I
E
-
Q
-
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
K
L
P
-
G
K
R
E
I
F
V
A
I
K
T
L
K
S
G
Y
T
E
-
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
--------------------------------------------------------------------------------------------
44
PsiBlast_CBE
68.56
67%
-112
- C2 -
4AW5
1
A:
[8-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
-
E
-
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
-
A
P
G
K
K
E
S
C
V
A
I
K
T
L
K
G
G
Y
T
E
-
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
-
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
-------------------------------------------------------------------------------------------
127
HHSearch
66.43
63%
-109
- C2 -
3KUL
2
EPHA8_HUMAN
A:
[43-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
-
K
-
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
V
P
-
G
Q
R
D
V
P
V
A
I
K
A
L
K
A
G
Y
T
E
-
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
R
G
R
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
H
D
G
-
Q
F
T
I
M
-
Q
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
-------
A
A
Y
T
T
-
T
-----
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
M
T
N
R
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
C
P
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
A
L
I
R
S
P
E
-------------------------------------------------------------------------------------------------
130
HHSearch
62.38
39%
-104
- C2 -
2OZO
1
ZAP70_HUMAN
A:
[331-601]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
K
R
D
N
L
L
I
A
-
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
M
R
--
K
K
Q
I
D
V
A
I
K
V
L
K
Q
G
T
E
K
-
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
-
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
R
E
-
E
I
P
V
S
-
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
--------------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
A
-------------------------------------------------------------------------------------------------
132
HHSearch
62.18
41%
-100
- C2 -
3CBL
3
A:
[109-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
L
N
H
E
D
L
V
L
G
-
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
-
N
---
T
L
V
A
V
K
S
C
R
E
T
L
P
P
-
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
-
R
L
R
V
K
-
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
---
G
---
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
----------------------------------------------------------------------------------------------------
122
HHSearch
61.29
41%
-101
- C2 -
4I4E
1
A:
[11-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
-
R
-
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
--
N
P
A
L
A
V
A
I
K
T
C
K
N
C
T
S
D
-
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
-
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
-
S
L
D
L
A
-
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
----------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
59.63
41%
-86
- C2 -
2H8H
1
SRC_HUMAN
A:
[198-517]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
--
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
-
T
S
K
P
Q
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
---
N
---
E
Y
T
A
R
Q
G
A
--
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
59.49
42%
-100
- C2 -
3VS5
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
59.32
42%
-83
- C2 -
2SRC
1
SRC_HUMAN
A:
[130-434]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
--
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
-
T
S
K
P
Q
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
---
N
---
E
Y
T
A
R
Q
G
A
--
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
59.23
42%
-97
- C2 -
2C0T
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
59.14
42%
-101
- C2 -
2C0I
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
59.12
42%
-100
- C2 -
3VRZ
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
59.05
44%
-97
- C2 -
2HK5
1
HCK_HUMAN
A:
[11-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
---
N
---
E
Y
T
A
R
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
--------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
58.92
42%
-102
- C2 -
2C0O
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
58.86
42%
-99
- C2 -
3VS3
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
58.76
42%
-103
- C2 -
3VS5
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
58.65
42%
-99
- C2 -
3VS4
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
58.56
42%
-95
- C2 -
1QCF
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
---
N
---
E
Y
T
A
R
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
58.51
42%
-98
- C2 -
3VS4
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
58.47
42%
-103
- C2 -
3VS6
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
58.45
42%
-98
- C2 -
2C0T
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
58.34
42%
-94
- C2 -
3VS1
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
123
HHSearch
58.30
37%
-99
- C2 -
4FYO
1
A:
[11-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
-
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
--
K
K
V
V
K
T
V
A
V
K
I
L
------P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
-
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
-
R
-
H
V
K
D
K
-
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
---
D
E
N
Y
Y
K
A
-------
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
-----------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
58.19
42%
-96
- C2 -
2ZV8
1
LYN_MOUSE
A:
[8-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
I
K
L
V
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
S
T
-----
K
V
A
V
K
T
L
K
P
G
T
M
S
-
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
-------------R
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
-----------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
58.15
42%
-100
- C2 -
3VRY
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
58.15
42%
-98
- C2 -
3VRY
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
58.14
42%
-97
- C2 -
3VRZ
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
58.08
42%
-99
- C2 -
2C0I
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
58.02
42%
-100
- C2 -
3VS3
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
57.91
41%
-87
- C2 -
1Y57
1
SRC_HUMAN
A:
[115-436]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
--
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
-
T
S
K
P
Q
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
---
N
---
E
Y
T
A
R
Q
G
A
--
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
57.88
42%
-100
- C2 -
3VS6
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
57.86
42%
-99
- C2 -
3VS0
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
57.76
42%
-103
- C2 -
3VS2
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
57.74
42%
-100
- C2 -
3VS2
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
57.61
41%
-81
- C2 -
1KSW
1
SRC_HUMAN
A:
[130-434]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
--
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
-
T
S
K
P
Q
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
-----
R
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
---
N
---
E
Y
T
A
R
Q
G
A
--
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
57.56
42%
-94
- C2 -
2ZVA
1
LYN_MOUSE
A:
[8-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
I
K
L
V
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
S
T
-----
K
V
A
V
K
T
L
K
P
G
T
M
S
-
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
----------
T
A
R
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
----------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
57.45
43%
-98
- C2 -
4DGG
1
SRC_CHICK
B:
[9-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
---------
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
57.45
42%
-101
- C2 -
2C0O
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
57.18
42%
-103
- C2 -
3VS1
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
56.69
43%
-99
- C2 -
3B2W
1
LCK_HUMAN
A:
[26-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
M
S
-
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
---
N
---
E
Y
T
A
--
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
---------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
56.69
42%
-95
- C2 -
3VS0
1
HCK_HUMAN
A:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
56.66
44%
-93
- C2 -
1YOL
1
SRC_HUMAN
B:
[9-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
56.60
41%
-99
- C2 -
2HCK
1
HCK_HUMAN
B:
[168-430]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
----------------
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
56.52
43%
-103
- C2 -
4FIC
1
SRC_CHICK
A:
[8-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
-----------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
56.50
43%
-95
- C2 -
4DGG
1
SRC_CHICK
A:
[9-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
56.48
42%
-95
- C2 -
3VS7
1
HCK_HUMAN
B:
[174-446]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-----------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
56.39
42%
-97
- C2 -
2ZV9
1
LYN_MOUSE
A:
[8-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
I
K
L
V
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
S
T
-----
K
V
A
V
K
T
L
K
P
G
T
M
S
-
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
--------------
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
-----------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
56.05
42%
-95
- C2 -
3A4O
1
LYN_HUMAN
X:
[9-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
I
K
L
V
-
K
-
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
N
S
T
-----
K
V
A
V
K
T
L
K
P
G
T
M
S
-
V
Q
A
--
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
P
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
---------------
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
T
A
T
E
-------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
55.84
43%
-103
- C2 -
3BYU
1
LCK_HUMAN
A:
[27-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
M
S
-
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-----------------------
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
---------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
55.71
43%
-103
- C2 -
2OFV
1
LCK_HUMAN
A:
[26-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
K
-----
V
A
V
K
S
L
K
Q
G
----------
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-------------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
55.63
43%
-101
- C2 -
4FIC
1
SRC_CHICK
B:
[11-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
-----------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
55.48
41%
-100
- C2 -
1AD5
1
HCK_HUMAN
B:
[168-430]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
-
K
L
G
A
G
Q
F
G
E
V
W
-----
M
A
T
Y
N
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-
V
E
A
--
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
-
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
----------------
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
55.42
43%
-96
- C2 -
4AGW
3
SRC_CHICK
B:
[11-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
55.36
43%
-95
- C2 -
4AGW
3
SRC_CHICK
A:
[10-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
55.36
44%
-91
- C2 -
3GEQ
1
SRC_CHICK
B:
[5-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
G
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
54.88
44%
-91
- C2 -
1YOL
1
SRC_HUMAN
A:
[6-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
54.61
43%
-89
- C2 -
2PL0
1
LCK_HUMAN
A:
[31-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
K
-----
V
A
V
K
S
L
K
Q
G
S
M
S
-
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
---
N
---
E
Y
T
A
R
E
G
A
--
K
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
-----------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
54.58
44%
-97
- C2 -
1YOM
1
SRC_HUMAN
B:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
54.05
46%
-90
- C2 -
2BDF
1
SRC_HUMAN
A:
[19-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
53.88
46%
-90
- C2 -
2BDF
1
SRC_HUMAN
B:
[19-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------------
A
--
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
53.87
43%
-96
- C2 -
2OG8
1
?
B:
[16-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
-----
K
V
A
V
K
S
L
K
Q
G
S
M
S
-
P
D
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
A
---------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
53.19
43%
-102
- C2 -
2OFV
1
?
B:
[26-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
G
H
T
K
-----
V
A
V
K
S
L
K
Q
G
------
A
--
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
-
E
P
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
-
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
-------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
-------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
T
----------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
52.69
46%
-91
- C2 -
2BDJ
1
SRC_HUMAN
A:
[19-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
52.35
44%
-87
- C2 -
1YOM
1
SRC_HUMAN
A:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
D
A
W
E
I
P
R
E
S
L
R
L
E
-
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
G
T
T
R
-----
V
A
I
K
T
L
K
P
G
T
M
S
-
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
-
E
P
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
-
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
--------------------------------------------------------------------------------------------------------
Add PDB User Result:
(108 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGFFKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTPPQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSGLVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGFSVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI
133
-
100%
-120
- C2 -
U133
1
A:
[601-882]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
-
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
----------------------------------------------------------------------------------------------
134
-
100%
-115
- C2 -
U134
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
--------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
135
-
100%
-115
- C2 -
U135
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
--------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
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I
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D
K
L
I
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A
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D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
136
-
100%
-116
- C2 -
U136
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
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P
S
C
V
T
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Q
K
V
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G
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V
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-----------
G
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L
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T
L
A
-------------------------------------------------------------------------------------------
137
-
100%
-109
- C2 -
U137
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
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V
T
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-----
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---------------
P
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L
I
R
A
P
--------------------------------------------------------------------------------------------------
138
-
100%
-109
- C2 -
U138
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
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---------------
P
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D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
139
-
100%
-106
- C2 -
U139
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
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---------------
P
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A
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--------------------------------------------------------------------------------------------------
140
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-109
- C2 -
U140
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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---------------
P
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A
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--------------------------------------------------------------------------------------------------
141
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100%
-120
- C2 -
U141
1
A:
[601-882]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
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--------------------
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----------------------------------------------------------------------------------------------
142
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- C2 -
U142
1
A:
[619-877]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
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A
---------------------------------------------------------------------------------------------------
143
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-106
- C2 -
U143
1
A:
[597-878]
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P
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---------------
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A
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--------------------------------------------------------------------------------------------------
144
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-106
- C2 -
U144
1
A:
[597-878]
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P
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---------------
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A
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--------------------------------------------------------------------------------------------------
145
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100%
-108
- C2 -
U145
1
A:
[597-878]
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P
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---------------
P
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--------------------------------------------------------------------------------------------------
146
-
100%
-109
- C2 -
U146
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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---------------
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R
A
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--------------------------------------------------------------------------------------------------
147
-
100%
-108
- C2 -
U147
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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---------------
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A
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--------------------------------------------------------------------------------------------------
148
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-109
- C2 -
U148
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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---------------
P
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R
A
P
--------------------------------------------------------------------------------------------------
149
-
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-106
- C2 -
U149
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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---------------
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--------------------------------------------------------------------------------------------------
150
-
100%
-106
- C2 -
U150
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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--------------------------------------------------------------------------------------------------
151
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-106
- C2 -
U151
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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--------------------------------------------------------------------------------------------------
152
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-106
- C2 -
U152
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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A
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--------------------------------------------------------------------------------------------------
153
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100%
-106
- C2 -
U153
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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--------------------------------------------------------------------------------------------------
154
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-116
- C2 -
U154
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
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A
-------------------------------------------------------------------------------------------
155
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99%
-110
- C2 -
U155
1
A:
[606-876]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
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---
T
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L
D
K
L
I
R
----------------------------------------------------------------------------------------------------
156
-
100%
-106
- C2 -
U156
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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---------------
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R
A
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--------------------------------------------------------------------------------------------------
157
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- C2 -
U157
1
B:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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--------------
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R
A
P
--------------------------------------------------------------------------------------------------
158
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-106
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U158
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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---------------
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R
A
P
--------------------------------------------------------------------------------------------------
159
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-109
- C2 -
U159
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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---------------
P
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--------------------------------------------------------------------------------------------------
160
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- C2 -
U160
1
A:
[619-877]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
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T
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A
---------------------------------------------------------------------------------------------------
161
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U161
1
A:
[597-878]
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P
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---------------
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--------------------------------------------------------------------------------------------------
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U162
1
A:
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---------------
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A
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--------------------------------------------------------------------------------------------------
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U163
1
A:
[597-878]
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P
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---------------
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--------------------------------------------------------------------------------------------------
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U164
1
B:
[597-878]
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--------------
I
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--------------------------------------------------------------------------------------------------
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U165
1
A:
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-----
T
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
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R
--
F
L
G
E
A
G
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M
G
Q
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H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
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T
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Y
M
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G
A
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K
F
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S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
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Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
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F
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I
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M
W
E
V
M
T
Y
G
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P
Y
W
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M
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A
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D
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F
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L
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T
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A
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M
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Q
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A
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R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
166
-
99%
-105
- C2 -
U166
1
B:
[602-872]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
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F
G
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Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
--------
D
F
L
G
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A
G
I
M
G
Q
F
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H
H
N
I
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K
-
K
P
M
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M
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A
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F
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R
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F
S
V
L
Q
L
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M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
I
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
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F
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M
T
Y
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Y
W
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L
S
N
H
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F
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L
P
T
P
M
D
C
P
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A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
--------------------------------------------------------------------------------------------------------
167
-
100%
-106
- C2 -
U167
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
--
F
L
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A
G
I
M
G
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H
H
N
I
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R
L
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V
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-
K
P
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M
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F
L
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F
S
V
L
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L
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L
R
G
I
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A
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M
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Y
L
A
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M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
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F
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M
W
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V
M
T
Y
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P
Y
W
E
L
S
N
H
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V
M
K
A
I
N
D
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F
R
L
P
T
P
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D
C
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A
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Y
Q
L
M
M
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C
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Q
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R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
168
-
100%
-108
- C2 -
U168
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
--
F
L
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A
G
I
M
G
Q
F
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H
H
N
I
I
R
L
E
G
V
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S
K
-
K
P
M
M
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T
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Y
M
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N
G
A
L
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K
F
L
R
E
K
D
G
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F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
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I
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W
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V
M
T
Y
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M
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A
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D
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F
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L
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T
P
M
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C
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A
I
Y
Q
L
M
M
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Q
Q
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R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
169
-
100%
-106
- C2 -
U169
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
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--
F
L
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A
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G
Q
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H
N
I
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R
L
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V
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-
K
P
M
M
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M
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A
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L
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K
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V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
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V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
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D
G
F
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L
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C
P
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A
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M
M
Q
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A
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P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
170
-
99%
-109
- C2 -
U170
1
B:
[619-876]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
G
-------
R
F
L
G
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A
G
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M
G
Q
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L
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V
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G
A
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V
L
Q
L
V
G
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L
R
G
I
A
A
G
M
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Y
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A
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M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
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F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
-------
M
K
A
I
N
-
G
F
R
L
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T
P
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A
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A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
----------------------------------------------------------------------------------------------------
171
-
99%
-109
- C2 -
U171
1
B:
[619-876]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
G
-------
R
F
L
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A
G
I
M
G
Q
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H
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I
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V
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-
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M
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F
L
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L
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L
R
G
I
A
A
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M
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Y
L
A
N
M
N
Y
V
H
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D
L
A
A
R
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I
L
V
N
S
N
L
V
C
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V
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F
G
L
S
R
V
L
E
D
-------------
P
I
R
W
T
A
P
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A
I
S
Y
R
K
F
T
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A
S
D
V
W
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F
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I
V
M
W
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V
M
T
Y
G
E
R
P
Y
W
-------
M
K
A
I
N
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
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L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
----------------------------------------------------------------------------------------------------
172
-
100%
-106
- C2 -
U172
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
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--
F
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A
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H
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V
L
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M
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R
G
I
A
A
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M
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Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
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N
I
L
V
N
S
N
L
V
C
K
V
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D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
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F
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V
M
W
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M
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Y
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P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
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L
P
T
P
M
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C
P
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A
I
Y
Q
L
M
M
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Q
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R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
173
-
100%
-101
- C2 -
U173
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
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V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
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A
I
K
T
L
K
A
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Y
T
E
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--
F
L
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A
G
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M
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H
N
I
I
R
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-
K
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V
L
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R
G
I
A
A
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M
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Y
L
A
N
M
N
Y
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D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
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D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
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I
V
M
W
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V
M
T
Y
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E
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P
Y
W
E
L
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M
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A
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L
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T
P
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C
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A
I
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M
M
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A
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K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
174
-
100%
-113
- C2 -
U174
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
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Y
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L
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-
S
S
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A
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M
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Y
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A
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Y
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A
A
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L
V
N
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N
L
V
C
K
V
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F
G
L
S
R
V
L
E
D
D
--------
G
G
K
I
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I
R
W
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A
P
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A
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S
Y
R
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F
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A
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Y
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I
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K
L
I
R
A
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D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
175
-
100%
-98
- C2 -
U175
1
A:
[619-875]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
--
F
L
G
E
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-----------------------------------------------------------------------------------------------------
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U176
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U177
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U178
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U179
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--------------
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--------------------------------------------------------------------------------------------------
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-120
- C2 -
U185
1
A:
[601-882]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
-
G
K
K
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V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
V
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F
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G
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A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
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G
V
I
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K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
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F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
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V
M
T
Y
G
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R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
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T
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M
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C
P
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A
I
Y
Q
L
M
M
Q
C
W
Q
Q
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R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
----------------------------------------------------------------------------------------------
186
-
100%
-106
- C2 -
U186
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
--
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
187
-
99%
-109
- C2 -
U187
1
B:
[619-876]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
G
-------
R
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
I
I
T
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Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
-------
M
K
A
I
N
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
----------------------------------------------------------------------------------------------------
188
-
100%
-109
- C2 -
U188
1
A:
[619-877]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
--
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
I
I
T
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Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
---------------------------------------------------------------------------------------------------
189
-
99%
-109
- C2 -
U189
1
B:
[619-876]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
G
-------
R
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
I
I
T
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Y
M
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N
G
A
L
D
K
F
L
R
E
K
D
G
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F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
-------
M
K
A
I
N
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
----------------------------------------------------------------------------------------------------
190
-
100%
-106
- C2 -
U190
1
B:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
--
F
L
G
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A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
I
I
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Y
M
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N
G
A
L
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F
L
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F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
191
-
99%
-109
- C2 -
U191
1
B:
[619-876]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
G
-------
R
F
L
G
E
A
G
I
M
G
Q
F
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H
H
N
I
I
R
L
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V
I
S
K
-
K
P
M
M
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Y
M
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G
A
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F
L
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V
L
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L
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L
R
G
I
A
A
G
M
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Y
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A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
-------
M
K
A
I
N
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
----------------------------------------------------------------------------------------------------
192
-
100%
-106
- C2 -
U192
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
--
F
L
G
E
A
G
I
M
G
Q
F
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H
H
N
I
I
R
L
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V
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-
K
P
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Y
M
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A
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L
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V
L
Q
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V
G
M
L
R
G
I
A
A
G
M
K
Y
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A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
193
-
100%
-103
- C2 -
U193
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
E
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A
I
K
T
L
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A
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T
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--
F
L
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A
G
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M
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H
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I
I
R
L
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-
K
P
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M
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V
L
Q
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M
L
R
G
I
A
A
G
M
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Y
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A
N
M
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Y
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H
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D
L
A
A
R
N
I
L
V
N
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N
L
V
C
K
V
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D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
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A
I
S
Y
R
K
F
T
S
A
S
D
V
W
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F
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I
V
M
W
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V
M
T
Y
G
E
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P
Y
W
E
L
S
N
H
E
V
M
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A
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N
D
G
F
R
L
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C
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A
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Y
Q
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M
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A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
194
-
100%
-116
- C2 -
U194
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
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M
L
K
-
S
S
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K
K
E
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P
V
A
I
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---
Y
T
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V
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Q
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R
G
I
A
A
G
M
K
Y
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A
N
M
N
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V
H
R
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L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-----------
G
G
K
I
P
I
R
W
T
A
P
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A
I
S
Y
R
K
F
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S
A
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V
W
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Y
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E
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P
Y
W
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D
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F
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L
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S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
195
-
100%
-113
- C2 -
U195
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
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-
S
S
G
K
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A
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A
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Y
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Y
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N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
--------
G
G
K
I
P
I
R
W
T
A
P
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A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
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M
W
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V
M
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Y
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P
Y
W
E
L
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N
H
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M
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A
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I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
196
-
100%
-116
- C2 -
U196
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
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-
S
S
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A
I
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---
Y
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M
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F
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V
L
Q
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M
L
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G
I
A
A
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M
K
Y
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A
N
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L
A
A
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N
I
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V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
-----------
G
G
K
I
P
I
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W
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A
P
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A
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S
Y
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K
F
T
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A
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W
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I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
197
-
100%
-115
- C2 -
U197
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
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V
C
K
V
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D
F
G
L
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R
V
L
E
D
D
--------
G
G
K
I
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A
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A
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Y
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F
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A
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I
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D
K
L
I
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A
P
D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
198
-
99%
-110
- C2 -
U198
1
A:
[606-876]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
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----
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A
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A
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N
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F
G
L
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V
L
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D
D
---
T
Y
T
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K
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E
A
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F
A
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V
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I
L
D
K
L
I
R
----------------------------------------------------------------------------------------------------
199
-
100%
-109
- C2 -
U199
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
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-----
T
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S
G
K
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--
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I
I
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N
L
V
C
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F
G
L
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V
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---------------
P
I
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W
T
A
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F
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R
A
P
--------------------------------------------------------------------------------------------------
200
-
100%
-109
- C2 -
U200
1
A:
[619-877]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
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F
G
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Y
K
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L
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S
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-----
V
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--
F
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-----------------
K
I
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A
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I
L
D
K
L
I
R
A
---------------------------------------------------------------------------------------------------
201
-
100%
-109
- C2 -
U201
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
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L
K
F
T
T
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C
V
T
R
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-----
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---------------
P
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A
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A
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L
I
R
A
P
--------------------------------------------------------------------------------------------------
202
-
100%
-108
- C2 -
U202
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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-----
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---------------
P
I
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K
L
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R
A
P
--------------------------------------------------------------------------------------------------
203
-
100%
-106
- C2 -
U203
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
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F
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-----
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---------------
P
I
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L
I
R
A
P
--------------------------------------------------------------------------------------------------
204
-
100%
-109
- C2 -
U204
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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-----
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---------------
P
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D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
205
-
100%
-106
- C2 -
U205
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
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I
H
P
S
C
V
T
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Q
K
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Y
-----
T
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--
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F
G
L
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V
L
---------------
P
I
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W
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A
P
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A
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Y
R
K
F
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A
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K
F
A
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I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
206
-
100%
-109
- C2 -
U206
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
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H
P
S
C
V
T
R
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Y
-----
T
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--
F
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N
L
V
C
K
V
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F
G
L
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V
L
---------------
P
I
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W
T
A
P
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A
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Y
R
K
F
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K
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A
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I
V
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I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
207
-
100%
-109
- C2 -
U207
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
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H
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S
C
V
T
R
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F
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Y
-----
T
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S
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K
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--
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-
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N
S
N
L
V
C
K
V
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D
F
G
L
S
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V
L
---------------
P
I
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W
T
A
P
E
A
I
S
Y
R
K
F
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A
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K
F
A
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I
V
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I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
208
-
100%
-106
- C2 -
U208
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
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F
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Y
-----
T
S
S
G
K
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A
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--
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-
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P
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Y
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A
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M
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N
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N
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N
L
V
C
K
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D
F
G
L
S
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V
L
---------------
P
I
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W
T
A
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A
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Y
R
K
F
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F
A
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V
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I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
209
-
100%
-109
- C2 -
U209
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
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L
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F
T
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H
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C
V
T
R
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-----
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--
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N
L
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F
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L
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V
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---------------
P
I
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W
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A
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F
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I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
210
-
100%
-116
- C2 -
U210
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
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---
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N
L
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F
G
L
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V
L
-----------
G
G
K
I
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A
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D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
211
-
99%
-105
- C2 -
U211
1
B:
[602-872]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
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I
H
P
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C
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T
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Q
K
V
I
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A
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-----
V
A
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K
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A
--------
D
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L
S
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V
I
---------------
P
I
R
W
T
A
P
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F
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A
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A
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R
P
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A
D
I
V
S
I
L
D
--------------------------------------------------------------------------------------------------------
212
-
100%
-109
- C2 -
U212
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
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L
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F
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C
V
T
R
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-----
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N
S
N
L
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F
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L
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---------------
P
I
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W
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A
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L
I
R
A
P
--------------------------------------------------------------------------------------------------
213
-
100%
-116
- C2 -
U213
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
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V
T
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V
L
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D
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--------
G
G
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L
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A
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S
L
K
T
L
A
-------------------------------------------------------------------------------------------
214
-
100%
-106
- C2 -
U214
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
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L
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F
T
T
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I
H
P
S
C
V
T
R
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-----
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M
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L
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L
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A
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A
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L
V
C
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D
F
G
L
S
R
V
L
---------------
P
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M
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K
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A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
215
-
100%
-109
- C2 -
U215
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
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L
K
F
T
T
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H
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V
T
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-----
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---------------
P
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Y
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K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
216
-
100%
-106
- C2 -
U216
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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L
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F
T
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V
T
R
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-----
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---------------
P
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K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
217
-
100%
-106
- C2 -
U217
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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F
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---------------
P
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L
I
R
A
P
--------------------------------------------------------------------------------------------------
218
-
100%
-116
- C2 -
U218
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
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-----------
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T
L
A
-------------------------------------------------------------------------------------------
219
-
100%
-106
- C2 -
U219
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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---------------
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L
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A
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--------------------------------------------------------------------------------------------------
220
-
100%
-109
- C2 -
U220
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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---------------
P
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L
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A
P
--------------------------------------------------------------------------------------------------
221
-
100%
-106
- C2 -
U221
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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---------------
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L
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R
A
P
--------------------------------------------------------------------------------------------------
222
-
100%
-109
- C2 -
U222
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
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---------------
P
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L
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A
P
--------------------------------------------------------------------------------------------------
223
-
99%
-105
- C2 -
U223
1
B:
[602-872]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
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---------------
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I
L
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--------------------------------------------------------------------------------------------------------
224
-
100%
-107
- C2 -
U224
1
B:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
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N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
--------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
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F
G
I
V
M
W
E
V
M
T
Y
G
E
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P
Y
W
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L
S
N
H
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V
M
K
A
I
N
D
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L
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M
D
C
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A
I
Y
Q
L
M
M
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Q
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A
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R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
225
-
100%
-106
- C2 -
U225
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
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G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
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A
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Y
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--
F
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H
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-
K
P
M
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Y
M
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G
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L
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L
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Y
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M
N
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N
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L
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N
S
N
L
V
C
K
V
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D
F
G
L
S
R
V
L
---------------
P
I
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W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
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M
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Y
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Y
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L
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N
H
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M
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A
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M
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A
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R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
226
-
100%
-120
- C2 -
U226
1
A:
[601-882]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
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F
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Y
K
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L
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-
G
K
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A
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D
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L
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L
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L
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A
A
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M
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Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
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V
M
T
Y
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L
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N
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A
I
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D
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A
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I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
----------------------------------------------------------------------------------------------
227
-
100%
-103
- C2 -
U227
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
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A
I
K
T
L
K
A
G
Y
T
E
K
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--
F
L
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A
G
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M
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H
H
N
I
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R
L
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-
K
P
M
M
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I
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M
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F
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V
L
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L
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L
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G
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A
A
G
M
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Y
L
A
N
M
N
Y
V
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D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
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M
W
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V
M
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Y
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P
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W
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L
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M
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L
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T
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C
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A
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R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
228
-
100%
-113
- C2 -
U228
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
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Y
K
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M
L
K
-
S
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G
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L
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A
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M
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Y
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A
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Y
V
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L
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A
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N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
--------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
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A
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I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
229
-
100%
-115
- C2 -
U229
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
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P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
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L
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V
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A
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L
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N
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N
L
V
C
K
V
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D
F
G
L
S
R
V
L
E
D
D
--------
G
G
K
I
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R
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L
P
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I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
230
-
100%
-120
- C2 -
U230
1
A:
[601-882]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
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-
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V
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L
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M
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A
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Y
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A
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Y
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R
D
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A
A
R
N
I
L
V
N
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N
L
V
C
K
V
S
D
F
--------------------
I
P
I
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A
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A
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F
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A
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I
L
D
K
L
I
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A
P
D
S
L
K
----------------------------------------------------------------------------------------------
231
-
99%
-105
- C2 -
U231
1
B:
[602-872]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
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I
H
P
S
C
V
T
R
Q
K
V
I
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A
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L
K
T
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-----
V
A
I
K
T
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A
--------
D
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L
S
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V
I
---------------
P
I
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W
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A
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A
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R
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F
A
D
I
V
S
I
L
D
--------------------------------------------------------------------------------------------------------
232
-
100%
-110
- C2 -
U232
1
A:
[605-885]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
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I
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A
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---
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-------
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I
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L
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A
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D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
233
-
100%
-106
- C2 -
U233
1
B:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
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I
H
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S
C
V
T
R
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F
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-----
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--
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L
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L
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V
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--------------
I
P
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I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
234
-
100%
-109
- C2 -
U234
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
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I
H
P
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C
V
T
R
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F
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-----
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--
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S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
235
-
100%
-103
- C2 -
U235
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
--
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
236
-
99%
-105
- C2 -
U236
1
B:
[602-872]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
--------
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
I
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
--------------------------------------------------------------------------------------------------------
237
-
100%
-98
- C2 -
U237
1
A:
[619-875]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
--
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
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G
V
I
S
K
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
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K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
---
T
Y
T
T
S
G
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
-----------------------------------------------------------------------------------------------------
238
-
100%
-103
- C2 -
U238
1
A:
[597-878]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
V
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
-----
T
S
S
G
K
K
E
V
P
V
A
I
K
T
L
K
A
G
Y
T
E
K
Q
R
--
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
--------------------------------------------------------------------------------------------------
239
-
100%
-115
- C2 -
U239
1
A:
[606-885]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
-
S
S
G
K
K
E
V
P
V
A
I
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T
L
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A
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Y
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F
L
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A
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M
G
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H
H
N
I
I
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L
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G
V
I
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Y
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P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
D
--------
G
G
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
-------------------------------------------------------------------------------------------
240
-
99%
-109
- C2 -
U240
1
B:
[619-876]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T
S
S
G
-----
V
A
I
K
T
L
K
A
G
-------
R
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
-
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
E
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
-------
M
K
A
I
N
-
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
----------------------------------------------------------------------------------------------------