@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ERBB2_HUMAN: (2013-07-20 )
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
Atome Classification :
(66 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720..---.....730.......740........750.......760.......770.......780.......790-.-......800.......810...---....820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.....---..980.......990..-......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVK---VLGSGAFGTVYKGIWIP-DGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTS-T-VQLVTQLMPYGCLLDHVRENRG---RLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFS---RMARDPQRFVVIQ-NED-LGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
22
PsiBlast_CBE
70.85
99%
-108
- C3 -
3PP0
1
B:
[5-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
-
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
---
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
--
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
---
R
M
A
R
D
P
Q
R
F
V
V
I
Q
-
N
E
-------
P
L
D
S
T
F
Y
R
S
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.59
99%
-111
- C3 -
3PP0
1
ERBB2_HUMAN
A:
[5-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
-
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
---
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
--
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
---
R
M
A
R
D
P
Q
R
F
V
V
I
Q
-
N
E
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
70.14
77%
-106
- C3 -
3W32
1
A:
[9-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.89
77%
-104
- C3 -
3IKA
1
EGFR_HUMAN
A:
[5-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
---------------
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
69.73
77%
-115
- C3 -
2GS7
1
B:
[9-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
---
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
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K
C
W
M
I
D
A
D
S
R
P
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F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G--------------------------
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
69.62
77%
-112
- C3 -
3W2O
1
A:
[8-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
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K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
----------------
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
69.51
77%
-114
- C3 -
3W2S
1
A:
[9-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
69.22
78%
-113
- C3 -
1M17
1
A:
[7-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
69.15
77%
-115
- C3 -
3VJN
1
A:
[9-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
69.13
77%
-116
- C3 -
3W33
1
A:
[9-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
----
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
69.08
77%
-113
- C3 -
2GS7
1
EGFR_HUMAN
A:
[11-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
----
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G--------------------------
D
V
V
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
69.02
78%
-126
- C3 -
2RGP
1
A:
[1-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-----
V
K
I
P
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
--------
N
F
Y
R
A
L
M
D
------
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
68.98
77%
-110
- C3 -
3W2P
1
A:
[8-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
--------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
68.96
77%
-105
- C3 -
2GS6
1
A:
[4-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
-------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
68.82
77%
-110
- C3 -
3W2Q
2
A:
[8-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
P
--------------
M
D
D
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
68.73
77%
-116
- C3 -
4JRV
1
?
A:
[3-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
---
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
68.63
77%
-112
- C3 -
3GT8
1
EGFR_HUMAN
C:
[7-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.62
78%
-122
- C3 -
1XKK
1
A:
[32-348]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-----
V
K
I
P
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
-------
S
N
F
Y
R
A
L
M
D
E
-----
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
68.42
74%
-110
- C3 -
3BCE
2
C:
[2-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
N
E
T
T
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
-
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
D
---
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
-
D
E
K
E
Y
N
A
D
G
-
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
---
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
-
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
68.32
77%
-111
- C3 -
3UG2
2
A:
[9-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
---------------
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
68.29
77%
-104
- C3 -
2ITO
1
A:
[1-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
---------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
68.27
77%
-116
- C3 -
4JR3
1
?
A:
[3-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
68.25
77%
-113
- C3 -
4JQ7
1
?
A:
[3-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
68.11
78%
-106
- C3 -
4I23
1
A:
[2-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
---
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
--
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
---------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
68.07
77%
-115
- C3 -
4JQ8
1
?
A:
[3-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
68.04
78%
-111
- C3 -
2R4B
1
ERBB4_HUMAN
A:
[16-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
N
------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
-
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
D
---
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
D
G
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
---
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
-
G
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
68.02
77%
-108
- C3 -
2ITT
1
A:
[2-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
---------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
67.93
78%
-107
- C3 -
3VJO
1
A:
[8-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
--
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
---
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
---------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
67.90
99%
-108
- C3 -
3RCD
1
ERBB2_HUMAN
C:
[9-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
-
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
---
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
-----------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
---
R
M
A
R
D
P
Q
R
F
V
V
I
Q
-
N
---------
L
D
S
T
F
Y
R
S
L
L
E
D
D
---
D
L
V
D
A
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
67.75
77%
-106
- C3 -
4I22
1
A:
[7-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
67.73
78%
-120
- C3 -
3BEL
1
A:
[1-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-----
V
K
I
P
V
A
I
K
E
L
------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
----------
N
F
Y
R
A
L
M
-------
V
V
D
A
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
67.73
77%
-105
- C3 -
4I24
1
EGFR_HUMAN
A:
[7-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
67.72
78%
-114
- C3 -
4HJO
1
A:
[18-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-----
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
67.72
77%
-105
- C3 -
2ITX
1
A:
[2-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
----
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
67.71
80%
-118
- C3 -
3LZB
1
EGFR_HUMAN
A:
[8-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
67.71
77%
-106
- C3 -
4G5J
3
A:
[4-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
----
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
----------
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
67.66
77%
-111
- C3 -
4G5P
1
EGFR_HUMAN
A:
[4-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-----------------------
D
V
V
D
A
D
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
67.60
77%
-117
- C3 -
3POZ
1
A:
[6-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-----
V
K
I
P
V
A
I
K
E
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
-------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
------
V
V
D
A
D
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
67.59
77%
-108
- C3 -
2ITU
1
A:
[1-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
----------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
67.58
77%
-104
- C3 -
2J6M
1
A:
[2-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
67.20
77%
-109
- C3 -
2ITN
1
A:
[1-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
---------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
-----------
L
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
67.13
77%
-110
- C3 -
2ITV
1
A:
[1-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
R
A
K
L
L
G
A
E
E
---------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
67.12
78%
-112
- C3 -
2R4B
1
B:
[16-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
T
A
P
N
Q
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
-------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
-
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
D
---
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
D
G
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
---
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
-
G
D
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
67.12
77%
-107
- C3 -
2ITP
1
A:
[2-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
------------------
M
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
67.10
80%
-115
- C3 -
3LZB
1
EGFR_HUMAN
B:
[8-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.98
99%
-109
- C3 -
3RCD
1
ERBB2_HUMAN
A:
[9-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
L
R
I
L
K
E
T
E
L
R
K
V
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
-
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
----
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
---
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
-----------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
---
R
M
A
R
D
P
Q
R
F
V
V
I
Q
-
N
---------
L
D
S
T
F
Y
R
S
L
L
E
D
D
---
D
L
V
D
A
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
66.86
77%
-108
- C3 -
2ITY
1
A:
[2-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
----------
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
-------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
66.75
77%
-108
- C3 -
2ITQ
1
A:
[2-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
S
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G-----------------------
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
66.68
77%
-101
- C3 -
4I24
1
B:
[7-321]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
-
M
H
L
P
S
P
T
D
S
N
F
Y
R
A
L
M
D
E
E
D
M
D
D
V
V
D
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
66.61
80%
-114
- C3 -
3LZB
1
EGFR_HUMAN
C:
[9-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
A
-----
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
66.15
80%
-115
- C3 -
3LZB
1
EGFR_HUMAN
D:
[8-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
----------------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
R
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
65.98
77%
-109
- C3 -
3UG1
1
A:
[9-330]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
Q
A
L
L
R
I
L
K
E
T
E
F
K
K
I
K
---
V
L
S
S
---
G
T
V
Y
K
G
L
W
I
P
-
E
G
E
K
V
K
I
P
V
A
I
K
E
-----
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
-
T
-
V
Q
L
I
M
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
K
D
---
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
E
Y
H
A
E
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
---
K
M
A
R
D
P
Q
R
Y
L
V
I
Q
G
D
-------------------
D
E
E
D
M
D
D
V
V
D
A
D
E
Y
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
65.22
74%
-118
- C3 -
3BBT
1
ERBB4_HUMAN
B:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
-
E
G
E
T
V
K
I
P
V
A
I
K
I
L
N
E
--
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
-
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
D
---
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
--------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
---
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
--
D
D
R
M
K
L
P
S
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
65.11
74%
-118
- C3 -
3BBT
1
D:
[8-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
R
I
L
K
E
T
E
L
K
R
V
K
---
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
---
E
T
V
K
I
P
V
A
I
K
I
L
N
E
---
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
L
S
P
-
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
H
K
D
---
N
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
----------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
---
R
M
A
R
D
P
Q
R
Y
L
V
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
63.08
60%
-115
- C3 -
3LMG
1
ERBB3_HUMAN
A:
[23-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
---
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
P
-
E
G
E
S
I
K
I
P
V
C
I
K
V
I
E
D
K
---
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
P
G
S
-
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
G
---
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
D
---------
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
61.84
60%
-117
- C3 -
3LMG
1
B:
[23-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
R
I
F
K
E
T
E
L
R
K
L
K
---
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
P
--
G
E
S
I
K
I
P
V
C
I
K
V
I
E
D
K
S
--
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
P
G
S
-
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
G
---
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
D
K
---------
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
61.38
60%
-113
- C3 -
3KEX
1
ERBB3_HUMAN
A:
[4-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
A
--
R
I
F
K
E
T
E
L
R
K
L
K
---
V
L
G
S
G
V
F
G
T
V
H
K
G
V
W
I
P
-
E
G
E
S
I
K
I
P
V
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
P
G
S
-
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
H
R
G
---
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
D
K
Q
L
L
-----
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
---
R
M
A
R
D
P
P
R
Y
L
V
I
K
-
R
E
S
--
G
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
57.85
34%
-93
- C3 -
4AOJ
1
NTRK1_HUMAN
A:
[38-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
R
D
I
V
L
K
W
---
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
---
K
M
L
V
A
V
K
A
L
K
E
A
-
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
-
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
DPG
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
---
A
L
A
Q
A
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
57.60
38%
-94
- C3 -
4BB4
1
A:
[9-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
-
P
G
K
K
E
S
C
-
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
-
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
---
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
------------
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
---
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
57.09
39%
-99
- C3 -
3H3C
1
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
--
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
-
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
---
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
---------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
56.41
41%
-98
- C3 -
4FYO
1
A:
[23-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
---
K
K
V
V
K
T
V
A
V
K
I
L
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
-
R
---
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
---
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
---
N
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
56.38
38%
-86
- C3 -
2XVD
1
A:
[10-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
K
A
-
P
G
K
K
E
S
C
-
V
A
I
K
T
L
---
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
-
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
N
D
G
---
Q
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
F
L
E
------
S
S
L
G
G
K
I
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
---
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
56.13
39%
-94
- C3 -
3FZR
1
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
--
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
-
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
---
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
-------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
56.04
39%
-98
- C3 -
3FZP
1
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
--
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
-
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
---
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
----------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
56.04
39%
-92
- C3 -
3FZT
1
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
--
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
-
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
---
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
----
D
E
---------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
53.62
39%
-95
- C3 -
3ET7
1
A:
[14-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
--
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
-
P
-
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
---
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
-------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Add PDB User Result:
(46 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
139
-
100%
-115
- C3 -
U139
1
A:
[696-993]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
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K
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I
W
I
P
D
G
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N
V
K
I
P
V
A
I
K
V
L
R
------
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
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L
L
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L
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G
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L
L
D
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V
R
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N
R
G
R
L
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D
L
L
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W
C
M
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I
A
K
G
M
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Y
L
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V
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L
V
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L
A
A
R
N
V
L
V
K
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N
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V
K
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D
F
G
L
A
R
L
L
D
I
D
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T
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Y
H
A
D
G
G
K
V
P
I
K
W
M
A
L
E
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I
L
R
R
R
F
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V
W
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Y
G
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T
V
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L
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A
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D
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I
P
A
R
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D
L
L
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G
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L
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P
P
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C
T
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V
Y
M
I
M
V
K
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W
M
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R
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L
V
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R
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A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
-
100%
-115
- C3 -
U140
1
A:
[696-993]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
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L
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K
V
K
V
L
G
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G
A
F
G
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P
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G
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N
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P
V
A
I
K
V
L
R
------
A
N
K
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L
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A
Y
V
M
A
G
V
G
S
P
Y
V
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R
L
L
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L
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L
V
T
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L
M
P
Y
G
C
L
L
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V
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N
R
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L
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D
L
L
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W
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M
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A
K
G
M
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Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
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L
A
R
L
L
D
I
D
E
T
E
Y
H
A
D
G
G
K
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K
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L
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L
R
R
R
F
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L
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A
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L
L
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K
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L
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P
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Y
M
I
M
V
K
C
W
M
I
D
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C
R
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R
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L
V
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F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
-
100%
-116
- C3 -
U141
1
A:
[711-991]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
----
V
K
I
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K
V
L
R
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N
T
S
P
K
A
N
K
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I
L
D
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A
Y
V
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A
G
V
G
S
P
Y
V
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L
L
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L
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T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
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V
R
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N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
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I
A
K
G
M
S
Y
L
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D
V
R
L
V
H
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L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
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L
L
D
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D
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T
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Y
H
A
D
G
G
K
V
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W
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A
L
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L
R
R
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F
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Y
G
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L
M
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F
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A
K
P
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D
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D
L
L
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L
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Y
M
I
M
V
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C
W
M
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R
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L
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S
E
F
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R
M
A
R
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P
Q
R
F
V
V
I
Q
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
-
100%
-111
- C3 -
U142
1
A:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
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N
V
K
I
P
V
A
I
K
V
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
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C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
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N
R
G
R
L
G
S
Q
D
L
L
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W
C
M
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A
K
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M
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Y
L
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V
R
L
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L
A
A
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N
V
L
V
K
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P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-------------
V
P
I
K
W
M
A
L
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S
I
L
R
R
R
F
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L
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L
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L
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L
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Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
-
100%
-126
- C3 -
U143
1
A:
[710-1025]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
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V
Y
K
G
I
W
I
P
----
V
K
I
P
V
A
I
K
V
L
R
E
----
K
A
N
K
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L
D
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A
Y
V
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A
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L
L
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C
L
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L
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Q
L
M
P
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G
C
L
L
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L
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D
L
L
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W
C
M
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A
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L
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L
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R
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L
A
A
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N
V
L
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P
N
H
V
K
I
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D
F
G
L
A
R
L
L
D
I
D
E
T
--------
V
P
I
K
W
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A
L
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S
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L
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R
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F
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L
L
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A
R
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P
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R
F
V
V
I
Q
N
E
D
L
-------
S
T
F
Y
R
S
L
L
E
D
-----
L
V
D
A
E
E
Y
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
-
100%
-108
- C3 -
U144
1
B:
[706-1009]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
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G
A
F
G
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G
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L
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L
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L
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D
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Y
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A
--
G
K
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K
W
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L
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L
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R
R
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V
I
Q
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------
P
L
D
S
T
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Y
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S
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
-
100%
-108
- C3 -
U145
1
B:
[706-1009]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
N
Q
A
Q
M
R
I
L
K
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T
E
L
R
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V
K
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G
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--
G
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------
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L
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S
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
-
100%
-105
- C3 -
U146
1
B:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
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H
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K
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D
F
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L
A
R
L
L
D
-----------
K
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K
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L
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R
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D
D
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D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
-
100%
-105
- C3 -
U147
1
B:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
S
P
L
D
S
T
F
Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
-
100%
-124
- C3 -
U148
1
A:
[710-1022]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
----
V
K
I
P
V
A
I
K
V
L
------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
--------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
---------
T
F
Y
R
S
L
L
-------
L
V
D
A
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
-
100%
-105
- C3 -
U149
1
B:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
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Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
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D
V
Y
M
I
M
V
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C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
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F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
S
P
L
D
S
T
F
Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
-
100%
-105
- C3 -
U150
1
B:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
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V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
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C
L
T
S
T
V
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L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
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N
R
G
R
L
G
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L
L
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W
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M
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I
A
K
G
M
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Y
L
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V
R
L
V
H
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D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
-----------
K
V
P
I
K
W
M
A
L
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S
I
L
R
R
R
F
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H
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V
W
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Y
G
V
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L
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A
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A
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L
L
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K
G
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L
P
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P
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Y
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I
M
V
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C
W
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I
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L
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F
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R
M
A
R
D
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F
V
V
I
Q
N
E
D
L
G
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A
S
P
L
D
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F
Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
-
100%
-115
- C3 -
U151
1
A:
[709-1026]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
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Y
K
G
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A
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V
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A
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V
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P
Y
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L
L
G
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C
L
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S
T
V
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L
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P
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G
C
L
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L
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D
L
L
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C
M
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I
A
K
G
M
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Y
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D
V
R
L
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D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
------------
K
V
P
I
K
W
M
A
L
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S
I
L
R
R
R
F
T
H
Q
S
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W
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L
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A
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W
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A
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L
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L
E
D
D
D
M
G
D
L
V
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
-
100%
-115
- C3 -
U152
1
A:
[709-1026]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
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Y
K
G
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W
I
P
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G
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N
V
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I
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I
K
V
L
R
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N
T
S
P
K
A
N
K
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I
L
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A
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A
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V
G
S
P
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S
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L
L
G
I
C
L
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S
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V
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L
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T
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L
M
P
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G
C
L
L
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V
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N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
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Y
L
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D
V
R
L
V
H
R
D
L
A
A
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N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
------------
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
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G
V
T
V
W
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L
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A
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L
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A
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V
I
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N
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D
L
G
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A
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L
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F
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S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
-
100%
-118
- C3 -
U153
1
D:
[711-990]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
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Y
K
G
I
W
I
P
D
G
E
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V
K
I
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V
A
I
K
V
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
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A
G
V
G
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P
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L
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C
L
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T
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L
L
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L
V
K
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N
H
V
K
I
T
D
F
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L
----------------
K
V
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I
K
W
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A
L
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I
L
R
R
R
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S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
-
100%
-115
- C3 -
U154
1
A:
[696-993]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
A
M
P
N
Q
A
Q
M
R
I
L
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I
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A
I
K
V
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------
A
N
K
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I
L
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A
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A
G
V
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A
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D
P
Q
R
F
V
V
I
Q
N
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
-
100%
-119
- C3 -
U155
1
A:
[704-1026]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
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M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
---------------------
D
M
G
D
L
V
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
-
100%
-121
- C3 -
U156
1
A:
[709-1024]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
----
V
K
I
P
V
A
I
K
V
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
-------
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
S
P
L
D
S
T
F
Y
R
S
L
L
E
------
L
V
D
A
E
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
-
100%
-107
- C3 -
U157
1
A:
[704-1027]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
D
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
---------------
D
D
D
M
G
D
L
V
D
A
E
E
Y
L
V
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
-
100%
-129
- C3 -
U158
1
A:
[710-1023]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
----
V
K
I
P
V
A
I
K
V
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
--------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
--------
T
F
Y
R
S
L
L
E
------
L
V
D
A
E
E
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
-
100%
-121
- C3 -
U159
1
A:
[709-1024]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
----
V
K
I
P
V
A
I
K
V
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
-------
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
S
P
L
D
S
T
F
Y
R
S
L
L
E
------
L
V
D
A
E
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
-
100%
-111
- C3 -
U160
1
A:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
S
P
L
D
S
T
F
Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
-
100%
-115
- C3 -
U161
1
A:
[696-993]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
------
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
D
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
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Q
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D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
-
100%
-115
- C3 -
U162
1
A:
[696-993]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
------
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
D
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
-
100%
-121
- C3 -
U163
1
A:
[709-1024]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
----
V
K
I
P
V
A
I
K
V
L
-------
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
-------
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
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S
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Y
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L
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F
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A
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P
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D
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I
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A
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E
I
P
D
L
L
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K
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E
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L
P
Q
P
P
I
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T
I
D
V
Y
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I
M
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C
W
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I
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P
R
F
R
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V
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M
A
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F
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V
I
Q
N
E
D
L
G
P
A
S
P
L
D
S
T
F
Y
R
S
L
L
E
------
L
V
D
A
E
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
-
100%
-116
- C3 -
U164
1
A:
[711-991]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
----
V
K
I
P
V
A
I
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V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
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A
G
V
G
S
P
Y
V
S
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L
L
G
I
C
L
T
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T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
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N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
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G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
D
G
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
-
100%
-126
- C3 -
U165
1
A:
[710-1025]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
----
V
K
I
P
V
A
I
K
V
L
R
E
----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
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N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
--------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
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I
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S
E
C
R
P
R
F
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E
L
V
S
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S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
-------
S
T
F
Y
R
S
L
L
E
D
-----
L
V
D
A
E
E
Y
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
-
100%
-108
- C3 -
U166
1
B:
[706-1009]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
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N
V
K
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K
V
L
R
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T
S
P
K
A
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L
D
E
A
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V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
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V
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N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
--
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
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D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
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A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
------
P
L
D
S
T
F
Y
R
S
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
-
100%
-111
- C3 -
U167
1
A:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
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L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
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D
V
R
L
V
H
R
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L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
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C
R
P
R
F
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L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
S
P
L
D
S
T
F
Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
-
100%
-119
- C3 -
U168
1
A:
[704-1026]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
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N
V
K
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P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
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T
V
Q
L
V
T
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L
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G
C
L
L
D
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V
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E
N
R
G
R
L
G
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D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
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L
L
D
I
D
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Y
H
A
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G
G
K
V
P
I
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A
L
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L
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Y
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V
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T
F
G
A
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P
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I
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L
L
E
K
G
E
R
L
P
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P
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I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
---------------------
D
M
G
D
L
V
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
-
100%
-108
- C3 -
U169
1
B:
[706-1009]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
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N
V
K
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I
K
V
L
R
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N
T
S
P
K
A
N
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E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
--
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
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A
R
E
I
P
D
L
L
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K
G
E
R
L
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Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
------
P
L
D
S
T
F
Y
R
S
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
-
100%
-105
- C3 -
U170
1
B:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
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A
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D
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I
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A
R
E
I
P
D
L
L
E
K
G
E
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L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
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F
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E
L
V
S
E
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R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
S
P
L
D
S
T
F
Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
-
100%
-124
- C3 -
U171
1
A:
[710-1022]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
----
V
K
I
P
V
A
I
K
V
L
------
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
--------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
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Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
---------
T
F
Y
R
S
L
L
-------
L
V
D
A
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
-
100%
-105
- C3 -
U172
1
B:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
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I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
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W
C
M
Q
I
A
K
G
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Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
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H
Q
S
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V
W
S
Y
G
V
T
V
W
E
L
M
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A
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P
D
L
L
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G
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I
C
T
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Y
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I
M
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W
M
I
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S
E
C
R
P
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F
R
E
L
V
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M
A
R
D
P
Q
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F
V
V
I
Q
N
E
D
L
G
P
A
S
P
L
D
S
T
F
Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
-
100%
-105
- C3 -
U173
1
B:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
E
N
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
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V
R
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N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
-----------
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
P
A
S
P
L
D
S
T
F
Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
-
100%
-115
- C3 -
U174
1
A:
[696-993]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
E
P
L
T
P
S
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
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W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
------
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
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T
V
Q
L
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P
Y
G
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L
L
D
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V
R
E
N
R
G
R
L
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Q
D
L
L
N
W
C
M
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A
K
G
M
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L
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L
A
A
R
N
V
L
V
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N
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V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
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Y
H
A
D
G
G
K
V
P
I
K
W
M
A
L
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I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
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T
F
G
A
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P
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I
P
A
R
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I
P
D
L
L
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L
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Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
-
100%
-119
- C3 -
U175
1
A:
[704-1026]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
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G
A
F
G
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V
Y
K
G
I
W
I
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T
S
P
K
A
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D
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A
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A
G
V
G
S
P
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L
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L
V
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L
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P
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L
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R
G
R
L
G
S
Q
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L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
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V
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L
V
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R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
D
G
G
K
V
P
I
K
W
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A
L
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S
I
L
R
R
R
F
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Y
G
V
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V
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L
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F
G
A
K
P
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L
L
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K
G
E
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L
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T
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V
Y
M
I
M
V
K
C
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R
P
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F
R
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L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
---------------------
D
M
G
D
L
V
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
-
100%
-111
- C3 -
U176
1
A:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
-----
K
A
N
K
E
I
L
D
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A
Y
V
M
A
G
V
G
S
P
Y
V
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L
L
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T
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L
M
P
Y
G
C
L
L
D
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V
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N
R
G
R
L
G
S
Q
D
L
L
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W
C
M
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I
A
K
G
M
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Y
L
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D
V
R
L
V
H
R
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L
A
A
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N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
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F
G
A
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D
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I
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A
R
E
I
P
D
L
L
E
K
G
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L
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P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
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S
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C
R
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R
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L
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F
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A
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F
V
V
I
Q
N
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D
L
G
P
A
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P
L
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T
F
Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
-
100%
-116
- C3 -
U177
1
A:
[711-991]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
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Y
K
G
I
W
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P
----
V
K
I
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V
A
I
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V
L
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N
T
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K
A
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I
L
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A
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A
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P
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L
L
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C
L
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L
L
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L
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L
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P
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V
Y
M
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M
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C
W
M
I
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R
P
R
F
R
E
L
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E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
-
100%
-119
- C3 -
U178
1
A:
[704-1026]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
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N
V
K
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N
T
S
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A
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L
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E
A
Y
V
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A
G
V
G
S
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Y
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R
L
L
G
I
C
L
T
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T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
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V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
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V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
D
I
D
E
T
E
Y
H
A
D
G
G
K
V
P
I
K
W
M
A
L
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I
L
R
R
R
F
T
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W
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Y
G
V
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V
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L
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L
L
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K
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L
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Y
M
I
M
V
K
C
W
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I
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C
R
P
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F
R
E
L
V
S
E
F
S
R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
---------------------
D
M
G
D
L
V
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
-
100%
-111
- C3 -
U179
1
A:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
I
C
L
T
S
T
V
Q
L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
V
R
E
N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
I
P
A
R
E
I
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D
L
L
E
K
G
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L
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I
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D
V
Y
M
I
M
V
K
C
W
M
I
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S
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C
R
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F
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L
V
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M
A
R
D
P
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V
I
Q
N
E
D
L
G
P
A
S
P
L
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Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
-
100%
-104
- C3 -
U180
1
A:
[724-982]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
-
D
G
E
N
V
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I
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V
A
I
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V
L
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N
T
S
P
K
A
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L
D
E
A
Y
V
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A
G
V
G
S
P
Y
V
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R
L
L
G
I
C
L
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T
V
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L
V
T
Q
L
M
P
Y
G
C
L
L
D
H
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N
R
G
R
L
G
S
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D
L
L
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W
C
M
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
-------------
G
K
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
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L
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F
G
A
K
P
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D
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I
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A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
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I
C
T
I
D
V
Y
M
I
M
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C
W
M
I
D
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C
R
P
R
F
R
E
L
V
S
E
F
S
R
M
A
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
-
100%
-111
- C3 -
U181
1
A:
[708-1021]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
I
P
D
G
E
N
V
K
I
P
V
A
I
K
V
L
R
-----
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
S
P
Y
V
S
R
L
L
G
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C
L
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L
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T
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L
M
P
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G
C
L
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N
R
G
R
L
G
S
Q
D
L
L
N
W
C
M
Q
I
A
K
G
M
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Y
L
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D
V
R
L
V
H
R
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L
A
A
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N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
-------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
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D
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W
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Y
G
V
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A
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A
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L
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Y
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I
M
V
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C
W
M
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D
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F
V
V
I
Q
N
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L
G
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A
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P
L
D
S
T
F
Y
R
S
L
L
E
D
D
D
M
G
D
L
V
D
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
-
100%
-119
- C3 -
U182
1
A:
[704-1026]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
S
G
A
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V
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Q
N
---------------------
D
M
G
D
L
V
D
A
E
E
Y
L
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
-
100%
-121
- C3 -
U183
1
A:
[709-1024]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
K
V
L
G
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----
V
K
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-------
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L
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L
L
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------
L
V
D
A
E
E
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
-
100%
-107
- C3 -
U184
1
A:
[704-1027]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
M
P
N
Q
A
Q
M
R
I
L
K
E
T
E
L
R
K
V
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R
M
A
R
D
P
Q
R
F
V
V
I
Q
N
E
D
L
G
---------------
D
D
D
M
G
D
L
V
D
A
E
E
Y
L
V
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------