@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GRK5_HUMAN: (2013-07-20 )
MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
Atome Classification :
(54 SA)
.........10........20....---....30........40........50.....--...60........70-----........80........90-.--.......100.......110.......120.......130.......-140.......150.......160.......170.......-180.......190.......200...---..-----..----210.......220.......230.....-..240-..---......250.......260.......270.......--280.......290.......300...-....310......---.320.......330...-.-...-340.....----...350......-.360.......370.......380.......390.......400...----....410.......420.......430.......440........450.......460.......470.......480..--.....490.......500.......510.......520.......530......-.540.......550.......560.......570.......580.......590
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELENIVANTVLLKAREGGGGKRKG---KSKKWKEILKFPHISQCEDLRRTIDRDYCSL--CDKQPIGRLLFRQFC-----ETRPGLECYIQFLDSVAEYE-V--TPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCK-ELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ-PVTKNTFRQYRVLGKGGFGEVCACQV---RA-----TG----KMYACKRLEKKRIKKRKGESMALNEKQI-LEK-V-NS---QFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMG--NPGFEEERALFYAAEILCGLEDLHRE-NTVYRDLKPENIL---LDDYGHIRISDLGLAVK-I-PEG-DL-IRGRV----GTVGYMAPEVLN-NQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETE----EVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAE-VKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFS--TVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLN-RNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
109
Fugue
91.72
69%
-101
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
--------------------
K
A
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
----
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
-------------------
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-----------------------------------------------------------
10
PsiBlast_CBE
91.33
71%
-100
- C1 -
2ACX
1
GRK6_HUMAN
B:
[14-535]
-------------
K
A
R
-------
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
----
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
---
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
----
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
--------------------
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
--------------------------------------------------------
15
PsiBlast_CBE
84.77
47%
-94
- C1 -
3C4W
1
RK_BOVIN
B:
[9-533]
-----
V
V
A
N
S
A
F
I
A
A
R
-
G
S
F
D
A
S
S
G
PAS
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
------
D
-
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
---
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
----
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
----------
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
13
PsiBlast_CBE
84.40
47%
-97
- C1 -
3C50
1
RK_BOVIN
B:
[30-533]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
----
A
G
D
-
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
---
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
----
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
--------
F
S
--
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
14
PsiBlast_CBE
84.29
47%
-102
- C1 -
3C4X
1
RK_BOVIN
B:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
-------------
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
---
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
----
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
----------------------
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
110
Fugue
83.21
48%
-98
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
---
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
Q
T
K
-
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
----
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
-------
G
--
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
4
PsiBlast_PDB
83.03
47%
-95
- C1 -
3C4X
1
RK_BOVIN
A:
[30-533]
-------------------------S--
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
----
A
G
D
-
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
---
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
----
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
--------
I
Q
D
V
G
A
F
S
--
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
8
PsiBlast_PDB
82.54
47%
-98
- C1 -
3C4W
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
----
A
G
D
-
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
---
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
----
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
---------
Q
D
V
G
A
F
S
--
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
7
PsiBlast_PDB
81.38
47%
-95
- C1 -
3C51
1
RK_BOVIN
A:
[31-533]
----------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
--
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
-----
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
-
T
--
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
--------
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
-
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
---
K
A
-----
T
G
----
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
K
-
V
-
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
---
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
-
K
A
G
-
Q
T
K
T
K
G
Y
A
----
G
T
P
G
F
M
A
P
E
L
L
L
-
G
E
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
A
----
V
T
Y
P
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
G
S
C
D
G
-
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
-------------
S
--
T
V
K
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
--------------------------------------------------------------
25
PsiBlast_CBE
71.52
37%
-90
- C1 -
3PVU
1
ARBK1_BOVIN
A:
[30-531]
-------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
-
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
KHLE
E
A
K
P
----
L
V
E
F
Y
E
E
I
K
K
Y
E
-
K
LE
T
E
E
E
R
L
V
-
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
-
L
S
L
-
V
-
S
T
GDC
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
---
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
-
K
--
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
----
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
------------------------
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
-----------------------------------------------------------------
24
PsiBlast_CBE
70.82
37%
-86
- C1 -
3PVW
1
ARBK1_BOVIN
A:
[29-531]
------------------------------
S
K
-
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
-
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
KHLE
E
A
K
P
----
L
V
E
F
Y
E
E
I
K
K
Y
E
-
K
LE
T
E
E
E
R
L
V
-
C
S
R
E
I
F
D
T
Y
I
M
K
E
L
L
A
C
S
H
P
F
S
K
S
A
I
E
H
V
Q
G
H
L
V
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
-
L
S
L
-
V
-
S
T
GDC
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
---
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
-
K
--
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
H
-
E
I
D
R
M
T
L
T
M
A
----
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
G
---------------------
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
-----------------------------------------------------------------
21
PsiBlast_CBE
70.53
37%
-85
- C1 -
3KRW
1
ARBK1_HUMAN
A:
[29-530]
-------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
-
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
NHLE
E
A
R
P
----
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
--
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
--
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
-
L
S
L
-
V
-
S
T
GDC
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
---
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
-
K
--
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
----
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------EE
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
-----------------------------------------------------------------
20
PsiBlast_CBE
69.81
37%
-83
- C1 -
3KRX
1
ARBK1_HUMAN
A:
[29-530]
-------------------------------
K
-
K
I
L
L
P
E
P
S
I
R
S
V
M
Q
-
K
Y
L
E
D
R
G
E
V
T
F
E
K
I
F
S
Q
K
L
G
Y
L
L
F
R
D
F
C
L
NHLE
E
A
R
P
----
L
V
E
F
Y
E
E
I
K
K
Y
E
K
L
--
E
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
K
E
L
L
A
--
H
P
F
S
K
S
A
T
E
H
V
Q
G
H
L
G
K
K
Q
V
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
K
F
T
R
F
C
Q
W
K
N
V
E
L
N
I
H
L
T
M
N
D
F
S
V
H
R
I
I
G
R
G
G
F
G
E
V
Y
G
C
R
K
---
A
D
-----
T
G
----
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
K
Q
G
E
T
L
A
L
N
E
R
I
M
-
L
S
L
-
V
-
S
T
GDC
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
L
D
L
M
N
G
G
D
L
H
Y
H
L
S
Q
H
G
--
V
--
F
S
E
A
D
M
R
F
Y
A
A
E
I
I
L
G
L
E
H
M
H
N
R
-
F
V
V
Y
R
D
L
K
P
A
N
I
L
---
L
D
E
H
G
H
V
R
I
S
D
L
G
L
A
C
D
-
F
-
S
K
K
-
K
--
P
H
A
S
V
----
G
T
H
G
Y
M
A
P
E
V
L
Q
K
G
V
A
Y
D
S
S
A
D
W
F
S
L
G
C
M
L
F
K
L
L
R
G
H
S
P
F
R
Q
H
K
T
K
D
K
-
H
E
I
D
R
M
T
L
T
M
A
----
V
E
L
P
D
S
F
S
P
E
L
R
S
L
L
E
G
L
L
Q
R
D
V
N
R
R
L
G
C
L
G
R
G
A
Q
E
-
V
K
E
S
P
F
F
R
S
L
D
W
Q
M
V
F
L
Q
K
Y
P
P
P
L
I
P
P
R
---------------EE
D
T
K
G
I
K
L
L
D
S
D
Q
E
L
Y
R
N
F
P
L
-
T
I
S
E
R
W
Q
Q
E
V
A
E
T
-
V
F
D
T
I
N
A
-----------------------------------------------------------------
11
PsiBlast_CBE
63.61
72%
25
- C1 -
3NYO
2
GRK6_HUMAN
B:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
----
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
----------------------------------
2
PsiBlast_PDB
62.88
72%
29
- C1 -
3NYN
2
GRK6_HUMAN
A:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
----
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
----------------------------------
3
PsiBlast_PDB
62.73
72%
30
- C1 -
3NYO
2
GRK6_HUMAN
A:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
----
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
----------------------------------
12
PsiBlast_CBE
62.49
72%
31
- C1 -
3NYN
2
GRK6_HUMAN
B:
[4-557]
-
E
L
E
N
I
V
A
N
T
V
L
L
K
A
R
E
G
G
G
G
N
R
K
G
---
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
--
C
E
R
Q
P
I
G
R
L
L
F
R
E
F
C
-----
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
-
V
--
T
P
D
D
K
R
K
A
C
G
R
Q
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
-
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
---
R
A
-----
T
G
----
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
-
L
E
K
-
V
-
N
S
---
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
--
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
-
V
-
P
E
G
-
Q
T
-
I
K
G
R
V
----
G
T
V
G
Y
M
A
P
E
V
V
K
-
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
----
E
E
Y
S
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
G
S
A
R
E
-
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
K
D
V
L
D
I
E
Q
F
S
--
T
V
K
G
V
E
L
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
V
P
P
D
L
D
W
K
G
Q
P
P
A
P
P
K
K
G
L
L
Q
R
L
F
S
----------------------------------
84
HHSearch
57.71
41%
-97
- C1 -
4GV1
5
AKT1_HUMAN
A:
[3-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
---------------------------------------------------------------------------------------------------------------------------
92
HHSearch
56.42
42%
-98
* C1 *
1O6L
1
AKT2_HUMAN
A:
[2-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
N
-
T
-
R
H
---
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
S
D
G
-
A
T
-
M
K
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
----
H
E
R
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
-
V
M
E
H
R
F
F
L
S
I
N
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
---------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
51.18
38%
-88
- C1 -
3TXO
1
A:
[23-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
E
-----
T
G
----
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
-
L
S
L
-
A
R
N
H
---
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
----
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
---
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
-
C
---------------
G
T
P
D
Y
I
A
P
E
I
L
Q
-
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
E
N
E
----
D
D
L
F
E
A
I
L
N
D
E
----
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
50.70
37%
-97
- C1 -
3G51
1
KS6A3_MOUSE
A:
[24-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
----------
I
-
L
V
E
-
V
-
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
------------------
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
50.43
32%
-92
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[27-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
----
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
50.43
32%
-90
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[27-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
----
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
49.87
38%
-99
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[30-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
------------------
I
-
L
A
D
-
V
-
N
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
----
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
49.76
37%
-93
- C1 -
3A61
1
KS6B1_HUMAN
A:
[19-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
V
T
GAN
T
G
----
K
I
F
A
M
K
V
L
K
--------------
A
E
R
N
I
-
L
E
E
-
V
-
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
Q
G
H
V
K
L
T
D
F
G
-----------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
90
HHSearch
49.64
38%
-91
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[21-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
-----
A
R
----
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
-
R
V
------
D
I
-
L
V
E
-
V
-
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
----
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
------
E
-
K
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
D
----
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
94
HHSearch
49.42
39%
-101
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
-
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
-
V
-
K
H
---
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
----
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
-
N
I
E
H
N
-
S
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
----
T
A
E
M
Y
D
N
I
L
N
K
P
----
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
---------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
49.19
32%
-91
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[27-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
W
T
LC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
----
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
49.10
31%
-89
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[16-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
----
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
49.08
31%
-86
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[16-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
----
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
49.03
31%
-83
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[16-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
----
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
48.99
31%
-82
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[16-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
-
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
WTLC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
----
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
48.64
37%
-88
- C1 -
3A60
1
KS6B1_HUMAN
A:
[19-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
V
T
GAN
T
G
----
K
I
F
A
M
K
V
L
K
K
A
M
----------
K
A
E
R
N
I
-
L
E
E
-
V
-
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
--------------------
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
48.14
38%
-101
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[30-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
-------------------
I
-
L
A
D
-
V
-
N
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
----
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
48.12
32%
-90
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[27-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
-----
T
G
----
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
-
V
-
N
F
---
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----------
V
K
G
R
T
W
T
LC
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
----
Q
I
Y
E
K
I
V
S
G
K
----
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
-
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
46.96
38%
-90
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[30-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
---
V
T
RPD--
S
G
----
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
------------
I
-
L
A
D
-
V
-
N
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------------------
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
L
I
L
K
A
K
----
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
P
D
G
A
E
E
-
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
46.91
37%
-88
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[25-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
R
------
D
I
-
L
V
E
-
V
-
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S----
E
-
K
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
46.48
37%
-85
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[25-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
----
K
I
-----
S
G
SDAR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
D
R
V
----------
L
V
E
-
V
-
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
----
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
---
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-------
K
K
-
A
Y
S
F
C
----
G
T
V
E
Y
M
A
P
E
V
V
N
-
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
K
----
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
P
D
G
V
E
E
-
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
46.32
37%
-93
- C1 -
3A60
1
KS6B1_HUMAN
B:
[19-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
--
Q
V
---
R
K
VTGAN
T
G
----
K
I
F
A
M
K
V
L
K
K
-------------------------
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
--
I
--
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
---
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S-------------
C
----
G
T
I
E
Y
M
A
P
E
I
L
M
-
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
C
K
----
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
G
D
A
G
E
-
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-----
L
------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
45.94
38%
-90
- C1 -
3HDN
1
SGK1_HUMAN
A:
[40-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
-
L
L
K
N
V
-
K
H
---
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
-
S
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
----
P
----
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
D
D
-
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
45.50
38%
-86
- C1 -
3HDM
1
SGK1_HUMAN
A:
[40-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
-----
E
E
----
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
-------------
V
-
L
L
K
N
V
-
K
H
---
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
--
Q
R
--
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
---
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
-
S
T
-
T
S
T
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
H
-
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
----
P
----
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
D
D
-
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
-----------------------------------------------------------------------------------------------------------------------------
103
HHSearch
41.07
31%
-99
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
K
Q
A
E
-
D
I
-
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
---
K
R
-----
T
Q
----
K
L
V
A
I
K
C
I
A
-----------
S
M
E
N
E
I
A
V
-
L
H
K
-
I
-
K
H
---
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
----
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
-
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
K
M
-
E
-
D
P
G
--------------
T
P
G
Y
V
A
P
E
V
L
A
-
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
----
A
K
L
F
E
Q
I
L
K
A
E
YEFD
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
-
A
L
Q
H
P
W
I
A
------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
40.10
40%
-66
- C1 -
4EKK
1
AKT1_HUMAN
A:
[6-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
39.97
40%
-64
- C1 -
3OW4
1
AKT1_HUMAN
B:
[6-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
39.39
40%
-61
- C1 -
3CQU
1
AKT1_HUMAN
A:
[7-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
38.97
40%
-63
- C1 -
3QKL
1
AKT1_HUMAN
A:
[6-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
38.84
40%
-64
- C1 -
3MVH
1
AKT1_HUMAN
A:
[7-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
38.26
40%
-60
- C1 -
3OCB
1
AKT1_HUMAN
A:
[6-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
38.08
40%
-63
- C1 -
3CQW
1
AKT1_HUMAN
A:
[7-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
37.85
40%
-64
- C1 -
4EKK
1
AKT1_HUMAN
B:
[6-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
37.21
40%
-65
- C1 -
3OCB
1
AKT1_HUMAN
B:
[6-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
37.02
40%
-63
- C1 -
3OW4
1
AKT1_HUMAN
A:
[6-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
36.51
40%
-67
- C1 -
4EKL
1
AKT1_HUMAN
A:
[6-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
35.67
40%
-60
- C1 -
3MV5
1
AKT1_HUMAN
A:
[7-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
-----
T
G
----
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
N
-
S
-
R
H
---
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
----
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
-
A
T
-
M
K
-
F
C
----
G
T
P
E
Y
L
A
P
E
V
L
E
-
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
----
D
H
E
K
L
F
E
L
I
L
M
E
E
----
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
-
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
------------------------------------------------------------------------------------------------------------------------------