@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GSK3A_HUMAN: (2013-07-20 )
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
Atome Classification :
(54 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....-------..120.......130.......140.......150------.------.....------.160.......170.......180.......190.......200.......210...-....220.......230.......240.......250.......260.......270.-...-----...---280.......290.......300.......310...-----------....320..-------.....330.......340.--.---......350.---......360-.......370..---.....380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEV-------AYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQ------D------KRFKN------RELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLT-IPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRG-EPN-----VSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-----------GQPIFPGDS-------GVDQLVEIIKVLGTPT-RE--Q---IREMNPNYTE---FKFPQIKAH-PWTKVFKSRTPP---EAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS
49
PsiBlast_CBE
94.06
84%
-130
- C1 -
1H8F
2
GSK3B_HUMAN
A:
[1-352]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
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Y
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D
T
K
V
I
G
N
G
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F
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Y
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A
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C
D
S
G
E
L
V
A
I
K
K
V
L
Q
------
G
------
K
A
F
K
N
------
R
E
L
Q
I
M
R
K
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H
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N
I
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L
R
Y
F
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Y
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E
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K
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E
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Y
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N
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D
Y
V
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E
T
V
Y
R
V
A
R
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Y
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R
A
K
Q
T
-
L
P
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I
Y
V
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L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
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S
F
G
I
C
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L
L
L
D
P
D
T
A
V
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A
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G
-
E
P
N
-----
V
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Y
---
I
C
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-
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--
Q
---
I
R
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M
N
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N
Y
T
E
---
F
A
F
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A
H
-
P
W
T
K
V
F
R
P
R
T
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P
---
E
A
I
A
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L
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Y
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A
R
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P
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E
A
C
A
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F
D
E
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D
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A
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N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
45
PsiBlast_CBE
93.70
86%
-130
- C1 -
3SD0
2
GSK3B_HUMAN
B:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
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T
P
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Q
G
P
D
R
P
Q
E
V
-------
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A
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L
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------
D
------
K
R
F
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N
------
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E
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Y
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Y
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E
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Y
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V
A
R
H
Y
S
R
A
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Q
T
-
L
P
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Y
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M
Y
Q
L
F
R
S
L
A
Y
I
H
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I
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Q
N
L
L
L
D
P
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A
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D
F
G
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A
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L
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R
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-
E
P
N
-----
V
S
Y
---
I
C
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R
Y
Y
R
A
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Y
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A
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A
E
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L
-----------
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Q
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I
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D
S
-------
G
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D
Q
L
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E
I
I
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V
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G
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P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
Y
T
E
---
F
K
F
P
Q
I
K
A
H
-
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
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R
L
L
E
Y
T
P
T
A
R
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P
L
E
A
C
A
H
S
F
F
D
E
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N
V
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L
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N
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R
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A
L
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N
F
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T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
48
PsiBlast_CBE
93.04
84%
-130
- C1 -
1H8F
2
GSK3B_HUMAN
B:
[1-350]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
-------
S
Y
T
D
T
K
V
I
G
N
G
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F
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V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
------
G
------
K
A
F
K
N
------
R
E
L
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I
M
R
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H
C
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I
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L
R
Y
F
F
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E
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Y
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N
L
V
L
D
Y
V
P
E
T
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Y
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V
A
R
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Y
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R
A
K
Q
T
-
L
P
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I
Y
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M
Y
Q
L
F
R
S
L
A
Y
I
H
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F
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I
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Q
N
L
L
L
D
P
D
T
A
V
L
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G
S
A
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Q
L
V
R
G
-
E
P
N
-----
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
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A
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C
V
L
A
E
L
L
L
-----------
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Q
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I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
Y
T
E
---
F
A
F
P
Q
I
K
A
H
-
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
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P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
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N
G
R
D
T
P
A
L
F
N
F
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Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
110
HHSearch
92.05
83%
-132
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[35-388]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
-------
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
------
D
------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
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E
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E
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Y
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N
L
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D
Y
V
P
E
T
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Y
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V
A
R
H
Y
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R
A
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Q
T
-
L
P
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I
Y
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L
Y
M
Y
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L
F
R
S
L
A
Y
I
H
S
F
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D
I
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Q
N
L
L
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D
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A
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G
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A
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-
E
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N
-----
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Y
---
I
C
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R
Y
Y
R
A
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A
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A
E
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-----------
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Q
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I
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D
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D
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E
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I
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V
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G
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P
T
-
R
E
--
Q
---
I
R
E
M
N
P
N
Y
T
E
---
F
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F
P
Q
I
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A
H
-
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W
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K
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F
R
P
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T
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P
---
E
A
I
A
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R
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E
Y
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P
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A
R
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P
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A
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A
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F
D
E
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N
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R
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A
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F
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E
L
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N
P
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L
A
T
I
L
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P
P
H
A
R
I
Q
A
A
A
--------------------------------
46
PsiBlast_CBE
91.88
86%
-128
- C1 -
3SD0
2
GSK3B_HUMAN
A:
[1-349]
-------------------------------------------------------------------------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
-------
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Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
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G
E
L
V
A
I
K
K
V
L
Q
------
D
------
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R
F
K
N
------
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E
L
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I
M
R
K
L
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H
C
N
I
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Y
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F
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E
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K
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E
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Y
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N
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D
Y
V
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E
T
V
Y
R
V
A
R
H
Y
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R
A
K
Q
T
-
L
P
V
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Y
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L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
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L
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D
F
G
S
A
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Q
L
V
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G
-
E
P
N
-----
V
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Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
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Y
T
S
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I
D
V
W
S
A
G
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V
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A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
---
I
R
E
M
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P
N
Y
T
E
---
F
K
F
P
Q
I
K
A
H
-
P
W
T
K
V
F
R
P
R
T
P
P
---
E
A
I
A
L
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L
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E
Y
T
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T
A
R
L
T
P
L
E
A
C
A
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F
F
D
E
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R
D
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N
V
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N
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R
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A
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F
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F
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E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
118
HHSearch
58.68
37%
-122
- C1 -
3N9X
3
?
A:
[11-374]
------------------------------------------------------------------------------------------------------------
R
E
N
L
Y
F
Q
G
I
KN
V
H
V
P
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
T
E
K
N
V
A
I
K
K
V
N
R
MFED
L
I
D
------
C
K
R
I
L
------
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
D
L
L
-
K
F
D
E
L
Y
I
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I
A
D
S
D
L
K
K
L
F
----
K
T
P
I
F
-
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
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E
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G
I
I
H
R
D
L
K
P
A
N
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L
L
N
Q
D
-
C
S
V
K
V
C
D
F
G
L
A
R
T
I
--------------
H
---
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
-
E
D
--
D
---
L
K
N
I
N
K
P
E
V
I
K
Y
I
K
L
F
P
H
R
K
P
I
-
N
L
K
Q
K
Y
-
P
S
I
S
D
---
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
K
K
L
E
-----------------------------------------------------------------------
52
PsiBlast_CBE
55.08
35%
-141
- C1 -
3EZR
2
CDK2_HUMAN
A:
[6-291]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
--------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
50
PsiBlast_CBE
54.26
35%
-133
- C1 -
3NIZ
1
?
A:
[23-307]
-----------------------------------------------------------------------------------------------------------------------------
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
G
R
-
I
V
A
L
K
R
I
R
------------------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
S
------
E
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
---
L
D
E
N
K
T
G
-
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
G
A
-
L
K
L
A
D
F
G
L
A
R
A
F
--
G
-
I
P
V
-----
R
--H
E
-
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-----------
G
K
P
L
F
P
G
V
T
-------
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
WP
Q
---
V
Q
E
L
-
P
L
W
K
Q
---
R
T
F
Q
V
F
E
K
K
-
P
W
S
S
I
I
P
G
F
C
-
Q
---
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
-----------------------------------------------------------------------------
51
PsiBlast_CBE
53.94
35%
-139
- C1 -
3EZV
1
CDK2_HUMAN
A:
[6-291]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
75
PsiBlast_CBE
53.35
35%
-140
- C1 -
3RAL
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
113
HHSearch
52.92
34%
-124
- C1 -
4IC7
1
MK07_HUMAN
A:
[57-368]
-----------------------------------------------------------------------------------------------------------------------------
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
------
A
FDV
V
T
N
A
K
R
T
L
------
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
----
H
S
S
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
-
P
A
E
HQYFM
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
---
I
Q
A
V
G
A
E
R
V
R
AYI
Q
S
L
P
P
R
Q
P
V
-
P
W
E
T
V
Y
-
P
G
A
D
R
---
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
-
E
P
D
---
C
A
P
P
F
D
F
A
---------------------------------------------------------
57
PsiBlast_CBE
52.58
35%
-136
- C1 -
3S1H
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
76
PsiBlast_CBE
52.23
35%
-139
- C1 -
3RAK
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
61
PsiBlast_CBE
52.20
35%
-138
- C1 -
3RPY
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
78
PsiBlast_CBE
51.39
35%
-133
- C1 -
3RAH
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
89
PsiBlast_CBE
51.37
35%
-134
- C1 -
3R83
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
92
PsiBlast_CBE
51.28
35%
-134
- C1 -
3R7U
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
66
PsiBlast_CBE
51.09
35%
-136
- C1 -
3RNI
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
91
PsiBlast_CBE
51.06
35%
-134
- C1 -
3R7V
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
63
PsiBlast_CBE
51.05
35%
-133
- C1 -
3RPR
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
67
PsiBlast_CBE
50.95
35%
-136
- C1 -
3RMF
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------------PSTA
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
96
PsiBlast_CBE
50.93
35%
-132
- C1 -
3R71
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
80
PsiBlast_CBE
50.79
35%
-133
- C1 -
3R9N
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
79
PsiBlast_CBE
50.73
35%
-129
- C1 -
3R9O
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
88
PsiBlast_CBE
50.57
35%
-133
- C1 -
3R8L
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
62
PsiBlast_CBE
50.55
35%
-134
- C1 -
3RPV
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
60
PsiBlast_CBE
50.54
35%
-135
- C1 -
3RZB
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
85
PsiBlast_CBE
50.50
35%
-133
- C1 -
3R8U
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
74
PsiBlast_CBE
50.41
35%
-134
- C1 -
3RJC
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
82
PsiBlast_CBE
50.24
35%
-132
- C1 -
3R9D
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VPS
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
90
PsiBlast_CBE
50.22
35%
-132
- C1 -
3R7Y
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
83
PsiBlast_CBE
50.19
35%
-136
- C1 -
3R8Z
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
---------TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
84
PsiBlast_CBE
50.17
35%
-135
- C1 -
3R8V
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
99
PsiBlast_CBE
50.13
35%
-132
- C1 -
3R1Y
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
95
PsiBlast_CBE
50.12
35%
-133
- C1 -
3R73
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
97
PsiBlast_CBE
50.10
35%
-132
- C1 -
3R6X
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
71
PsiBlast_CBE
50.06
35%
-132
- C1 -
3RK9
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
56
PsiBlast_CBE
50.03
35%
-135
- C1 -
3SQQ
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
--------------
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
94
PsiBlast_CBE
49.83
35%
-135
- C1 -
3R7E
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
81
PsiBlast_CBE
49.69
35%
-131
- C1 -
3R9H
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VPSTAI
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
70
PsiBlast_CBE
49.49
35%
-135
- C1 -
3RKB
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VPS
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
114
HHSearch
49.43
34%
-120
- C1 -
4B99
1
MK07_HUMAN
A:
[56-368]
-----------------------------------------------------------------------------------------------------------------------------
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
------
A
FDV
V
T
N
A
K
R
T
L
------
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
----
H
S
S
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
---Q
Y
F
M
-----
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
---
I
Q
-----
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
-
P
W
E
T
V
Y
P
-
G
A
D
R
---
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
-
P
D
---
C
A
P
P
F
D
F
A
F
--------------------------------------------------------
86
PsiBlast_CBE
49.37
35%
-131
- C1 -
3R8P
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VPS
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
87
PsiBlast_CBE
49.35
35%
-132
- C1 -
3R8M
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
------------E--
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
59
PsiBlast_CBE
49.27
35%
-133
- C1 -
3S00
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
98
PsiBlast_CBE
49.26
35%
-129
- C1 -
3R28
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
53
PsiBlast_CBE
49.24
35%
-126
- C1 -
4GCJ
5
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
D
------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
68
PsiBlast_CBE
49.21
35%
-133
- C1 -
3RM7
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
55
PsiBlast_CBE
48.90
35%
-131
- C1 -
4EZ3
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
72
PsiBlast_CBE
48.67
35%
-133
- C1 -
3RK7
2
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
58
PsiBlast_CBE
48.11
35%
-133
- C1 -
3S0O
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
--
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
54
PsiBlast_CBE
47.97
35%
-122
- C1 -
4EZ7
7
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
D
------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
73
PsiBlast_CBE
47.55
35%
-131
- C1 -
3RK5
1
CDK2_HUMAN
A:
[12-297]
-----------------------------------------------------------------------------------------------------------------------------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
------
L
Y
L
V
F
E
F
L
H
Q
D
L
---
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-
E
V
--
V
WPG
V
T
S
M
-
P
D
Y
K
P
----
S
F
P
K
W
A
R
Q
-
D
F
S
K
V
----
V
P
P
LD
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
-----------------------------------------------------------------------------
115
HHSearch
40.00
30%
-110
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[5-289]
-----------------------------------------------------------------------------------------------------------------------------
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
I
K
I
F
Y
--------------
N
K
I
A
M
------
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
----
K
K
I
--
H
L
V
F
E
F
I
D
H
T
V
L
D
---
E
L
Q
H
Y
C
H
G
-
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
-
S
G
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
I
Y
-----
D
D
E
---
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-----------
G
N
P
Y
L
P
S
S
S
-------
D
L
D
L
L
H
K
I
V
L
K
V
G
N
L
S
-
P
H
--
L
Q
N
-
I
F
S
K
S
P
I
F
A
G
---
V
V
L
P
Q
V
Q
H
P
K
N
A
R
K
K
-
Y
P
K
L
N
G
---
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
------------------------------------------------------------------------------