@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GSK3B_HUMAN: (2013-07-20 )
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
Atome Classification :
(44 SA)
.........10........20........30........40........50...-------.....60........70.......-.80........------90------.....------....100.......110.......120........130.......140.......150.......160.......170.......180.......190.......200.......210..-----...---...220.......230.......240.......250-----------.......260------........270.....-..--280.........290-..--.......-300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEV-------SYTDTKVIGNGSFGVVYQAKLCDS-GELVAIKKVLQ------D-------KRFKN------RELQIMRKLDHCNIVRLRYFFYSSGE-KKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG-EPN-----VSY---ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-----------GQPIFPGDS-------GVDQLVEIIKVLGTPT-RE--Q--IREMNPNYTE---FK--FPQIKAH-PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
46
PsiBlast_CBE
95.08
100%
-129
- C1 -
3SD0
2
GSK3B_HUMAN
B:
[1-349]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
-------
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
L
Q
------
D
-------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
-
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
-
E
P
N
-----
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
--
I
R
E
M
N
P
N
Y
T
E
---
F
K
--
F
P
Q
I
K
A
H
-
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
-------------------------------------
49
PsiBlast_CBE
94.89
99%
-130
- C1 -
1H8F
2
GSK3B_HUMAN
A:
[1-352]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
-------
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
L
Q
------
G
-------
K
A
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
-
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
-
E
P
N
-----
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
--
I
R
E
M
N
P
N
Y
T
E
---
F
A
--
F
P
Q
I
K
A
H
-
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
----------------------------------
48
PsiBlast_CBE
94.26
99%
-132
- C1 -
1H8F
2
GSK3B_HUMAN
B:
[1-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
-------
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
L
Q
------
G
-------
K
A
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
-
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
-
E
P
N
-----
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
--
I
R
E
M
N
P
N
Y
T
E
---
F
A
--
F
P
Q
I
K
A
H
-
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
104
HHSearch
93.16
100%
-130
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[35-388]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
-------
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
L
Q
------
D
-------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
-
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
-
E
P
N
-----
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
--
I
R
E
M
N
P
N
Y
T
E
---
F
K
--
F
P
Q
I
K
A
H
-
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
Q
A
A
A
--------------------------------
47
PsiBlast_CBE
92.80
100%
-128
- C1 -
3SD0
2
GSK3B_HUMAN
A:
[1-350]
----------------------------------
S
K
V
T
T
V
V
A
T
P
G
Q
G
P
D
R
P
Q
E
V
-------
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
-
G
E
L
V
A
I
K
K
V
L
Q
------
D
-------
K
R
F
K
N
------
R
E
L
Q
I
M
R
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
G
E
-
K
K
D
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
-
E
P
N
-----
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
-------
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
-
R
E
--
Q
--
I
R
E
M
N
P
N
Y
T
E
---
F
K
--
F
P
Q
I
K
A
H
-
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
N
V
K
L
P
N
G
R
D
T
P
A
L
F
N
F
T
T
Q
E
L
S
S
N
P
P
L
A
T
I
L
I
P
P
H
A
R
I
------------------------------------
112
HHSearch
56.77
37%
-116
- C1 -
3N9X
3
?
A:
[11-374]
---------------------------------------------
R
E
N
L
Y
F
Q
G
I
KN
V
H
V
P
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
T
-
E
K
N
V
A
I
K
K
V
N
R
MFED
L
I
D
-------
C
K
R
I
L
------
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
D
L
L
K
F
D
E
--
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
----
K
T
P
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
D
-
C
S
V
K
V
C
D
F
G
L
A
R
T
I
--------------
H
---
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
CFPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
P
T
-
E
D
--
D
--
L
K
N
I
N
K
P
E
V
I
K
Y
I
K
L
--
F
P
H
R
K
P
I
-
N
L
K
Q
K
Y
-
P
S
I
S
D
D
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
K
K
L
E
-----------------------------------------------------------------------
107
HHSearch
54.45
35%
-121
- C1 -
4IC7
1
MK07_HUMAN
A:
[56-368]
-------------------------------------------------------------
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
-
G
Q
Q
V
A
I
K
K
I
P
N
------
A
FDV
V
T
N
-
A
K
R
T
L
------
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
-
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
----
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
-
P
A
E
HQYFM
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
--
I
Q
A
V
G
A
E
R
V
R
AYI
Q
S
--
L
P
P
R
Q
P
V
-
P
W
E
T
V
Y
-
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
-
E
P
D
---
C
A
P
P
F
D
F
A
---------------------------------------------------------
53
PsiBlast_CBE
53.18
33%
-131
- C1 -
3EZR
2
CDK2_HUMAN
A:
[5-294]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
--------------------VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
--------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
51
PsiBlast_CBE
52.96
36%
-128
- C1 -
3NIZ
1
?
A:
[23-311]
--------------------------------------------------------------
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
--
D
S
Q
G
R
I
V
A
L
K
R
I
R
-------------------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
E
L
H
H
P
N
I
V
S
L
I
D
V
I
H
S
-------
E
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
---
D
E
N
K
T
G
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
G
A
-
L
K
L
A
D
F
G
L
A
R
A
F
--
G
-
I
P
V
-----
R
--H
E
-
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
-----------
G
K
P
L
F
P
G
V
T
-------
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
WP
Q
--
V
Q
E
L
-
P
L
W
K
Q
---
R
T
--
F
Q
V
F
E
K
K
-
P
W
S
S
I
I
-
P
G
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
-
D
P
Q
I
------------------------------------------------------------------------
52
PsiBlast_CBE
52.66
33%
-129
- C1 -
3EZV
1
CDK2_HUMAN
A:
[5-294]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
--------------------VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
92
PsiBlast_CBE
52.47
33%
-132
- C1 -
3RAL
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
--------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
78
PsiBlast_CBE
52.21
33%
-130
- C1 -
3RPY
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
--------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
93
PsiBlast_CBE
51.69
33%
-129
- C1 -
3RAK
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
--------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
57
PsiBlast_CBE
51.49
33%
-116
- C1 -
2WPA
1
CDK2_HUMAN
A:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
83
PsiBlast_CBE
51.40
33%
-127
- C1 -
3RNI
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
-----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
84
PsiBlast_CBE
51.32
33%
-128
- C1 -
3RMF
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
-------------------PSTA
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
67
PsiBlast_CBE
51.17
33%
-117
- C1 -
2BKZ
1
CDK2_HUMAN
A:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
73
PsiBlast_CBE
51.04
33%
-126
- C1 -
3SQQ
2
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
-----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
--------------
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
74
PsiBlast_CBE
50.96
33%
-128
- C1 -
3S1H
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
--------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
79
PsiBlast_CBE
50.88
33%
-126
- C1 -
3RPV
2
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
-----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
91
PsiBlast_CBE
50.59
33%
-126
- C1 -
3RJC
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
-----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
56
PsiBlast_CBE
50.51
33%
-118
- C1 -
2WPA
1
CDK2_HUMAN
C:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
87
PsiBlast_CBE
50.48
33%
-128
- C1 -
3RKB
2
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
-----------------
T
E
G
VPS
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
59
PsiBlast_CBE
50.20
33%
-120
- C1 -
2WIP
1
CDK2_HUMAN
A:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
55
PsiBlast_CBE
50.00
33%
-119
- C1 -
2WXV
1
CDK2_HUMAN
A:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
80
PsiBlast_CBE
49.98
33%
-123
- C1 -
3RPR
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
--------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
66
PsiBlast_CBE
49.88
33%
-116
- C1 -
2BKZ
1
CDK2_HUMAN
C:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
76
PsiBlast_CBE
49.52
33%
-124
- C1 -
3S00
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
-----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
88
PsiBlast_CBE
49.44
33%
-124
- C1 -
3RK9
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
-----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
60
PsiBlast_CBE
49.44
33%
-119
- C1 -
2WIH
1
CDK2_HUMAN
C:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
70
PsiBlast_CBE
49.24
33%
-119
- C1 -
4GCJ
5
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
108
HHSearch
49.20
35%
-115
- C1 -
4B99
1
MK07_HUMAN
A:
[55-367]
-------------------------------------------------------------
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
-
G
Q
Q
V
A
I
K
K
I
P
N
------
A
FDV
V
T
N
-
A
K
R
T
L
------
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
-
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
----
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
---Q
Y
F
M
-----
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
-----------
R
R
Q
L
F
P
G
K
N
-------
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
-
P
A
--
V
--
I
Q
-----
R
V
R
A
Y
I
Q
S
--
L
P
P
R
Q
P
V
-
P
W
E
T
V
Y
P
-
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
-
P
D
---
C
A
P
P
F
D
F
A
---------------------------------------------------------
77
PsiBlast_CBE
49.06
33%
-127
- C1 -
3RZB
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
--------------------P
S
T
A
I
-
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
58
PsiBlast_CBE
48.96
33%
-123
- C1 -
2WIP
1
CDK2_HUMAN
C:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
72
PsiBlast_CBE
48.89
33%
-123
- C1 -
4EZ3
2
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
-----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
61
PsiBlast_CBE
48.87
33%
-119
- C1 -
2WIH
1
CDK2_HUMAN
A:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
89
PsiBlast_CBE
48.78
33%
-124
- C1 -
3RK7
2
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
-----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
54
PsiBlast_CBE
48.77
33%
-119
- C1 -
2WXV
1
CDK2_HUMAN
C:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
90
PsiBlast_CBE
48.28
33%
-123
- C1 -
3RK5
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
-----------------
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
TH
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
62
PsiBlast_CBE
47.94
33%
-115
- C1 -
2C4G
1
CDK2_HUMAN
C:
[8-297]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
119
HHSearch
46.57
32%
-126
- C1 -
2FST
3
MK14_HUMAN
X:
[30-324]
-------------------------------------------------------------
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
T
-
G
L
R
V
A
V
K
K
L
S
R
------
P
FQSIIHA
K
R
T
-
Y
------
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
-
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
----------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
-
C
E
L
K
I
L
D
--------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
-----------
G
R
T
L
F
P
G
T
D
-------
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
-
A
E
--
L
--
L
K
K
I
S
S
E
S
A
R
NYI
Q
S
--
L
T
Q
M
P
K
M
-
N
F
A
N
V
F
I
-
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
-----------------------------------------------------------------------
75
PsiBlast_CBE
46.24
33%
-124
- C1 -
3S0O
1
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
----------------
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
--
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
71
PsiBlast_CBE
46.23
33%
-114
- C1 -
4EZ7
7
CDK2_HUMAN
A:
[11-300]
-------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
-
G
E
V
V
A
L
K
K
I
R
L
------
D
-------
T
E
T
E
G
VP
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
-------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
--
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
-
K
L
A
D
F
G
L
A
R
A
F
--
G
-
V
P
V
-----
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
-------
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
--
E
--
V
--
V
W
P
G
V
T
S
M
P
D
---
Y
K
PS
F
P
K
W
A
R
Q
-
D
F
S
K
V
V
-
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
Q
D
V
T
K
P
--------------------------------------------------------------------------
109
HHSearch
40.28
30%
-105
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[4-289]
-------------------------------------------------------------
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
-
G
Q
I
V
A
I
K
I
F
Y
---------------
N
K
I
A
M
------
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
-----
K
K
I
--
H
L
V
F
E
F
I
D
H
T
V
L
D
---
E
L
Q
H
Y
C
H
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
-
S
G
I
T
K
L
C
D
F
G
F
A
R
T
-----
D
I
Y
-----
D
D
E
---
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
-----------
G
N
P
Y
L
P
S
S
S
-------
D
L
D
L
L
H
K
I
V
L
K
V
G
N
L
S
-
P
H
--
L
Q
N
I
F
S
K
S
P
I
F
A
G
---
V
V
--
L
P
Q
V
Q
H
P
K
N
A
R
K
K
-
Y
P
K
L
N
G
L
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
------------------------------------------------------------------------------