@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HIPK2_HUMAN: (2013-07-20 )
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
Atome Classification :
(8 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210......-.220.......230-...---.....240.......250...-..-..260.......------270---.........280.......290.........300.......310.......320.......330....---------------------.-----------..340----------........350...-....360.---......370..-.-.-.-..380.......390....-----------...400....-------...410......-.420.......430.........440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWK-RGTNEIVAIKILK--NHP---SYARQGQIEVSILARLSTESA-DD-YNFVRAYECFQH------K-----NHTCLVFEMLEQNLYDFLKQ--NKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPS---------------------R-----------QPYR-----------VKVIDFGSASHVSK-AVCSTYLQ---SRYYRAPEIIL-G-L-P-FCEAIDMWSLGCVIAELFL-----------GWPLYPGASE-------YDQIRYISQTQG-LPAEYLLSAGTK--TTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
43
HHSearch
84.88
35%
-98
- C1 -
3N9X
2
?
A:
[22-369]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
V
P
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
-
K
N
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E
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N
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A
I
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V
N
--
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ED
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D
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------
D
DLLKF
D
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T
--
P
I
--
F
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E
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I
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I
L
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N
L
L
L
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E
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I
I
H
R
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K
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A
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C
L
L
N
Q
------------------------------------
D
C
S
-----------
V
K
V
C
D
F
G
L
A
R
T
I
--------
H
V
V
---
T
R
W
Y
R
A
P
E
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I
L
L
Q
-
E
-
N
-
Y
T
K
S
I
D
I
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S
T
G
C
I
F
A
E
L
L
N
MLQSHINDPTN
R
F
P
L
F
P
G
S
S
C
FPH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
-
T
P
T
E
D
D
----------------------------------
L
K
N
I
N
K
P
E
V
I
K
Y
I
K
L
F
P
H
-
R
K
P
I
N
L
K
Q
K
Y
--------
P
S
I
S
D
D
G
I
N
L
L
E
S
M
L
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N
P
N
K
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I
T
I
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A
L
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H
P
Y
L
K
D
V
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
82.42
31%
-90
- C1 -
3LLT
1
?
A:
[20-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
I
V
H
F
S
W
K
K
G
M
L
L
N
N
A
F
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F
G
R
V
L
L
C
Q
H
-
I
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N
K
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Y
Y
A
V
K
V
V
R
--
N
I
K
---
K
Y
T
R
S
A
K
I
E
A
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I
Q
N
D
D
I
-
N
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-
N
N
I
V
K
Y
H
G
K
F
M
Y
------
Y
-----
D
H
M
C
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E
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--
N
N
Y
N
G
F
H
I
E
D
I
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L
Y
C
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E
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L
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L
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E
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I
L
L
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D
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Y
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E
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S
L
I
T
V
R
R
VTDG
K
K
I
Q
I
Y
R
T
-----------
K
S
T
G
-----------
I
K
L
I
D
F
G
C
A
T
F
K
S
D
--
Y
H
G
S
I
I
N
---
T
R
Q
Y
R
A
P
E
V
I
L
-
N
-
L
-
G
-
W
D
V
S
S
D
M
W
S
F
G
C
V
L
A
E
L
Y
T
-----------
G
S
L
L
F
R
T
H
E
H
-------
M
E
H
L
A
M
M
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I
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Q
-
P
I
P
K
N
M
L
Y
E
A
T
K
T
N
G
S
K
Y
V
N
K
D
------
E
L
K
L
A
W
P
E
N
------
A
S
S
I
N
S
I
K
H
V
K
K
C
L
P
L
Y
K
----------------
I
I
K
H
E
L
F
C
D
F
L
Y
S
I
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Q
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D
P
T
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R
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S
P
A
E
L
L
K
H
K
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
81.77
35%
-94
- C1 -
1Z57
1
CLK1_HUMAN
A:
[12-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
H
V
A
V
K
I
V
K
--
N
V
D
---
R
Y
C
E
A
A
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-
F
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M
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F
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------
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G
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--
N
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P
F
R
L
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H
I
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F
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I
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D
---------------------
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A
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NR
D
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D
-----------
I
K
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V
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A
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A
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R
-----
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E
H
S
-------------
S
A
G
R
Y
V
S
R
A
C
K
P
L
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E
F
----------
M
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A
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P
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F
D
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
80.21
30%
-96
- C1 -
2VAG
1
CLK1_HUMAN
A:
[12-334]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
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V
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I
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H
K
A
G
G
R
H
V
A
V
K
I
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--
N
V
D
---
R
Y
C
E
A
A
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E
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Q
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L
E
H
L
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-
N
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------
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-----
G
H
I
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I
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D
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--
N
G
F
L
P
F
R
L
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M
A
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Q
I
C
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F
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H
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E
N
I
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F
V
Q
S
D
Y
--------------------
T
-----------
E
A
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N
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E
R
T
L
INP
D
I
K
V
V
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F
G
S
A
T
Y
D
D
E
-
H
-
H
S
T
L
V
S
---
T
R
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Y
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A
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I
L
-
A
-
L
-
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-
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E
Y
Y
L
-----------
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F
T
V
F
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T
H
D
S
-------
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E
H
L
A
M
M
E
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L
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M
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-
T
R
--
K
R
K
Y
F
H
H
D
--------
R
L
D
W
-
D
E
H
S
S
--------
A
G
R
Y
V
S
R
A
C
K
P
L
K
E
F
M
L
S
Q
D
V
E
----------
H
E
R
L
F
D
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M
L
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Y
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A
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R
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L
K
H
P
F
F
D
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
69.03
33%
-96
- C1 -
3ZDU
3
CDKL3_HUMAN
A:
[2-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
-
K
N
T
G
Q
I
V
A
I
K
I
F
Y
----------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
-------
N
L
V
N
L
I
E
V
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R
Q
------
K
-----
K
K
I
H
L
V
F
E
F
I
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T
V
L
D
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L
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--
Y
-
C
H
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R
L
R
K
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L
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Q
I
L
R
A
I
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L
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N
N
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I
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N
I
L
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Q
------------------------------------
S
G
I
-----------
T
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C
D
F
G
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A
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T
----
D
I
Y
D
D
E
V
A
---
T
R
W
Y
R
A
P
E
L
V
L
-
K
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T
-
S
-
Y
G
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C
M
I
I
E
M
A
T
-----------
G
N
P
Y
L
P
S
S
S
D
-------
L
D
L
L
H
K
I
V
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V
G
-
N
L
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--
S
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I
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A
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V
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----
L
P
Q
V
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--
H
P
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N
-----------
A
R
K
-
K
Y
----------------------
P
K
L
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-
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H
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T
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
67.38
31%
-87
- C1 -
4EOI
2
CDK2_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
-
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
LE
G
V
P
---
S
T
A
I
R
---
E
I
S
L
L
K
E
L
N
H
P
-------
N
I
V
K
L
L
D
V
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T
------
E
-----
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
--
S
A
L
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P
L
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L
F
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L
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G
L
A
F
C
H
S
H
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V
L
H
R
D
L
K
P
E
N
L
L
I
-------------------------
N
-----------
T
E
G
A
-----------
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-
P
V
-
R
T
Y
T
H
EVV
T
L
W
Y
R
A
P
E
I
L
L
-
G
-
C
-
K
Y
Y
S
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S
L
G
C
I
F
A
E
M
V
T
-----------
R
R
A
L
F
P
G
D
S
E
-------
I
D
Q
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
--
M
P
-----
D
Y
K
P
S
F
P
K
W
------------------
A
R
Q
-------
D
F
S
K
V
V
P
P
L
D
E
D
G
R
-------------
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
59.42
31%
-93
- C1 -
1J1B
1
GSK3B_HUMAN
A:
[53-343]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
L
V
A
I
K
K
V
L
--
Q
D
K
---
R
F
---
K
N
R
E
L
Q
I
M
R
K
L
D
H
-------
C
N
I
V
R
L
R
Y
F
F
Y
S
S
GEKKD
E
-----
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
-----------------------------------
D
T
A
V
-----------
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
N
V
S
Y
I
C
---
S
R
Y
Y
R
A
P
E
L
I
F
-
G
-
A
T
D
-
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
-----------
G
Q
P
I
F
P
G
D
S
G
-------
V
D
Q
L
V
E
I
I
K
V
L
G
-
T
P
T
R
E
Q
I
R
E
M
N
P
-------------
N
Y
T
E
F
K
F
P
Q
I
K
A
H
P
---------
W
T
K
-
V
F
R
----------------------
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
52.61
32%
-91
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[10-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
-
K
E
T
H
E
I
V
A
I
K
K
F
K
------------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
-
E
---
N
I
V
E
L
K
E
A
F
R
R
------
R
-----
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
--
M
P
-
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
---------------------
V
--------------------------
L
K
L
C
D
F
G
F
A
R
N
L
S
E
------------
T
R
W
Y
R
S
P
E
L
L
L
-
G
-
A
-
P
-
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
-----------
G
Q
P
L
F
P
G
E
S
E
-------
I
D
Q
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------