@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : IGF1R_HUMAN: (2013-07-20 )
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC

Atome Classification :

(67 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.....-------..890-.........900.......910.......920.......930.......940.......950.......960.......970.......980........990.......1000.......1010......1020-....--..1030......1040......1050......1060.......1070......1080......1090...---.-.----.1100....---..--1110......1120......1130......1140---.-....----.1150......1160-......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360....
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRK-------YGG---AKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEY-FSAADVYVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP---E-M----ENNPVLAPP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
7 PsiBlast_PDB 68.0399% -98 - C2 -3I81 A:[6-307] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP---E------ENNPVLAPP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYR-----LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
11 PsiBlast_PDB 67.88100% -94 - C2 -3NW7 A:[8-307] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP---E-M----ENNPVLAPP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
25 PsiBlast_CBE 67.7999% -96 - C2 -3LW0 IGF1R_HUMAN B:[1-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AADVYVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
23 PsiBlast_CBE 67.6299% -94 - C2 -3LW0 D:[1-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AADVYVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
13 PsiBlast_PDB 67.5899% -96 - C2 -3LW0 IGF1R_HUMAN A:[1-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AADVYVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
24 PsiBlast_CBE 67.1299% -94 - C2 -3LW0 IGF1R_HUMAN C:[1-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AADVYVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
9 PsiBlast_PDB 66.53100% -94 - C2 -3NW5 A:[6-307] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP---E-M----ENNPVLAPP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
4 PsiBlast_PDB 66.35100% -99 - C2 -3LVP IGF1R_HUMAN A:[39-336] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP---E-M----E--PVLAPP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIY--------GGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
10 PsiBlast_PDB 65.99100% -94 - C2 -3NW6 A:[7-307] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP---E-M----ENNPVLAPP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
8 PsiBlast_PDB 65.40100% -90 - C2 -2OJ9 A:[5-307] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP---E-------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
14 PsiBlast_PDB 64.94100% -95 - C2 -3QQU IGF1R_HUMAN A:[6-300] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR------------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN----------------------------------------------------------------------------------
22 PsiBlast_CBE 64.71100% -88 - C2 -1JQH IGF1R_HUMAN B:[6-308] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP-----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMT--------YYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
28 PsiBlast_CBE 64.31100% -90 - C2 -3QQU IGF1R_HUMAN B:[3-301] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR-------------------P---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK---------------------------------------------------------------------------------
26 PsiBlast_CBE 64.20100% -93 - C2 -3QQU D:[4-300] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP---E-M---------LAPP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN----------------------------------------------------------------------------------
27 PsiBlast_CBE 63.60100% -92 - C2 -3QQU IGF1R_HUMAN C:[4-300] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEWEVAREKITMS-RELGQGSFGMVYEGVAKGVVK-DEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP---E-M--------VLAPP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN----------------------------------------------------------------------------------
19 PsiBlast_PDB 61.9779% -97 - C2 -3EKK A:[5-306] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSVYVPDEWEVSREKITLL-RELGQGSFGMVYEGNARDIIK-GEAE--TRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP---E-A----ENNPGRPPP---TL--QEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMV---A-HDFT----VKIGDF-------------------LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEEN----------------------------------------------------------------------------------
18 PsiBlast_PDB 60.7479% -90 - C2 -1I44 A:[9-306] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEWEVSREKITLL-RELGQGSFGMVYEGNARDIIK-GEAE--TRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP---E-A----ENNPGRPPP---TL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A-HDFT----VKIGDFGMT-----------------LPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK---------------------------------------------------------------------------------
20 PsiBlast_PDB 60.4379% -90 - C2 -3EKN A:[8-307] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVPDEWEVSREKITLL-RELGQGSFGMVYEGNARDIIK-GEAE--TRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP---E-A----ENNPGRPPP---TL--QEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMV---A-HDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK---------------------------------------------------------------------------------
30 PsiBlast_CBE 59.7880% -85 - C2 -3ETA B:[12-305] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLL-RELGQGSFGMVYEGNARDIIK-GEAE--TRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP---E-A----ENNPGRPPP---TL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A-HDFT----VKIGDFGMTRDIYET-DYYRK--KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK---------------------------------------------------------------------------------
31 PsiBlast_CBE 59.7480% -84 - C2 -3ETA INSR_HUMAN A:[12-305] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLL-RELGQGSFGMVYEGNARDIIK-GEAE--TRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP---E-A----ENNPGRPPP---TL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A-HDFT----VKIGDFGMTRDIYET-DYYRKG-KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK---------------------------------------------------------------------------------
57 PsiBlast_CBE 54.6341% -91 - C2 -4AOJ NTRK1_HUMAN A:[33-315] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH-----HIKRRDIVLK-WELGEGAFGKVFLAECHNLLP----K--MLVAVKALKEA-SESARQDFQREAELLTMLQHQ-HIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP---D-----------PGPL---GL--GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---G-QGLV----VKIGDFG-----------------TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ----------------------------------------------------------------------------------------------------
71 PsiBlast_CBE 54.1941% -96 - C2 -1FGI B:[16-299] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVVLAEAIGL-----PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR--------------------QL-SS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLA-------DYYKK---GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-----------------------------------------------------------------------------------------------------
56 PsiBlast_CBE 53.6241% -90 - C2 -4AOJ NTRK1_HUMAN B:[33-315] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH-----HIKRRDIVLK-WELGEGAFGKVFLAECHNLLP----K--MLVAVKALKEA-SESARQDFQREAELLTMLQHQ-HIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP---D------------GPL---GL--GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---G-QGLV----VKIGDF--------------------LPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ----------------------------------------------------------------------------------------------------
78 PsiBlast_CBE 52.9041% -86 - C2 -3JS2 FGFR1_HUMAN A:[23-306] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVVLAEAIGLDK-DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGL------------HNPEEQLSS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-----------------------------------------------------------------------------------------------------
129 HHSearch 52.8741% -91 * C2 *4I4E A:[9-273] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYEIQRERIELG-RCIGEGQFGDVHQGIYMS--P--NPA--LAVAIKTCKNCTSDSVREKFLQEALTMRQFDHP-HIVKLIGVITEN-PVWIIMELCTLGELRSFLQVRK-----------------YSL---DL--ASLILYAYQLSTALAYLESKRFVHRDIAARNVLV---S-SNDC----VKLGDF--------------------LPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLST---------------------------------------------------------------------------------------------------
53 PsiBlast_CBE 52.8544% -88 - C2 -2XB7 A:[3-292] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYCFAGKTSSISDLKEVPRKNITLI-RGLGHGAFGEVYEGQVS--------P--LQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP---R-P----SQPSSLA------M--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDFGMA---------------AMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE----------------------------------------------------------------------------------------------------
48 PsiBlast_CBE 52.4844% -89 - C2 -4FNY A:[20-301] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSISDLKEVPRKNITLI-RGLGH---GEVYEGQVSG-------P--LQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP---R-P--------SLA------M--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDF-----------------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE----------------------------------------------------------------------------------------------------
81 PsiBlast_CBE 52.4141% -87 - C2 -3C4F B:[8-291] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVVLAEAIGLDK-DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP-----------------EEQLSS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-----------------------------------------------------------------------------------------------------
61 PsiBlast_CBE 52.4141% -88 - C2 -3RHX B:[12-295] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVVLAEAIGL-----PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR--------------------QL-SS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLA-------DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-----------------------------------------------------------------------------------------------------
52 PsiBlast_CBE 52.4144% -94 - C2 -2XBA A:[3-292] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYCFAGKTSSISDLKEVPRKNITLI-RGL-------VYEGQVS--------P--LQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP---R-P----SQPSSLA------M--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDFGMARDIY-----------AMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE----------------------------------------------------------------------------------------------------
63 PsiBlast_CBE 52.1841% -91 - C2 -4F65 B:[15-298] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVVLAEAIGLD----PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRP-------------------QL-SS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADF-------HI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-----------------------------------------------------------------------------------------------------
40 PsiBlast_CBE 51.9243% -91 - C2 -3AOX A:[19-317] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------STIMTDYNPNYCFAGKTSSISDLKEVPRKNITLI-RGLG----GEVYEGQVS--------P--LQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP---R-P----SQPSSLA------M--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDFGMARDIYRA--------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE----------------------------------------------------------------------------------------------------
55 PsiBlast_CBE 51.8441% -89 - C2 -4AOJ C:[33-315] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH-----HIKRRDIVLK-WELGEGAFGKVFLAECHNLLP--QDK--MLVAVKALKEA-SESARQDFQREAELLTMLQHQ-HIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP---D------------GPL---GL--GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---G-QGLV----VKIGDFGM-----------------MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ----------------------------------------------------------------------------------------------------
82 PsiBlast_CBE 51.8141% -88 - C2 -3C4F FGFR1_HUMAN A:[8-291] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVVLAEAIGLDK-DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP-----------------EEQLSS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-----------------------------------------------------------------------------------------------------
83 PsiBlast_CBE 51.7741% -92 - C2 -3GQL C:[23-306] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVVLAEAIGLDK-DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP------------------EQLSS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLAR-----------------PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-----------------------------------------------------------------------------------------------------
37 PsiBlast_CBE 51.7043% -85 - C2 -4DCE ALK_HUMAN A:[16-307] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLKEVPRKNITLI-RGLGH---GEVYEGQVS------PSP--LQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP---R-P----SQPSSLA------M--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDF---------------GGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE----------------------------------------------------------------------------------------------------
94 PsiBlast_CBE 51.6840% -84 - C2 -3RI1 ? A:[18-302] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KWEFPRDKLTLG-KPLGEGCFGQVVMAEAVGIDK-DKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP---P------------EQM---TF--KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLV---T-ENNV----MKIADFGLARDINNI-DYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-----------------------------------------------------------------------------------------------------
86 PsiBlast_CBE 51.6441% -88 - C2 -3V5Q NTRK3_HUMAN A:[11-285] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIKRRDIVLK-REL------KVFLAECYNLSP-TKDK--MLVAVKAL--P-TLAARKDFQREAELLTNLQHE-HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP-------------------EL-GL--SQMLHIASQIASGMVYLASQHFVHRDLATRNCLV---G-ANLL----VKIGDFGM--DVYST-DYYR----TMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI---------------------------------------------------------------------------------------------------------
38 PsiBlast_CBE 51.5243% -87 - C2 -4FOC A:[36-327] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLKEVPRKNITLI-RGLGHGAFGEVYEGQVS-------SP--LQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP---R-P----SQPSSLA------M--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDFGMARDIYR---------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE----------------------------------------------------------------------------------------------------
36 PsiBlast_CBE 51.5243% -88 - C2 -4DCE B:[17-307] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNYSFAGKTSSISDLKEVPRKNITLI-RGLGH----EVYEGQVS-------SP--LQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP---R-P----SQPSSLA------M--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDF----------------GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE----------------------------------------------------------------------------------------------------
45 PsiBlast_CBE 51.4945% -84 - C2 -4FNZ A:[10-301] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGKTSSISDLKEVPRKNITLI-RGLGH---GEVYEGQVSG------SP--LQVAVKTLPEVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRP---R-P----SQPSSLA------M--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDF----------------GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE----------------------------------------------------------------------------------------------------
68 PsiBlast_CBE 51.4841% -93 - C2 -4F63 FGFR1_HUMAN A:[15-298] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPL-----GQVVLAEAIGL-----PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP-----------------EEQLSS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-----------------------------------------------------------------------------------------------------