@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : IKKA_HUMAN: (2013-07-21 )
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHLSTIIHEANEEQGNSMMNLDWSWLTE
Atome Classification :
(24 SA)
.........10..-......20........30........40...-----.....--50..--..-----....-60........70........80........90........100.......110.......120.......130....-...140.......150--.--......160........170.-......180.......190.---......200.......210.......220.......230.......240.......250------.......260....--...270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MERPPGLRPGAGG-PWEMRERLGTGGFGNVCLYQHRELDLKIAIK-----SCRLE--LSTK--NR-----ERWC-HEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLH-ENKIIHRDLKPENIVL--Q--DVGGKIIH-KIIDLGYAKDVD-QGSLCTSFVGTLQYLAPELF---ENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEV------RFSSHLPQPNSLCS--LVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHLSTIIHEANEEQGNSMMNLDWSWLTE
110
HHSearch
51.44
32%
-75
- C1 -
4GV1
5
AKT1_HUMAN
A:
[8-254]
------------
N
-
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----
I
L
K
K
E
V
I
V
A
K
D
--
E
V
-----
A
H
T
L
-
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
-----
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
---
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
---
K
D
G
H
--
I
-
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
---
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
-
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
-------------
I
------------
R
F
P
R
T
L
G
P
--
E
----
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
50.66
30%
-80
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-266]
----
R
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
-----
C
I
A
------------------
S
M
E
-
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
-----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
---
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
--
S
L
D
E
D
S
K
I
-
M
I
S
D
F
G
L
S
K
M
E
D
-
P
G
--------
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
-
N
D
A
K
L
F
E
Q
I
L
K
-------------
A
E
Y
------
E
F
--
D
S
P
Y
W
D
D
I
S
D
--
S
A
K
D
----
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
47.91
33%
-77
- C1 -
2ACX
1
GRK6_HUMAN
B:
[192-430]
---------------------
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
-----
K
L
E
K
K
--
R
I
K
K
R
K
G
E
-----
A
M
A
L
-
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
-----
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
--
A
-
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
--
D
--
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
V
P
-
E
G
Q
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
---
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
---------
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
------
R
F
S
---
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
47.32
33%
-73
- C1 -
2ACX
1
GRK6_HUMAN
A:
[192-430]
---------------------
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
-----
K
L
E
K
K
--
R
I
K
K
R
K
G
E
-----
A
M
A
L
-
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
-----
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
-
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
--
D
--
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
V
P
-
E
G
Q
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
---
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
------
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
------
R
F
S
---
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
43.87
33%
-82
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[14-219]
---------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----
F
I
K
K
R
--
Q
S
R
A
--
S
R
R
G
V
S
R
E
E
I
E
-
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
----
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
43.12
33%
-75
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[14-219]
---------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----
F
I
K
K
R
--
Q
S
R
A
--
S
R
RGVSR
E
E
I
E
-
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
----
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
42.47
33%
-77
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[14-219]
---------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----
F
I
K
K
R
--
Q
S
R
A
--
S
R
R
G
V
S
R
E
E
I
E
-
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
----
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
42.41
33%
-77
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[14-219]
---------------
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----
F
I
K
K
R
--
Q
S
R
A
--
S
R
RGVSR
E
E
I
E
-
R
E
V
S
I
L
R
Q
V
L
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
----
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
E
S
---
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-
D
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
37.99
33%
-88
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[20-218]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
-----
C
I
A
K
---------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
-----
Y
L
I
M
Q
L
V
S
G
G
E
L
---
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
SL
D
E
D
S
K
I
M
---
I
S
D
F
G
--------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
37.14
33%
-91
- C1 -
2JC6
1
KCC1D_HUMAN
C:
[24-222]
---------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
------
C
I
P
K
--
K
A
-------------
S
I
E
N
E
I
A
V
L
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
-----
Y
L
V
M
Q
L
V
S
G
G
E
L
---
F
D
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
-
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YS
Q
--
D
E
E
S
K
I
M
---
I
S
---------------------
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
37.07
33%
-93
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[20-218]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
-----
C
I
A
K
E
--------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
-----
Y
L
I
M
Q
L
V
S
G
G
E
L
---
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
SL
D
E
D
S
K
I
M
---
I
S
D
F
------------------
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
36.73
33%
-77
- C1 -
4BDK
3
?
A:
[20-238]
-----------------
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
ISK----------
A
L
--
N
V
-----
E
T
----
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
------
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
---
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
--
S
Q
E
E
D
C
L
I
-
K
I
T
D
F
G
H
S
K
I
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
36.63
33%
-74
- C1 -
2WTD
4
CHK2_HUMAN
A:
[20-238]
-----------------
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K---------
P
A
L
--
N
V
-----
E
T
----
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
------
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
---
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
--
S
Q
E
E
D
C
L
I
-
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
36.61
33%
-91
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[20-218]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
-----
C
I
A
K
E
------------------
E
-
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
-----
Y
L
I
M
Q
L
V
S
G
G
E
L
---
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
SL
D
E
D
S
K
I
M
---
I
S
D
F
-------------------
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
36.50
33%
-66
- C1 -
2XM9
1
CHK2_HUMAN
A:
[20-238]
-----------------
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K---------
P
A
L
--
N
V
-----
E
T
----
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
------
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
---
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
--
S
Q
E
E
D
C
L
I
-
K
I
T
D
F
G
H
S
K
I
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
36.47
33%
-74
- C1 -
4BDF
2
?
A:
[20-238]
-----------------
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K--------------
N
V
-----
E
T
----
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
------
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
---
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
--
S
Q
E
E
D
C
L
I
-
K
I
T
D
F
G
H
S
K
I
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
36.22
33%
-76
- C1 -
4BDG
2
?
A:
[20-238]
-----------------
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K--------------
N
V
-----
E
T
----
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
------
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
---
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
--
S
Q
E
E
D
C
L
I
-
K
I
T
D
F
G
H
S
K
I
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
35.65
33%
-90
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[20-218]
---------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
-----
C
I
A
K
----------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
-----
Y
L
I
M
Q
L
V
S
G
G
E
L
---
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
-
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
--
Y
SL
D
E
D
S
K
I
M
---
I
S
D
F
-----------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
---
A
Q
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
35.02
33%
-71
- C1 -
2CN5
1
CHK2_HUMAN
A:
[20-238]
-----------------
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
KR-------------
N
V
-----
E
T
----
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
------
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
---
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
--
S
Q
E
E
D
C
L
I
-
K
I
T
D
F
G
H
S
K
I
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
34.96
33%
-70
- C1 -
2WTI
3
CHK2_HUMAN
A:
[20-238]
-----------------
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K---------
P
A
L
--
N
V
-----
E
T
----
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
------
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
---
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
--
S
Q
E
E
D
C
L
I
-
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
34.89
33%
-67
- C1 -
4A9T
4
CHK2_HUMAN
A:
[20-238]
-----------------
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K---------
P
A
L
--
N
V
-----
E
T
----
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
------
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
---
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
--
S
Q
E
E
D
C
L
I
-
K
I
T
D
F
G
H
S
K
I
L
G
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
34.33
33%
-73
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[20-238]
-----------------
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K---------
P
A
L
--
N
V
-----
E
T
----
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
------
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
---
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
--
S
Q
E
E
D
C
L
I
-
K
I
T
D
F
G
H
S
K
I
L
--
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
34.21
33%
-71
- C1 -
2CN8
1
CHK2_HUMAN
A:
[20-238]
-----------------
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K--------------
N
V
-----
E
T
----
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
------
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
---
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
--
S
--
S
Q
E
E
D
C
L
I
-
K
I
T
D
F
G
H
S
K
I
L
---
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
---
V
S
L
K
D
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
12.52
33%
27
- C1 -
3NYO
1
GRK6_HUMAN
B:
[194-431]
---------------------
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
-----
K
L
E
K
K
--
R
I
K
K
RK
G
E
-----
A
M
A
L
-
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
-----
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
-
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
--
D
--
D
H
G
----
H
I
R
I
S
D
L
G
L
A
V
H
V
P
-
E
G
Q
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
---
K
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
---------
K
K
I
K
R
E
E
------
V
E
R
L
V
K
E
V
PEEYSE
R
F
S
---
P
Q
A
R
S
L
C
S
QL
L
C
K
D
P
A
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------