@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : INSR_HUMAN: (2013-07-21 )
MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS
Atome Classification :
(73 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.....--------..910-........920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020...-...1030.....--.1040....-..1050........1060.......1070......1080.-.....1090----......-1100......1110......1120...---......-1130-..--......1140......1150......1160....---.-.1170---.......1180....-..1190......1200......1210......1220......1230......1240......1250......1260......1270......1280----......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFAL--------ERGC--RLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLL-RELGQGSFGMVY--EGNARDIIK-GEAE--TRVAVKTVN-ESASLRERIEFLNEASVMKGFTCH-HVVRLLGVV----SKGQPT-LVVMELMAHGDLKSYLRSLRP---EAE---NNPGRP-PP---TL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A-HDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTF----LEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS
12
PsiBlast_PDB
61.38
99%
-97
- C2 -
3EKK
1
A:
[4-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
A
E
---
N
N
P
G
R
P
-
P
P
---
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
-------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
----
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
-------------------------------------------------------------------------
17
PsiBlast_PDB
59.89
80%
-94
- C2 -
3I81
1
A:
[6-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
-
E
---
N
N
P
V
L
A
-
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
11
PsiBlast_PDB
59.37
99%
-91
- C2 -
1I44
1
A:
[9-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
E
V
S
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
A
E
---
N
N
P
G
R
P
-
P
P
---
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
-----------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
----
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
30
PsiBlast_CBE
59.29
79%
-91
- C2 -
3LW0
3
IGF1R_HUMAN
A:
[2-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----------------
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
27
PsiBlast_CBE
58.88
79%
-89
- C2 -
3LW0
3
D:
[2-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----------------
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
13
PsiBlast_PDB
58.76
99%
-92
- C2 -
3EKN
1
A:
[8-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
A
E
---
N
N
P
G
R
P
-
P
P
---
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
----
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
29
PsiBlast_CBE
58.75
79%
-90
- C2 -
3LW0
4
IGF1R_HUMAN
B:
[2-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----------------
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
24
PsiBlast_CBE
58.73
80%
-90
- C2 -
3NW7
1
A:
[8-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
M
E
---
N
N
P
V
L
A
-
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
28
PsiBlast_CBE
58.55
79%
-89
- C2 -
3LW0
4
IGF1R_HUMAN
C:
[2-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----------------
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
23
PsiBlast_CBE
58.55
100%
-87
- C2 -
3ETA
1
B:
[12-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
A
E
---
N
N
P
G
R
P
-
P
P
---
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
----
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
9
PsiBlast_PDB
58.40
100%
-87
- C2 -
3ETA
1
INSR_HUMAN
A:
[12-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
I
K
-
G
E
A
E
--
T
R
V
A
V
K
T
V
N
-
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
-
H
V
V
R
L
L
G
V
V
----
S
K
G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
A
E
---
N
N
P
G
R
P
-
P
P
---
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
----
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
19
PsiBlast_PDB
57.73
80%
-90
- C2 -
3NW5
1
A:
[6-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
M
E
---
N
N
P
V
L
A
-
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
20
PsiBlast_PDB
57.51
80%
-90
- C2 -
3NW6
1
A:
[7-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
M
E
---
N
N
P
V
L
A
-
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
15
PsiBlast_PDB
57.42
77%
-96
- C2 -
3LVP
2
IGF1R_HUMAN
A:
[39-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
M
E
-----
P
V
L
A
-
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
--------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
34
PsiBlast_CBE
56.48
80%
-91
- C2 -
3QQU
1
IGF1R_HUMAN
A:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-----------------
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-------------------------------------------------------------------------
18
PsiBlast_PDB
56.35
80%
-88
- C2 -
2OJ9
1
A:
[5-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
------------
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
31
PsiBlast_CBE
56.14
80%
-88
- C2 -
3QQU
1
D:
[4-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
M
--------
L
A
-
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-------------------------------------------------------------------------
33
PsiBlast_CBE
55.82
80%
-86
- C2 -
3QQU
1
IGF1R_HUMAN
B:
[3-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
------------------
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
25
PsiBlast_CBE
55.64
80%
-85
- C2 -
1JQH
1
IGF1R_HUMAN
B:
[6-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----------------
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
--------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
------------------------------------------------------------------------
32
PsiBlast_CBE
55.38
80%
-86
- C2 -
3QQU
1
IGF1R_HUMAN
C:
[4-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
E
V
A
R
E
K
I
T
M
S
-
R
E
L
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
V
K
-
D
E
P
E
--
T
R
V
A
I
K
T
V
N
-
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
-
H
V
V
R
L
L
G
V
V
----
S
Q
G
Q
P
T
-
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
---
E
M
-------
V
L
A
-
P
P
---
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
-
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
----
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-------------------------------------------------------------------------
127
HHSearch
53.11
43%
-80
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[33-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------
C
V
H
H
I
K
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
L
P
----
K
--
M
L
V
A
V
K
A
L
K
-
E
-
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
---
D
---------
P
G
-
P
L
---
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
-----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
----
K
D
V
H
A
R
L
Q
A
L
A
Q
---------------------------------------------------------------------------------------
61
PsiBlast_CBE
52.83
42%
-89
- C2 -
3V5Q
1
NTRK3_HUMAN
A:
[11-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
-
R
E
L
------
K
V
F
--
L
A
E
C
Y
N
L
S
P
-
T
K
D
K
--
M
L
V
A
V
K
A
L
---
P
-
T
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
G
D
G
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
----------------
E
L
---
G
L
--
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
A
N
L
L
----
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
-
D
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
E
C
I
T
Q
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
----
K
E
I
Y
K
I
L
--------------------------------------------------------------------------------------------
128
HHSearch
52.42
39%
-82
* C2 *
4I4E
1
A:
[9-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
-
R
C
I
G
E
G
Q
F
G
D
V
H
--
Q
G
I
Y
M
S
--
P
--
N
P
A
--
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
-
H
I
V
K
L
I
G
V
I
----
T
E
N
-
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
----------------
S
L
---
D
L
--
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
-
S
N
D
C
----
V
K
L
G
D
F
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
-----------------------------------------------------------------------------------------
49
PsiBlast_CBE
50.96
45%
-90
- C2 -
2XBA
1
A:
[13-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
-------
V
Y
--
E
G
Q
V
S
--------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
---
R
-------
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
-----------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
50
PsiBlast_CBE
50.84
45%
-84
- C2 -
2XB7
1
A:
[13-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
--------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
---
R
-------
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
---------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
46
PsiBlast_CBE
50.72
44%
-80
- C2 -
4DCE
1
ALK_HUMAN
A:
[16-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
---
G
E
V
Y
--
E
G
Q
V
S
------
P
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
---------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
45
PsiBlast_CBE
50.66
44%
-80
- C2 -
4DCE
1
B:
[17-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
S
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
----
E
V
Y
--
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
56
PsiBlast_CBE
50.56
44%
-85
- C2 -
4AT4
1
A:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
-
R
E
L
G
E
G
A
F
G
K
V
F
--
L
A
E
C
Y
N
L
C
-----
K
--
I
L
V
A
V
K
T
L
K
-
D
-
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
V
E
G
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---
D
A
V
L
--
M
A
---
P
-
P
T
---
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
E
N
L
L
----
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
-
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
----
K
G
I
H
T
L
L
Q
N
------------------------------------------------------------------------------------------
57
PsiBlast_CBE
50.48
44%
-84
- C2 -
4AT3
1
A:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
-
R
E
L
G
E
G
A
F
G
K
V
F
--
L
A
E
C
Y
N
L
C
-----
K
--
I
L
V
A
V
K
T
L
----
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
V
E
G
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---
D
A
V
L
--
M
A
--
N
P
-
P
T
---
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
E
N
L
L
----
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
-
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
----
K
G
I
H
T
L
L
Q
N
------------------------------------------------------------------------------------------
66
PsiBlast_CBE
50.28
40%
-91
- C2 -
1FGI
1
B:
[16-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
P
N
R
V
--
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------QL-
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
55
PsiBlast_CBE
50.25
44%
-83
- C2 -
4AT5
2
A:
[10-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
R
H
N
I
V
L
K
-
R
E
L
G
E
G
A
F
G
K
V
F
--
L
A
E
C
Y
N
L
------
K
--
I
L
V
A
V
K
T
L
K
-
D
-
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
-
H
I
V
K
F
Y
G
V
C
----
V
E
G
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---
D
A
V
L
--
M
A
E
G
N
P
-
P
T
---
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
E
N
L
L
----
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
-
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
----
K
G
I
H
T
L
L
Q
N
------------------------------------------------------------------------------------------
51
PsiBlast_CBE
49.87
44%
-77
- C2 -
4FNZ
1
A:
[10-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
---
G
E
V
Y
--
E
G
Q
V
S
G
------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
---
R
-------
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
59
PsiBlast_CBE
49.60
42%
-83
- C2 -
4AOJ
1
NTRK1_HUMAN
B:
[33-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
----------
H
I
K
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
L
P
----
K
--
M
L
V
A
V
K
A
L
K
-
E
-
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
---
D
-----------G
P
L
---
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
----
K
D
V
------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
49.51
43%
-84
- C2 -
4FNY
1
A:
[20-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
---
G
E
V
Y
--
E
G
Q
V
S
G
-------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
-----
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
-----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
58
PsiBlast_CBE
49.37
42%
-82
- C2 -
4AOJ
1
C:
[33-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
----------
H
I
K
R
R
D
I
V
L
K
-
W
E
L
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
L
P
--
Q
D
K
--
M
L
V
A
V
K
A
L
K
-
E
-
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
-
H
I
V
R
F
F
G
V
C
----
T
E
G
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
---
D
-----------G
P
L
---
G
L
--
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
-
Q
G
L
V
----
V
K
I
G
D
F
G
M
-----------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
----
K
D
V
------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
48.94
39%
-82
- C2 -
3C4F
1
B:
[8-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
D
K
-
D
K
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P----------------
E
EQL
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
-
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
73
PsiBlast_CBE
48.66
39%
-88
- C2 -
4F65
6
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
D
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P---------------
P
E
E
Q
L
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
-----------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
72
PsiBlast_CBE
48.65
39%
-87
- C2 -
4F65
4
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
D
----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
------------------QL-
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
-------
H
I
-
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
96
PsiBlast_CBE
48.35
40%
-93
- C2 -
4FEQ
1
A:
[22-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
F
T
L
G
-
R
M
L
G
K
---
G
S
V
R
--
E
A
Q
L
K
-----
D
G
S
F
--
V
K
V
A
V
K
M
L
------------
F
L
R
E
A
A
C
M
K
E
F
D
H
P
-
H
V
A
K
L
V
G
V
S
----------P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
-----
I
-----------
P
-----
L
--
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
---
A
-
E
D
M
T
----
V
C
V
A
D
F
G
---------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
--------------------------------------------------------------------------------------------
62
PsiBlast_CBE
48.34
39%
-85
- C2 -
3RHX
2
B:
[12-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------QL-
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
36
PsiBlast_CBE
48.17
43%
-81
- C2 -
4ANS
1
A:
[24-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
--
A
F
G
E
V
Y
--
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
---
R
-------
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
85
PsiBlast_CBE
48.11
39%
-79
- C2 -
3GQL
1
FGFR1_HUMAN
B:
[23-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
D
K
-
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P---------------
P
E
EQL
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
-----------------------------------------------------------------------------------------------
75
PsiBlast_CBE
47.82
39%
-87
- C2 -
4F64
3
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
--
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P----------------
E
EQL
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
-
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
37
PsiBlast_CBE
47.74
44%
-80
- C2 -
2YFX
1
A:
[9-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
--
A
F
G
E
V
Y
--
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
87
PsiBlast_CBE
47.59
41%
-88
- C2 -
3TCP
1
B:
[31-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
-
K
I
L
G
E
---
G
S
V
M
--
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
--------------
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
---
R
L
E
---
T
G
P
K
H
I
-
P
-----
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
--------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
-----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------
48
PsiBlast_CBE
47.56
44%
-78
- C2 -
4FOB
1
A:
[36-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
S
----
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
92
PsiBlast_CBE
47.50
41%
-87
- C2 -
3BPR
1
MERTK_HUMAN
A:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
-
K
I
L
G
E
G
E
F
G
S
V
M
--
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
I
EMS
S
-----P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
---
R
L
E
---
T
G
P
K
H
I
-
P
-----
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
-----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------
83
PsiBlast_CBE
47.45
39%
-84
- C2 -
3C4F
1
FGFR1_HUMAN
A:
[8-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
D
K
-
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P----------------
E
E
Q
L
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
-
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
40
PsiBlast_CBE
47.45
44%
-81
- C2 -
3AOX
5
A:
[26-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
----
G
E
V
Y
--
E
G
Q
V
S
--------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
47
PsiBlast_CBE
47.38
44%
-79
- C2 -
4FOC
1
A:
[36-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
38
PsiBlast_CBE
47.35
43%
-79
- C2 -
4ANQ
1
A:
[24-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
--
A
F
G
E
V
Y
--
E
G
Q
V
---------
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
---
R
-------
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
35
PsiBlast_CBE
47.22
49%
-80
- C2 -
3ZBF
1
?
A:
[32-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
L
T
L
R
-
L
L
L
G
S
---
G
E
V
Y
--
E
G
T
A
V
D
I
L
G
V
G
S
G
E
--
I
K
V
A
V
K
T
L
K
-
K
G
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
N
H
P
-
N
I
L
K
Q
L
G
V
C
----
L
L
N
E
P
Q
-
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
M
---
A
T
F
---
Y
G
P
L
L
-------
T
L
--
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
V
K
D
Y
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
-------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
----
H
R
I
Q
D
Q
L
Q
-------------------------------------------------------------------------------------------
77
PsiBlast_CBE
47.14
39%
-88
- C2 -
4F63
3
FGFR1_HUMAN
A:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
-----
G
Q
V
V
--
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P----------------
E
EQL
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
-
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
94
PsiBlast_CBE
46.98
41%
-90
- C2 -
2P0C
2
MERTK_HUMAN
A:
[31-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
-
K
I
L
G
--
E
F
G
S
V
M
--
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
-------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
---
R
L
E
---
T
G
P
K
H
I
-
P
-----
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
-----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------
44
PsiBlast_CBE
46.90
44%
-79
- C2 -
4FOD
2
A:
[16-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
S
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
-------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
105
PsiBlast_CBE
46.89
39%
-83
- C2 -
3RI1
1
?
A:
[18-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
--
M
A
E
A
V
G
I
D
K
-
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P-----------------EQM
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
-
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
74
PsiBlast_CBE
46.84
39%
-85
- C2 -
4F64
3
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
-----
P
N
RV
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------QL-
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
88
PsiBlast_CBE
46.81
41%
-88
- C2 -
3TCP
1
MERTK_HUMAN
A:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
-
K
I
L
G
-----
S
V
M
--
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
I
E------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
---
R
L
E
---
T
G
P
K
H
I
-
P
-----
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
-----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------
81
PsiBlast_CBE
46.74
40%
-76
- C2 -
3JS2
1
FGFR1_HUMAN
A:
[23-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
-
P
N
R
V
--
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGL----------
H
N
-
P
E
E
Q
L
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
-
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
84
PsiBlast_CBE
46.69
39%
-85
- C2 -
3GQL
1
C:
[23-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
D
K
-
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P-----------------EQL
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
-----------------------------------------------------------------------------------------------
130
HHSearch
46.53
34%
-82
- C2 -
4FYO
1
A:
[11-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
--
K
G
Y
Y
Q
M
----
K
K
V
V
--
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
-
Y
I
V
R
M
I
G
I
C
----
E
-
A
E
S
W
-
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
R
H
-----------------
V
---
K
D
--
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
---
V
-
T
Q
H
Y
----
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----
A
A
V
E
L
R
L
R
N
Y
-----------------------------------------------------------------------------------------
93
PsiBlast_CBE
46.27
41%
-88
- C2 -
2P0C
1
B:
[31-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
-
K
I
L
G
E
---
G
S
V
M
--
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
-------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
---
R
L
E
---
T
G
P
K
H
I
-
P
-----
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
-----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------
89
PsiBlast_CBE
46.19
41%
-85
- C2 -
3BRB
2
B:
[31-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
I
L
G
-
K
I
L
G
E
G
E
F
G
S
V
M
--
E
G
N
L
K
Q
--
E
-
D
G
T
S
--
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
-
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
---
R
L
E
---
T
G
P
K
H
I
-
P
-----
L
--
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
-----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
----------------------------------------------------------------------------------
76
PsiBlast_CBE
46.16
39%
-84
- C2 -
4F63
3
B:
[15-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
-
G
Q
V
V
--
L
A
E
A
I
G
L
-----
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------QL-
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
134
HHSearch
46.06
35%
-78
- C2 -
1QCF
1
HCK_HUMAN
A:
[73-442]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
APGNM
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
---
D
T
V
K
H
Y
K
I
R
T
L
D
---
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
------
H
Y
K
K
-
G
N
D
G
L
C
Q
K
L
S
---
V
P
C
M
S
S
K
----
P
Q
K
P
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
-
K
K
L
G
A
G
Q
F
G
E
V
W
--
M
A
T
Y
N
K
-------
H
--
T
K
V
A
V
K
T
M
K
-
P
G
S
M
S
--
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
-
K
L
V
K
L
H
A
V
V
----
T
-
K
E
P
I
-
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
-
K
Q
---
P
L
--
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
---
S
-
A
S
L
V
----
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
R
E
G
A
-
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
----
E
Y
I
Q
S
V
L
D
D
F
Y
T
---------------------------------------------------------------------------------------
86
PsiBlast_CBE
45.85
39%
-75
- C2 -
3GQL
1
FGFR1_HUMAN
A:
[23-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
D
K
-
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P-----------------EQL
S
S
--
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
-------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
-----------------------------------------------------------------------------------------------
43
PsiBlast_CBE
45.14
44%
-75
- C2 -
3LCS
3
A:
[30-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
G
M
P
N
-
D
P
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
41
PsiBlast_CBE
45.06
44%
-75
- C2 -
3L9P
4
A:
[50-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
G
------
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
99
PsiBlast_CBE
44.48
39%
-80
- C2 -
2IVS
5
RET_HUMAN
A:
[17-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
K
N
L
V
L
G
-
K
T
L
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
K
G
-
R
A
G
Y
--
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
H
P
-
H
V
I
K
L
Y
G
A
C
----
S
Q
D
G
P
L
-
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
---
V
G
P
GYL-----
R
-
A
L
---
T
M
--
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
-
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
-
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
44.40
39%
-81
- C2 -
3RI1
1
FGFR2_HUMAN
B:
[18-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
C
F
G
Q
V
V
--
M
A
E
A
V
G
I
D
----
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P-----------------EQM
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
-
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
98
PsiBlast_CBE
44.30
39%
-78
- C2 -
2PWL
1
FGFR2_HUMAN
A:
[29-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
D
K
-
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------------------EQM
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
-
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
97
PsiBlast_CBE
43.99
39%
-78
- C2 -
2PWL
1
FGFR2_HUMAN
B:
[29-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
D
K
L
T
L
G
-
K
P
L
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
D
K
-
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
----
T
Q
D
G
P
L
-
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
PG----------------EQM
T
F
--
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
-
E
N
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
-
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
--------------------------------------------------------------------------------------------
42
PsiBlast_CBE
43.98
44%
-73
- C2 -
3LCT
3
A:
[27-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
N
Y
C
F
A
G
K
----
T
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
-
R
G
L
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
G
M
P
N
-
D
P
S
P
--
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
-
N
I
V
R
C
I
G
V
S
----
L
Q
S
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
----------
R
P
S
Q
P
-
S
S
L--
A
M
--
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
-
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
-------------------------------------------------------------------------------------------
Add PDB User Result:
(38 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS
139
-
100%
-90
- C2 -
U139
1
D:
[1013-1309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
-----
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
-------------------------------------------------------------------------
140
-
100%
-86
- C2 -
U140
1
A:
[999-1291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
A
S
D
----
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
141
-
100%
-87
- C2 -
U141
1
B:
[1017-1310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
142
-
100%
-86
- C2 -
U142
1
A:
[999-1291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
A
S
D
----
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
143
-
100%
-92
- C2 -
U143
1
A:
[1011-1310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
144
-
100%
-101
- C2 -
U144
1
B:
[1016-1290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
----
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
------------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
------
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
--------------------------------------------------------------------------------------------
145
-
100%
-91
- C2 -
U145
1
A:
[1009-1310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
146
-
100%
-92
- C2 -
U146
1
A:
[1011-1310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
147
-
100%
-92
- C2 -
U147
1
B:
[997-1291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Y
L
S
A
S
D
----
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
----
M
V
Y
E
G
N
A
R
------
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
---------------
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
148
-
100%
-87
- C2 -
U148
1
B:
[1017-1310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
149
-
100%
-92
- C2 -
U149
1
B:
[997-1291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Y
L
S
A
S
D
----
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
----
M
V
Y
E
G
N
A
R
------
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
---------------
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
150
-
100%
-90
- C2 -
U150
1
D:
[1013-1309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
-----
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
-------------------------------------------------------------------------
151
-
100%
-92
- C2 -
U151
1
A:
[1011-1310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
152
-
99%
-88
- C2 -
U152
1
A:
[996-1291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
Y
L
S
A
S
D
----
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
---
M
V
Y
E
G
N
A
R
-----
D
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
---------------
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
153
-
100%
-92
- C2 -
U153
1
B:
[997-1291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Y
L
S
A
S
D
----
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
----
M
V
Y
E
G
N
A
R
------
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
---------------
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
154
-
99%
-88
- C2 -
U154
1
A:
[996-1291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
Y
L
S
A
S
D
----
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
---
M
V
Y
E
G
N
A
R
-----
D
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
---------------
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
155
-
100%
-92
- C2 -
U155
1
A:
[1011-1310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
156
-
100%
-92
- C2 -
U156
1
A:
[1011-1310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
157
-
100%
-92
- C2 -
U157
1
B:
[997-1291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Y
L
S
A
S
D
----
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
----
M
V
Y
E
G
N
A
R
------
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
---------------
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
158
-
100%
-92
- C2 -
U158
1
B:
[997-1291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Y
L
S
A
S
D
----
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
----
M
V
Y
E
G
N
A
R
------
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
---------------
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
159
-
100%
-92
- C2 -
U159
1
A:
[1018-1292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
----
E
T
R
V
A
V
K
T
V
N
E
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
---
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
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D
F
T
V
K
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D
F
G
M
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D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
------------------------------------------------------------------------------------------
160
-
100%
-101
- C2 -
U160
1
B:
[1016-1290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
----
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
------------
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
------
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
--------------------------------------------------------------------------------------------
161
-
100%
-92
- C2 -
U161
1
A:
[1018-1292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
----
E
T
R
V
A
V
K
T
V
N
E
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
---
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
------------------------------------------------------------------------------------------
162
-
100%
-97
- C2 -
U162
1
A:
[1007-1309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
C
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
-------------------------------------------------------------------------
163
-
100%
-92
- C2 -
U163
1
A:
[1018-1292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
----
E
T
R
V
A
V
K
T
V
N
E
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
---
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
------------------------------------------------------------------------------------------
164
-
100%
-92
- C2 -
U164
1
A:
[1018-1292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
----
E
T
R
V
A
V
K
T
V
N
E
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
---
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
------------------------------------------------------------------------------------------
165
-
99%
-96
- C2 -
U165
1
A:
[1010-1291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
---
M
V
Y
E
G
N
A
R
D
------
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
N
--------
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
----------------
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
166
-
100%
-92
- C2 -
U166
1
B:
[997-1291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Y
L
S
A
S
D
----
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
----
M
V
Y
E
G
N
A
R
------
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
----
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
---------------
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------
167
-
100%
-92
- C2 -
U167
1
A:
[1018-1292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
----
E
T
R
V
A
V
K
T
V
N
E
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
---
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
------------------------------------------------------------------------------------------
168
-
100%
-97
- C2 -
U168
1
A:
[1013-1310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
--
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-------
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
169
-
99%
-98
- C2 -
U169
1
A:
[1017-1290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
------
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
---
S
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
---------
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
--
D
I
Y
E
T
D
Y
Y
R
----
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
--------------------------------------------------------------------------------------------
170
-
100%
-97
- C2 -
U170
1
A:
[1007-1309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
C
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
-------------------------------------------------------------------------
171
-
100%
-92
- C2 -
U171
1
A:
[1018-1292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
----
E
T
R
V
A
V
K
T
V
N
E
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
---
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
------------------------------------------------------------------------------------------
172
-
100%
-92
- C2 -
U172
1
A:
[1011-1310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
173
-
100%
-95
- C2 -
U173
1
A:
[1009-1310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
E
N
N
P
G
R
P
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
------------------------------------------------------------------------
174
-
100%
-92
- C2 -
U174
1
A:
[1018-1292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
----
E
T
R
V
A
V
K
T
V
N
E
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
---
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
------------------------------------------------------------------------------------------
175
-
100%
-91
- C2 -
U175
1
B:
[1015-1290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
-----------
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
--------------------------------------------------------------------------------------------
176
-
99%
-96
- C2 -
U176
1
A:
[1010-1291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
W
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
---
M
V
Y
E
G
N
A
R
D
------
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
N
--------
P
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
----------------
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-------------------------------------------------------------------------------------------