@TOME V2.3
(Nov 2016)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : INSR_HUMAN: (2013-07-21 )
MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS

Atome Classification :

(73 SA) .........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.....--------..910-........920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020...-...1030.....--.1040....-..1050........1060.......1070......1080.-.....1090----......-1100......1110......1120...---......-1130-..--......1140......1150......1160....---.-.1170---.......1180....-..1190......1200......1210......1220......1230......1240......1250......1260......1270......1280----......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380
(Atome) (Ident) (Tito) (Num) (Ligand) (Uniprot) MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFAL--------ERGC--RLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLL-RELGQGSFGMVY--EGNARDIIK-GEAE--TRVAVKTVN-ESASLRERIEFLNEASVMKGFTCH-HVVRLLGVV----SKGQPT-LVVMELMAHGDLKSYLRSLRP---EAE---NNPGRP-PP---TL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A-HDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTF----LEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS
12 PsiBlast_PDB 61.3899% -97 - C2 -3EKK A:[4-306] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSSVYVPDEWEVSREKITLL-RELGQGSFGMVY--EGNARDIIK-GEAE--TRVAVKTVN-ESASLRERIEFLNEASVMKGFTCH-HVVRLLGVV----SKGQPT-LVVMELMAHGDLKSYLRSLRP---EAE---NNPGRP-PP---TL--QEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMV---A-HDFT----VKIGDF-------------------LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTF----LEIVNLLKDDLHPSFPEVSFFHSEEN-------------------------------------------------------------------------
17 PsiBlast_PDB 59.8980% -94 - C2 -3I81 A:[6-307] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYVPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP---E-E---NNPVLA-PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYR-----LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
11 PsiBlast_PDB 59.3799% -91 - C2 -1I44 A:[9-306] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEWEVSREKITLL-RELGQGSFGMVY--EGNARDIIK-GEAE--TRVAVKTVN-ESASLRERIEFLNEASVMKGFTCH-HVVRLLGVV----SKGQPT-LVVMELMAHGDLKSYLRSLRP---EAE---NNPGRP-PP---TL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A-HDFT----VKIGDFGMT-----------------LPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTF----LEIVNLLKDDLHPSFPEVSFFHSEENK------------------------------------------------------------------------
30 PsiBlast_CBE 59.2979% -91 - C2 -3LW0 IGF1R_HUMAN A:[2-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
27 PsiBlast_CBE 58.8879% -89 - C2 -3LW0 D:[2-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
13 PsiBlast_PDB 58.7699% -92 - C2 -3EKN A:[8-307] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVPDEWEVSREKITLL-RELGQGSFGMVY--EGNARDIIK-GEAE--TRVAVKTVN-ESASLRERIEFLNEASVMKGFTCH-HVVRLLGVV----SKGQPT-LVVMELMAHGDLKSYLRSLRP---EAE---NNPGRP-PP---TL--QEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMV---A-HDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTF----LEIVNLLKDDLHPSFPEVSFFHSEENK------------------------------------------------------------------------
29 PsiBlast_CBE 58.7579% -90 - C2 -3LW0 IGF1R_HUMAN B:[2-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
24 PsiBlast_CBE 58.7380% -90 - C2 -3NW7 A:[8-307] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YVPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP---EME---NNPVLA-PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
28 PsiBlast_CBE 58.5579% -89 - C2 -3LW0 IGF1R_HUMAN C:[2-304] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKG---LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
23 PsiBlast_CBE 58.55100% -87 - C2 -3ETA B:[12-305] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLL-RELGQGSFGMVY--EGNARDIIK-GEAE--TRVAVKTVN-ESASLRERIEFLNEASVMKGFTCH-HVVRLLGVV----SKGQPT-LVVMELMAHGDLKSYLRSLRP---EAE---NNPGRP-PP---TL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A-HDFT----VKIGDFGMTRDIYET-DYYRK--KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTF----LEIVNLLKDDLHPSFPEVSFFHSEENK------------------------------------------------------------------------
9 PsiBlast_PDB 58.40100% -87 - C2 -3ETA INSR_HUMAN A:[12-305] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVSREKITLL-RELGQGSFGMVY--EGNARDIIK-GEAE--TRVAVKTVN-ESASLRERIEFLNEASVMKGFTCH-HVVRLLGVV----SKGQPT-LVVMELMAHGDLKSYLRSLRP---EAE---NNPGRP-PP---TL--QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMV---A-HDFT----VKIGDFGMTRDIYET-DYYRKG-KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTF----LEIVNLLKDDLHPSFPEVSFFHSEENK------------------------------------------------------------------------
19 PsiBlast_PDB 57.7380% -90 - C2 -3NW5 A:[6-307] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYVPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP---EME---NNPVLA-PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
20 PsiBlast_PDB 57.5180% -90 - C2 -3NW6 A:[7-307] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYVPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP---EME---NNPVLA-PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
15 PsiBlast_PDB 57.4277% -96 - C2 -3LVP IGF1R_HUMAN A:[39-336] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP---EME-----PVLA-PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIY--------GGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
34 PsiBlast_CBE 56.4880% -91 - C2 -3QQU IGF1R_HUMAN A:[6-300] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLR-----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEEN-------------------------------------------------------------------------
18 PsiBlast_PDB 56.3580% -88 - C2 -2OJ9 A:[5-307] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP---E------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
31 PsiBlast_CBE 56.1480% -88 - C2 -3QQU D:[4-300] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP---EM--------LA-PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEEN-------------------------------------------------------------------------
33 PsiBlast_CBE 55.8280% -86 - C2 -3QQU IGF1R_HUMAN B:[3-301] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLR------------------P---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
25 PsiBlast_CBE 55.6480% -85 - C2 -1JQH IGF1R_HUMAN B:[6-308] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADVYVPDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP----------------PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMT--------YYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEENK------------------------------------------------------------------------
32 PsiBlast_CBE 55.3880% -86 - C2 -3QQU IGF1R_HUMAN C:[4-300] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDEWEVAREKITMS-RELGQGSFGMVY--EGVAKGVVK-DEPE--TRVAIKTVN-EAASMRERIEFLNEASVMKEFNCH-HVVRLLGVV----SQGQPT-LVIMELMTRGDLKSYLRSLRP---EM-------VLA-PP---SL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMV---A-EDFT----VKIGDFGMTRDIYET-DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF----LEIISSIKEEMEPGFREVSFYYSEEN-------------------------------------------------------------------------
127 HHSearch 53.1143% -80 - C2 -4AOJ NTRK1_HUMAN A:[33-319] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A----------CVHHIKRRDIVLK-WELGEGAFGKVF--LAECHNLLP----K--MLVAVKALK-E-ASESARQDFQREAELLTMLQHQ-HIVRFFGVC----TEGRPL-LMVFEYMRHGDLNRFLRSHGP---D---------PG-PL---GL--GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---G-QGLV----VKIGDFG-----------------TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI----KDVHARLQALAQ---------------------------------------------------------------------------------------
61 PsiBlast_CBE 52.8342% -89 - C2 -3V5Q NTRK3_HUMAN A:[11-289] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIKRRDIVLK-REL------KVF--LAECYNLSP-TKDK--MLVAVKAL---P-TLAARKDFQREAELLTNLQHE-HIVKFYGVC----GDGDPL-IMVFEYMKHGDLNKFLRAHGP----------------EL---GL--SQMLHIASQIASGMVYLASQHFVHRDLATRNCLV---G-ANLL----VKIGDFGM--DVYST-DYYR----TMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNI----KEIYKIL--------------------------------------------------------------------------------------------
128 HHSearch 52.4239% -82 * C2 *4I4E A:[9-274] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYEIQRERIELG-RCIGEGQFGDVH--QGIYMS--P--NPA--LAVAIKTCK-NCTSDSVREKFLQEALTMRQFDHP-HIVKLIGVI----TEN-PV-WIIMELCTLGELRSFLQVRKY----------------SL---DL--ASLILYAYQLSTALAYLESKRFVHRDIAARNVLV---S-SNDC----VKLGDF--------------------LPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRF----TELKAQLSTI-----------------------------------------------------------------------------------------
49 PsiBlast_CBE 50.9645% -90 - C2 -2XBA A:[13-292] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISDLKEVPRKNITLI-RGL-------VY--EGQVS--------P--LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVS----LQSLPR-FILLELMAGGDLKSFLRETRP---R-------PSQP-SSL--AM--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDFGMARDIY-----------AMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF----AIILERIE-------------------------------------------------------------------------------------------
50 PsiBlast_CBE 50.8445% -84 - C2 -2XB7 A:[13-292] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ISDLKEVPRKNITLI-RGLGHGAFGEVY--EGQVS--------P--LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVS----LQSLPR-FILLELMAGGDLKSFLRETRP---R-------PSQP-SSL--AM--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDFGMA---------------AMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF----AIILERIE-------------------------------------------------------------------------------------------
46 PsiBlast_CBE 50.7244% -80 - C2 -4DCE ALK_HUMAN A:[16-307] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGK----TSSISDLKEVPRKNITLI-RGLGH---GEVY--EGQVS------PSP--LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVS----LQSLPR-FILLELMAGGDLKSFLRETRP----------RPSQP-SSL--AM--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDF---------------GGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF----AIILERIE-------------------------------------------------------------------------------------------
45 PsiBlast_CBE 50.6644% -80 - C2 -4DCE B:[17-307] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNYSFAGK----TSSISDLKEVPRKNITLI-RGLGH----EVY--EGQVS-------SP--LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVS----LQSLPR-FILLELMAGGDLKSFLRETRP----------RPSQP-SSL--AM--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDF----------------GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF----AIILERIE-------------------------------------------------------------------------------------------
56 PsiBlast_CBE 50.5644% -85 - C2 -4AT4 A:[10-286] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKRHNIVLK-RELGEGAFGKVF--LAECYNLC-----K--ILVAVKTLK-D-ASDNARKDFHREAELLTNLQHE-HIVKFYGVC----VEGDPL-IMVFEYMKHGDLNKFLRAHGP---DAVL--MA---P-PT---ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---G-ENLL----VKIGDFGMSRDVYST-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNI----KGIHTLLQN------------------------------------------------------------------------------------------
57 PsiBlast_CBE 50.4844% -84 - C2 -4AT3 A:[10-286] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKRHNIVLK-RELGEGAFGKVF--LAECYNLC-----K--ILVAVKTL----ASDNARKDFHREAELLTNLQHE-HIVKFYGVC----VEGDPL-IMVFEYMKHGDLNKFLRAHGP---DAVL--MA--NP-PT---ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---G-ENLL----VKIGDFGMSR--YST-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNI----KGIHTLLQN------------------------------------------------------------------------------------------
66 PsiBlast_CBE 50.2840% -91 - C2 -1FGI B:[16-299] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVVLAEAIGL-----PNRV--TKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGAC----TQDGPL-YVIVEYASKGNLREYLQARR-------------------QL-SS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLA-------DYYKK---GRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF----KQLVEDL--------------------------------------------------------------------------------------------
55 PsiBlast_CBE 50.2544% -83 - C2 -4AT5 A:[10-286] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKRHNIVLK-RELGEGAFGKVF--LAECYNL------K--ILVAVKTLK-D-ASDNARKDFHREAELLTNLQHE-HIVKFYGVC----VEGDPL-IMVFEYMKHGDLNKFLRAHGP---DAVL--MAEGNP-PT---ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---G-ENLL----VKIGDFGMSRDVYST-DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNI----KGIHTLLQN------------------------------------------------------------------------------------------
51 PsiBlast_CBE 49.8744% -77 - C2 -4FNZ A:[10-301] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYSFAGK----TSSISDLKEVPRKNITLI-RGLGH---GEVY--EGQVSG------SP--LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVS----LQSLPR-FILLELMAGGDLKSFLRETRP---R-------PSQP-SSL--AM--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDF----------------GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF----AIILERIE-------------------------------------------------------------------------------------------
59 PsiBlast_CBE 49.6042% -83 - C2 -4AOJ NTRK1_HUMAN B:[33-310] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH----------HIKRRDIVLK-WELGEGAFGKVF--LAECHNLLP----K--MLVAVKALK-E-ASESARQDFQREAELLTMLQHQ-HIVRFFGVC----TEGRPL-LMVFEYMRHGDLNRFLRSHGP---D-----------GPL---GL--GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---G-QGLV----VKIGDF--------------------LPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI----KDV------------------------------------------------------------------------------------------------
52 PsiBlast_CBE 49.5143% -84 - C2 -4FNY A:[20-301] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSISDLKEVPRKNITLI-RGLGH---GEVY--EGQVSG-------P--LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVS----LQSLPR-FILLELMAGGDLKSFLRETRP----------RP-----SL--AM--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIGDF-----------------CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF----AIILERIE-------------------------------------------------------------------------------------------
58 PsiBlast_CBE 49.3742% -82 - C2 -4AOJ C:[33-310] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ACVH----------HIKRRDIVLK-WELGEGAFGKVF--LAECHNLLP--QDK--MLVAVKALK-E-ASESARQDFQREAELLTMLQHQ-HIVRFFGVC----TEGRPL-LMVFEYMRHGDLNRFLRSHGP---D-----------GPL---GL--GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---G-QGLV----VKIGDFGM-----------------MLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSI----KDV------------------------------------------------------------------------------------------------
82 PsiBlast_CBE 48.9439% -82 - C2 -3C4F B:[8-291] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVV--LAEAIGLDK-DKPNRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGAC----TQDGPL-YVIVEYASKGNLREYLQARRPP----------------EEQLSS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLARDIHHI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF----KQLVEDL--------------------------------------------------------------------------------------------
73 PsiBlast_CBE 48.6639% -88 - C2 -4F65 FGFR1_HUMAN A:[15-298] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVV--LAEAIGLDK---PNRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGAC----TQDGPL-YVIVEYASKGNLREYLQARRPP---------------PEEQLSS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADF-----------YYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF----KQLVEDL--------------------------------------------------------------------------------------------
72 PsiBlast_CBE 48.6539% -87 - C2 -4F65 B:[15-298] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVV--LAEAIGLD----PNRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGAC----TQDGPL-YVIVEYASKGNLREYLQARRP------------------QL-SS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADF-------HI-DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF----KQLVEDL--------------------------------------------------------------------------------------------
96 PsiBlast_CBE 48.3540% -93 - C2 -4FEQ A:[22-297] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EQQFTLG-RMLGK---GSVR--EAQLK-----DGSF--VKVAVKML------------FLREAACMKEFDHP-HVAKLVGVS----------PMVILPFMKHGDLHAFLLASR-----I-----------P-----L--QTLVRFMVDIACGMEYLSSRNFIHRDLAARNCML---A-EDMT----VCVADFG---------------------VKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENIL--------------------------------------------------------------------------------------------
62 PsiBlast_CBE 48.3439% -85 - C2 -3RHX B:[12-295] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVV--LAEAIGL-----PNRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGAC----TQDGPL-YVIVEYASKGNLREYLQARR-------------------QL-SS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLA-------DYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF----KQLVEDL--------------------------------------------------------------------------------------------
36 PsiBlast_CBE 48.1743% -81 - C2 -4ANS A:[24-315] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPNYCFAGK----TSSISDLKEVPRKNITLI-RGLG--AFGEVY--EGQV---------P--LQVAVKTLP-EVCSEQDELDFLMEALIISKFNHQ-NIVRCIGVS----LQSLPR-FILMELMAGGDLKSFLRETRP---R-------PSQP-SSL--AM--LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPG-PGRV----AKIADFGMARDIYR-------GGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF----AIILERIE-------------------------------------------------------------------------------------------
85 PsiBlast_CBE 48.1139% -79 - C2 -3GQL FGFR1_HUMAN B:[23-303] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WELPRDRLVLG-KPLGEGAFGQVV--LAEAIGLDK-DKPNRVTKVAVKMLK-SDATEKDLSDLISEMEMMKMIGKHKNIINLLGAC----TQDGPL-YVIVEYASKGNLREYLQARRPP---------------PEEQLSS--KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLV---T-EDNV----MKIADFGLAR-----------------PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTF----KQLV-----------------------------------------------------------------------------------------------