@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : IRAK1_HUMAN: (2013-07-21 )
MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
Atome Classification :
(43 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210...------....220.......230-.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330-.......340.......350.......360-..-.....370.......380.......390.....---..400-.........410.......420.....---..430.......440.......450.......460.......470.......480-.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEE------LKIGEGGFGCVYRAVMR-NTVYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQD-SPSLIHGDIKSSNVLLDERLTPKLGDFGLA-RF-SRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIK---TGR---LAVDTDTFSFGVVVLETLAGQRAVKTH---GARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRP-GPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
104
HHSearch
88.74
38%
-90
- C2 -
2NRU
1
IRAK4_HUMAN
A:
[12-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
S
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
-
N
T
T
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
---
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
-
S
E
K
F
A
Q
-------
T
V
M
T
S
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
----
G
E
---
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
---
R
E
-
P
Q
L
L
L
D
I
K
E
E
I
-
E
D
E
E
-------------------------
K
T
I
E
D
Y
I
D
K
K
M
-
N
D
A
D
S
T
S
V
E
A
M
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
85.23
36%
-89
- C2 -
3UIM
1
BAK1_ARATH
A:
[19-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
S
L
R
E
L
Q
V
A
S
D
N
F
S
N
K
------
N
I
L
G
R
G
G
F
G
K
V
Y
K
G
R
L
A
D
G
T
L
V
A
V
K
R
L
K
E
--------
G
E
L
Q
F
Q
T
E
V
E
M
I
S
M
A
V
H
R
N
L
L
R
L
R
G
F
C
M
T
P
T
E
R
L
L
V
Y
P
Y
M
A
N
G
S
V
A
S
C
L
R
E
R
P
E
S
Q
P
P
L
D
W
P
K
R
Q
R
I
A
L
G
S
A
R
G
L
A
Y
L
H
D
H
C
D
P
K
I
I
H
R
D
V
K
A
A
N
I
L
L
D
E
E
F
E
A
V
V
G
D
F
G
L
A
-
K
L
-
M
D
Y
K
D
--------
T
H
V
T
T
A
V
R
G
T
I
G
H
I
A
P
E
Y
L
S
---
T
G
K
---
S
S
E
K
T
D
V
F
G
Y
G
V
M
L
L
E
L
I
T
G
Q
R
A
F
D
L
A
RLA
N
D
D
D
V
M
L
L
D
W
V
K
G
L
L
K
E
K
---------------------------
K
L
E
A
L
V
D
V
D
L
Q
G
N
Y
K
D
E
E
V
E
Q
L
I
Q
V
A
L
L
C
T
Q
S
S
P
M
E
R
P
K
M
S
E
V
V
R
M
L
E
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.05
34%
-93
- C2 -
2OIC
1
IRAK4_HUMAN
A:
[9-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
-
N
T
T
V
A
V
K
K
-----------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
-----
A
------
T
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
----
G
E
---
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
-------------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
-
T
S
V
E
-----
A
M
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.92
34%
-92
- C2 -
2NRY
1
IRAK4_HUMAN
A:
[15-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
-
N
T
T
V
A
V
K
K
L
A
A
---
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
-
S
---------
T
V
M
T
S
R
---
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
----
G
E
---
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
-------------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
-
T
S
V
E
-----
A
M
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
63.59
33%
-55
- C2 -
2NRU
1
IRAK4_HUMAN
C:
[15-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
-
N
T
T
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
-----
A
S
E
K
F
A
Q
T
V
M
-----
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
----
G
E
---
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
-------------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
-
T
S
V
E
-----
A
M
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
63.21
33%
-53
- C2 -
2NRU
1
IRAK4_HUMAN
D:
[15-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
-
N
T
T
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
-----
A
S
E
K
F
A
Q
T
V
M
-----
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
----
G
E
---
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
-------------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
-
T
S
V
E
-----
A
M
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
63.02
33%
-54
- C2 -
2NRU
1
IRAK4_HUMAN
B:
[15-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
F
Y
E
L
K
N
V
T
N
N
F
D
E
R
PISVGG
N
K
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
-
N
T
T
V
A
V
K
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
-
L
D
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
-
H
H
--
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
-----
A
S
E
K
F
A
Q
T
V
M
-----
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
----
G
E
---
I
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
D
E
H
-------------------------
R
E
P
Q
L
L
L
D
I
K
E
E
I
E
D
E
E
K
T
I
E
D
Y
I
D
K
K
M
N
D
A
D
S
-
T
S
V
E
-----
A
M
Y
S
V
A
S
Q
C
L
H
E
K
K
N
K
R
P
D
I
K
K
V
Q
Q
L
L
Q
E
M
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
51.15
33%
-85
- C2 -
3PPZ
1
CTR1_ARATH
A:
[35-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
C
D
L
-----
N
I
K
E
--------
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
-
G
S
D
V
A
V
K
I
L
M
E
-----
A
E
R
V
N
E
-
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
-
K
S
G
A
R
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
-
N
P
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
G
L
S
-
R
L
----------
K
A
S
T
F
L
S
S
K
S
A
A
G
T
P
E
W
M
A
P
E
V
L
R
---
D
E
P
---
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
L
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
49.57
33%
-87
- C2 -
3P86
1
CTR1_ARATH
A:
[35-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
W
C
D
L
-----
N
I
K
E
--------
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
-
G
S
D
V
A
V
K
I
L
M
E
Q
-
D
F
H
A
E
R
V
N
E
-
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
-
K
S
G
A
R
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
-
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
----------------------------
G
T
P
E
W
M
A
P
E
V
L
R
---
D
E
P
---
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
44.17
32%
-82
- C2 -
3PPK
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
42.34
32%
-75
- C2 -
4FK3
1
BRAF_HUMAN
A:
[31-222]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
---
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
--------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M---
N
P
---
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
42.15
32%
-72
- C2 -
3PSB
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
42.14
32%
-77
- C2 -
4EHE
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
W
S
G
S
H
--------
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
41.71
32%
-75
- C2 -
3PPJ
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
41.58
32%
-75
- C2 -
3D4Q
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
--------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
41.52
32%
-76
- C2 -
3D4Q
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
--------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
41.48
32%
-76
- C2 -
3PPK
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
--------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
41.35
32%
-76
- C2 -
3TV4
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
W
S
G
S
H
--------
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
41.14
32%
-79
- C2 -
3PRF
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
41.06
32%
-75
- C2 -
3PPJ
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
--------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
40.48
32%
-73
- C2 -
3OG7
1
BRAF_HUMAN
A:
[31-222]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
A
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
------
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
---------------------------
G
S
I
L
W
M
A
P
E
V
I
R
----
N
P
---
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
40.36
32%
-71
- C2 -
3PRF
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
40.35
32%
-71
- C2 -
4E4X
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
W
S
G
S
H
--------
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
40.08
32%
-77
- C2 -
3TV6
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
W
S
----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
39.94
32%
-74
- C2 -
1UWH
1
BRAF_HUMAN
A:
[15-206]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
A
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
--------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
39.80
32%
-80
- C2 -
4E4X
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
W
S
---------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
39.70
32%
-72
- C2 -
3PSB
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
--------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
39.66
32%
-72
- C2 -
3TV6
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
W
S
G
S
H
--------
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
39.64
32%
-69
- C2 -
3IDP
1
BRAF_HUMAN
A:
[35-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T------------------------
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
-NP-
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
39.42
32%
-72
- C2 -
4EHG
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-------------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
39.16
32%
-68
- C2 -
3II5
1
B:
[42-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-------------------------
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
38.79
32%
-72
- C2 -
4EHG
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
-----------------------
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
38.77
32%
-70
- C2 -
3PRI
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
--------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
38.55
32%
-68
- C2 -
4JVG
1
?
C:
[23-214]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
---
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
--------------------------
S
I
L
W
M
A
P
E
V
I
R
MQD
S
N
P
---
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
38.40
32%
-71
- C2 -
3SKC
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
W
S
G
S
H
--------
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
38.32
32%
-70
- C2 -
4G9R
1
B:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
38.03
32%
-69
- C2 -
1UWJ
1
BRAF_HUMAN
A:
[15-206]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
-
S
--------------------
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
38.00
32%
-70
- C2 -
3PRI
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
--------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
37.41
32%
-75
- C2 -
4EHE
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
37.40
32%
-74
- C2 -
4JVG
1
?
A:
[23-214]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
---
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
---------------------
S
I
L
W
M
A
P
E
V
I
R
MQD
S
N
P
---
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
37.39
32%
-70
- C2 -
3IDP
1
B:
[35-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-------------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
36.73
32%
-64
- C2 -
3C4C
1
BRAF_HUMAN
A:
[19-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
---
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
--------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
S
N
P
---
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
36.71
32%
-73
- C2 -
3SKC
1
BRAF_HUMAN
A:
[43-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
-
G
D
V
-
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
--
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
-
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
---
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
---
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-------------------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
---
M
Q
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------